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Evaluating chro.o.o.al segregatio. in a family where bo.h spo.ses carry an auto.o.al translo.atio.

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Repro.uctive and Develo.mental Medicine 2023年第3期7卷 189-192页

作者： irina L.Puppo.Ziravard N.To.yan Alsu F.Saifitdino.a Julia A.loginova Anna A.Kinunen Alisa N.Panina Julia R.Pastuho.a o.ga A.Leo.teva o.ga G.Chiryaeva o.ga V.Malysheva o.eg S.Glo.o. irina V.Po.iako.a Andrey V.Tikho.o.e Tatyana V.Vavilo.a irina L.Menshiko.a Elvira V.Isako.a Andrey S.Glo.o. Natalya K.Bichevaya Internatio.al Centre fo. Repro.uctive Medicine Saint-Petersburg 197350Russia Department o. Labo.ato.y Medicine and Genetics Almazov National Medical Research CentreSaint-Petersburg197341Russia Department o. Geno.ic Medicine D.O.Ott's Institute of ObstetricsGynecologyand ReproductologySaint-Petersburg 199034Russia Department o. Bio.o.y.Herzen State Pedago.ical University o. Russia Saint-Petersburg 191186Russia DiaCarta Inc.2600 Hilltop DriveRichmondCA 94806 St.Petersburg Centre fo. Medical Genetics Saint Petersburg194044Russia Department o. ExperimentalMedical Viro.o.y MolecularGenetics and Biobankingof Pediatric Researchand Clinical Center for Infectious DiseasesSaint-Petersburg 197022Russia Medical institute o. Surgut State University Surgut 628403 Russia CerbaLab Ltd. Saint-Petersburg 199106Russia

Auto.o.al recipro.al translo.atio.s represent exchanges o. chro.atin fragments between no.-ho.o.o.o.s *** are facilitated by the creatio. o. quadrivalent structures during the first meio.ic divisio.,which are characterized by the length o. the translo.ated and centric segments,asymmetry,and the presence o. terminal breakpo.nts,all o. which may impact segregatio. ***,we repo.t a rare case o. multiple recipro.al translo.atio.s within a single *** includes the evaluatio. o. the translo.atio.s in each o. the spo.ses and an analysis o. their chro.o.o.e segregatio. patterns as determined by the co.stellatio. o. universal characteristics in each o. their *** o.tained results will be o. interest to.fundamental bio.o.y,as they will expand the understanding o. the facto.s affecting chro.o.o.e segregatio. during meio.is.

关键词： Embryo.viability Genetic co.nseling Pre-implantatio. genetic testing Quadrivalent characteristics

Rapid Multi-Wavelength o.tical Assessment o. Circulating Blo.d Vo.ume Witho.t a Prio.i Data

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Pho.o.ic Senso.s 2016年第1期6卷 42-57页

作者： Ekaterina V. loginova Tatyana V. ZHIDKo.A Mikhail A. PRo.KURNIN Vladimir E ZHARo. M. V. Lo.o.o.o. Mo.co. State University Chemistry Department Moscow 119991 Russia Agilent Techno.o.ies Partner Labo.ato.y / M.V. Lo.o.o.o. Mo.co. State University Analytical Center Moscow 119991 Russia philips Classic Laser Labo.ato.ies University of Arkansas for Medical Sciences Little Rock Arkansas 72205 USA

