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A selective approach to the surgical management of periampullary cancer patients and its outcome

Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 628-633页

作者： Omar j Shah irfan Robbani Parveen Shah Sadaf A Bangri irfan j khan Mohammad Y Bhat Manmohan Singh Departments of Surgical Gastroenterology Sher-i-Kashmir Institute of Medical Sciences Srinagar Kashmir India Radiodiagnosis & Imaging Sher-i-Kashmir Institute of Medical Sciences Srinagar Kashmir India Pathology Sher-i-Kashmir Institute of Medical Sciences Srinagar Kashmir India Departments of Surgical Gastroenterology Sher-i-Kashmir Institute of Medical Sciences Srinagar Kashmir India Departments of Surgical Gastroenterology Sher-i-Kashmir Institute of Medical Sciences Srinagar Kashmir India

BACKGROUND： Pancreaticoduodenectomy is a high risk, complex, technically challenging operation associated with significant perioperative morbidity and mortality. This study on the surgical management of periampullary cancer patients is based on our experience in a period of nearly 13 years. METHODS： The study was conducted on two groups of patients： group A included 42 patients who were treated between january 2000 and September 2005 and group B included 134 patients who were treated between October 2005 to October 2012. Preoperative, intraoperative and postoperative details of all these patients were collected, tabulated and analyzed to assess the impact of the selective approach introduced in the department with effect from October 2005. RESULTS： Intraoperative details revealed highly significant differences in the management of the two groups of patients in respect of operative time （250.4 vs 126.6 minutes; P〈0.001）, operative blood loss （1070.2 vs 414.9 mL; P〈0.001） and intraoperative blood transfusion （1A vs 0.2 units; P〈0.001）. Variations between the two groups in the frequency of complications were found to be statistically insignificant. However, the difference between the two groups in the overall morbidity of patients （47.6% vs 26.1%; P=0.009） and the length of their hospital stay （11.8 vs 7.8 days; P〈0.001） were significant. CONCLUSION： A selective approach applied to the surgical management of periampullary cancer patients is a step in the right direction.

关键词： pancreaticoduodenectomy superior approach technique Whipple's operation

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Central pancreatectomy:a new technique for resection of selected pancreatic tumors

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 93-96页

作者： Omar j Shah irfan Robbani Parvez Nazir Athar B khan Department of Surgical Gastroenterology Sheri-Kashmir Institute of Medical Sciences Department of Radiodiagnosis/Imaging Sheri-Kashmir Institute of Medical Sciences

BACKGROUND:Pancreatic tumors located in the neck region usually require pancreaticoduodenectomy or *** small benign tumors enucleation is not usually feasible due to their size and localization;then pancreatectomy is often *** pancreatectomy consists of a limited resection of the midportion of the pancreas and can be offered in benign and low-grade malignant tumors of the neck of the *** study aimed to evaluate whether central pancreatectomy has a place in pancreatic surgery. METHODS:In this study,which covered a period of 14 months,we performed central pancreatectomy in four selected *** evaluation and operative frozen section biopsy in indicated cases allowed proper selection for the *** details,complications and follow-up were recorded. RESULTS:Four patients,two with serous cystadenoma,and one with an islet cell tumor,and one with a hydatid cyst, were identified for the *** mean tumor size was 3 cm,the mean operative time was 217.5 minutes,and the mean blood loss was 382.5 *** was no morbidity or mortality in this *** endocrine or exocrine deficiency was observed in any patient during a mean follow-up of 22.7 months. CONCLUSIONS:Central pancreatectomy is a procedure that offers excellent results in benign and low-grade malignant *** preserves functional elements(endocrine and exocrine)of the pancreas and also eliminates the infective and hematological effects of ***,central pancreatectomy should be included in the armamentarium of pancreatic surgery,and in order to obtain good results,proper indications and adequate experience are recommended.

关键词： central pancreatectomy benign pancreatic tumors low-grade malignant tumor

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Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis

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Chinese journal of Natural Medicines 2018年第3期16卷 225-230页

作者： Umar Farooq Ajmal khan Sadia Naz Abdur Rauf Haroon khan Afsar khan irfan Ullah Syed Majid Bukhari Department of Chemistry COMSATS Institute of Information Technology UoN Chair of Oman's Medicinal Plants and Marine Natural Products University of Nizwa Department of Geology University of Swabi Anbar Department of Pharmacy Abdul Wali Khan University Department of Pharmacy Abasyn University

Two new sesquiterpenes, trivially named ricinusoids A(1) and ricinusoids B(2), were isolated from ethyl acetate fraction of Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic techniques, including 1 D-and 2 D-NMR, UV, IR spectroscopy, and mass spectrometry. The compounds(1-2) were also assessed for in-vivo sedative and analgesic like effects in open field and acetic acid induced writhing tests respectively at 5, 10, and 20 mg·kg^(–1) i.p. Pretreatment of both test compounds caused significant(P ≤ 0.05) reduction in locomotive activity like sedative agents and abdominal constrictions like analgesics. Both compounds(1-2) possessed marked sedative and antinociceptive effects in animal models.

