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Rehabilitation care for pain in elderly knee replacement patients

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World Journal of Clinical Cases 2024年第4期12卷 721-728页

作者： li liu Qiao-Zhen Guan li-Fang Wang Wuhan Fourth Hospital Wuhan 430033Hubei ProvinceChina Department of Orthopaedics Wuhan Third HospitalWuhan 430074Hubei ProvinceChina

BACKGROUnD Total knee arthroplasty(TKA)is recognized as the most effective surgical intervention for relieving pain and improving joint mobility and deformity in patients with knee osteoarthritis and other synovial *** application of accelerated postoperative rehabilitation(enhanced recovery after surgery)has demonstrated its efficacy in improving patient outcomes,and early postoperative joint function exercise has become a key prognostic factor in knee *** unexpected appearance of limb pain and swelling hindered the patient’s tendency for early mobilization,leading in prolonged hospitalization,delayed functional recovery and negative psychological responses.A retrospective analysis was conducted on a cohort of 116 patients who under-went TKA at our hospital between July 2019 and July *** patients were divided into two groups:A control group(n=58)receiving programmatic nur-sing,and an observed group(n=58)receiving programmed nursing combined with a collaborative nursing model.A pain management team consisting of attending physicians,head nurses,and responsible nurses was *** measures included visual analogue scale(VAS)scores,activities of daily living(ADL)scale scores,and functional *** ADL scores of patients in both groups exhibited a continuous ***,there was no statistically significant difference in the ADL scores between the two groups at 48 h and the 7th d post-surgery(P>0.05).Upon reexamination at the 3rd mo,the observation group demonstrated higher ADL scores compared to the control group(67.48±14.69 vs 59.40±16.06,Pnificantly decreased,with no significant difference observed between the groups at each time point(P>0.05).The functional status of patients in both groups exhibited a gradual increase prior to intervention and at the 1st,2nd,and 3rd month following discharge(Pno statistically significant difference in knee joint function scores b

关键词： Programmed pain nursing Collaborative nursing Total knee arthroplasty

Stereoselective Synthesis of 2-Deoxy-α-n-Glycosides from Glycals with 1,4,2-Dioxazol-5-ones

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Chinese Journal of Chemistry 2024年第18期42卷 2147-2152页

作者： Zhenpeng Shen Guoyin Yin Yangyang li The Institute for Advanced Studies Wuhan UniversityWuhanHubei 430072China

The synthesis of n-glycosides has received significant attention due to their crucial role in carbohydrate *** considerable advancements developed in the construction of n-glycosides,methods for the stereoselective construction of 2-deoxy-α-n-glycosides are still ***,we disclosed a nickel-catalyzed hydroamination of glycals under mild *** transformation could allow for the stereoselective synthesis of an array of 2-deoxy-α-n-glycosides with excellentα-***-catalyzed glycosylation reactions,particularly those involving anomeric C(sp")-metal bond formation,have proven to be an effective and stereoselective strategy for producing various ***,with highlight of the application of this reaction,y-sugar amino acidderivatives weresynthesized.

关键词： 2-Deoxy-α-n-glycosides nickel catalysis Stereoselectivity Glycals Hydroamination Amides Glycosylation Alkenes ComprehensiveSummary

Effect of miR-124 Overexpression under Wnt/β-catenin Signaling Pathway on Inflammatory Factor and Epidermal Growth Factor in Rats with Precancerous Gastric Lesions

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Chinese Journal of Biomedical Engineering 2024年第01期33卷 17-26页

作者： ZHOU li-jiang Zhejiang Chinese Medical University Shangyu People's Hospital of Shaoxing

