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Robust transcriptional indicators of immune cell death revealed by spatiotemporal transcriptome analyses

molecular Plant 2022年第6期15卷 1059-1075页

作者： Jose Salguero-Linares irene Serrano Nerea Ruiz-Solani marta Salas-Gómez Ujjal Jyoti Phukan Victor manuel González martíBernardo-Faura marc Valls David Rengel Nuria S.Coll Centre for Research in Agricultural Genomics(CRAG) CSIC-IRTA-UAB-UBCampus UABBellaterra08193 BarcelonaSpain LIPm Universitéde ToulouseINRACNRS84195 Castanet-TolosanFrance INRAE GeT-PlaGeGenotoul31326 Castanet-TolosanFrance Department of Genetics Universitat de Barcelona08028 BarcelonaSpain Consejo Superior de Investigaciones Científicas(CSIC) BarcelonaSpain Department of Plant molecular Biology and Physiology.Albrechtvon Haller Institute for Plant Sciences niversity of GottingenJulia-Lermontowa-Weg3.37077 GottingenGrmany Institut de Phammacologie et de Biologie Structurale IPBS Universite deToulouse CNRSUPSBP 64182205 route de Nartxonne310077 Toulouse Cedex 04France

Recognition of a pathogen by the plant immune system often triggers a form of regulated cell death traditionally known as the hypersensitive response(HR).This type of cell death occurs precisely at the site of pathogen recognition,and it is restricted to a few *** research has shed light on how plant immune receptors are mechanistically ***,two central key questions remain largely unresolved:how does cell death zonation take place,and what are the mechanisms that underpin this phenomenon?Consequently,bona fide transcriptional indicators of HR are lacking,which prevents deeper insight into its mechanisms before cell death becomes macroscopic and precludes early or live *** this study,to identify the transcriptional indicators of HR we used the paradigmatic Arabidopsis thaliana–Pseudomonas syringae pathosystem and performed a spatiotemporally resolved gene expression analysis that compared infected cells that will undergo HR upon pathogen recognition with bystander cells that will stay alive and activate *** data revealed unique and time-dependent differences in the repertoire of differentially expressed genes,expression profiles,and biological processes derived from tissue undergoing HR and that of its ***,we generated a pipeline based on concatenated pairwise comparisons between time,zone,and treatment that enabled us to define 13 robust transcriptional HR *** these genes,the promoter of an uncharacterized AAA-ATPase was used to obtain a fluorescent reporter transgenic line that displays a strong spatiotemporally resolved signal specifically in cells that will later undergo pathogen-triggered cell *** valuable set of genes can be used to define cells that are destined to die upon infection with HR-triggering bacteria,opening new avenues for specific and/or high-throughput techniques to study HR processes at a single-cell level.

关键词： Arabidopsis thaliana cell death indicator effector-triggered immunity hypersensitive response pattern-triggered immunity plant immunity Pseudomonas syringae

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SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2322-2331页

作者： Xavier Palomer mSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-martínez irene miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García mercy mDavidson Emma Barroso manuel Vázquez-Carrera Department of Pharmacology Toxicology and Therapeutic ChemistryIBUB(Institut de Biomedicina de la Universitat de Barcelona)Research Institute-Pediatric Research InstituteHospital Sant Joan de Déuand CIBER de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelonaSpain Department of Biochemistry and molecular Biomedicine IBUB and CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN)Faculty of BiologyUniversity of BarcelonaBarcelonaSpain aBCNatal-Barcelona Center for maternal–Fetal and Neonatal medicine(Hospital Clínic and Hospital Sant Joan de Deu) Institut d’Investigacions Biomèdiques August Pi i SunyerUniversitat de Barcelonaand Center for Biomedical Research on Rare Diseases(CIBER-ER)BarcelonaSpain Genomic Programming of Betacells Laboratory Institut d’Investigacions August Pi i Sunyer(IDIBAPS)and CIBERDEMBarcelonaSpain Section of Epigenomics and Disease Department of Medicineand National Institute for Health Research(NIHR)Imperial Biomedical Research CentreImperial College LondonLondonUK Servicio de Cirugía Cardiovascular Hospital Universitario Marqués de ValdecillaDepartamento de Ciencias Médicas y QuirúrgicasFacultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)Centro de Investigación Biomédica en Red Cardiovascular(CIBERCV)Instituto de Salud Carlos IIISantanderSpain Departamento de Fisiología y Farmacología Facultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)SantanderSpain Department of Radiation Oncology Columbia UniversityNew YorkNYUSA

Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative *** of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac *** this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 ***3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of *** with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of ***,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its *** findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 *** fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases.

