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Catheter-directed thrombolysis in inflammatory bowel diseases:Report of a case

World Journal of Gastroenterology 2012年第34期18卷 4791-4793页

作者： Péter Ilonczai Judit Tóth László Tóth istván altorjay Zoltán Boda Károly Palatka Division of Haemostasis 2nd Department of MedicineMedical and Health Science CentreUniversity of Debrecen4032 DebrecenHungary Euromedic Diagnostics Hungary Ltd. Medical and Health Science CentreUniversity of Debrecen4032 DebrecenHungary Department of Pathology Medical and Health Science CentreUniversity of Debrecen4032 DebrecenHungary Division of Gastroenterology 2nd Department of MedicineMedical and Health Science CentreUniversity of Debrecen4032 DebrecenHungary

In patients with inflammatory bowel diseases (IBD) the prevalence of thrombosis is 6.2%, the average incidence of thromboembolism (TE) is 3.6 times higher compared to normal population. The TE is a common extraintestinal complication of IBD, squarely associated with the IBD activity. The application of antico-agulant and thrombolytic therapy in severe IBD is an unresolved issue. Herein we report the first case in literature of an active IBD patient with an upper limb acute arterial occlusion and successful catheter-directed thrombolysis (CDT). A 46-year-old male patient is reported who had Crohn's disease for 10 years. His right hand suddenly became cold and painful. Angiography proved acute occlusion of the brachial and radial artery. Vascular surgery intervention was not applicable. Endoscopy showed extended, severe inflammation of the colon. Despite the severe endoscopic findings, frequent bloody stools and moderate anaemia, CDT with recombinant tissue plasminogen activator was performed. The control angiography proved improvement, the radial artery pulse appeared. no bleeding complication was observed. This case supports that CDT-after careful estimation of the bleeding risk-can be effective and safe in patients with severe or life-threatening TE and active IBD.

关键词： Inflammatory bowel disease Crohn's dis-ease Thromboembolism Catheter-directed thromboly-sis Gastrointestinal haemorrhage

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Effect of IBD sera on expression of inducible and endothelial nitric oxide synthase in human umbilical vein endothelial cells

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World Journal of Gastroenterology 2006年第11期12卷 1730-1738页

作者： Károly Palatka Zoltán Serf(o|″)z(o|″) Zoltán Veréb Róbert Bátori Beáta Lontay Zoltán Hargitay Zoltán nemes Miklós Udvardy Ferenc Erd(o|″)di istván altorjay Department of Gastroenterology University of Debrecen Nagyerdei k(o|¨)rút 98.Debrecen H-4001Hungary Department of Experimental Zoology BLRI-HAS TihanyHungary Institute of Immunology University of Debrecen Nagyerdei k(o|¨)rút 98.Debrecen H-4001 Hungary Department of Medical Chemistry University of Debrecen Nagyerdei k(o|¨)rút 98.Debrecen H-4001Hungary Department of Pathology Gyula Kenezy Hospital DebrecenBartók Béla út 10.Debrecen H-4026Hungary Institute of Pathology University of Debrecen Nagyerdei k(o|¨)rút 98.Debrecen H-4001Hungary Institute of Internal Medicine University of Debrecen Nagyerdei k(o|¨)rút 98.Debrecen H-4001Hungary

AIM： To study the expression of endothelial and inducible nitric oxide synthases （enOS and inOS） and their role in inflammatory bowel disease （IBD）. METHODS： We examined the effect of sera obtained from patients with active Crohn＇s disease （CD） and ulcerative colitis （UC） on the function and viability of human umbilical vein endothelial cells （HUVEC）. HUVECs were cultured for 0-48 h in the presence of a medium containing pooled serum of healthy controls, or serum from patients with active CD or UC. Expression of enOS and inOS was visualized by immunofluorescence, and quantified by the densitometry of Western blots. Proliferation activity was assessed by computerized image analyses of Ki-67 immunoreactive cells, and also tested in the presence of the nOS inhibitor, 10^-4 mol/L L-nAME. Apoptosis and necrosis was examined by the annexin-V-biotin method and by propidium iodide staining, respectively. RESULTS： In HUVEC immediately after exposure to UC, serum enOS was markedly induced, reaching a peak at 12 h. In contrast, a decrease in enOS was observed after incubation with CD sera and the enOS level was minimal at 20 h compared to control （18%±16% vs 23%± 15% P〈0.01）. UC or CD serum caused a significant increase in inOS compared to control （UC： 300%±21%; CD： 275% ± 27% vs 108% ± 14%, P〈0.01）. Apoptosis/necrosis characteristics did not differ significantly in either experiment. Increased proliferation activity was detected in the presence of CD serum or after treatment with L-nAME. Cultures showed tube-like formations after 24 h treatment with CD serum. COnCLUSIOn： IBD sera evoked changes in the ratio of enOS/inOS, whereas did not influence the viability of HUVEC. These involved down-regulation of enOS and up-regulation of inOS simultaneously, leading to increased proliferation activity and possibly a reduced antiinflammatory protection of endothelial cells.

