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Comparison of Propofol and Fentanyl for Preventing Emergence Agitation Following Sevoflurane Anesthesia in Pediatric Patients: A Single-Center Study in Bangladesh

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Pharmacology & Pharmacy 2024年第6期15卷 223-235页

作者： Md. Saiful islam Khan Md. Abir Tazim Chowdhury Farzana Fardousi Munama Magdum Md. Ahaduzzaman Taneem Mohammad Shamima Akter Suriya Akter Md. Saiful islam Azad Md. Mozaffer Hossain M. Abdur Rahman Department of Cardiothoracic Anesthesia Evercare Hospital Dhaka Bangladesh Department of Cardiothoracic and Vascular Surgery Evercare Hospital Dhaka Bangladesh Department of Pathology National Institute of Cancer Research & Hospital Dhaka Bangladesh Department of Preventive and Social Medicine National Institute of Preventive and Social Medicine Dhaka Bangladesh Department of Anesthesia Sheikh Sayera Khatun Medical College Gopalgonj Bangladesh Department of Anesthesia Dhaka Medical College Dhaka Bangladesh Department of Anesthesia Combined Military Hospital Dhaka Bangladesh Department of Cardiac Anesthesia National Institute of Cardiovascular Disease Dhaka Bangladesh Department of Anesthesia Bangladesh Medical College Dhaka Bangladesh

Background: Emergence agitation (EA) is a common phenomenon observed in pediatric patients following general anesthesia. This study aimed to assess the efficacy of propofol and fentanyl in preventing EA and to compare their associated complications or side effects. Methods: This prospective randomized observational comparative study was conducted at Dhaka Medical College Hospital from July 2013 to June 2014. The study aimed to evaluate the effects of propofol and fentanyl on EA in children aged 18 to 72 months undergoing circumcision, herniotomy, and polypectomy operations. Ninety children were included in the study, with 45 in each group. Patients with psychological or neurological disorders were excluded. Various parameters including age, sex, weight, American Society of Anesthesiologists (ASA) class, duration of anesthesia, Saturation of Peripheral Oxygen (SPO2), heart rate (HR), respiratory rate (RR), Pediatric Anesthesia Emergence Delirium (PAED) score, duration of post-anesthesia care unit (PACU) stay, incidence of laryngospasm, nausea, vomiting, and rescue drug requirement were compared between the two groups. Results: Age, sex, weight, ASA class, and duration of anesthesia were comparable between the two groups. Perioperative SpO2 and HR were similar in both groups. However, the PAED score was significantly higher in the fentanyl group during all follow-ups except at 30 minutes postoperatively. The mean duration of PACU stay was significantly longer in the fentanyl group. Although the incidence of laryngospasm was higher in the fentanyl group, it was not statistically significant. Conversely, nausea or vomiting was significantly higher in the fentanyl group. The requirement for rescue drugs was significantly higher in the fentanyl group compared to the propofol group. Conclusion: Both propofol and fentanyl were effective in preventing emergence agitation in pediatric patients undergoing various surgical procedures under sevoflurane anesthesia. However, propo

关键词： Emergence Agitation (EA) General Anesthesia Propofol Fentanyl Pediatric Patients Pediatric Anesthesia Emergence Delirium (PAED) Score Bangladesh

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Increasingβ-hexosaminidase A activity using genetically modified mesenchymal stem cells

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Neural Regeneration Research 2024年第1期19卷 212-219页

作者： Alisa A.Shaimardanova Daria S.Chulpanova Valeriya V.Solovуeva Shaza S.Issa Aysilu I.Mullagulova Angelina A.Titova Yana O.Mukhamedshina Anna V.Timofeeva Alexander M.Aimaletdinov islam R.Nigmetzyanov Albert A.Rizvanov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia Department of Histology Cytology and EmbryologyKazan State Medical UniversityKazanRussia

