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Context-dependent role of sirtuin 2 in inflammation

neural Regeneration Research 2025年第3期20卷 682-694页

作者： noemíSola-Sevilla Maider Garmendia-Berges MCarmen Mera-delgado Elena Puerta Department of Pharmaceutical Sciences Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain navarra Institute for Health Research(IdiSnA) PamplonaSpain

Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(nAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3(nLRP3). However, whether sirtuin 2-mediated pathways induce a pro-or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.

关键词： interferon inflammation lipopolysaccharide neuroinflammation nLRP3 nuclear factorκB sirtuin 2

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Tourism versus nature conservation: reconciliation of common interests and objectives——an analysis through Picos de Europa national Park

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Journal of Mountain Science 2018年第11期15卷 2505-2516页

作者： LóPEZ iv.n PARDO Mercedes Department of Psychology and Sociology University of Zaragoza Department of Social Analysis University Carlos Ⅲ of Madrid

nature tourism and particularly tourism in national parks have acquired significant importance in contemporary societies. Post-Fordist consumers have reevaluated the meanings of ‘nature' and ‘natural spaces' and now avoid standardization to seek singularity. Tourism in national parks is a consequence of this tendency and has both positive and negative aspects. The purpose of this sociological research is to describe the most relevant conflicts in the Picos de Europa national Park(Spain) involving the park's conservation, local economic development,and tourism. Seven in-depth interviews and three focus groups were addressed to key local *** this research were identified three chief areas of existing or potential inter-related conflicts and the main actors interacting with them. The first is on population, particularly, the negative consequences of depopulations on the local socio-economic development and the environment. A second source of conflicts identified is caused by the difficult conciliation between commercial exploitation and conservation of the protected natural area. More precisely, this specific form of tourism positively contributes to the economy of local communities whilst problems can arise for the conservation goals of national Parks. Thirdly, in this research is also analyzed the institutional governance and the inter and intra-governmental conflicts as well as with the Park's management body. These findings provide important information for the improved management of tourism and conflicting interests in natural parks.

关键词： national parks Environmental conservation nature tourism Mountain traditional economy Picos de Europa Spain

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nO-ARBITRAGE SYMMETRIES

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Acta Mathematica Scientia 2022年第4期42卷 1373-1402页

作者： iv.n DEGAnO Sebastián FERRAnDO Alfredo GOnZáLEZ Departamento de Matemática.Facultad de Ciencias Exactas y naturales Universidad Nacional de Mar del Plata 7600Argentina Department of Mathematics Ryerson University350 Victoria St.TorontoOntario M5B 2K3Canada

The no-arbitrage property is widely accepted to be a centerpiece of modern financial mathematics and could be considered to be a financial law applicable to a large class of(idealized) *** paper addresses the following basic question:can one characterize the class of transformations that leave the law of no-arbitrage invariant?We provide a geometric formalization of this question in a non probabilistic setting of discrete time-the so-called trajectorial *** paper then characterizes,in a local sense,the no-arbitrage symmetries and illustrates their meaning with a detailed *** context makes the result available to the stochastic setting as a special case.

关键词： no arbitrage symmetry convexity preserving maps non-probabilistic markets

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Bilinear Model Proposal for Seismic Analysis Using Triple Friction Pendulum (TFP) Bearings

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Open Journal of Civil Engineering 2017年第1期7卷 14-31页

作者： iv.n delgado Roberto Aguiar Pablo Caiza Departamento de Ciencias de la Tierra y la Construcción Universidad de Fuerzas Amadas ESPE Av. Gral. Rumiñ ahui s/n Quito Ecuador

An analytical model is presented for seismic analysis of triple friction pendulum bearings and validated using 81 bearing tests, each subjected to three cycles, with a duration of 12 seconds and using 250, 200 and 100 tons vertical loads. The main objective is to develop formulas for bilinear behavior using maximum, average and minimum friction coefficients to check which is the closest to the real behavior in the laboratory tests and comparatives curves plotting to observe the standard derivation. Parameters such as friction coefficients, effective stiffness, damping factor and vibration periods are analyzed to understand the structural behavior of the TPF bearings.

