Phytochemical Screening and Evaluation of Pharmacological Potential of Baliospermum solanifolium Leaf Extract
作者机构：Pharmacy DisciplineKhulna UniversityKhulna-9208Bangladesh
出 版 物：《Clinical Complementary Medicine and Pharmacology》 (临床补充医学和药理学（英文）)
年 卷 期：2024年第4卷第1期
页 面：69-75页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Baliospermum solanifolium Antioxidant Antidiabetic Antidiarrheal Antibacterial Analgesic
摘 要：Background:Baliospermum solanifolium is a traditional medicinal plant,locally known as“dantigaachafrom Eu-phorbiaceae family,and has been used in different diseases treatments likes helminthiasis,skin diseases,diabetes,snake-bite,and ***:Depending on the traditional uses of *** and the lack of scientific works,we aimed to conduct some pharmacological tests on its ***:Active constituents of *** were assessed by qualitative ***(2,2-diphenyl-1-picrylhydrazyl)was used for free radical scavenging *** change and mortality rate were used as indicators to assess the toxicity of *** antidiabetic potential was evaluated by oral glucose toler-ance test(OGTT)and alpha-glucosidase enzyme inhibitory *** antidiarrheal activity,castor oil-induced mice were *** test was carried out by disk diffusion assay and MIC ***,analgesic activity was done by acetic acid-induced writhing ***:*** contains alkaloids,carbohydrates,glycosides,flavonoids,tannis,phenolics *** toxicity test ensured the safety of the *** DPPH,the extract showed antioxidant activity with an IC50(con-centration needed to scavenge 50%DPPH)value of 61.65μg/*** phenolic,flavonoid and tannin contents were determined as 124 mg GAE/g,440 mg QE/g and 344 mg GAE/g dried extract,*** OGTT,the ex-tract reduced the blood glucose level *** the alpha-glucosidase inhibitory activity,the plant showed a concentration-dependent reduction of the enzyme at IC50 of 8.53 mg/*** the antidiarrheal test,*** inhibit defecation 30.69%and 53.41%at dose 250 mg/kg and 500 mg/kg,*** extract also showed antibacterial activity against four bacterial strains in the disk diffusion method and minimum inhibitory concen-tration(MIC)values were 62.5μg/mL,62.5μg/mL,125μg/mL and 62.5μg/mL against four bacterial strains,*** an
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