关键词： Ricinus communis Sesquiterpenoids Euphorbiaceae Spectroscopic techniques Antinociceptive activity

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A review on promising phytochemical, nutritional and glycemic control studies on Moringa oleifera Lam. in tropical and sub-tropical regions

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Asian Pacific journal of Tropical Biomedicine 2016年第10期6卷 896-902页

作者： Hafiz irfan Muhammad Mohd Zaini Asmawi Nurzalina Abdul Karim khan Discipline of Pharmacology School of Pharmaceutical Sciences Universiti Sains Malaysia Department of Pharmacology Faculty of Pharmacy University of Sargodha Discipline of Pharmaceutical Technology School of Pharmaceutical Sciences Universiti Sains Malaysia

Plants have provided sources to find novel compounds. These plants are being used as therapeutic purposes since the birth of mankind. The traditional healers normally utilize medicinal plants as crude drugs while scientists using the folk claim as guides to explore medicinal plants. Moringa oleifera is a famous edible plant having therapeutic and nutritive values. The present study was designed to cumulate the research data regarding to what extent, phytochemical, nutritional and glycemic control studies has been explored using its different extracts. The articles indicated that the powder, aqueous, methanol and ethanol extracts of Moringa oleifera(leaves, pods, seeds, stem and root bark) have significant therapeutic herbal potential to treat diabetes mellitus. Collectively, the mechanism behind is intestinal glucose inhibition, insulin release as well as decrease in insulin resistance probably regeneration of b-cells of pancreas, increase in glutathione and reduction in malondialdehyde. Conclusively, this article give descriptive information about antidiabetic effect, claimed marker compounds and proposed antihyperglycemic mechanism of a single plant. It can be suggested a potential herbal source to treat diabetes mellitus as being widely accepted by major population as nutrition and therapeutic agent.

关键词： Antihyperglycemic Aqueous Ethanol Moringa oleifera Antidiabetic

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Thermo-diffusion effects on MHD stagnation point flow towards a stretching sheet in a nanofuid

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Propulsion and Power Research 2014年第3期3卷 151-158页

作者： Umar khan Naveed Ahmed Sheikh irfan Ullah khan Syed Taluseef Mohyud-din Deparment of Mathematics Faculty of SciencesHITEC UniversityTarila CantPakistan COMSA IS Institute of Information Technology University RoadAbbottabadPakistan

Thermodiffusion effects on stagnation point flow of a nanofuid towards a stretching surface with applied magnetic field is *** transforms are applied to reduce the equations that govem the flow to a system of nonlinear ordinary differential ***-K utta-Fehlberg method is applied to solve the sy *** are compared with existing solutions that are special cases to our *** graphical analysis is carried out to study the effects of different emerging parameters such as stretching ratio A,mag netic infuence parameter M,Prandtl number Pr,Lewis number Le,Brownian motion parameter Nb,thermophoresis parameter Nr,nanofluid Lewis number Ln,modified Dufour parameter Nd and Dufour solutal number Ld coupled with comprehensive *** effects of local Nusselt number,local Sherwood number and nanofluid Sherwood number are also discussed.

关键词： Nanofluid Stretching sheet Thermodiffusion Numerical solution Nusselt number Sherwood number Nanofluid Sherwood number

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Screening outcomes of household contacts of multidrug-resistant tuberculosis patients in Peshawar,Pakistan

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Asian Pacific journal of Tropical Medicine 2016年第9期9卷 886-889页

作者： Arshad javaid Mazhar Ali khan Mir Azam khan Sumaira Mehreen Anila Basit Raza Ali khan Muhammad Ihtesham irfan Ullah Afsar khan Ubaid Ullah Post Graduate Medical Institute Lady Reading Hospital Programmatic Management of Drug Resistant TB Unit Lady Reading Hospital Peshawar Medical College Kohat University of Science and Technology Kohat

Objective:To assess the profile of TB/multidrug-resistant TB(MDR-TB) among household contacts of MDR-TB ***:Close contacts of MDR-TB patients were traced in the cross-sectional *** clinical,radiological and bacteriological were performed to rule out the evidence of TB/***:Between january 2012 and December 2012,a total of 200 index MDR-TB patients were initiated on MDR-TB treatment,out of which home visit and contacts screening were conducted for 154 index *** 610 contacts who could be studied,41(17.4%) were diagnosed with MDR-TB and 10(4.2%) had *** most common symptoms observed were cough,chest pain and ***:The high incidence of MDR-TB among close contacts emphasize the need for effective contact screening programme of index MDR-TB cases in order to cut the chain of transmission of this disease.

