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Dental mesenchymal stromal/stem cells in different microenvironments— implications in regenerative therapy

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World Journal of Stem Cells 2021年第12期13卷 1863-1880页

作者： ivana Okić-Đorđević Hristina Obradović Tamara Kukolj Anđelija Petrović Slavko Mojsilović Diana Bugarski Aleksandra Jauković Laboratory for Experimental Hematology and Stem Cells Institute for Medical ResearchUniversity of BelgradeBelgrade 11129Serbia

Current research data reveal microenvironment as a significant modifier of physical functions,pathologic changes,as well as the therapeutic effects of stem *** comparing regeneration potential of various stem cell types used for cytotherapy and tissue engineering,mesenchymal stem cells(MSCs)are currently the most attractive cell source for bone and tooth regeneration due to their differentiation and immunomodulatory potential and lack of ethical issues associated with their *** microenvironment of donors and recipients selected in cytotherapy plays a crucial role in regenerative potential of transplanted MSCs,indicating interactions of cells with their microenvironment indispensable in MSC-mediated bone and dental *** a variety of MSC populations have been procured from different parts of the tooth and tooth-supporting tissues,MSCs of dental origin and their achievements in capacity to reconstitute various dental tissues have gained attention of many research groups over the *** review discusses recent advances in comparative analyses of dental MSC regeneration potential with regards to their tissue origin and specific microenvironmental conditions,giving additional insight into the current clinical application of these cells.

关键词： Microenvironment Dental mesenchymal stem cells Modulation of regenerative potential Tissue origin Hypoxia microenvironment Inflammatory microenvironment Clinical application

The cerebellum, the hypothalamus and behavior

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Natural Science 2013年第7期5卷 832-834页

作者： ivana gritti Department Clinical Science-Luigi Sacco School of Medicine and Surgery University of Milan Milano Italy

The cerebellum has been classically considered as the subcortical center for motor control. However, accumulating experimental evidence has revealed that it also plays an important role in cognition, for instance, in learning and memory, as well as in emotional behavior and nonsomatic activities, such as visceral and immunological responses.

关键词： Cerebellum Hypothalamus Behavior Memory Plasticity Learning Repair

Anorectal hemangioma, a rare cause of lower gastrointestinal bleeding, treated with selective embolization: A case report

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World Journal of gastrointestinal Surgery 2024年第8期16卷 2735-2741页

作者： Barbora Pospisilova Jaromir Frydrych Antonin Krajina JuliusÖrhalmi ivana M Kajzrlikova Petr Vitek Department of Internal Medicine Hospital in Frydek-MistekFrydek-Mistek 73801Czech Republic Department of Radiodiagnostic Hospital in Jablonec nad NisouJablonec nad Nisou 46601Czech Republic Department of Radiology University Hospital Hradec KraloveHradec Kralove 50005Czech Republic Department of Surgery Hospital HoroviceHorovice 26831Czech Republic Faculty of Medicine University of OstravaOstrava 70300Czech Republic

BACKgROUND Anorectal hemangioma is a rare and frequently misdiagnosed cause of lower gastrointestinal(gI)***,we present a minimally invasive therapy with selective *** SUMMARY A 21-year-old male patient experienced painless rectal bleeding since childhood and was treated for ulcerative *** studies later revealed specific characteristics for vascular lesions-anorectal *** severity of rectal bleeding caused symptomatic anemia and possible surgical treatment was asso-ciated with a high risk of fecal ***,we present selective emboli-zation,a minimally invasive therapeutic approach that is proven as an alternative therapeutic method of *** patient significantly improved temporarily and had a small ischemic ulcer,which healed with a control colonoscopy and deve-loped no *** Awareness of the clinical and radiological features of gI hemangiomas may help improve diagnostics and avoid inappropriate therapeutic procedures.