关键词： Crohn's disease Human umbilical vein endothelial cells Inflammatory bowel disease nitric oxide synthase Ulcerative colitis

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Optimal design of the fillet weld fastening the wind turbine column

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China Welding 2024年第3期33卷 39-43页

作者： Imre Timár istván W.Árpád Mechanical Engineering Department Faculty of EngineeringUniversity of PannoniaVeszprem H-8200Hungary Mechanical Engineering Department Faculty of EngineeringUniversity of DebrecenDebrecen H-4032Hungary

This paper deals with the optimal design of the fillet weld of wind turbine column subjected to bending *** the premise of determined the force acting on the column,in order to further optimize the fillet weld,the minimum volume of corner seam was determined in the case of non-linear design *** constraints relate to the maximal stresses and fatigue of welding seam.A numer-ical solution to this problem is given by genetic optimization *** optimisation calculation result indicated that the active condi-tion(constraint)was the stress from the static *** and meaningful information is provided for the engineering field.

关键词： fillet weld optimal design genetic algorithm static and dynamic load

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Chebyshev polynomial-based Ritz method for thermal buckling and free vibration behaviors of metal foam beams

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 891-910页

作者： n.D.nGUYEn T.n.nGUYEn Faculty of Civil Engineering Ho Chi Minh City University of Technology and EducationHo Chi Minh City 71309Viet Nam Faculty of Engineering and Technology Kien Giang UniversityChau Thanh 92000Viet Nam

This study presents the Chebyshev polynomials-based Ritz method to examine the thermal buckling and free vibration characteristics of metal foam *** analyses include three models for porosity distribution and two scenarios for thermal *** material properties are assessed under two conditions,i.e.,temperature dependence and temperature *** theoretical framework for the beams is based on the higher-order shear deformation theory,which incorporates shear deformations with higher-order *** governing equations are established from the Lagrange equations,and the beam displacement fields are approximated by the Chebyshev *** simulations are performed to evaluate the effects of thermal load,slenderness,boundary condition(BC),and porosity distribution on the buckling and vibration behaviors of metal foam *** findings highlight the significant influence of temperature-dependent(TD)material properties on metal foam beams'buckling and vibration responses.

关键词： Ritz method Chebyshev function buckling vibration metal foam beam higher-order beam theory(HOBT)

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Compression properties of cost-efficient porous expanded clay reinforced AA7075 syntactic foams fabricated by industrial-oriented die casting technology

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China Foundry 2024年第1期21卷 60-70页

作者： İsmail Cem Akgün Çağın Bolat Ali Gökşenli Faculty of Mechanical Engineering Istanbul Technical University34437İstanbulTurkey Faculty of Engineering Samsun University55420SamsunTurkey

In today’s manufacturing industries,hard competition between rival firms makes it compulsory for researchers to design lighter and cheaper machine components due to the megatrends of cost-effectiveness and *** this point,aluminum syntactic foams(ASFs)are new-generation engineering composites and come into the upfront as a *** to their features like low density,sufficient elongation,and perfect energy absorption ability,these advanced foams have been considerably seductive for many industrial sectors *** this study,an industrial-oriented automatic die casting technology was used for the first time to manufacture the combination of AA7075/porous expanded clay(PEC).Micro evaluations(optical and FESEM)reveal that there is a homogenous particle distribution in the foam samples,and inspections are compatible with the other ASF ***,T6 aging heat treatment was operated on one half of the produced foams to explore the probable impact of aging on the compressive *** results show that PEC particles can be an alternative to expensive hollow spheres used in the previous ***,a favorable relationship is ascertained between the aging treatment and mechanical properties such as compression strength and plateau strength.