GM2 gangliosidoses are a group of autosomal-recessive lysosomal storage disorde *** diseases result from a deficiency of lysosomal enzymeβ-hexosaminidase A(HexA),which is responsible for GM2 ganglioside *** deficiency causes the accumulation of GM2-gangliosides mainly in the nervous system cells,leading to severe progressive neurodegeneration and *** date,there is no treatment for these ***-mediated gene therapy is considered a promising treatment for GM2 *** study aimed to evaluate the ability of genetically modified mesenchymal stem cells(MSCs-HEXA-HEXB)to restore HexA deficiency in Tay-Sachs disease patient cells,as well as to analyze the functionality and biodistribution of MSCs in *** effectiveness of HexA deficiency cross-correction was shown in mutant MSCs upon intera ction with *** results also showed that the MSCs-HEXA-HEXB express the functionally active HexA enzyme,detectable in vivo,and intravenous injection of the cells does not cause an immune response in *** data suggest that genetically modified mesenchymal stem cells have the potentials to treat GM2 gangliosidoses.

关键词： adeno-associated viral vectors cell therapy cell-mediated gene therapy gene therapy GM2 gangliosidosis Sandhoff disease Tay-Sachs disease β-hexosaminidase

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Study the Structural, Electronic, Optical Properties of CZTS Compound after Doping Ba at Zn Site and Si at Sn Site Using Density Functional Theory (DFT)

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Materials Sciences and Applications 2024年第9期15卷 305-319页

作者： Fatema Najrin Rabeya Bakar Sarna Sayedul Hasan Shariful islam Budrun Neher Md. Mahbubur Rahman Bhuiyan Farid Ahmed Department of Physics Jahangirnagar University Bangladesh Department of Physics Sunamganj Science and Technology University Santiganj Bangladesh

The structural, electronic, and optical properties of Cu2Zn1−xBaxSn1−ySiyS4 compounds have been calculated using GGA-PBE function within the framework of Density Functional Theory (DFT). In the present work, lattice parameters remained the same, that is tetragonal crystal structure for 0% and 100% doping concentration. The electronic band gap of Cu2Zn1−xBaxSn1−ySiyS4 compounds has been gradually increased for continuous increment of doping concentration where the highest electronic band gap is 1.117 eV for Cu2BaSiS4 structure. Moreover, the band gap changes from direct to indirect band gap with the increase of doping concentration in the parent compound. The absorption coefficient has been found to be high (> 104 cm−1) in UV-region for all the doping concentration which makes the studied compound as a potential candidate of absorber layer in the UV detector. The theoretical study of the effect of double doping in the CZTS compound is very interesting for improving the quality of it and it would be a reference for the theoretical and experimental researchers.

关键词： Photovoltaics Absorber Layer Density Functional Theory (DFT) Band Gap Solar Cell

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新型模块化农业机器人设计分析与冗余协同控制

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机械工程学报 2024年

作者：潘宇真魏佳炜 KHAN Rezwan Al islam 陈雄王洪波商慧亮复旦大学工程与应用技术研究院复旦大学信息科学与工程学院

提出了基于模块化理论的多场景农业机器人，可应用于农业大棚、户外场景等。通过搭载不同的模块化农机设备，实现多种作物的监测、授粉、药物喷洒、采摘等任务，实现了农场自主运行，降低了人工成本。该农业机器人采用悬挂减震系统、独... 详细信息

提出了基于模块化理论的多场景农业机器人，可应用于农业大棚、户外场景等。通过搭载不同的模块化农机设备，实现多种作物的监测、授粉、药物喷洒、采摘等任务，实现了农场自主运行，降低了人工成本。该农业机器人采用悬挂减震系统、独立转向驱动结构和双地形轨道轮设计，可以适应室内平地、轨道、室外农田等多种场景，实现多种运动模态和工作场景的自主切换。针对高精度的底盘机械臂协同运动控制，建立对应的运动学和动力学模型，并根据样机参数分析其控制精度。针对需要遍历目标任务点的工作，提出新型的冗余协同控制策略。试验结果表明，农业机器人样机各项参数均满足工作要求，冗余协同控制策略相比传统的间歇式的效率最多可以提升30%，动力学上的误差也得到数值验证，从数学模型和仿真角度量化了样机参数、遍历效率、控制精度等因素的影响，为进一步的改进和优化提供了指导。试验结果支持机器人在农业场景的设计和实际应用，为农业生产提供高效、精确的解决方案。

