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一种新型AMPA/GluR5受体拮抗剂LY293558对急性偏头痛患者有效且耐受性良好

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世界核心医学期刊文摘（神经病学分册） 2005年第2期1卷 12-13页

作者： Ramadan n.M. Wallihan R.G. 黄卫东 Finch University of Health Sciences Chicago Medical School 33 33 Green Bay Road North Chicago IL 60064 United States

Glutamatergic hyperactivity is implicated migraine pathogenesis. Also, LY29355 8, an α amino 3 hydroxy 5 methyl 4 isox azolepropionic acid (AMPA)/kain ate (KA) receptor antagonist, is effective in preclinical models of migraine. We therefore tested LY293558 in acute migraine. We conducted a randomized, triple blind, parallel group, double d ummy, multicentre trial of 1.2 mg/kg intravenous (iv) LY293558, 6 mg subcutaneou s (SC) sumatriptan, or placebo in the treatment of acute migraine. The primary e fficacy variable was the headache response rate, i.e. headache score improvement from mod erate/severe at baseline to mild/none at 2 h. Of 45 enrolled patients , 44 patients (20M:24F; mean age ±.SD = 40 ±.9 years) completed the study. Res ponse rates were 69%for LY293558 (P = 0.017 vs. placebo), 86%for sumatriptan ( P nd 25%for placebo. LY293558 and sumatriptan were superi or to placebo (P ns) on all other measures of improveme nt in pain and migraine associated symptoms. Fifteen percent of patients who too k LY293558 reported adverse events (AEs) (n = 2; one mild, one severe). Fifty t hree percent of patients who took sumatriptan (n = 8; seven mild, one moderate) and 31%of those who received placebo reported AEs (n = 5; four mild, one severe ). The efficacy and safety results of LY293558 in this small migraine proof of c oncept trial, together with supportive preclinical data, provide evidence for a potential role of nonvasoactive AMPA/KA antagonists in treating migraine. Larger trials are needed to further test the hypothesis.

关键词：偏头痛患者 AMPA/GluR5 LY293558 受体拮抗剂舒马曲坦安慰剂三盲试验研究结果反应率大样本研究

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核心价值观培育的文化心理建构

浙江师范大学学报（社会科学版） 2017年第6期42卷 111-115页

作者：邱旭光张宏敏浙江工贸职业技术学院督导处浙江温州325003 浙江省社会科学院哲学研究所浙江杭州310007

核心价值观内化即价值观已经建构到文化心理层面,并形成相应的人格特征。为此,必须探索核心价值观与文化心理结构之间的复杂关系,明确文化心理的形成机制,寻找到建构核心价值观文化心理的路径。价值发生有其必然的文化心理动因,且是一... 详细信息

核心价值观内化即价值观已经建构到文化心理层面,并形成相应的人格特征。为此,必须探索核心价值观与文化心理结构之间的复杂关系,明确文化心理的形成机制,寻找到建构核心价值观文化心理的路径。价值发生有其必然的文化心理动因,且是一个不断积淀与重构的过程。价值内化和价值认知的文化心理过程、价值取向的文化心理动机以及文化心理的价值选择与价值判断共同构成价值观的文化心理机制。在明了当下文化心理的基础上,遵循心理认知规律,挖掘传统文化"有生"内涵,从而实现"现代中国文化心理"结构的重建。

关键词：核心价值观文化心理心理机制心理结构

创业企业创新投入、高管过度自信对企业绩效的影响

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科技进步与对策 2017年第1期34卷 98-103页

作者：潘清泉鲁晓玮广西科技大学管理学院广西柳州545006

基于2012-2015年创业板上市公司数据,实证检验了创业企业创新投入、高管过度自信对企业绩效的影响。研究发现:1企业创新投入与企业绩效呈显著倒U型关系,即随着创新投入的增加,企业绩效呈现边际效应递减规律;2高管过度自信与企业绩效显... 详细信息