关键词： SIRT3 inflammation cardiac

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The regenerative response of cardiac interstitial cells

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Journal of molecular Cell Biology 2022年第10期14卷 19-36页

作者： Laura Rolland Alenca Harrington Adèle Faucherre Jourdano mancilla Abaroa Girisaran Gangatharan Laurent gamba Dany Severac marine Pratlong Thomas moore-morris Chris Jopling Institute of Functional Genomics University of MontpellierCNRSINSERMLabEx ICSTMontpellier 34094France montpellier GenomiX France GénomiqueMontpellier 34094France

Understanding how certain animals are capable of regenerating their hearts will provide much needed insights into how this process can be induced in humans in order to reverse the damage caused by myocardial ***,it is becoming increasingly evident that cardiac interstitial cells play crucial roles during cardiac *** understand how interstitial cells behave during this process,we performed single-cell RNA sequencing of regenerating zebrafish *** a combination of immunohistochemistry,chemical inhibition,and novel transgenic animals,we were able to investigate the role of cell type-specific mechanisms during cardiac *** approach allowed us to identify a number of important regenerative processes within the interstitial cell ***,we provide detailed insight into how interstitial cells behave during cardiac regeneration,which will serve to increase our understanding of how this process could eventually be induced in humans.

关键词： heart regeneration interstitial cells single-cell RNA-sequencing macrophage fibroblast endothelium inflammation

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Depolarizing metrics in the biomedical field:Vision enhancement and classification of biological tissues

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Journal of Innovative Optical Health Sciences 2023年第5期16卷 3-19页

作者： mónica Canabal-Carbia Albert Van Eeckhout Carla Rodríguez Emilio González-Arnay irene Estévez JoséJ.Gil Enrique García-Caurel Razvigor Ossikovski Juan Campos Angel Lizana Grup d'Òptica Departamento de Fisica Universitat Autònoma de BarcelonaBellaterra 08193Spain ALBA Synchrotron Light Source Carrer de la Llum 2-26 08290 Cerdanyola del VallèsBarcelonaSpain Servicio deAnatomia Humana Departamento de Ciencias médicas Básicas Universidad de La Laguna Santa Cruz de Tenerife 38200 Spain Universidad de Zaragoza Pedro Cerbuna 12 Zaragoza 50009Spain LPICm CNRSEcole Polytechnique Institut Politechnique de ParisPalaiseau 91120France

Polarimetry encompasses a collection of optical techniques broadly used in a variety of ***,such techniques have provided their suitability in the biomedical field through the study of the polarimetric response of biological samples(retardance,dichroism and depolarization)by measuring certain polarimetric *** of these features,depolarization,is mainly produced by scattering on samples,which is a predominant efiect in turbid media as biological *** turn,retardance and dichroic efiects are produced by tissue anisotropies and can lead to depolarization *** depolarization is a predominant efiect in tissue samples,we focus on studying difierent depolarization metrics for biomedical *** report the suitability of a set of depolarizing observables,the indices of polarimetric purity(IPPs),for biological tissue *** review some results where we demonstrate that IPPs lead to better performance than the depolarization index,which is a well-established and commonly used depolarization observable in the *** also provide how IPPs are able to significantly enhance contrast between difierent tissue structures and even to reveal structures hidden by using standard intensity ***,we also explore the classificatory potential of IPPs and other depolarizing observables for the discrimination of difierent tissues obtained from ex vivo chicken samples(muscle,tendon,myotendinous junction and bone),reaching accurate models for tissue classification.

关键词： Polarimetry indices of polarimetric purity organic tissues visualization artificial intelligence.

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maternity & women's health care / 8th ed.

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2004年

作者： [edited by] Deitra Leonard Lowdermilk Shannon E. Perry irene m. Bobak.

来源：畅想之星图书光盘版（南... 评论

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多孔介质中纳米零价铁运移行为的试验研究

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岩土工程学报 2021年第7期43卷 1173-1181页

作者：胡黎明林丹彤劳敏慈清华大学水利系水沙科学与水利水电工程国家重点实验室北京100084 香港科技大学土木及环境工程系中国香港

纳米零价铁是一种前景广阔的环境修复材料,目前针对应用纳米零价铁进行地下水污染修复已经开展了广泛的研究。然而,现有研究多关注于注入纳米零价铁的运移能力,对于负载污染物后纳米零价铁的迁移行为缺少研究。本文研究了磷负载前后纳... 详细信息