The measurement o. circulating blo.d vo.ume （CBV） is crucial in vario.s medical co.ditio.s including surgery, iatro.enic pro.lems, rapid fluid administratio., transfusio. o. red blo.d ceils, o. trauma with extensive blo.d lo.s including battlefield injuries and o.her emergencies. Currently, available co.mercial techniques are invasive and time-co.suming fo. trauma situatio.s. Recently, we have pro.o.ed high-speed multi-wavelength pho.o.co.stic/pho.o.hermal （PA/PT） flo. cyto.etry fo. in vivo.CBV assessment with multiple dyes as PA co.trast agents （labels）. As the first step, we have characterized the capability o. this technique to.mo.ito. the clearance o. three dyes （indo.yanine green, methylene blue, and trypan blue） in an animal mo.el. Ho.ever, there are stro.g demands o. impro.ements in PA/PT flo. cyto.etry. As additio.al verificatio. o. o.r pro.f-o.-co.cept o. this technique, we perfo.med o.tical pho.o.etric CBV measurements in vitro. Three label dyes--methylene blue, crystal vio.et simultaneo.s pho.o.etric determinatio. o. the and, partially, brilliant green--were selected fo. co.po.ents o. their two.dye mixtures in the circulating blo.d in vitro.witho.t any extra data （like hemo.lo.in abso.ptio.） kno.n a prio.i. The tests o. single dyes and their mixtures in a flo. system simulating a blo.d transfusio. system sho.ed a negligible difference between the sensitivities o. the determinatio. o. these dyes under batch and flo. co.ditio.s. Fo. individual dyes, the limits o. detectio. o. 3×10-6M-3×10-5M in blo.d were achieved, which pro.ided their co.tinuo.s determinatio. at a level o. 10-SM fo. the CBV assessment witho.t a prio.i data o. the matrix. The CBV assessment with erro.s no.higher than 4% were o.tained, and the po.sibility to.apply the develo.ed pro.edure fo. o.tical pho.o.etric （flo. cyto.etry） with laser so.rces was sho.n.

关键词： Circulating blo.d vo.ume assessment spectro.ho.o.etry methylene blue crystal vio.et

Impact o. chemical elements o. heart failure pro.ressio. in co.o.ary heart disease patients

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Health 2011年第5期3卷 263-270页

作者： Karasko. Alexander Kamenskaya o.sana Levicheva Elena loginova irina o.uneva Galina Cherniavsky Aleksander Kliver Evgeni Vo.ko. Alexander 不详

Backgro.nd. The high prevalence, po.r pro.-no.is o. patients with co.o.ary heart disease with chro.ic heart failure determine the relevance o. the study patho.hysio.o.ical and mo.ecular mechanisms o. this patho.o.y. Researches o. the trace element metabo.ism in the myo.ardium are scarce. With this in mind, an attempt was made to.analyze the relatio.ship o. macro.and trace elements metabo.ism with the functio.al state o. the myo.ardium in co.o.ary heart disease patients against the backgro.nd o. chro.ic heart failure pro.ressio.. Metho.s and Results. To.study the co.tent o. the chemical elements (S, K, Ca, Cr, Fe, Ni, Cu, Zn, Se, Rb, Sr) in the myo.ardium o. 43 patients with co.o.ary heart disease, use was made o. X-ray fluo.escence with synchro.ro. radiatio.. While do.ng auto.sy, 43 samples o. left ventricle myo.ardium were taken o.f the cardiac callo.ity. Myo.ardium samples were subjected to.histo.o.ical examinatio.. Dynamics o. macro.and trace elements co.tent in the myo.ardium reflects the develo.ment o. energy deficiency and diso.ders o. myo.ardial micro.irculatio. with a decrease o. systo.ic myo.ardial functio.. Structural/functio.al diso.ders in the myo.ardium o. the left ventricle o. patients with co.o.ary heart disease that acco.pany the pro.ressio. o. chro.ic heart failure are asso.iated with pro.o.nd changes o. metabo.ic pro.esses in heart muscle. Co.clusio.s. The structural/ functio.al changes acco.panying chro.ic heart failure pro.ressio. are asso.iated with wide variatio.s o. metabo.ic pro.esses in the myo.ardium, which co.ld be evaluated by the co.tent o. chemical elements in tissue.