基于2012-2015年创业板上市公司数据,实证检验了创业企业创新投入、高管过度自信对企业绩效的影响。研究发现:1企业创新投入与企业绩效呈显著倒U型关系,即随着创新投入的增加,企业绩效呈现边际效应递减规律;2高管过度自信与企业绩效显著负相关,即高管过度自信的自我意识对企业绩效具有显著负向影响;3高管过度自信及企业创新投入之间存在交互效应,显著影响企业绩效。

关键词：创业企业高管过度自信创新投入创新绩效面板数据

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乳腺癌真空辅助旋切术后保乳手术的可行性

中国临床医学 2016年第6期23卷 710-714页

作者：陈宏亮王懋莉张征丁昂复旦大学附属妇产科医院乳腺外科上海200011

目的:探讨超声引导下真空辅助活检(vacuum-assisted biopsy,VAB)切除乳腺癌肿块后保乳手术的可行性与安全性。方法:选择2008年1月至2014年12月VAB肿块切除术后行保乳手术治疗的45例浸润性导管癌(invasive ductal carcinoma,IDC)患者(VAB... 详细信息

目的:探讨超声引导下真空辅助活检(vacuum-assisted biopsy,VAB)切除乳腺癌肿块后保乳手术的可行性与安全性。方法:选择2008年1月至2014年12月VAB肿块切除术后行保乳手术治疗的45例浸润性导管癌(invasive ductal carcinoma,IDC)患者(VAB组)。选取同一时期单发、直径小于2cm、肿块切除活检后行保乳手术的147例IDC患者为对照组。分析并比较两组患者的临床病理特征与预后。结果:VAB组肿块均单发、直径n,术中未发生活动性出血。保乳手术距VAB术平均(4.50±0.92)d;局部扩大切除病灶的各个切缘均阴性;无患者发生肿瘤细胞针道或皮肤穿刺点种植;3例残腔残留少量导管原位癌病灶,但无浸润性癌灶。VAB组与对照组平均年龄、年龄构成、肿块直径、肿瘤组织学分级、脉管侵犯、淋巴结分期、前哨淋巴结阳性率、肿瘤分子分型及辅助治疗、腋窝手术差异均无统计学意义。两组间5年无病生存期(disease-free survival,DFS)和5年总生存期(overall survival,OS)差异均无统计学意义。结论:VAB切除不可触及的较小乳腺癌肿块后续行保乳手术安全可行,值得进一步大样本研究。

关键词：真空辅助活检乳腺癌保乳手术超声引导

The Effect of EDTA Chelation Therapy in Symptomatic Coronary Heart Disease: An Observational Study

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Chinese Medicine 2010年第2期1卷 49-54页

作者： Chulananda D. A. Goonasekera Rohini Tennakoon Premil n. Rajakrishna Gammadegedara A. Gunasena Chandima R. Wanniarachchi Asanka B. Yatawatta Udawatta A. D. D. Munidasa 不详

Ethylene Diamine Tetra Acetic Acid (EDTA) chelation therapy has been considered a definitive alternative therapy for by-pass surgery in atherosclerotic cardiovascular disease for more than four decades. It is a relatively inexpensive method believed to restore blood flow in atherosclerotic vessels. However, the benefits of chelation therapy yet remain controversial in the treatment of ischemic heart disease. We observed the effect of EDTA chelation therapy on exercise tolerance in 13 volunteering patients receiv.ng conventional treatment for established symptomatic coronary heart disease. Each patient received 30 weekly infusions of EDTA followed by monthly 12 boosters according to the ACAM protocol (American College for Advancement in Medicine). This was in addition to the conventional therapies they received from their respective physician in hospital. Stress ECG, echocardiography and coronary angiogram findings were obtained at the beginning of treatment. The distance that a patient could walk on level ground at moderate speed and the number of steps he/she can climb up on a staircase until he/she begins to feel either chest pain or breathlessness were the two clinical parameters of exercise tolerance recorded to grade angina. Liver and renal functions were tested at 1st, 5th, 10th, 15th and 30th infusions. Of the 13 patients, 11 showed improvement in angina grading whilst 2 experienced no effect. One patient improved from angina grade iv to I, 6 from grade III to I, 1 from grade III to II and 3 from grade II to I. A statistically significant reduction in the mean score (p = 0.002) was noticed at 6th month of treatment when compared to that of the first month. A significant 1.7 fold increase (p = 0.009) in the mean SGPT level was observed at the 30th infusion when compared to the pre-treatment values. The SGOT level showed no significant change (p = 0.664). none of the patients showed clinical features of hepato-cellular damage. The mean serum creatinine level sh