关键词： Hemangioma Vascular malformation gastrointestinal hemorrhage Rectal bleeding Phlebolith Selective embolization Case report

gut peptide changes in patients with obstructive jaundice undergoing biliary drainage:A prospective case control study

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World Journal of Clinical Cases 2022年第17期10卷 5551-5565页

作者： Tajana Pavic Stipe Pelajic Nina Blazevic Dominik Kralj Milan Milosevic ivana Mikolasevic Ivan Lerotic Davor Hrabar Department of gastroenterology and Hepatology University Hospital Center Sestre MilosrdniceZagreb 10000Croatia Andrija Stampar School of Public Health WHO Collaborative Centre for Occupational Health University of ZagrebSchool of MedicineZagreb 10000Croatia Department of gastroenterology University Hospital Center RijekaRijeka 51000Croatia

BACKgROUND Biliary obstruction is a relatively common condition that affects approximately 5 in 1000 people *** is very common in patients with biliary obstruction and since it is associated with significant morbidity and mortality,it is important to identify factors and mechanisms involved in its *** To determine the influence of obstructive jaundice on the hormones controlling appetite and nutritive *** This was a prospective case control study performed in a tertiary center in Zagreb,*** with biliary obstruction undergoing internal biliary drainage from September 2012 until August 2013 were *** excluding patients who developed procedure related complications or were lost in the follow-up,out of initial 73 patients,55 patients were included in the analysis,including 34 with benign and 21 with malignant ***,40 non-jaundiced controls were also ***,nutritional status,and serum ghrelin,cholecystokinin(CCK),interleukin 6(IL-6),and tumor necrosis factorα(TNF-α)were determined at admission,48 h and 28 d after internal biliary *** square test was used for categorical *** variables were analysed for normality by Kolmogorov-Smirnov test and relevant non-parametric(Mann-Whitney,Kruskal-Wallis,and Friedman)or parametric(t-test and analysis of variance)tests were *** Patients with obstructive jaundice were significantly malnourished compared to controls,regardless of disease *** ghrelin and CCK levels were significantly higher in patients with obstructive *** bilirubin concentrations were negatively correlated with ghrelin levels and positively correlated with TNF-α,but had no correlation with CCK *** internal biliary drainage,a significant improvement of nutritional status was observed although serum concentrations of ghrelin,IL-6,and TNF-α remained significantly elevated even 28 d after the *** level

关键词： ghrelin Cholecystokinin Biliary obstruction Malnutrition

Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

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World Journal of Clinical Cases 2020年第17期8卷 3697-3707页

作者： Jelena Saponjski Djuro Macut Dragana Sobic-Saranovic Sanja Ognjanovic ivana Bozic Antic Djordje Pavlovic Vera Artiko Center for Nuclear Medicine Clinical Center of SerbiaBelgrade 11000Serbia Clinic for Endocrinology Diabetes and Metabolic DiseasesClinical Center of SerbiaFaculty of MedicineUniversity of BelgradeBelgrade 11000Serbia Center for Nuclear Medicine Clinical Center of Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia University Children's Clinic Belgrade 11000Serbia

BACKgROUND Neuroendocrine tumors of appendix(ANETs)known as carcinoids,are rare endocrine neoplasms originated from enterochromaffin cells of gastrointestinal *** are the third most frequent(16.7%)gastrointestinal neuroendocrine tumors,with the incidence of 0.08-0.2 cases/100000 during one *** ANETs occur in 0.2%-0.7%of emergency surgical resections because of suspected appendicitis which is usually the first manifestation of *** there are a lot of papers about application of somatostatin receptor scintigraphy in gastrointestinal neuroendocrine tumors,there are very rare sporadic cases described about ANETs *** To establish the role of somatostatin receptor scintigraphy(SRS)in the management of patients with neuroendocrine tumors of appendix(ANET).METHODS The total of 35 patients was investigated,23 females and 12 males,average age(43.7±17.3 years).All patients had histological diagnosis of ANET(34 carcinoids of appendix and one tubular carcinoid).Majority of tumors have been found incidentally during surgery of:Acute appendicitis(n=15),perforated appendicitis(n=2),ileus(n=3),hysterectomy(n=3),ruptured ovarian cyst(n=2),caecal volvulus(n=1),while 9 patients had diagnosis of appendiceal tumor before the *** patients had tumor grade(g)g1,12 g2 and 6 *** right hemicolectomy was performed in 13,while the rest of the patients had appendectomy *** was done early(2 h)and late(24 h)after *** of 740 MBq technetium-99 m ethylenediamine-N,N’-diacetic acid Hydrazinonicotinyl-Tyr3-Octreotide(technetium-99 m-Tektrotyd,Polatom,Poland).SRS was performed for restaging in all the patients after *** There were 12 true positive(TP),19 true negative,3 false positive and 1 false negative SRS *** of the method was 92.31%,specificity was 86.36%,positive predictive value was 80.00%,negative predictive value was 95.00%and accuracy 88.57%.Receiver operating characteristics analysis showed t

