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World Journal of Otorhinolaryngology 2024年第2期11卷 18-24页

作者： K m Abidur Rahman Khalid majeed Emma Finnegan ivan Keogh Ear Noseand Throat/Head and Neck SurgeryGalway University HospitalGalway H91 YR71Ireland Academic Department of Otorhinolaryngology and Head and Neck Surgery University of GalwayGalway H91 TK33Ireland

BACKGROUND Endoscopic ear surgery(EES)provides a magnified,high-definition view of the otological surgical *** allows otologists to avoid surgical incisions and associated postoperative *** is an ideal technique for the perfor-mance and teaching of *** To examine the efficacy of total Endoscopic Push Through Tragal Cartilage Tympanoplasty(EPTTCT),at our institution over a 10-year *** A retrospective analysis of 168 cases of EPTTCT for closure of small to medium tympanic membrane perforations from 2013-2023 was *** sex,age range(pediatric vs adult),etiology of injury,success rate,complications,and postoperative hearing status were *** Graft uptake results indicated success in 94%of patients,with less than a 2%complication *** pure tone audiometry demonstrated hearing status improvement in 69%of *** EPTTCT has been shown to be effective in tympanic membrane perforation closures with minimal *** study further demonstrates the efficacy and safety of these procedures in a single-center review.

关键词： Total endoscopic ear surgery Otology Tympanoplasty Hearing Perforation Tragal cartilage graft

Boron-containing compounds as labels,drugs,and theranostic agents for diabetes and its complications

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World Journal of Diabetes 2024年第6期15卷 1060-1069页

作者： marvin A Soriano-Ursúa R ivan Cordova-Chávez Eunice D Farfan-García George Kabalka Department of Physiology Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico Department of Physiology Instituto Politécnico NacionalMexico City 11340Mexico Department of Biochemistry Instituto Politécnico NacionalMexico City 11340Mexico Department of Chemistry The University of TennesseeKnoxvilleTN 37996United States

Diabetes is a disease with a high global *** strategies have failed to limit the advancement and impact of the *** early diagnosis and treatment will require the development of new *** this sense,boroncontaining compounds have been reported as agents with the ability to reduce glycemia and *** have also been used for labeling and measuring carbohydrates and other molecules linked to the initial stages of diabetes and its *** addition,certain boron compounds bind to molecules related to diabetes development and their biological activity in the regulation of elevated ***,it should be noted that some boron compounds appear to exert beneficial effects on diabetes complications such as accelerating wound healing while ameliorating pain in diabetic patients.

关键词： Boron Carbohydrates metabolism Diabetes Boronodipyrromethene

Large-scale error-tolerant programmable interferometer fabricated by femtosecond laser writing

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Photonics Research 2024年第3期12卷 I0028-I0040页

作者： ILYA KONDRATYEV VERONIKA ivanOVA SUREN FLDZHYAN ARTEm ARGENCHIEV NIKITA KOSTYUCHENKO SERGEY ZHURAVITSKII NIKOLAY SKRYABIN ivan DYAKONOV mIKHAIL SAYGIN STANISLAV STRAUPE ALEXANDER KORNEEV SERGEI KULIK Quantum Technology Centre and Faculty of Physics M.V.Lomonosov Moscow State UniversityMoscow 119991Russia Russian Quantum Center Moscow 121205Russia Laboratory of Quantum Engineering of Light South Ural State UniversityChelyabinsk 454080Russia

We introduce a programmable eight-port interferometer with the recently proposed error-tolerant architecture capable of performing a broad class of *** interferometer has been fabricated with femtosecond laser writing,and it is the largest programmable interferometer of this kind to *** have demonstrated its advantageous error tolerance by showing an operation in a broad wavelength range from 920 to 980 nm,which is particularly relevant for quantum photonics due to efficient photon sources existing in this wavelength *** work highlights the importance of developing novel architectures of programmable photonics for information processing.

关键词： interferometer laser femtosecond

Delayed postpancreatectomy hemorrhage as the role of endovascular approach:Four case reports

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World Journal of Clinical Cases 2024年第31期12卷 6462-6471页

作者： Igor Petrovic ivan Romic Ana m Alduk Nino Ticinovic Oliver m Koltay Klara Brekalo Ante Bogut Department of Hepatobiliary Surgery and Transplantation University Hospital Center ZagrebZagreb 10000Croatia Department of Surgery University Hospital Centre ZagrebZagreb 10000Croatia Department of Radiology University of Zagreb School of MedicineUniversity Hospital Center ZagrebZagreb 10000Croatia Department of Radiology University Hospital Centre ZagrebZagreb 10000Croatia Department of medical School University of ZagrebZagreb 10000Croatia Department of Internal medicine Clinic with Dialysis Center University Clinical Hospital MostarMostar 88000Bosnia and Herzegovina

