The regenerative response of cardiac interstitial cells

作     者：Laura Rolland Alenca Harrington Adèle Faucherre Jourdano Mancilla Abaroa Girisaran Gangatharan Laurent Gamba Dany Severac Marine Pratlong Thomas Moore-Morris Chris Jopling Laura Rolland;Alenca Harrington;Adèle Faucherre;Jourdano Mancilla Abaroa;Girisaran Gangatharan;Laurent Gamba;Dany Severac;Marine Pratlong;Thomas Moore-Morris;Chris Jopling

作者机构：Institute of Functional GenomicsUniversity of MontpellierCNRSINSERMLabEx ICSTMontpellier 34094France Montpellier GenomiXFrance GénomiqueMontpellier 34094France 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2022年第14卷第10期

页      面：19-36页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：MRI is supported by the French National Research Agency(ANR-10-INBS-04,‘Investments for the future') MGX acknowledges financial support from France Génomique National infrastrusture,funded as part of Investissement d‘Avenir’program managed by Agence National pour la Recherche(ANR-10-INBS-09) The Jopling lab is part of the Laboratory of Excellence lon Channel Science and Therapeutics supported by a grant from the ANR Work in the Jopling lab is supported by grants from the‘la Fondation Leducq'and from the ANR(ANR-20-CE14-003 MetabOx-Heart) A.H.was supported by European Research Area Network on Cardiovascular Diseases(ERA-CVD,ANR-18-ECVD-0006)awarded to T.M.-M 

主　　题：heart regeneration interstitial cells single-cell RNA-sequencing macrophage fibroblast endothelium inflammation 

摘      要：Understanding how certain animals are capable of regenerating their hearts will provide much needed insights into how this process can be induced in humans in order to reverse the damage caused by myocardial ***,it is becoming increasingly evident that cardiac interstitial cells play crucial roles during cardiac *** understand how interstitial cells behave during this process,we performed single-cell RNA sequencing of regenerating zebrafish *** a combination of immunohistochemistry,chemical inhibition,and novel transgenic animals,we were able to investigate the role of cell type-specific mechanisms during cardiac *** approach allowed us to identify a number of important regenerative processes within the interstitial cell ***,we provide detailed insight into how interstitial cells behave during cardiac regeneration,which will serve to increase our understanding of how this process could eventually be induced in humans.