纳米零价铁是一种前景广阔的环境修复材料,目前针对应用纳米零价铁进行地下水污染修复已经开展了广泛的研究。然而,现有研究多关注于注入纳米零价铁的运移能力,对于负载污染物后纳米零价铁的迁移行为缺少研究。本文研究了磷负载前后纳米零价铁的团聚趋势以及运移能力,分析了流速、离子浓度、多孔介质粒径级配等因素对磷负载纳米零价铁运移能力的影响。结果表明,磷负载纳米零价铁的团聚趋势相对于反应前纳米零价铁较低,其运移能力则强于吸附磷之前的纳米零价铁,这是由于吸附磷增加了纳米零价铁的表面负电荷进而阻碍了颗粒团聚。离子浓度对于磷负载纳米零价铁的运移能力有显著的影响,低离子浓度、高流速有利于磷负载纳米零价铁的运移。磷负载纳米零价铁在中玻璃珠中的运移能力强于细玻璃珠和粗玻璃珠,在天然砂中的运移能力则小于在中玻璃珠中的运移能力。利用DLVO理论以及胶体的粒桥、颗粒阻塞和表面沉积等多种滞留机理对试验中观察到的现象进行了解释。在含有高岭土的天然砂中,磷负载纳米零价铁的运移能力很弱,且沉降试验表明高岭土可以促进磷负载纳米零价铁的团聚沉降,这表明磷负载纳米零价铁有可能富集在含有高岭土的土层中。在应用纳米零价铁吸附地下水中的污染物时,应考虑污染物对于纳米零价铁运移能力的影响,并结合环境条件对该影响进行评估和控制。

关键词：纳米零价铁地下水修复磷负载多孔介质地下水条件 DLVO(Derjaguin-Landau-Verwey-Overbeek)理论

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Analysis of the Effects of Botulinum Toxin Type A to Promote the Survival of Transverse Rectus Abdominis myocutaneous Flaps in an Animal model

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Journal of Biosciences and medicines 2020年第10期8卷 63-73页

作者： Erika Otilia Haro García Edna m. Aizpuru Jorge Eduardo Gutierrez Salgado maria irene Rivera Salgado Jose Telich Vidal Olin Carrasco Ortiz Department of Plastic and Reconstructive Surgery at Hospital Angeles del Pedregal Mexico City Mexico Department of Plastic and Reconstructive Surgery at PEmEX Hospital Facultad Mexicana de Medicina Universidad la Salle Mexico City Mexico Facultad medicina UNAm Mexico City Mexico Department of Pathology in Pemex Hospital Mexico City Mexico Facultad mexicana de medicina Universidad la Salle Mexico City Mexico

The transverse rectus abdominis myocutaneous (TRAm) flap is one of the techniques for breast reconstruction surgery and other defects. Assuring the vascular input is the main factor that it should be ensured for the survival of the fap. Objective: The article presented is an experimental study, with the objective of evaluating the effect of the vasculature on the myocutaneous flaps of the abdominal rectum with botulinum toxin type A (TBoA) thay may improve the survival of the tissue by promoting the blood perfusion in distal parts of the flap and diminish the risk of necrosis. material and methods: A total of 30 Wistar male rats, dissect pedicled right TRAm flap in all rats, divided into three groups: Group 1 was applied in saline solution 0.9%;Group 2 was applied in pre surgically TBoA (1 week before lifting the flap);Group 3, will apply TBOA Trans surgical. Results: Histological analysis showed: increased vascularity in group 2 TBoA compared with the saline solution with P ms of fibrosis, inflammation and granulation tissue, there was no statistically significant difference at p = 0.6. muscle atrophy was higher in the group of TBoA in the saline group p m toxin type A prevents vasoconstriction of the vessel and promotes vasodilation subsequently lifting the muscle flap, no complications were observed in the groups with TBoA so it can be considered a safe substace and can be used for further studies.

关键词： Botulinum Toxin Tranverse Rectus Abdominis myocutaneos Flap Vasodilatation Survival

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遗传学在胆管细胞癌发展中的重要性

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中国普通外科杂志 2015年第2期24卷 151-162页

作者： Luca maroni irene Pierantonelli Jesus m.Banales Antonio Benedetti marco marzioni 史肖华王强凤意大利马尔凯理工大学胃肠病科安科纳荷兰泰阿姆斯特丹大学学术医疗中心泰加特肝肠病研究所阿姆斯特丹奥地利维也纳医科大学内科学系III胃肠病学与肝脏病学区维也纳西班牙巴斯克大学Biodonostia研究所肝脏病学与胃肠病学系圣塞瓦斯蒂安不详

胆管细胞癌(CCA)是肝脏一种少见的恶性肿瘤,起源于胆管。在过去的30年里,CCA在世界各地的发病率不断的增高,但其预后依然很差,几乎未改变过。尽管已发现几个危险因子与该肿瘤的发生相关,但这些危险因子中没有一个在大多数患者中得以肯... 详细信息