关键词： Somatostatin receptor scintigraphy Carcinoid Appendix Follow up Nuclear medicine Radionuclide

Is there a future for international brands in China？

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China International Business 2010年第5期 44-45页

作者： ivana CASABURI

We began talking about market globalization in the eighties, yet it was not until the early nineties that companies began to rise to the challenge. At the time, the Chinese market was experiencing the heady first stage of a more open economy, busy earning itself the reputation of being the world＇s manufacturing base. This enabled many multina- tionals to embrace what Professor Theodore Levitt of Harvard Business School saw as the greatest advantage of market globalization： more efficient production to meet universal needs.

关键词：中国市场国际品牌制造业基地经济体系跨国企业全球化年代收入

Acute pancreatitis as a complication of acute COVID-19 in kidney transplant recipients

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World Journal of Clinical Cases 2024年第6期12卷 1104-1110页

作者： Nikolina Basic-Jukic ivana Juric Lea Katalinic Vesna Furic-Cunko Vibor Sesa Anna Mrzljak Department of Nephrology Arterial HypertensionDialysis and TransplantationUniversity Hospital Centre ZagrebZagreb 10000Croatia Department of Medicine School of MedicineZagreb 10000Croatia Department of gastroenterology and Hepatology University Hospital Centre ZagrebZagreb 10000Croatia

BACKgROUND Acute pancreatitis is a rare extrapulmonary manifestation of coronavirus disease 2019(COVID-19)but its full correlation with COVID-19 infection remains *** To identify acute pancreatitis’occurrence,clinical presentation and outcomes in a cohort of kidney transplant recipients with acute *** A retrospective observational single-centre cohort study from a transplant centre in Croatia for all adult renal transplant recipients with a functioning kidney allograft between March 2020 and August 2022 to record cases of acute pancreatitis during acute *** were obtained from hospital electronic medical *** acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection was proven by a positive SARS-CoV-2 real-time reverse transcriptase-polymerase chain reaction on the nasopharyngeal *** Four hundred and eight out of 1432(28.49%)patients who received a renal allograft developed COVID-19 *** analyzed cohort included 321 patients(57%males).One hundred and fifty patients(46.7%)received at least one dose of the anti-SARS-CoV-2 vaccine before the *** hundred twenty-five(39.1%)patients required hospitalization,141(44.1%)developed pneumonia and four patients(1.3%)required mechanical *** included immunosuppression modification in 233 patients(77.1%)and remdesivir in 53 patients(16.6%),besides the other supportive *** the study cohort,only one transplant recipient(0.3%)developed acute pancreatitis during acute COVID-19,presenting with abdominal pain and significantly elevated pancreatic *** survived without complications with a stable kidney allograft *** Although rare,acute pancreatitis may complicate the course of acute COVID-19 in kidney transplant *** mechanism of injury to the pancreas and its correlation with the severity of the COVID-19 infection in kidney transplant recipients warrants further research.

