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Highly compliant planar Hall effect sensor with sub 200 nT sensitivity

npj Flexible Electronics 2019年第1期3卷 25-30页

作者： Pablo Nicolás Granell Guoliang Wang Gilbert Santiago Cañon Bermudez Tobias Kosub Federico Golmar Laura Steren jürgen fassbender Denys Makarov Helmholtz-Zentrum Dresden-Rossendorf e.V. Institute of Ion Beam Physics and Materials ResearchBautzner Landstrasse 40001328 DresdenGermany Instituto Nacional de Tecnología Industrial(INTI) Centro de Micro-y Nanoelectrónica del Bicentenario(CMNB)Av.Gral Paz 5445B1650KNA San MartínBuenos AiresArgentina Escuela de Ciencia y Tecnología UNSAMCampus MigueleteB1650KNA San MartínBuenos AiresArgentina Consejo Nacional de Investigaciones Científicas y Técnicas C1425FQB Ciudad Autónoma de Buenos AiresArgentina Instituto de Nanociencia y Nanotecnología B1650KNA San MartínBuenos AiresArgentina Dpto.Materia Condensada Centro Atómico ConstituyentesB1650 San MartínBuenos AiresArgentina

Being a facet of flexible electronics,mechanically reshapeable magnetic field sensorics enable novel device ideas for soft robotics,interactive devices for virtual-and augmented reality and point of care *** applications demand mechanically compliant yet robust sensor devices revealing high sensitivity to small magnetic *** push the detection limit of highly compliant and linear magnetic field sensors to be in the sub-µT range,we explore a new fundamental concept for magnetic field sensing,namely the planar Hall effect in magnetic thin *** their remarkable bendability down to 1 mm,these compliant planar Hall effect sensors allow for an efficient detection of magnetic fields as small as 200 nT with a limit of detection of 20 *** demonstrate the application potential of these devices as a direction(angle)as well as proximity(distance)sensors of tiny magnetic fields emanating from magnetically functionalized *** their intrinsic linearity and simplicity of fabrication,these compliant planar Hall effect sensors have the potential to become a standard solution for low field applications of shapeable magnetoelectronics in point of care applications and on-skin interactive electronics.

关键词： interactive planar limit

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Treatment of Coats' disease: an analysis of pooled results

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International journal of Ophthalmology(English edition) 2019年第4期12卷 668-674页

作者： janelle fassbender Adeniran Sarah M Duff Michael Mimouni Nathan Lambert Aparna Ramasubramanian Department of Ophthalmology & Visual Sciences University of Louisville School of Medicine Rambam Hospital University of Utah

AIM: To elucidate the association of treatment modality to vitreoretinal fibrosis and traction retinal detachment(TRD) in Coats' ***: A PubMed search for Coats' disease with included studies describing eyes with clinical features and treatment course of Coats' disease. Binary logistic regression with fibrosis at presentation and treatment type as independent variables was performed to determine predictors of TRD historically(since 1921) and in the antivascular endothelial growth factor(VEGF) era(since2007). Odds ratios(OR) with 95% confidence intervals(CI)***: Of 175 articles described 1183 eyes. Vitreoretinal fibrosis increased from presentation(5.4%) to follow-up(15.5%) and TRD increased from 0.44% to 3.9% at follow up. Laser was protective against vitreoretinal fibrosis(OR0.6, 95%CI 0.4-0.9) but TRD was borderline(OR 0.6, 95%CI0.3-1.1). Cryotherapy showed a higher association with TRD(OR 1.9, 95%CI 1.0-3.7) than with vitreoretinal fibrosis(OR 0.8, 95%CI 0.5-1.2). Similarly, intravitreal anti-VEGF alone was not associated with fibrosis(OR 1.1, 95%CI 0.6-1.8) nor TRD(OR 1.1, 95%CI 0.5-2.6) but the combination of laser and anti-VEGF therapy was protective [Fibrosis: 0.1(0.03, 0.35); TRD: 0.05(0.01, 0.23)] compared to anti-VEGF plus cryotherapy(P<0.001). Disease stage ≤2 B or ≥3 A was not associated with ***: Vitreoretinal fibrosis and TRD increase after treatment in Coats' disease. The combination of antiVEGF agents and cryotherapy may lead to higher risk for TRD. Presence of pre-treatment fibrosis is the highest risk factor for post-treatment worsening of vitreoretinal fibrosis and TRD.

关键词： Coats’ disease cryotherapy anti-vascular endothelial growth factor traction retinal detachment vitreoretinal fibrosis

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选择性视网膜色素上皮光凝治疗中心性浆液性脉络膜视网膜病变

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上海医学 2006年第12期29卷 888-889,F0004页

作者：毕燕龙 Bernd fassbender C Framme 同济大学附属同济医院眼科上海200065 德国累根斯堡大学眼科医院

20世纪90年代初，国外提出了采用微脉冲激光进行选择性视网膜色素上皮细胞光凝（selective retinal pigment epithelium laser treatment，SRT）治疗黄斑部疾病的新概念。在最早开展这一项目的德国累根斯堡大学眼科医院中收集、整理了... 详细信息

20世纪90年代初，国外提出了采用微脉冲激光进行选择性视网膜色素上皮细胞光凝（selective retinal pigment epithelium laser treatment，SRT）治疗黄斑部疾病的新概念。在最早开展这一项目的德国累根斯堡大学眼科医院中收集、整理了一组采用SRT治疗中心性浆液性脉络膜视网膜病变（CSC）的病例，现报道如下。

关键词：视网膜色素上皮细胞脉络膜视网膜病变中心性浆液性光凝治疗黄斑部疾病脉冲激光眼科医院 SRT

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Relevance of long QT syndrome in clinical neurology