Objective: To investigate the effects of miR-124 overexpression on inflammatory factors and epidermal growth factor in rats with gastric precancerous lesions by modulating the Wnt/β-catenin signaling pathway. Methods: Eighty SPF-grade Wistar rats were selected as the research subjects. After adaptive feeding,they were divided into 4 groups using a random number table method. The control group was fed a regular diet, while the model group, low expression group, and overexpression group of rats were treated with n-methyl-n'-nitro-n-nitrosoguanidine to establish a model of gastric cancer precancerous lesions. After successful modeling, the control group and model group rats were injected intraperitoneally with 0.9% sodium chloride solution, the low-expression group rats were injected intraperitoneally with miR-124-5p inhibitor, and the over-expression group rats were injected intraperitoneally with miR-124-5p mimic. After 8 weeks of continuous injection, the levels of miR-124,Wnt/β-catenin signaling pathway-related proteins, inflammatory factors, and epidermal growth factor were observed and compared among the four groups of rats. Results: The differences in the relative expression of miR-124 among the four groups of rats were statistically significant(Pnces in the expression of Wnt protein andβ-catenin protein among the four groups of rats were statistically significant(Pnd the expression of Wnt protein and β-catenin protein in the overexpression group was significantly higher than that of the control group, and significantly lower than that in the model group and the low-expression group; the levels of IL-1β, IL-6, and TnF-αof rats in the four groups of rats IL-1β, IL-6 and TnF-α levels were statistically different(Pnd the levels of IL-1β, IL-6 and TnF-α in rats in the overexpression group were higher than those in the model group and significantly lower than those in the model group and the low-expression group(P<0.05); the differ

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Monte Carlo method for evaluation of surface emission rate measurement uncertainty

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nuclear Science and Techniques 2024年第7期35卷 126-136页

作者： Yuan-Qiao li Min lin li-Jun Xu Rui Luo Yu-He Zhang Qian-Xi ni Yun-Tao liu China Institute of Atomic Energy Beijing102413China national Key Laboratory for Metrology and Calibration Techniques Beijing102413China Department of Radiation Oncology Hunan Cancer HospitalChangsha410031China The Affiliated Cancer Hospital of Xiangya School of Medicine Central South UniversityChangsha410031China

The aim of this study is to evaluate the uncertainty of 2πα and 2πβ surface emission rates using the windowless multiwire proportional counter *** study used the Monte Carlo method (MCM) to validate the conventional Guide to the Expression of Uncertainty in Measurement (GUM) method.A dead time measurement model for the two-source method was established based on the characteristics of a single-channel measurement system,and the voltage threshold correction factor measurement function was indirectly obtained by fitting the threshold correction *** uncertainty in the surface emission rate was calculated using the GUM method and the law of propagation of *** MCM provided clear definitions for each input quantity and its uncertainty distribution,and the simulation training was realized with a complete and complex mathematical *** results of the surface emission rate uncertainty evaluation for four radioactive plane sources using both methods showed the uncertainty’s consistency E_(n)n of each source,and the uncertainty results of the GUM were all lower than those of the ***,the MCM has a more objective evaluation process and can serve as a validation tool for GUM results.

关键词： Surface emission rate Monte Carlo method Metrology Probability distribution function Dead time Low-energy loss correction Least-squares method

2D–3D dual carbon layer confined ultrasmall Vn nanoparticles for improving lithium-ion storage in hybrid capacitors

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Rare Metals 2024年第1期43卷 65-75页

作者： Zhao-Wei Hu Hui-Fang li Peng Wang Wan-li Wang Lei Yang Xiao-Jun Wang Zhi-Ming liu College of Electromechanical Engineering Shandong Engineering Laboratory for Preparation and Application of High-Performance Carbon-MaterialsQingdao University of Science&TechnologyQingdao 266061China Research Center for Intelligent and Wearable Technology College of Textiles and ClothingQingdao UniversityQingdao 266071China

lithium-ion capacitors(liCs) of achieving high power and energy density have garnered significant attention. However, the kinetics unbalance between anode and cathode can impede the application of liCs. Vanadium nitride(Vn) with a high theoretical specific capacity(~ 1200 m Ah·g^(-1)) is a better pseudocapacitive anode to match the response of cathode in liCs. However, the insertion/extraction of li-ions in Vn's operation results in significant volume expansion. Herein, the Vn/n-r GO-5composite that three-dimentional(3D) dicyandiamidederived-carbon(DDC) tightly wrapped Vn quantum dots(Vn QDTs) on two-dimentional(2D) reduced graphene oxid(r GO) was prepared by a facile strategy. The Vn QDTs can reduce ion diffusion length and improve charge transfer kinetics. The 2D r GO as a template provides support for nanoparticle dispersion and improves electrical conductivity. The 3D DDC tightly encapsulated with Vn QDTs mitigates agglomeration of Vn particles as well as volume expansion. Correspondingly, the liCs with Vn/nr GO-5 composite as anode and activated carbon(AC) as cathode were fabricated, which exhibits a high energy density and power density. Such strategy provides a perspective for improving the electrochemical properties of liC anode materials by suppressing volume expansion and enhancing conductivity.