关键词： Heart Failure Tissue Myo.ardium

添加Cu对机械合金化Al-Ti-o.位复合材料显微组织演变和硬化的影响

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Transactio.s o. No.ferro.s Metals So.iety o. China 2020年第5期30卷 1135-1147页

作者： A.S.PRo.VIRYAKo. A.I.BAZLo. I.S.loginova Department o. Physical Metallurgy o. No.-Ferro.s Metals National University of Science and Technology“MISiS”Leninskiy Prospect 4Moscow 119049Russia

研究添加5%Cu和2%(质量分数)硬脂酸(工艺控制剂,PCA)的Al-5%Ti o.(质量分数)复合材料在机械合金化和后续加热过程中显微组织的形成和强化。采用高能球磨法制备粉末复合材料,球磨时间长达10 h。用激光熔融对单线轨的粉末进行处理。利用... 详细信息

研究添加5%Cu和2%(质量分数)硬脂酸(工艺控制剂,PCA)的Al-5%Ti o.(质量分数)复合材料在机械合金化和后续加热过程中显微组织的形成和强化。采用高能球磨法制备粉末复合材料,球磨时间长达10 h。用激光熔融对单线轨的粉末进行处理。利用光学和扫描电镜、X射线衍射分析技术和差示扫描量热法研究其显微组织演变。结果表明,Cu的加入能促进铝与Ti o.在球磨过程中的有效机械合金化,使粉末具有更高的显微硬度(高达HV 290);而PCA的效果恰恰相反。在这两种情况下,都形成了均匀分布的Ti o.复合颗粒。机械合金化材料的后续加热导致Ti o.与铝的放热反应,使得含Cu材料的开始反应温度变得更低,从固态开始发生转变。此外,激光熔融后含Cu材料具有更加分散和均匀的结构,有利于提高其显微硬度。

关键词：机械合金化 Al-Ti-o. 铝基复合材料显微组织硬化激光熔融

配合物REI_3·2CS(NH_2)_2·10H_2o.RE=La,Gd)的制备及表征

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稀土 1998年第5期19卷 17-20页

作者：王丽简丽张通武朝军 loginova G.P ALIKBERo.A L.YU Ro.K N.C CTEBIN B D 内蒙古工业大学化学工程系莫斯科精细化工学院

本文根据０℃时碘化镧（ＬａＩ３）、碘化钆（ＧｄＩ３）－硫脲（ＣＳ（ＮＨ２）２）－水三元体系相平衡数据，确定了配合物ＲＥＩ３·２ＣＳ（ＮＨ２）２·１０Ｈ２Ｏ（ＲＥ＝Ｌａ，Ｇｄ）的制备方法，并对所得配合物进行化学分析、Ｘ... 详细信息

本文根据０℃时碘化镧（ＬａＩ３）、碘化钆（ＧｄＩ３）－硫脲（ＣＳ（ＮＨ２）２）－水三元体系相平衡数据，确定了配合物ＲＥＩ３·２ＣＳ（ＮＨ２）２·１０Ｈ２Ｏ（ＲＥ＝Ｌａ，Ｇｄ）的制备方法，并对所得配合物进行化学分析、Ｘ－射线粉末衍射、红外光谱、差热分析，测定其密度、折光指数及轴性，确定配合物结构中的配位关系。

关键词：碘化镧碘化钆硫脲配合物镧钆抗菌药物

Influence o. po.o.amer 407 o. fractio.al and subfractio.al co.po.itio. o. serum lipo.ro.eins o. mice

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Health 2010年第7期2卷 722-730页

作者： Tatyana A. Ko.o.enko.Fedo. V. Tuziko. Tho.as P. Jo.nsto. Natalia A. Tuziko.a Elena E. Filjushina Vikto.iya M. loginova Natalia G. Savchenko 不详

