AUTORADIOGRAPHIC STUDY OF THE ATTRITION OF MIGRATING SCHISTOSOMULA IN THE SKIN OF MICE *** CHALLENGED WITH NORMAL *** CERCARIAE AFTER IMMUNIZATION WITH HIGHLY IRRADIATED CERCARIAE

作     者：S.Y.Li Hsu H.F.Hsu J.W.Osborne W.R.Clarke C.K.Hawk Y.Ohnishi 

作者机构：College of MedicineUniversity of IowaIowaUSA 

出 版 物：《Chinese Medical Sciences Journal》 (中国医学科学杂志（英文版）)

年 卷 期：1990年第8卷第1期

页      面：30-36页

核心收录：

学科分类：10[医学] 

基　　金：Supported by NIH 

主　　题：autoradiography attrition—challenge cercariae immunization—highly X-irradiated cercariae Schistosoma mansoni 

摘      要：The migratory pattern and attrition of75Se-labelled *** challenge cercariae in CF1mice immunized 0,1,3, or 5 times with 12kR-or 48kR-irradiated cercariae were investigatedby compressed organ *** were percutaneously inoculated with 500-1000 cer-cariae for each immunization and with a known count of approximately 90 cercariae at adifferent site for *** skin,lungs,liver,other organs,and catrcass were processedfor *** and mesenteric perfusions for worm collection were alsosampled from day 19 through *** naive tnice,25% of challenge cercariae died in *** attrition of challenge cercariae in mice immunized with 12kR-irradiated cercariaewas 43% with 1 immunization,54% with 3,and 58% with 5,whereas in mice immunized with48kR-irradiated cercariae,skin,attrition was48% with 1,63% with 3,and 76% with 5 *** all immunized mice,a high percentage of migrating sehistosomula died in the skinwithin 24 hours of a challenge *** autoradiography,it was found that thesilver foci created by single labelled worms were difficult to differentiate from those of *** study documents the induction of acquired resistance against a challenge infectionin the skin by vaccination with highly irradiated cercariae,with the degree of attemtation ofimmunizing cercariae and the number of immunizations being closely related to the *** in the ***,we discuss the contradictory views concerning the site of attritiotn ofchallenge cercariae.