BACKGROUND Pancreatic resection is still associated with high morbidity rates and delayed postpancreatectomy hemorrhage(PPH)is the most feared complication as it may lead to hemorrhagic shock or serious septic ***,endovascular approach represent safe and efficient method for minimally invasive management of extraluminal *** SUmmARY We describe four patients whose postoperative recovery after pancreatic resection was complicated by postoperative pancreatic fistula(POPF)and visceral artery *** all cases endovascular approach was utilized and it resulted in satisfactory *** discuss modern diagnostic and therapeutic approach in this clinical *** PPH is relatively uncommon,but it is a leading cause of surgical mortality after pancreatic *** monitoring and meticulous follow-up are required for all patients post-operatively,especially in the case of confirmed POPF,which is the most significant risk factor for the development of a *** as a diagnostic and therapeutic method may be an optimal first-line treatment for the management of delayed *** our experience,endovascular treatment for hemorrhagic complications of pancreatic resections has shown satisfactory results.

关键词： Pancreas Resection Hemorrhage Angiography Embolization Surgery Case report

Deep Transfer Learning Approach for Robust Hand Detection

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Intelligent Automation & Soft Computing 2023年第4期36卷 967-979页

作者： Stevica Cvetkovic Nemanja savic ivan Ciric Faculty of Electronic Engineering University of NisNis18000Serbia Faculty of mechanical Engineering University of NisNis18000Serbia

Human hand detection in uncontrolled environments is a challenging visual recognition task due to numerous variations of hand poses and background image *** achieve highly accurate results as well as provide real-time execution,we proposed a deep transfer learning approach over the state-of-the-art deep learning object *** method,denoted as YOLOHANDS,is built on top of the You Only Look Once(YOLO)deep learning architecture,which is modiﬁed to adapt to the single class hand detection *** model transfer is performed by modifying the higher convolutional layers including the last fully connected layer,while initializing lower non-modiﬁed layers with the generic pre-trained *** address robustness issues,we introduced a comprehensive augmentation procedure over the training image dataset,speciﬁcally adapted for the hand detection *** evaluation of the proposed method,which is performed on a challenging public dataset,has demonstrated highly accurate results,comparable to the state-of-the-art methods.

关键词： Deep learning model object detection hand detection transfer learning data augmentation

Innate Igm antibodies to mannose in patients with gastric cancer

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Cancer Biology & medicine 2024年第3期21卷 193-197页

作者： maxim Petrovich Nikulin Nadezhda Vladimirovna Shilova Alexander Dmitrievich Lipatnikov ivan Sokratovich Stilidi Alexandra Vladimirovna Semyanikhina Nikolai Vladimirovich Bovin Nikolai Nikolaevich Tupitsyn Federal State Budgetary Institution"National medical Research Center for Oncology Named After N.N.Blokhin"of the ministry of Health of Russia MoscowRussia State Research Center"Institute of Bioorganic Chemistry Named After Academicians m.m.Shemyakin and Yu.A.Ovchinnikov"of the Russian Academy of Sciences MoscowRussia National medical Research Center for Obstetrics Gynecology and Perinatology Named After Academician VI.Kulakov of the Ministry of Health of Russian FederationMoscowRussia

Gastric cancer(GC) remains one of the most common lethal diseases. Every year, about 1 million people fall ill and almost 800 thousand people die worldwide~1. Surgical treatment has reached its limit. The current advances in immunology and detection of epidermal growth factor molecules(EGFR) in gastric cancer cells allowed to improve the treatment results;however, the metastatic form of this disease is still incurable.

关键词： Gastric cancer gastric

Exploring van der Waals materials with high anisotropy:geometrical and optical approaches

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Light(Science & Applications) 2024年第4期13卷 645-653页

作者： Aleksandr S.Slavich Georgy A.Ermolaev mikhail K.Tatmyshevskiy Adilet N.Toksumakov Olga G.matveeva Dmitriy V.Grudinin Kirill V.Voronin Arslan mazitov Konstantin V.Kravtsov Alexander V.Syuy Dmitry m.Tsymbarenko mikhail S.mironov Sergey m.Novikov ivan Kruglov Davit A.Ghazaryan Andrey A.Vyshnevyy Aleksey V.Arsenin Valentyn S.Volkov Kostya S.Novoselov moscow Center for Advanced Studies Kulakova str.20Moscow 123592Russia. Emerging Technologies Research Center XPANCEOInternet CityEmmay TowerDubaiUnited Arab Emirates. Donostia International Physics Center(DIPC) Donostia/San-Sebastián 20018Spain. Institute of materials Ecole Polytechnique Federale de Lausanne1015 LausanneSwitzerland. Department of Chemistry Lomonosov Moscow State UniversityMoscow 119991Russia. Laboratory of Advanced Functional materials Yerevan State UniversityYerevan 0025Armenia. National Graphene Institute(NGI) University of ManchesterManchester M139PLUK. Department of materials Science and Engineering National University of SingaporeSingapore 03-09 EASingapore. Institute for Functional Intelligent materials National University of Singapore117544 SingaporeSingapore