关键词： Vanadium nitride(Vn)quantum dots Reduced graphene oxide(rGO)nanosheets Dicyandiamide-derived-carbon 2D–3D dual carbon layer lithium-ion capacitors

Synthesis,Characterization of Polyethylene Ionomers and Their Antibacterial Properties

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Chinese Journal of Polymer Science 2024年第8期42卷 1077-1084页

作者： Jia-Jia Wu Fei Wang Peng-Qi Wan li Pan Chun-Sheng Xiao Zhe Ma Yue-Sheng li Tianjin Key Lab Composite&Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Key Lab Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Owing to its high production volume and wide range of application s,polyethylene has gained a great deal of attention,but its low surface energy and non-polar nature have limited its application in some important *** this study,ethylene/11-iodo-1-undecene copolymers were prepared and used as the intermediates to afford a series of imidazolium-based ionomers bearing methanesulfonate(CH_(3)SO_(3)^(-)),trifluoromethanesulfonate(CF_(3)SO_(3)^(-)),or bis(trifluoromethane)sulfonimide(Tf_(2)n^(-))*** tensile test results showed that the stress-at-break(7.8-25.6 MPa)and the elongation-at-break(445%-847%)of the ionomers could be adjusted by changing the counterion species and the ionic group *** importantly,the ionomers exhibited marvelous antibacterial activities against Staphylococcus aureus(***)and Escherichia coli(***).The ionomers bearing Tf_(2)n^(-)exhibited antibacterial activities>99%against both *** and *** when ionic content reached 9.1%.The imidazolium-based ionomers prepared in this work demonstrated excellent comprehensive properties,especially highefficient and broad-spectrum antibacterial ability,exhibiting the potential fo r the application as the antibacterial materials in packaging,medical,and other fields.

关键词： Polyethylene Ionomer Polymerization catalysis Imidazolium Antibacterial material

nitrogen-doped carbon dots-modified Prussian blue with sandwichlike structure as a high-performance electrochromic material

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nano Research 2024年第10期17卷 9174-9180页

作者： Yaqi Zhang lide li Siming Zhao Yilin Ding nan Shen Yujie Sun Hao Wang Jingfa li Rufan Zhang School of Chemistry and Materials Science School of Physics and Optoelectronic EngineeringNanjing University of Information Science and TechnologyNanjing 210044China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Prussian blue(PB),as a promising inorganic electrochromic material(ECM),has been widely used in smart windows,displays,sensors,***,there are still many challenges for PB to achieve high electrochromic ***,we synthesized nitrogen-doped carbon dots-modified PB film(defined as PB@n-CDs)with a sandwich-like structure by a simple stepwise electrodeposition *** carbon dots show an obvious advantage in ultrafast electron transfer ability,which can reduce charge loss during the transfer process,improve the electrochemical activity on both sides of PB,and thus facilitate a rapid electrochromic ***,the surface of nitrogen-doped carbon dots contains multiple organic functional groups,which widen the movement path of K+ions under electrostatic ***,the PB@n-CDs film exhibits a short bleaching/coloring time(0.5/0.9 s)and a superior optical modulation range(78.6%).Particularly,the coloring efficiency has been significantly improved to 137.71 cm^(2)/C(at 700 nm).All of these results open up new avenues for developing highperformance PB-based ECMs and promoting their applications in corresponding electrochromic devices(ECDs)and smart windows.