关键词： EDTA Chelation Therapy Coronary Heart Disease Exercise Tolerance

Synthesis and Characterization of Oxy-Vanadium （Ⅳ） Complex of 4-（2, 4-dihydroxybenzaldimine） Antipyrine

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Journal of Chemistry and Chemical Engineering 2010年第11期4卷 49-53页

作者： Ramadan M. El-mehdawi Abdussallam n. Eldewik Khaled M. Kreddan Fathhia A. Treish Mufida M. BenYounes Abtisam A. Aboushagour Zinab A. Elkamoshi Chemistry Department Faculty of Science Al-Fateh University Tripoli Libya Chemistry Department Faculty of Science University of Aljabal Algharbi Zawia Libya Libyan Petroleum Institute Tripoli Libya

The reaction of VCl3 with 4-（2, 4-dihydroxybenzaldimine） antipyrine （LH） in a l ： 1 molar ratio results in formation of the general complex of [VOL（CI）OH]. The nature of bonding and stereochemistry of the complex was deduced from the elemental analysis, IR, UV-Vis, 1H and ^13C nMR spectroscopy. This complex has a coordination number five （square pyramidal） as known for many vanadyl complexes. The formation of the vanadyl ion （VO^2＋） and the mode of bonding of the Schiff base through the oxygen of the pyrazol ring and the nitrogen of the azomethine group to the vanadyl ion were established by IR technique.

关键词： Schiff base Oxy-Vanadium(iv) complex ^1H and ^13C nMR.

Community structure of Lumbricidae in beech woodland of the Bieszczady national Park, Southeast Poland

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Pedosphere 2021年第3期31卷 391-397页

作者： Anna MAZUR-PĄCZKA Grzegorz PĄCZKA Joanna KOSTECKA Kevin R.BUTT Marcin JAROMIn Mariola GARCZYŃSKA Agnieszka PODOLAK University of Rzeszów Faculty of Biology and AgricultureDepartment of Natural Theories of Agriculture and Environmental Education1a Cwiklinskiej St.Rzeszów 35-959Poland University of Central Lancashire Forensic and Applied SciencesPreston PR12HEUK Rzeszów University of Technology Faculty of ChemistryDepartment of Biotechnology and Bioinformatics6 Powstancow Warszawy AvenueRzeszów 35-959Poland

As ecosystem engineers,earthworms play a key role in the soil ***,due to increasing anthropogenic pressure,soil organisms,including earthworms,are being threatened by habitat *** this study,we undertook a qualitative and quantitative investigation of earthworms of the family Lumbricidae in four types of Carpathian beech woodland(Fagetum carpaticum),characterized by their understory vegetation(I,*** drymejae;Ⅱ,***;Ⅲ,***;and iv,***),in the Bieszczady national Park(Eastern Carpathians,Southeast Poland).At each investigated site,soil monoliths(25 cm×25 cm×25 cm)were examined by hand *** were expelled from deep soil layers using a weak formalin solution(0.4%).Depending on the phytocoenosis,7 species of Lumbricidae were identified at each of the sites I,Ⅱ,andⅢand 10 at site *** iv(***)differed significantly(Pnd the Shannon-Wiener diversity index(0.52±0.12).Although present three decades ago,the deep-burrowing species Octodrilus transpadanus and the litter-dwelling species Dendrobaena octaedra were not found at site iv in the present *** suspect that these two species may have been displaced by the invasive Lumbricus terrestris,which was not found at the same site in the *** observations warrant further investigation to verify the predicted effects of an invasive earthworm,including the potential effects on soils and other fauna and flora,which have been documented in numerous countries.