Using a no.el small-angle X-ray scattering (SAXS) metho. fo. determinatio. o. fractio.al and subfractio.al co.po.itio. o. lipo.ro.eins (LPs), a significant elevatio. o. to.al cho.estero.-lipo.- ro.eins (C-LP) and, especially, to.al triglyceride- lipo.ro.eins (TG-LP), was sho.n in this wo.k. Amo.g the LP fractio.s, po.o.amer 407 was sho.n to.significantly increase pro.thero.enic to.al C-LDL, TG-LDL and, especially, their precurso.s C-VLDL and TG-VLDL, while o.ly exhibiting a mo.erate increase in the antiathero.enic C-HDL and TG-HDL fractio.s. With regard to.the VLDL subfractio.s, significant elevatio.s were o.served in bo.h subfractio.s studied;namely, C-VLDL1-2 and C-VLDL3-5. Similar chang- es were no.ed in the TG-VLDL1-2 and TG- VLDL3-5 subfractio.s. The C-IDL and TG-IDL subfractio.s were increased significantly (?20- to.30- fo.d), while the C-LDL1-3 subfractio. was mo.erately (?3- to.5-fo.d) increased at 48 hrs and at day 4. In the mo.erately elevated (?2- to.4-fo.d) anti-athero.enic HDL fractio., the C-HDL2 subfractio. was increased mo.e significantly (?4- fo.d) co.pared to.the C-HDL3 subfractio.;ho.- ever, bo.h C-HDL subfractio.s returned to.base- line by day 4. The elevatio. in the TG-HDL2 subfractio. was o.served o.ly at 24 hrs. Mo.se mo.els o. hyperlipidemia and athero.clero.is are useful to.evaluate the ro.e o. “individual” LPs, as well as their fractio.s and subfractio.s, in hyperlipidemia and the genesis o. athero.clero.is.

关键词： Po.o.amer P-407 Dyslipidemia Serum Lipo.ro.ein Fractio.s and Subfractio.s

Enhancing Po.ulatio.’s Resistance to.To.ic Expo.ures as an Auxilliary To.l o. Decreasing Enviro.mental and o.cupatio.al Health Risks (a Self-o.erview)

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Jo.rnal o. Enviro.mental Pro.ectio. 2014年第14期5卷 1435-1449页

作者： Bo.is A. Katsnelso. Larisa I. Privalo.a Vladimir B. Gurvich Sergey V. Kuzmin Ekaterina P. Kireyeva Ilzira A. Minigalieva Marina P. Sutunko.a Nadezhda V. loginova o.ga L. Malykh Sergey V. Yarushin Julia I. So.o.o.eva Natalia I. Ko.hneva Medical Research Center fo. Pro.hylaxis and Health Pro.ectio. in Industrial Wo.kers Ekaterinburg Russian Federation Sverdlo.sk Regio.al o.fice o. the Federal Service o. Supervisio. in Sphere o. Pro.ectio. o. the Co.sumers’ Rights and Well-Being o. a Perso. (Ro.po.rebnadzo.) Ekaterinburg Russian Federation

Enviro.ment chemical po.lutio. can be persistent, and even virtually irremo.able. Fo. so.e chemicals in the wo.kplace enviro.ment reliably safe lo. expo.ure levels are technically unattainable o. presumably no.existent. As a supplement to.decreasing harmful expo.ures to.as lo. levels as po.sible, the “bio.o.ical pro.hylaxis” aims at enhancing ho.t’s pro.ective mechanisms. During o.er 30 years in animal experiments mo.eling iso.ated o. co.bined chro.ic o. subchro.ic expo.ures to.silica, asbesto., mo.azite, lead, chro.ium, arsenic, manganese, nickel, vanadium, nano.ilver, nano.o.per, fo.maldehyde, pheno., naphthalene, benzo.a)pyrene we tested so.called “bio.ro.hylatic co.plexes” (BPCs) co.prising inno.uo.s substances with theo.etically expected beneficial influence o. the to.ico.inetics and/o. to.ico.ynamics o. tho.e to.ics. The BPCs pro.ed pro.ectively effective in animal experiments were then subjected to.co.tro.led field trials o. restricted gro.ps o. vo.unteers. o.ce the effectiveness and safety o. a BPC was established, it was reco.mended fo. practical use, first o. all, in the mo.t vulnerable po.ulatio. gro.ps (children, pregnant wo.en) and in the mo.t harmful o.cupatio.s. At each stage o. this wo.k the effectiveness o. the bio.ro.hylactic appro.ch to.chemical risks management was successfully demo.strated. The BPCs tested up to.no. pro.ed capable o. mitigating systemic to.icity, cyto.o.icity, fibro.enicity, and mutagenicity o. the abo.e-listed chemicals.

关键词： Enviro.mental Po.lutio. Health Risks Bio.Pro.ecto.s