关键词： Tuberculosis Household contacts MDR-TB Peshawar Pakistan

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Feasibility-Guided Constraint-Handling Techniques for Engineering Optimization Problems

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Computers, Materials & Continua 2021年第6期67卷 2845-2862页

作者： Muhammad Asif jan Yasir Mahmood Hidayat Ullah khan Wali khan Mashwani Muhammad irfan Uddin Marwan Mahmoud Rashida Adeeb khanum Ikramullah Noor Mast Institute of Numerical Sciences Kohat University of Science&TechnologyKohatPakistan Department of Economics Abbottabad University of Science&TechnologyAbbottabadPakistan Institute of Computing Kohat University of Science&TechnologyKohatPakistan Faculty of Applied Studies King Abdulaziz UniversityJeddahSaudi Arabia jinnah College for Women University of PeshawarPeshawarPakistan Department of Physics Kohat University of Science&TechnologyKohatPakistan

The particle swarm optimization(PSO)algorithm is an established nature-inspired population-based meta-heuristic that replicates the synchronizing movements of birds and *** is essentially an unconstrained algorithm and requires constraint handling techniques(CHTs)to solve constrained optimization problems(COPs).For this purpose,we integrate two CHTs,the superiority of feasibility(SF)and the violation constraint-handling(VCH),with a *** CHTs distinguish feasible solutions from infeasible ***,in SF,the selection of infeasible solutions is based on their degree of constraint violations,whereas in VCH,the number of constraint violations by an infeasible solution is of more ***,a PSO is adapted for constrained optimization,yielding two constrained variants,denoted SF-PSO and *** SF-PSO and VCH-PSO are evaluated with respect to ve engineering problems:the Himmelblau’s nonlinear optimization,the welded beam design,the spring design,the pressure vessel design,and the three-bar truss *** simulation results show that both algorithms are consistent in terms of their solutions to these problems,including their different available *** of the SF-PSO and the VCHPSO with other existing algorithms on the tested problems shows that the proposed algorithms have lower computational cost in terms of the number of function evaluations *** also report our disagreement with some unjust comparisons made by other researchers regarding the tested problems and their different variants.

关键词： Constrained evolutionary optimization constraint handling techniques superiority of feasibility violation constraint-handling technique swarm based evolutionary algorithms particle swarm optimization engineering optimization proble

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Structural and functional roles of ether lipids

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Protein & Cell 2018年第2期9卷 196-206页

作者： john M. Dean irfan j. Lodhi Division of Endocrinology Metabolism and Lipid Research Department of Medicine Washington University School of Medicine Saint Louis MO 63110 USA

Ether lipids, such as plasmalogens, are peroxisome- derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. This seem- ingly simple biochemical change has profound structural and functional implications. Notably, the tendency of ether lipids to form non-lamellar inverted hexagonal structures in model membranes suggests that they have a role in facilitating membrane fusion processes. Ether lipids are also important for the organization and stability of lipid raft microdomains, cholesterol-rich membrane regions involved in cellular signaling. In addition to their structural roles, a subset of ether lipids are thought to function as endogenous antioxidants, and emerging studies suggest that they are involved in cell differentiation and signaling pathways. Here, we review the biology of ether lipids and their potential signifi- cance in human disorders, including neurological diseases, cancer, and metabolic disorders.

关键词： ether lipids plasmalogen phospholipid peroxisomes cancer metabolic disorders

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A review of recent advancements in finite element formulation for sandwich plates

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Chinese journal of Aeronautics 2019年第4期32卷 785-798页

作者： Shehzaib irfan Faisal SIDDIQUI Aerospace Engineering Department College of Aeronautical Engineering National University of Sciences and TechnologyRisalpur

Use of composite structures is exponentially growing in different fields due to their higher strength-to-weight ratio. This application trend requires that accurate theoretical explanations and their finite element models be developed for analyzing sandwich plates before finalizing the designs. This paper reviews the recent research trends of finite element formulations developed for analyzing sandwich plates. This paper reviews the finite element models developed after the year 2000. Initially, the finite element formulations based on first order shear deformation theory, higher order shear deformation theories, mixed solid-shell elements, zig-zag theories and global–local theories are presented. Then, some finite element formulations developed to analyze a very new class of structures called piezoelectric structures are presented. At the end, some formulations to analyze a very critical phenomenon called buckling are presented.

关键词： Buckling Finite element FSDT HSDT Laminated composites Piezoelectric Sandwich plates Zig-zag theory

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