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World journal of Neurology 2013年第3期3卷 25-28页

作者： Marcus M Unger Klaus fassbender Department of Neurology Saarland University 66421 Homburg Germany

Long QT syndrome(LQTS) is a cardiac conduction disorder that predisposes patients at potentially fatal cardiac events. Inherited conditions and acquired factors contribute to LQTS. A number of frequently prescribed CNS-active drugs prolong the QT interval. The clinical neurologist may encounter LQTS when initiating a pharmacotherapy or when increasing the dosage of drugs. The clinical neurologist may also encounter LQTS during the diagnostic work-up of patients with unexplained loss of consciousness, because LQTS may present as convulsive syncope. Some studies report an association of LQTS and stroke. Awareness of LQTS may help to recognize and prevent potentially fatal cardiac events associated with LQTS. This concise article highlights the clinically most relevant aspects of LQTS in the field of neurology.

关键词： Cardiac conduction disorder Adverse drug effects Antipsychotics Antidepressants Torsades de pointes Syncope Seizure disorder Stroke

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Targets for high repetition rate laser facilities:needs,challenges and perspectives

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High Power Laser Science and Engineering 2017年第3期5卷 10-40页

作者： I.Prencipe j.Fuchs S.Pascarelli D.W.Schumacher R.B.Stephens N.B.Alexander R.Briggs M.Büscher M.O.Cernaianu A.Choukourov M.De Marco A.Erbe j.fassbender G.Fiquet P.Fitzsimmons C.Gheorghiu j.Hund L.G.Huang M.Harmand N.j.Hartley A.Irman T.Kluge Z.Konopkova S.Kraft D.Kraus V.Leca D.Margarone j.Metzkes K.Nagai W.Nazarov P.Lutoslawski D.Papp M.Passoni A.Pelka j.P.Perin j.Schulz M.Smid C.Spindloe S.Steinke R.Torchio C.Vass T.Wiste R.Zaffino K.Zeil T.Tschentscher U.Schramm T.E.Cowan Lawrence Berkeley National Laboratory USA 25Institute of Microelectronics of Barcelona National Center of Microelectronic Spanish Research Council Spain 26University of St. Andrews UK

A number of laser facilities coming online all over the world promise the capability of high-power laser experiments with shot repetition rates between 1 and 10 Hz. Target availability and technical issues related to the interaction environment could become a bottleneck for the exploitation of such facilities. In this paper, we report on target needs for three different classes of experiments: dynamic compression physics, electron transport and isochoric heating, and laser-driven particle and radiation sources. We also review some of the most challenging issues in target fabrication and high repetition rate operation. Finally, we discuss current target supply strategies and future perspectives to establish a sustainable target provision infrastructure for advanced laser facilities.

关键词： high-energy density physics target design and fabrication

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对儿童时期曾患嗜铬细胞瘤患者进行进一步诊断性检查具有重要意义

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 12-12页

作者： Beck O. fassbender W. j. Beyer P. 李开 Paediatric Haematology and O ncology Johann Wolfgang Goethe-University Frankfurt Germany

We report on our experience with two patients with pheochromocytoma. One patie nt underwent surgery of pheochromocytoma at the age of 30 y; 18 y later, medulla ry thyroid carcinoma (MTC) was detected in his son. Subsequently, multiple endoc rine neoplasia (MEN) type 2A was diagnosed by genetic examination in both father and son. Further diagnostic procedures also revealed an MTC in the father. The other patient suffered from bifocal pheochromocytoma of the left suprarenal glan d. Diagnostic work-up revealed papillary thyroid carcinoma, which was also dete cted in the mother 8 mo later. Whereas a point mutation in SDHB gene was found i n the son, no genetic abnormality was detected in the mother. Conclusion: Every pheochromocytoma in childhood warrants further diagnostic work-up, including ge netic examination. In addition, clinical data of patients suffering from pheochr omocytoma and papillary thyroid carcinoma should be collected by an internationa l registry, and a joint effort should be undertaken in order to define possible underlying mutated genes in these patients.

关键词：嗜铬细胞瘤诊断性检查左侧肾上腺乳头状甲状腺癌甲状腺髓样癌临床病例资料基因异常基因点突变基因突变基因检查

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人多形核白细胞(PMN)内地红霉素的浓度

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德国医学 1999年第5期16卷 309-309页

作者： K.Borner E.Borner H.Lode M.fassbender M.Rau B.Goetschi P.Koeppe 杨燕 Free University Berlin Clinic Benjamin Franklin and City Hospital Zehlendorf-HeckeshomBerlinGermany 同济医科大学附属同济医院

方法研究设计 10名志愿者(5男,5女)连续5天服用地红霉素,1天1次,每次500mg(相当于440mg地红霉素代谢物)。与以前的研究(1天2次服用红霉素,1000mg/d;1天2次服用克拉霉素,500mg/d;1天1次服用阿奇霉素,500mg/d,连续3天)相比较。标本采集... 详细信息

方法研究设计 10名志愿者(5男,5女)连续5天服用地红霉素,1天1次,每次500mg(相当于440mg地红霉素代谢物)。与以前的研究(1天2次服用红霉素,1000mg/d;1天2次服用克拉霉素,500mg/d;1天1次服用阿奇霉素,500mg/d,连续3天)相比较。标本采集分别在服药后第1,3,5天的0,4,8,24h采集志愿者的血样及尿样,血、尿及多形核细胞溶胞产物于-80℃储存备用。溶胞产物的制备:PMN从采集的肝素肮凝静脉血中分离。具体步骤见表1。

关键词：地红霉素多形核白细胞胞内浓度

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