Involvement of glucose transporter overexpression in the protection or damage after ischemic stroke

作     者：Iván Alquisiras-Burgos Penélope Aguilera Iván Alquisiras-Burgos;Penélope Aguilera

作者机构：Laboratorio de Patología Vascular CerebralInstituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezInsurgentes Sur#3877Col.La FamaTlalpanCiudad de MéxicoMéxico 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第4期

页      面：783-784页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the CONACYT(CB-2012-01-182266 to PA) Iván Alquisiras Burgos is a doctoral student from Programa de Doctorado en Ciencias Biomédicas Universidad Nacional Autónoma de México(UNAM)and beneficiary of scholarship No.275610 from CONACYT 

主　　题：metabolism damage homeostasis 

摘      要：Cerebral ischemia and resultant energy collapse:The ischemic stroke is a complex neurological condition that can be devastating for patients and their *** disease is the second leading cause of death worldwide and is characterized by a sudden decrease in cerebral blood flow due to major blood vessel *** stroke generates two damaged zones with distinctive metabolic *** first is the ischemic core,the region directly irrigated by the occluded artery.A reduction to less than 20%of the baseline blood flow levels defines the area;therefore,depletion of glucose and adenosine triphosphate(ATP)cause an irreversible failure in the energy metabolism that leads to loss of ionic homeostasis,acidosis,and *** second is the region surrounding the ischemic core,called the penumbra,characterized by significantly depressed tissue perfusion that is barely sufficient to support basal oxygen,glucose,and ATP levels.