关键词：模块化农业机器人多用途机械臂多场景自主切换冗余协同控制

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Malware Attacks Detection in IoT Using Recurrent Neural Network(RNN)

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Intelligent Automation & Soft Computing 2024年第2期39卷 135-155页

作者： Abeer Abdullah Alsadhan Abdullah A.Al-Atawi Hanen karamti Abid Jameel islam Zada Tan N.Nguyen Computer Science Department Imam Abdulrahman Bin Faisal UniversityDamam32232Saudi Arabia Department of Computer Science Applied CollegeUniversity of TabukTabuk47512Saudi Arabia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Sciences and Information Technology Hazara UniversityMansehraPakistan Faculty of Computing Department of Software EngineeringInternational Islamic UniversityIslamabadPakistan Department of Architectural Engineering Sejong UniversitySeoul05006Korea

IoT(Internet of Things)devices are being used more and more in a variety of businesses and for a variety of tasks,such as environmental data collection in both civilian and military *** are a desirable attack target for malware intended to infect specific IoT devices due to their growing use in a variety of applications and their increasing computational and processing *** this study,we investigate the possibility of detecting IoT malware using recurrent neural networks(RNNs).RNNis used in the proposed method to investigate the execution operation codes of ARM-based Internet of Things apps(OpCodes).To train our algorithms,we employ a dataset of IoT applications that includes 281 malicious and 270 benign pieces of *** trained model is then put to the test using 100 brand-new IoT malware samples across three separate LSTM *** exposure was not previously conducted on these *** newly crafted malware samples with 2-layer neurons had the highest accuracy(98.18%)in the 10-fold cross validation experiment.A comparison of the LSTMtechnique to other machine learning classifiers shows that it yields the best results.

关键词： Malware malicious code code obfuscation IoT machine learning deep learning

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Beyond Stitches: Analysis of Disease Burden in a Bangladeshi RMG Factory

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Health 2024年第7期16卷 688-702页

作者： Mariam Zaman Tayeb Ahmmed Nabila Binte Hossain S. M. Raysul Haque Ariful islam Joarder Kamran ul Baset Department of Procurement SM Group Dhaka Bangladesh Department of Neurosurgery Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Public Health Independent University Bangladesh (IUB) Dhaka Bangladesh Department of Cardiology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh

Introduction: Bangladesh has experienced remarkable growth in RMG over the past 25 years. With the knitwear industry providing more than 4 million direct jobs, providing better occupational health and safety of workers remains a challenge. Aim of the study: The aim of the study was to analyze the disease burden of a RMG factory, and to highlight occupational health risks. Methods: A cross-sectional study design was employed for this analysis. A 17-month data entry (January 2020 - May 2021) was gathered from the factory in-house clinic. The socio-demographic and clinical diagnosis entries of 8421 entries were analyzed. Result: The population of the factory workers is 5370, where 40% (2148) are female workers and 60% (3222) are male workers. The mean age of respondents is 30 years, with a SD of ±7 years. Among the chief complaints, the most common was vomiting (14%;2262) fever (14%;2247), runny nose (11%;1842), cough (9%;1465), and loose motion (8%;1364). In the diagnosis categories, gastrointestinal diseases were more predominantly diagnosed (35%;2978), followed by viral fever (21%;1772), neurological diseases (16.5%;1389) and musculoskeletal disorders (9%;768). The average cost of medicine for each respondent is BDT 36. The factory covered costs of all medication for 99% (8380) of respondents. Only 0.5% (37) was referred to a tertiary hospital for further evaluation. Conclusion: Garments workers suffer mostly from long-term occupational health hazards. Factory owners and policy makers can contribute in various ways to improving primary healthcare options for workers.