关键词： Triple Friction Pendulum Bearings

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Involvement of glucose transporter overexpression in the protection or damage after ischemic stroke

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neural Regeneration Research 2022年第4期17卷 783-784页

作者： iv.n Alquisiras-Burgos Penélope Aguilera Laboratorio de Patología Vascular Cerebral Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezInsurgentes Sur#3877Col.La FamaTlalpanCiudad de MéxicoMéxico

Cerebral ischemia and resultant energy collapse:The ischemic stroke is a complex neurological condition that can be devastating for patients and their *** disease is the second leading cause of death worldwide and is characterized by a sudden decrease in cerebral blood flow due to major blood vessel *** stroke generates two damaged zones with distinctive metabolic *** first is the ischemic core,the region directly irrigated by the occluded artery.A reduction to less than 20%of the baseline blood flow levels defines the area;therefore,depletion of glucose and adenosine triphosphate(ATP)cause an irreversible failure in the energy metabolism that leads to loss of ionic homeostasis,acidosis,and *** second is the region surrounding the ischemic core,called the penumbra,characterized by significantly depressed tissue perfusion that is barely sufficient to support basal oxygen,glucose,and ATP levels.

关键词： metabolism damage homeostasis

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A charged star with geometric Karmarkar condition

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Communications in Theoretical Physics 2023年第8期75卷 139-149页

作者： Gabino Estevez-delgado Joaquin Estevez-delgado Rafael Soto-Espitia Antonio Rendón Romero Jorge Mauricio Paulin-Fuentes Facultad de Químico Farmacobiología de la Universidad Michoacana de San nicolás de Hidalgo Facultad de Ciencias Físico Matemáticas de la Universidad Michoacana de San nicolás de Hidalgo Edificio BCiudad Universitaria Facultad de Ingeniería Civil de la Universidad Michoacana de San nicolás de Hidalgo Edificio A Ciudad Universitaria Facultad de Ingeniería Mecánica de la Universidad Michoacana de San nicolás de Hidalgo Edificio W Ciudad Universitaria División Académica de Ciencias Básicas de la Universidad Juárez Autónoma de Tabasco

In this paper,we analyse an analytical solution of the Einstein–Maxwell field equations that considers matter with anisotropic pressures in a static and spherically symmetric *** report the manner in which we obtained the solution,which is by means of the Karmarkar *** the model,we assume a state equation that describes the interaction of matter from quarks P=(c^(2)ρ-4B_(g))/3 and we consider the presence of electric charge,which can generate that the radial and tangential pressures are not *** a graphic manner,we analyse the physical properties of the model,taking as the observational data those of mass 1M⊙and radius7.69 km which were reported for the star Her *** charge values are found between 5.57×10^(18)C≤Q≤1.31×10^(20)C and the interval of the Bag constant Bg∈[118.7,122.13]MeV/fm^(3).Also,we show the stability of the configuration by means of the static stability criteria of Harrison–Zeldovich–novikov((?M)/?ρc>0),as well as in regards to infinitesimal radial adiabatic perturbation,since the adiabatic indexγ>3.3 which guarantees the stability of the solution.

关键词： general relativity exact solutions anisotropic fluid Karmarkar condition

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Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

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World Journal of Clinical Cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-navas Francisco Pozo Muñoz Rogelio Garcia Cisneros Maria Jose Garcia Larrosa Maria del Mar Callejon Gil Ignacio Garcia delgado Maria Belen Jimenez Martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BACKGROUnD Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiv.ness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiv.ness of the HCU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management

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Addressing inclusion,innovation,and sustainability challenges through the lens of economic geography:Introducing the hierarchical regional innovation system

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Geography and Sustainability 2024年第1期5卷 1-12页

作者： iv.n Tartaruga Fernanda Sperotto Luís Carvalho Centre of Studies in Geography and Spatial Planning(CEGOT) Faculty of Arts and HumanitiesUniversity of PortoPorto 4150-564Portugal School of Economics and Management University of PortoPortoPortugal