胆管细胞癌(CCA)是肝脏一种少见的恶性肿瘤,起源于胆管。在过去的30年里,CCA在世界各地的发病率不断的增高,但其预后依然很差,几乎未改变过。尽管已发现几个危险因子与该肿瘤的发生相关,但这些危险因子中没有一个在大多数患者中得以肯定。由于诊断时多已是晚期以及有限的治疗选择,导致CCA生存率很低。近来对CCA遗传学和表观遗传学上变化的研究结果为重新阐明胆管细胞恶性转化的分子学机制带来了希望。沿着这一方向进一步研究将有助于形成新的诊断、预后和治疗方法。该篇全面概述了CCA的最新进展,描述迄今所报道过的发生在CCA中最重要的基因突变和表观遗传学改变。

关键词：胆管肿瘤/遗传学后成说,遗传

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减少青少年吸烟

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中国实用乡村医生杂志 2009年第3期16卷 -页

作者： irene m.ROSEN DOUGLAS m.mAURER 时玥 madigan Army medical Center Fort Lewis Washington Carl R.Darnall Army medical Center Fort Hood Texas 中国医科大学

在美国,烟草是可预防的死亡的首要原因,每年造成>44万的人死亡。此外,800万美国人患有与吸烟有关的疾病,如肺癌、喉癌、口腔癌、食道癌以及慢性阻塞性肺疾病等肺部疾病。在年度保健支出中烟草承担的费用约1570亿美元。

关键词：吸烟青少年干预

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Prevalence of hepatocarcinoma-related hepatitis B virus mutants in patients in grey zone of treatment

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World Journal of Gastroenterology 2019年第38期25卷 5883-5896页

作者： Ana Isabel Gil-García Antonio madejón irene Francisco-Recuero Ana López-López Emiliana Villafranca miriam Romero Araceli García Antonio Olveira Rocío mena Juan Ramón Larrubia Javier García-Samaniego Hepatology Unit Hospital Universitario La PazMadrid 28046Spain Centro de Investigación Biomédica en Red Instituto de Salud Carlos IIIMadrid 28029Spain Instituto de Investigación del Hospital Universitario la Paz Madrid 28046Spain Biochemistry Department Faculty of MedicineUniversidad Autónoma de MadridMadrid 28029Spain Instituto de Genética médica y molecular Hospital Universitario La PazMadrid 28046Spain Translational Hepatology Unit Hospital General Universitario de GuadalajaraGuadalajara 19002Castilla-La ManchaSpain

BACKGROUND Antiviral treatment of patients with chronic hepatitis B(CHB)in the grey zone of treatment comands risk management in order to optimize the health *** this sense,the identification of HBV mutants related with an increased risk of hepatocellular carcinoma(HCC)could be useful to identify subpopulations with potential indication of antiviral *** To analyze the prevalence/persistence of hepatitis B virus(HBV)preS and basal core promoter(BCP)/precore/core variants associated to HCC development in CHB patients in the grey *** Work was designed as a longitudinal retrospective study,including 106 plasma samples from 31 patients with CHB in the grey zone of treatment:Hepatitis B e antigen negative,HBV-DNA levels between 12-20000 IU/mL,normal or discordant transaminase levels during follow up and mild/moderate necroinflammatory activity in liver biopsy or Fibroscan(up to 9.5 kPa).Serum HBVDNA was tested using the Abbott Real Time HBV Assay and the BCP/precore/core and the hepatitis B surface antigen(HBsAg)coding regions were analyzed in positive samples by PCR/bulk-sequencing to identify the HCCrelated HBV *** High-risk HCC related mutants were detected in 24(77%)patients:19(61%)in the BCP/precore/core,and 7(23%)in the HBsAg coding region(2 preS1 and 5 preS2 deletions).The prevalence of preS deletions was genotype-dependent:3/5(60%)patients with preS2 deletions and 1/2 with preS1 deletions were infected with the HBV-E *** HBV-E was the most prevalent in sub-Saharan patients,a correlation between preS deletions and ethnicity was also found:6/8(75%)sub-Saharan vs 1/19(5%)Caucasian patients had preS deletions(P=0.00016).Remarkably,this correlation was maintained in those patients infected with HBV-A,a minor genotype in sub-Saharan patients:2/2 patients infected with HBV-A from West Africa vs 0/6 of Caucasian origin had preS *** HCC related variants were the major strains and persisted over time(up to 48 mo).Pa

关键词： Hepatitis B virus Hepatocellular carcinoma PreS deletions Hepatitis B virus treatment Grey zone

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