关键词： RMG Disease Burden Work Related Disease Communicable Disease Occupational Safety

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Phytochemical Screening and Evaluation of Pharmacological Potential of Baliospermum solanifolium Leaf Extract

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 69-75页

作者： Amit Mazumder Rabindra Nath Acharyya Milton Kumar Kundu Pritam Kundu Md.Amirul islam Md.Mustafizur Rahman Pharmacy Discipline Khulna UniversityKhulna-9208Bangladesh

Background:Baliospermum solanifolium is a traditional medicinal plant,locally known as“dantigaacha”from Eu-phorbiaceae family,and has been used in different diseases treatments likes helminthiasis,skin diseases,diabetes,snake-bite,and ***:Depending on the traditional uses of *** and the lack of scientific works,we aimed to conduct some pharmacological tests on its ***:Active constituents of *** were assessed by qualitative ***(2,2-diphenyl-1-picrylhydrazyl)was used for free radical scavenging *** change and mortality rate were used as indicators to assess the toxicity of *** antidiabetic potential was evaluated by oral glucose toler-ance test(OGTT)and alpha-glucosidase enzyme inhibitory *** antidiarrheal activity,castor oil-induced mice were *** test was carried out by disk diffusion assay and MIC ***,analgesic activity was done by acetic acid-induced writhing ***:*** contains alkaloids,carbohydrates,glycosides,flavonoids,tannis,phenolics *** toxicity test ensured the safety of the *** DPPH,the extract showed antioxidant activity with an IC50(con-centration needed to scavenge 50%DPPH)value of 61.65μg/*** phenolic,flavonoid and tannin contents were determined as 124 mg GAE/g,440 mg QE/g and 344 mg GAE/g dried extract,*** OGTT,the ex-tract reduced the blood glucose level *** the alpha-glucosidase inhibitory activity,the plant showed a concentration-dependent reduction of the enzyme at IC50 of 8.53 mg/*** the antidiarrheal test,*** inhibit defecation 30.69%and 53.41%at dose 250 mg/kg and 500 mg/kg,*** extract also showed antibacterial activity against four bacterial strains in the disk diffusion method and minimum inhibitory concen-tration(MIC)values were 62.5μg/mL,62.5μg/mL,125μg/mL and 62.5μg/mL against four bacterial strains,*** an

关键词： Baliospermum solanifolium Antioxidant Antidiabetic Antidiarrheal Antibacterial Analgesic

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全新世安达曼海周边区域火灾历史及其影响因素

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地球科学进展 2024年第6期39卷 616-631页

作者：梁诗晴罗传秀向荣 ARIFUL islam 魏海成苏翔万随杜恕环张兰兰杨艺萍黄云林刚中国科学院南海海洋研究所中国科学院边缘海与大洋地质重点实验室广东广州510301 中国科学院大学北京100049 中国科学院青海盐湖研究所青海省盐湖地质与环境重点实验室青海西宁810008 丹麦技术大学丹麦罗斯基勒4000

火事件的发生与气候变化以及植被变化密切相关,系统性地研究全新世火活动的时空演化规律,可以更清晰地理解火活动机制与区域性气候、植物变化的关联,同时有助于预测未来火的演化趋势。为了解安达曼海周边地区火灾活动的演化以及可能的... 详细信息

火事件的发生与气候变化以及植被变化密切相关,系统性地研究全新世火活动的时空演化规律,可以更清晰地理解火活动机制与区域性气候、植物变化的关联,同时有助于预测未来火的演化趋势。为了解安达曼海周边地区火灾活动的演化以及可能的驱动因素,以安达曼海南部的海洋钻孔ADM-C1为研究材料,对其全新世以来的炭屑记录进行深入分析,并综合安达曼海周边地区其余的5个炭屑记录,重建了全新世以来安达曼海周边地区火灾活动的演变过程。研究表明,尽管点火、火灾天气和植被组成在各地不尽相同,导致火灾发生频率在区域和地方范围有所不同,但在广泛的气候变化背景下,全新世安达曼海周边各地的火事件发生频率变化具有广泛同步性。全新世安达曼海周边的火灾活动发生频率受到区域性植被和降水变化影响,并最终受控于印度夏季风强度的变化。与末次冰消期相比,12.0~9.0 ka BP安达曼海周边区域火灾活动的发生频率呈下降趋势,反映了印度夏季风降水逐步增加以及木本植物含量逐渐上升的区域环境;9.0~5.0 ka BP较低的区域火灾活动发生频率同时受到较高的印度夏季风降水量和区域木本植物含量的制约;5.0 ka BP后高频的区域火灾活动更多反映了印度夏季风降水的降低。此外,研究结果还表明全新世安达曼海周边区域火灾活动发生频率与厄尔尼诺—南方涛动强度、印度洋偶极子位相和热带辐合带位置的变化相关。