The world is facing dramatic challenges related to environmental sustainability at an accelerating *** this context,the field of economic geography(EG)has been playing an important role in understanding both the socioeconomic and technological dimensions of these challenges,as it deals with a variety of complementary notions and *** from this lens,our aim is to explore a conceptual framework that can help us to understand environmental changes relating to multi-dimensional territorial development,notably in eco-nomic contexts where inequality is high,and stratification based on hierarchies regulate social and economic *** on the territory concept,we propose the original notion of a hierarchical regional innovation system(HRIS)that emphasises the pervasive role of hierarchies(powers)in regional innovation systems and illustrate its value with evidence and case studies from extant literature on sustainability *** HRIS can help us understand and promote development paths considering the contribution of inclusive eco-innovations(another original conceptual amalgam).Through some empirical cases from other studies in low-carbon transitions,we show the application of the HRIS(and inclusive eco-innovation)*** conclusion,we provide incen-tives to explore new regional innovation systems,alongside the HRIS,adapted to different regions worldwide and centred on the inclusiv.ness of people and places.

关键词： Inclusive eco-innovation Inclusive innovation Hierarchical regional innovation system(HRIS) Territorial development Sustainable development Sustainability transitions

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Towards Fully Secure 5G Ultra-Low Latency Communications: A Cost-Security Functions Analysis

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Computers, Materials & Continua 2023年第1期74卷 855-880页

作者： Borja Bordel Ramón Alcarria Joaquin Chung Rajkumar Kettimuthu Tomás Robles iv.n Armuelles Universidad Politecnica de Madrid MadridEspana Argonne national Laboratory LemontILUSA Universidad de Panama PanamaPanama

Future components to enhance the basic,native security of 5G networks are either complex mechanisms whose impact in the requiring 5G communications are not considered,or lightweight solutions adapted to ultrareliable low-latency communications(URLLC)but whose security properties remain under *** different 5G network slices may have different requirements,in general,both visions seem to fall short at provisioning secure URLLC in the *** this work we address this challenge,by introducing cost-security functions as a method to evaluate the performance and adequacy of most developed and employed non-native enhanced security mechanisms in 5G *** categorize those new security components into different groups according to their purpose and deployment *** propose to analyze them in the context of existing 5G architectures using two different ***,using model checking techniques,we will evaluate the probability of an attacker to be successful against each security ***,using analytical models,we will analyze the impact of these security mechanisms in terms of delay,throughput consumption,and ***,we will combine both approaches using stochastic cost-security functions and the PRISM model checker to create a global *** results are first evidence of how a 5G network that covers and strengthened all security areas through enhanced,dedicated non-native mechanisms could only guarantee secure URLLC with a probability of∼55%.

关键词： 5G networks security analysis secure low latency communications URLLC eMBBC

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Simulation of Fluid Flow in a Channel Induced by Three Types of Fin-Like Motion

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Journal of Bionic Engineering 2007年第3期4卷 165-176页

作者： Wojciech Kowalczyk Antonio delgado Institute of Fluid Mechanics University of Erlangen-NurembergCauerstr. 4D-91058 ErlangenGermany

One of many interesting research activities in biofluidmechanics is dedicated to investigations of locomotion in water. Some of propulsion mechanisms observed in the underwater world are used in the development process of underwater autonomic vehicles （AUV）. In order to characterise several solutions according to their manoeuvrability, influence on the surrounding fluid and energetic efficiency, a detailed analysis of fin-like movement is indispensable. In the current paper an analysis of undulatory, oscillatory and combined fin-like movements by means of numerical simulation is carried out. The conservation equation of mass and the conservation equation of momentum axe solved with the Finite Volume Method （FWM） by use of the software CFX-10.0. The undulatory and oscillatory fin movements axe modelled with an equation that is implemented within an additional subroutine and joined with the main solver. n carried out in the computational domain, in which one fin is fixed in a flow-through water duct. Simulations axe carded out in the range of the Re number up to 105. The results show significant influence of applied fin motion on the velocity distribution in the surrounding fluid.

关键词： biofluid dynamics fro-like movement fish propulsion computational fluid dynamics

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