关键词： die casting porous materials metal matrix sytanctic foams expanded clay compressive deformation

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Predicting effects of tunnel throttling of annular freeway vehicular flow by a continuum model

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第4期11卷 733-746页

作者： Zhongmin Huang M.n.Smirnova n.n.Smirnov Zuojin Zhu Faculty of Engineering Science University of Science and Technology of ChinaHefei 230026China Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Faculty of Mechanics and Mathematics Lomonosov Moscow State UniversityMoscow 119992Russia

Fluid flow throttling is common in industrial and building services *** tunnel throttling of vehicular flow is caused by the abrupt number reduction of roadway lane,as the tunnel has a lower lane number than in the roadway normal *** predict the effects of tunnel throttling of annular freeway vehicular flow,a three-lane continuum model is ***Ⅲof the tunnel is completely blocked due to the need of tunnel rehabilitation,*** exists mandatory net lane-changing rate from laneⅢto laneⅡjust upstream of the tunnel entrance,which is described by a model of random number generated through a golden section *** net-changing rate between adjacent lanes is modeled using a lane-changing time expressed explicitly in algebraic *** paper assumes that the annular freeway has a total length of 100 km,a two-lane tunnel of length 2 km with a speed limit of 80 km/*** free flow speeds on lanesⅠ,ⅡandⅢare assumed to be 110,100 and 90 km/h *** on the three-lane continuum model,numerical simulations of vehicular flows on the annular freeway with such a tunnel are conducted with a reliable numerical method of 3rd-order *** results reveal that the vehicular flow has a smaller threshold of traffic jam formation in comparison with the case without tunnel *** fuel consumption can be estimated by interpolation with time averaged grid traffic speed and an assumed curve of vehicle *** vehicle fuel consumption is lane number dependent,distributes with initial density concavely,ranging from 5.56 to 8.00 *** throttling leads to an earlier traffic jam formation in comparison with the case without tunnel throttling.

关键词： Effects of tunnel throttling Vehicle fuel consumption Travel time Threshold of traffic jam formation Continuum model

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Towards defining soil quality of Mediterranean calcareous agricultural soils:Reference values and potential core indicator set

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International Soil and Water Conservation Research 2024年第1期12卷 145-155页

作者： Germán A.Durán Daniel Sacristán Edelweis Farrús Jaume Vadell Institut de Recerca i FormacióAgrària i Pesquera de les Illes Balears C/Eusebi Estada14507009PalmaSpain Plant Biology Department University of Valencia46100BurjassotValenciaSpain Soil and Environmental Quality Department Centro de Investigaciones sobre Desertificación-CIDE(CSIC-Universitat de València-Generalitat Valenciana)Carretera Moncada-Náquera km 4.546113MoncadaValenciaSpain Universitat de les Illes Balears Cra.De Valldemossakm 7507122PalmaSpain

To avoid soil degradation,adapt to climate change and comply with the Sustainable Development goals 2030(Un General Assembly),establishing the quality/fertility of the agricultural soils of the Mediterranean region and evaluate how these evolve with time is *** enables adequate management practices to be *** Mediterranean calcareous region has received little attention in this sense,in spite its soil ***,24 different representative calcareous agricultural soils of the Mediterranean region,including the main management strategies of agricultural soils(rainfed and irrigated),were sampled from the island of Mallorca;and their physical,chemical and biological properties *** values obtained for most of the soil characteristics allowed to establish an initial approach to the reference values for the type of calcareous agricultural soils considered,and to clearly distinguish the effect of rainfed or irrigation management practices on soils properties and *** enzyme activities were not stimulated by the irrigation conditions assayed or they were only in dry conditions,suggesting optimum enzyme activities could be obtained when alternating dry and humid soil *** organic carbon,calcium carbonate and active lime revealed of significant importance in the collection of ***,the results obtained clearly indicate the heterogeneity of the region and its implications on the different soil ***,this study could serve as a starting point to adequately establish the quality(fertility)for Mediterranean calcareous agricultural soils and their reference values by conducting further research in this region and including more type of soils.

关键词： Soil fertility Mediterranean agricultural soils Calcareous soils Soil enzymes Soil management

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Weather influenced nestling growth of an insectivorous but not a granivorous grassland passerine in Argentina

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Avian Research 2024年第2期15卷 156-162页

作者： Martín Alejandro Colombo Adrian Jauregui Luciano n.Segura Laboratorio de Ecología de Aves.Institute“Dr.Raúl A.Ringuelet”(ILPLA)-UnLP/COnICET Boulevard 1201437La PlataB1900Buenos AiresArgentina