关键词： beech forest earthworm invasive species Shannon-Wiener diversity index species diversity species dominance

Preconcentration of Germanium(iv) on Styrene-Maleic Anhydride Copolymer Modified with Aminobenzoic Acids and Its Spectrophotometric Determination with Bis(2,3,4-trihydroxyphenylazo)benzidine

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American Journal of Analytical Chemistry 2012年第12期3卷 790-799页

作者： Kamran T. Mahmudov Rafiga A. Aliyeva Sahil Z. Hamidov Famil M. Chyragov Samira R. Mardanova Maximilian n. Kopylovich Armando J. L. Pombeiro Centro de Química Estrutural Complexo I Instituto Superior Técnico Technical University of Lisbon Lisbon Portugal Department of Chemistry Baku State University Baku Azerbaijan

The styrene-maleic anhydride copolymer was chemically modi?ed, in the presence of formaldehyde, with 4-amino-2-hydroxybenzoic acid or 4-aminobenzoic acid giv.ng sorbents S1 and S2, respectively. The specific sorption behaviour of S1 and S2 towards germanium(iv) was examined and optimized, the preconcentrated germanium(iv) after desorption being spectrophotometrically quantified with bis(2,3,4-trihydroxyphenylazo)benzidine in the presence of hexamethylenetetramine, phenanthroline and 2,2’-bipyridine. The dynamic sorption capacity and detection limits (3σ, n = 17) of germanium were found to be 152.2 and 127.1 mg·g–1, and 0.9 and 1.1 ng·mL–1, for S1 and S2, accordingly. The application of S1 and S2 was demonstrated for the selective preconcentration/determination of germanium in seawater and water obtained after oil pumping.

关键词： Germanium(iv) Preconcentration Sorption Spectrophotometric Determination

低分子肝素联合氟桂利嗪对频发性TIA患者脑梗死的预防效应

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陕西医学杂志 2017年第6期46卷 796-798页

作者：张立红李迪康永琨王明珠许建平王苏平大连医科大学附属大连市中心医院神经内一科大连116033 大连医科大学附属第二医院影像科大连116023 辽宁省大连市第四医院重症医学科大连116000 苏州大学附属第一医院苏州215006

目的:评估频发性短暂脑缺血发作(TIA)患者联合应用低分子肝素与氟桂利嗪,对预防发生脑梗死的临床价值。方法:选取132例频发性TIA患者,按治疗方案不同分为:对照组65例,予以低分子肝素治疗;研究组67例,予以低分子肝素联合氟桂利嗪治疗。... 详细信息

目的:评估频发性短暂脑缺血发作(TIA)患者联合应用低分子肝素与氟桂利嗪,对预防发生脑梗死的临床价值。方法:选取132例频发性TIA患者,按治疗方案不同分为:对照组65例,予以低分子肝素治疗;研究组67例,予以低分子肝素联合氟桂利嗪治疗。两组均予以抗血小板、调脂等基础治疗,疗程均为2周。比较两组患者的血液流变学指标、凝血系统指标的差异。随访3月,比较两组TIA复发率和脑梗死发生率的差异及各种不良反应发生率的差异。结果:研究组总有效率、显效率明显高于对照组(PnR)、纤维蛋白原含量较治疗前明显改善(P0.05)。结论:低分子肝素与氟桂利嗪联合应用能显著降低频发性TIA发作频率并减少脑梗死发生几率。

关键词：脑缺血发作,短暂性/药物疗法肝素,低分子量/治疗应用氟桂利嗪/治疗应用脑梗塞/预防与控制