关键词：炭屑古火印度夏季风全新世安达曼海

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In Vitro Antioxidant and Radio Protective Activities of Lycopene from Tomato Extract against Radiation—Induced DNA Aberration

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Journal of Biosciences and Medicines 2024年第2期12卷 202-213页

作者： Safaiatul islam Abu Hena Mostofa Kamal Md. Ziaur Rahman Protul Kumar Roy A.Y.K. Md. Masud Rana Molecular Radiobiology and Biodosimetry Division Institute of Food and Radiation Biology Bangladesh Atomic Energy Commission Savar Bangladesh

Background: The accumulation of free radicals is linked to a number of diseases. Free radicals can be scavenged by antioxidants and reduce their harmful effects. It is therefore essential to look for naturally occurring antioxidants that come from plants, as synthetic antioxidants are toxic, carcinogenic and problematic for the environment. Lycopene is one of the carotenoids, a pigment that dissolves in fat and has antioxidant properties. Materials and Methods: The antioxidant and free radical scavenging activity were assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The impact of lycopene on bacteria (E. coli) susceptibility to γ-radiation was examined by radio sensitivity assay. The study also examined the induction of strand breaks in plasmid pUC19 DNA and how lycopene extract protected the DNA from γ-radiation in vitro. Results: At varying concentrations, lycopene demonstrated its ability to scavenge free radicals such as 2, 2-diphenyl-1-picrylhydrazyl (DPPH). IC50 for lycopene was determined at 112 μg/mL which was almost partial to IC50 of standard antioxidant L-ascorbic acid. The D10 value 180 Gy of E. coli was found to be >2-fold higher in the extract-containing lycopene sample than in the extract-free controls. The lycopene extracts inhibited the radiation-induced deterioration of the plasmid pUC19 DNA. At an IC50 concentration, lycopene provided the highest level of protection. Conclusion: Lycopene functions as an efficient free radical scavenger and possible natural antioxidant source. For cancer patients and others who frequently expose themselves to radiation, lycopene may be a useful plant-based pharmaceutical product for treating a variety of diseases caused by free radicals.

关键词： Radio Protective Antioxidants Free Radical DNA Damage pUC19 Plasmid Gamma Irradiation DPPH

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不同铜线芯直径超声波焊接头性能的研究

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兵器材料科学与工程 2024年第5期47卷 8-12页

作者：沈中华张永祺赵伦龚涛梁召峰许龙周光平 Md Shafiqul islam 广西高校先进制造与自动化技术重点实验室广西桂林541006 深圳职业技术大学超声技术研究所广东深圳518055 瑞典布京理工学院机械学院布莱金厄卡尔斯克鲁纳37179

对3种不同的线芯直径的10 mm双铜(Cu)导线接头进行超声波焊接试验。通过剥离试验、孔隙率计算、温度测量、扫描电子显微镜(SEM)研究分析了铜导线接头性能和失效形式。结果表明:线芯直径与接头抗剥离力正相关,线芯直径越粗接头力学性能... 详细信息

对3种不同的线芯直径的10 mm双铜(Cu)导线接头进行超声波焊接试验。通过剥离试验、孔隙率计算、温度测量、扫描电子显微镜(SEM)研究分析了铜导线接头性能和失效形式。结果表明:线芯直径与接头抗剥离力正相关,线芯直径越粗接头力学性能越好。两根线芯直径为0.1 mm导线焊接的接头抗剥离强度未达标,失效形式为结合面完全分离无线芯断裂。直径增至0.2 mm时,接头抗剥离强度均达到标准,失效形式变为结合面处线芯的韧性断裂。焊接时的峰值温度有效影响了接头孔隙率,但孔隙率并不能完全作为判断接头成型质量的依据,部分导线在高温下仅发生塑性变形,而未能实现原子键合。此外,通过观察接头剖面发现,焊接接头形成了外紧内松的结构,与压块接触的接头上侧和与焊头接触的接头下侧几乎无空隙,而接头中间内侧则存在大量空隙。

关键词：超声波焊接铜导线力学行为断口形貌

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