nestling growth of birds can be affected by weather *** general,it is expected that higher temper-atures favor growth by improving food availability and nestling metabolism,while rain hinders it by reducing foraging ***,most of these patterns have been described in insectivorous cavity-nesting birds in temperate *** tested these predictions in two neotropical grassland ground-nesting birds with contrasting nestling diets and therefore potentially different responses to *** measured nestlings of the Hellmayr’s Pipit(Anthus hellmayri,an insectivorous passerine)and the Grassland Yellow-Finch(Sicalis luteola,which feeds its nestlings exclusively with seeds)during three breeding seasons(2017-2020)in central-eastern *** took measurements of tarsus and body mass,modeled growth curves using nonlinear mixed-effects models,and evaluated the effects of minimum daily temperature and precipitation during the growth period and the 30 days prior to *** pipits(60 nestlings from 21 nests),minimum temperatures during the growth period were positively associated with tarsus and body mass ***,there was a positive association between precipitation during the pre-hatching period and tarsus ***,none of the weather variables analyzed had significant effects on nestling growth of finches(131 nestlings from 35 nests).Dietary contrast between species may explain the different *** activity and abundance can be affected by weather variations within the span of a breeding season,whereas seeds may depend on conditions from previous years,making the effects harder to *** with reduced asymptotic size can have reduced chances of ***,pipit populations could be impacted if they experience cold and dry conditions during their breeding season,which is of major relevance in the current context of climate change.

关键词： Finches Grassland birds neotropical birds Pipits Precipitation Temperature

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Inclusion of CoTiO_(3) to ameliorate the re/dehydrogenation properties of the Mg–na–Al system

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Journal of Magnesium and Alloys 2024年第3期12卷 1215-1226页

作者： n.A.Ali n.Y.Yusnizam n.A.Sazelee Sami-ullah Rather Haizhen Liu M.Ismail Energy Storage Research Group Faculty of Ocean Engineering TechnologyUniversiti Malaysia Terengganu21030 Kuala NerusTerengganuMalaysia Department of Chemical and Materials Engineering King Abdulaziz UniversityP.O.Box80204Jeddah 21589Saudi Arabia Guangxi novel Battery Materials Research Center of Engineering Technology School of Physical Science and TechnologyGuangxi UniversityNanning 530004China State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures Nanning 530004China

For the first time,the MgH_(2)–naAlH_(4)(ratio 4:1)destabilized system with CoTiO_(3) addition has been *** CoTiO_(3)-doped MgH_(2)–naAlH_(4) sample begins to dehydrogenate at 130℃,which is declined by 40℃ compared to the undoped MgH_(2)–naAlH_(4).Moreover,the de/rehydrogenation kinetics characteristics of the CoTiO_(3)-doped MgH_(2)–naAlH_(4) were greatly *** the inclusion of CoTiO_(3),the MgH_(2)–naAlH_(4) composite absorbed 5.2 wt.%H_(2),higher than undoped MgH_(2)–naAlH_(4).In the context of dehydrogenation,the CoTiO_(3)-doped MgH_(2)–naAlH_(4) sample desorbed 2.6 wt.%H_(2),almost doubled compared to the amount of hydrogen desorbed from the undoped MgH_(2)–naAlH_(4) *** activation energy obtained by the Kissinger analysis for MgH_(2) decomposition was significantly lower by 35.9 kJ/mol than the undoped MgH_(2)–naAlH_(4) *** reaction mechanism demonstrated that new phases of MgCo and AlTi_(3) were generated in situ during the heating process and are likely to play a substantial catalytic function and be useful in ameliorating the de/rehydrogenation properties of the destabilized MgH_(2)–naAlH_(4) system with the inclusion of CoTiO_(3).

关键词： Destabilize system Magnesium hydride Sodium alanate Hydrogen storage Additive.

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Marinoan glaciation in the Indian subcontinent——Anatomy and global implications

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Journal of Palaeogeography 2024年第2期13卷 293-308页

作者： H.n.Bhattacharya Department of Earth Sciences Techno India UniversityWest BengalSector VSalt LakeKolkata700091India

Detailed sedimentological analysis of the Pokaran Boulder Bed,representing the most basal unit of the neoproterozoic-Lower Cambrian Marwar Supergroup,clearly indicates its glacial *** glacial sediments are interpreted as an ice-contact submarine fan *** on the detrital and inherited zircon population of the Marwar Supergroup sediments and interlayered pyroclastic deposits,a Marinoan cryochron of the Cryogenian Period is envisaged for the Pokaran Boulder *** well-preserved Ediacaran elements in the post-glacial sedimentary succession also support a Cryogenian to Early Cambrian age of the Marwar *** glacial deposition at the base of the Marwar Supergroup strengthens the regional correlation between the studied sediments with the Lesser Himalayan Blaini-Krol-Tal sediments and the Haqf Supergroup of *** available zircon ages and paleomagnetic data of the Malani Igneous suite,along with the Marinoan glacial deposits,detrital zircon ages,and Ediacaran fossil elements of the Marwar Supergroup add significant information to the neoproterozoic Earth history.

关键词： neoproterozoic Marinoan glaciation Diamictites Pokaran Boulder Bed Marwar Supergroup

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