关键词： Acute pancreatitis COVID-19 Kidney transplant Angiotensin-converting enzyme-2 receptor Immunosuppressive agents

Bicuspid aortic valve with associated aortopathy, significant left ventricular hypertrophy or concomitant hypertrophic cardiomyopathy: A diagnostic and therapeutic challenge

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World Journal of Clinical Cases 2023年第18期11卷 4251-4257页

作者： ivana Sopek Merkaš Nenad Lakušić Mladen Predrijevac KrešimirŠtambuk Maja Hrabak Paar Department of Cardiology Special Hospital for Medical Rehabilitation Krapinske TopliceKrapinske Toplice 49217Croatia Department of Clinical Medicine Faculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Internal Medicine Family Medicine and History of MedicineFaculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Cardiovascular Surgery Magdalena Clinic for Cardiovascular DiseasesKrapinske Toplice 49217Croatia Department of Cardiology Magdalena Clinic for Cardiovascular DiseasesKrapinske Toplice 49217Croatia Department of Diagnostic and Interventional Radiology University Hospital Centre ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia

Due to its prevalence of 0.5%to 2%in the general population,with a 75%predominance among men,bicuspid aortic valve is the most common congenital heart *** is frequently accompanied by other cardiac congenital anomalies,and clinical presentation can vary significantly,with stenosis being the most common manifestation,often resulting in mild to moderate concentric hypertrophy of the left *** is the primary diagnostic modality utilized for establishing the diagnosis,and it is often the sole diagnostic tool relied upon by ***,due to the heterogeneous clinical presentation and possible associated anomalies(which are often overlooked in clinical practice),it is necessary to employ various diagnostic methods and persist in finding the accurate diagnosis if multiple inconsistencies *** employing this approach,we can effectively manage these patients and provide them with appropriate *** a clinical case from our practice,we provide an overview of the literature on bicuspid aortic valve with aortophaty and the possible association with hypertrophic cardiomyopathy,diagnostic methods,and treatment *** review article highlights the critical significance of achieving an accurate diagnosis in patients with bicuspid aortic valve and significant left ventricular *** is crucial to exclude other possible causes of left ventricular outflow tract obstruction,such as sub-or supra-aortic obstructions,and hypertrophic cardiomyopathy.

关键词： Bicuspid aortic valve Left ventricular hypertrophy Left ventricular tract obstruction Hypertrophic cardiomyopathy Aortopathy Multimodal imaging

FAIR Data and Metadata:gNSS Precise Positioning User Perspective

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Data Intelligence 2023年第1期5卷 43-74页

作者： ivana Ivánová Ryan Keenan Christopher Marshall Lori Mancell Eldar Rubinov Ryan Ruddick Nicholas Brown graeme Kernich Spatial Sciences School of Earth and Planetary ScienceCurtin UniversityPerthWestern Australia6102Australia Positioning Insights Carlton NorthVictoria3054Australia FrontierSI Cnr Village St and Fishplate LnDocklandsVictoria3008Australia geoscience Australia Cnr Jerrabomberra Ave and Hindmarsh DriveSymonstonAustralian Capital Territory2609Australia

The FAIR principles of Wilkinson et al.[1]are finding their way from research into application domains,one of which is the precise positioning with global satellite navigation systems(gNSS).Current gNSS users demand that data and services are findable online,accessible via open protocols(by both,machines and humans),interoperable with their legacy systems and reusable in various *** metadata are essential in seamless communication between gNSS data and service providers and their users,and,for decades,geodetic and geospatial standards are efficiently implemented to support ***,gNSS user community is transforming from precise positioning by highly specialised use by geodetic professionals to every-day precise positioning by autonomous vehicles or wellness obsessed ***,rapid technological developments allow alternative ways of offering data and services to their *** transforming circumstances warrant a review whether metadata defined in generic geospatial and geodetic standards in use still support FAIR use of modern gNSS data and services across its novel user *** paper reports the results of current gNSS users'requirements in various application sectors on the way data,metadata and services are *** engaged with gNSS stakeholders to validate our findings and to gain understanding on their perception of the FAIR *** results confirm that offering FAIR gNSS data and services is fundamental,but for a confident use of these,there is a need to review the way metadata are offered to the *** standard compliant gNSS community metadata profile and providing relevant metadata with data on-demand,the approach outlined in this paper,is a way to manage current gNSS users'expectations and the way to improve FAIR gNSS data and service delivery for both humans and the machines.

关键词： FAIR Metadata Standards Profile Precise positioning gNSS users Spatial data infrastructure