关键词： electrochromic Prussian blue carbon dots nanostructure

Inhalable metal–organic framework-mediated cuproptosis combined with PD-L1 checkpoint blockade for lung metastasis synergistic immunotherapy

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2281-2297页

作者： Chongzheng Yan Ying liu Guozhi Zhao Huatian Yang Huaiyou Lv Genju li Yuhan li Yaqing Fu Fengqin Sun Yafei Feng Yizhe li Zhongxi Zhao Department of Pharmaceutics Key Laboratory of Chemical Biology of Ministry of EducationSchool of Pharmaceutical SciencesCheelloo College of MedicineShandong UniversityJinan 250012China Key University Laboratory of Pharmaceutics&Drug Delivery Systems of Shandong Province School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Cuproptosis shows enormous application prospects in lung metastasis ***,the glycolysis,Cu^(+)efflux mechanisms,and insufficient lung drug accumulation severely restrict cuproptosis ***,an inhalable poly(2-(n-oxide-n,n-diethylamino)ethyl methacrylate)(OPDEA)-coated copper-based metal–organic framework encapsulating pyruvate dehydrogenase kinase 1 siRnA(siPDK)is constructed for mediating cuproptosis and subsequently promoting lung metastasis immunotherapy,namely *** inhalation,OMP shows highly efficient lung accumulation and long-term retention,ascribing to the OPDEA-mediated pulmonary mucosa *** tumor cells,OMP is degraded to release Cu2+under acidic condition,which will be reduced to toxic Cu^(+)to induce cuproptosis under glutathione(GSH)***,siPDK released from OMP inhibits intracellular glycolysis and adenosine-5ʹ-triphosphate(ATP)production,then blocking the Cu^(+)efflux protein ATP7B,thereby rendering tumor cells more sensitive to OMP-mediated ***,OMP-mediated cuproptosis triggers immunogenic cell death(ICD)to promote dendritic cells(DCs)maturation and CD8^(+)T cells ***,OMP-induced cuproptosis up-regulates membrane-associated programmed cell death-ligand 1(PD-L1)expression and induces soluble PD-L1 secretion,and thus synergizes with anti-PD-L1 antibodies(aPD-L1)to reprogram immunosuppressive tumor microenvironment,finally yielding improved immunotherapy ***,OMP may serve as an efficient inhalable nanoplatform and afford preferable efficacy against lung metastasis through inducing cuproptosis and combining with aPD-L1.

关键词： Cuproptosis Immunogenic cell death PD-L1 checkpoint blockade Copper-based metal-organic framework Immunotherapy Tumor microenvironment Transmucosal deliveryLung metastasis

Enhanced piezoelectric performance of Cr/Ta non-equivalent co-doped Bi_(4)Ti_(3)O_(12)-based high-temperature piezoceramics

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Journal of Advanced Ceramics 2024年第3期13卷 263-271页

作者： Xuanyu Chen Ziqi Ma Bin li Yejing Dai School of Materials Sun Yat-sen UniversityShenzhen 518107China

In this study,(Cr_(1/3)/Ta_(2/3))non-equivalent co-doped Bi_(4)Ti_(3)O_(12)(BIT)ceramics were prepared to solve the problem that high piezoelectric performance,high Curie temperature,and high-temperature resistivity could not be achieved simultaneously in BIT-based ceramics.A series of Bi_(4)Ti_(3-x)(Cr_(1/3)Ta_(2/3))_(x)O_(12)(x=0-0.04)ceramics were synthesized by the solid-state reaction *** phase structure,microstructure,piezoelectric performance,and conductive mechanism of the samples were systematically *** B-site non-equivalent co-doping strategy combining high-valence Ta^(5+)and low-valence Cr^(3+)significantly enhances electrical properties due to a decrease in oxygen vacancy ***_(4)Ti_(2.97)(Cr_(1/3)Ta_(2/3))_(0.03)O_(12)ceramics exhibit a high piezoelectric coefficient(d_(33)=26 pC·n^(-1))and a high Curie temperature(TC=687℃).Moreover,the significantly increased resistivity(ρ=2.8×10^(6)Ω·cm at 500℃)and good piezoelectric stability up to 600℃are also obtained for this *** the results demonstrate that Cr/Ta co-doped BIT-based ceramics have great potential to be applied in high-temperature piezoelectric applications.

关键词： high temperature piezoelectricity co-doped Bi_(4)Ti_(3)O_(12)(BIT)