The emergence of van der Waals(vdW)materials resulted in the discovery of their high optical,mechanical,and electronic anisotropic properties,immediately enabling countless novel phenomena and *** success inspired an intensive search for the highest possible anisotropic properties among vdW ***,the identification of the most promising among the huge family of vdW materials is a challenging quest requiring innovative ***,we suggest an easy-to-use method for such a survey based on the crystallographic geometrical perspective of vdW materials followed by their optical *** our approach,we found As2S3 as a highly anisotropic vdW *** demonstrates high in-plane optical anisotropy that is~20%larger than for rutile and over two times as large as calcite,high refractive index,and transparency in the visible range,overcoming the century-long record set by *** these benefits,As2S3 opens a pathway towards nextgeneration nanophotonics as demonstrated by an ultrathin true zero-order quarter-wave plate that combines classical and the Fabry–Pérot optical phase ***,our approach provides an effective and easy-to-use method to find vdW materials with the utmost anisotropic properties.

关键词： anisotropy anisotropic high

Floristic Composition, Population Structure, and Recruitment Status of Plant Species: A Case Study of Farmer-managed Natural Regeneration Practices in Arid and Semi-Arid Lands in Kenya

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Open Journal of Forestry 2024年第2期14卷 141-154页

作者： Simon Kosgei Choge Samson Okoth Ojunga Dub Isacko Dokata William Kimen Chepkirui Justus musau Faith milkah muniale ivan Kiplagat Kiptui Kenya Forestry Research Institute-Rift Valley Eco-Region Research Program Marigat Kenya Kenya Forestry Research Institute-Lake Victoria Eco-Region Research Program Kisumu Kenya Kenya Forestry Research Institute-Rift Valley Eco-Region Research Program Londiani Kenya CRIFSUP Project World Vision Kenya Nairobi Kenya

The technique of Farmer managed Natural Regeneration (FmNR) is being promoted as a cost-effective approach for restoring degraded arable dry lands. Its effectiveness has been observed in many countries across the globe, where it is a traditional practice, and is now being encouraged across the African continent. This study aimed to evaluate the impact of FmNR on floristic Composition, Vegetation Structure, and Regeneration Status of woody Plant Species in the severely degraded Central Rift, Kenya. The study systematically assessed how FmNR influenced species composition, vegetation structure and regeneration status from two sample plots involved in FmNR practices. Transect lines and quadrats methods were utilized to collect data, specifically regarding the floristic composition, vegetation structure, and regeneration status of woody plant species. Quadrats and sub-quadrats of varying sizes (10 m by 10 m, 5 m by 5 m, and 1 m by 1 m) were nested along the transect lines for data collection. Furthermore, measurements of tree growth and development, including root collar diameter, diameter at breast height (D130) and heights within the study blocks, were taken. The data was then analyzed using R-software. Results showed a marked progressive increase in numbers of trees, saplings, seedlings, shrubs and herbs in all FmNR sites and reductions in all non-FmNR sites. The study advocates for widespread promotion of the FmNR practice both as an environmental conservation and restoration strategy.

关键词： Farmer managed Natural Regeneration FmNR Floristic Composition Vegetation Structure Regeneration Biodiversity

Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique minard-Colin Caroline Chopinet michael Dussiot Denise mAdams Tristan mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERm U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UmR 5220 Villeurbanne 69100France Service de Radiologie mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERm U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UmR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(mRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

GSTm1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1514-1520页

作者： miroslav Stamenkovic Vesna Lukic Sonja Suvakov Tatjana Simic ivan Sencanic marija Pljesa-Ercegovac Vesna Jaksic Sinisa Babovic marija matic Aleksandra Radosavljevic Ana savic-Radojevic Tatjana Djukic University Eye Clinic Medical Center ZvezdaraBelgrade 11000Serbia Faculty of Special Education and Rehabilitation University of BelgradeBelgrade 11000Serbia Institute of medical and Clinical Biochemistry Belgrade 11000Serbia Faculty of medicine University of BelgradeBelgrade 11000Serbia Hospital for Eye Diseases Clinical Center of SerbiaBelgrade 11000Serbia

AIm： To evaluate glutathione transferase theta 1 and mu 1（GSTT1 and GSTm1） polymorphisms as determinants of primary open angle glaucoma（POAG） risk, independently or in combination with cigarette smoking, hypertension and diabetes ***： A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. multiplex-polymerase chain reaction method was used for the analysis of GSTm1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or χ~2 test. Logistic regression analysis was used for assessing the risk for disease ***： The presence of GSTm1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma（P=0.044） which increased up to 4.36 when combined with GSTm1-null carriers（P=0.024）. When glutathione transferase（GST） genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively （OR=3.52, P=0.003; OR=10.02, P〈0.001; OR=4.53, P=0.002）. CONCLUSION： The results obtained indicate that both GSTm1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.

关键词： GSTm1 GSTT1 primary open angle glaucoma risk smoking hypertension diabetes mellitus