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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

Shale gas reservoirs: Theoretical, practical and research issues

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Petroleum Research 2016年第1期1卷 10-26页

作者： Roberto aguilera Schulich School of Engineering University of CalgaryCalgaryCanada

Shale gas reservoirs are found all over the *** endowment worldwide is estimated at 10,000 tcf by the GFREE team in the Schulich School of Engineering at the University of *** shale gas work and production initiated successfully in the Unites States and extended to Canada will have application,with modifications,in several other countries in the ***‘modifications’qualifier is important as each shale gas reservoir should be considered as a research project by itself to avoid fiascos and major financial *** gas reservoirs are best represented by at least quadruple porosity *** of the production obtained from shale reservoirs is dominated by diffusion *** approximate boundary between viscous and diffusion-like flow is estimated with Knudsen *** flow is present,for example,when the architecture of the rock is dominated by mega pore throat,macro pore throat,meso pore throat and sometimes micro pore *** flow on the other hand is observed at the nano pore throat *** process speed concept has been used successfully in conventional reservoirs for several ***,the concept discussed in this paper for tight gas and shale gas reservoirs,with the support of core data,has been developed only recently,and permits differentiating between viscous and diffusion dominated *** is valuable,for example,in those cases where the formation to be developed is composed of alternating stacked layers of tight sands and shales,or where there are lateral variations due to facies *** approach to develop the concept of a super-giant shale gas reservoir is presented as well as a description of GFREE,a successful research program for tight *** paper closes with examples of detailed original gas-in-place(OGIP)calculations for 3 North American shale gas reservoirs including free gas in natural fractures and the porous network within the organic matter,gas in the non-organic matter,adsorbed gas,a

关键词： shale gas reservoirs process or delivery speed quadruple porosity model Knudsen number pore throat level

Potential distribution of a montane rodent (Cricetidae, Handleyomys chapmani) through time in Mexico: the importance of occurrence data

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Journal of Mountain Science 2021年第8期18卷 2024-2033页

作者： cano Ivonne GUEVARA Lazaro Department of Zoology Institute of BiologyNational Autonomous University of Mexico04510Mexico CityMexico

Ecological Niche Modeling uses the geographic coordinates of species presence records as the primary input to estimate potential geographic *** is little known whether carrying out rigorous data pre-processing is necessary before building niche models to be transferred to different time *** we compared the current,past,and future potential distributions projected by niche models built from two different databases,an open-access database and a database compiled ad hoc,for Handleyomys chapmani,a rodent closely associated with montane cloud forests in *** models predicted different spatial patterns of climatic suitability for the three periods *** on our current knowledge of cloud forest species in Mexico,the distributions predicted by the model built from the ad hoc database are more ecologically realistic than those obtained from the open-access *** models built using the open-access database were particularly inaccurate at the limits of the geographic range,predicting larger,more diffuse distributions for the three *** conclude that pre-processing occurrence data is crucial for mountain species,as the number of localities and even minor inaccuracies in the geographic coordinates can translate into very different climatic conditions due to abrupt altitudinal ***,the predicted shifts in the potential distribution of *** over time indicate that this species is highly susceptible to climate change.

关键词： Cloud forests Ecological Niche Modeling Handleyomys chapmani Maxent Rodentia

PLANE WAVES NUMERICAL STABILITY OF SOME EXPLICIT EXPONENTIAL METHODS FOR CUBIC SCHRODINGER EQUATION

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Journal of Computational Mathematics 2016年第4期34卷 385-406页

作者： Begona cano Adolfo Gonzalez-Pachon Departamento de Matemdtica Aplicada Universidad de Valladolid IMUVA Paseo de Beldn 7 47011 VaUadolid Spain Departamento de Matemdtica Aplicada Universidad de Valladolid IMUVA Paseo de Beldn 7 47011 Valladolid Spain

Numerical stability when integrating plane waves of cubic SchrSdinger equation is thor- oughly analysed for some explicit exponential methods. We center on the following second- order methods： Strang splitting and Lawson method based on a one-parameter family of 2-stage 2nd-order explicit Runge-Kutta methods. Regions of stability are plotted and numerical results are shown which corroborate the theoretical results. Besides, a tech- nique is suggested to avoid the possible numerical instabilities which do not correspond to continuous ones.

关键词： Numerical stability Exponential splitting Lawson methods Projection ontoinvariant quantities Plane waves SchrSdinger equation.

Between plaza and peak: a montological perspective on verticality and urbanization in highland Peru

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Journal of Mountain Science 2023年第10期20卷 2783-2803页

作者： Andreas HALLER Domenico BRANCA Deyvis cano Institute for Interdisciplinary Mountain Research Austrian Academy of SciencesInnsbruck 6020Austria Department of Humanities and Social Sciences University of SassariSassari 07100Italy Programa Académico de Ingeniería Ambiental Universidad de HuánucoHudnuco 10001Peru

Under the influence of concentrated and extended urbanization,Andean cities and the different altitudinal zones of their“hinterlands”are experiencing profound changes in land cover—from the central plazas up to the highest *** complex regional-geographic characteristics of these socioecological systems,such as the vertical complementarity of land use,require a montological perspective on verticality and urbanization:it transcends disciplinary approaches and can be crucial to properly interpret the trajectories of land cover change and formulate hypotheses for future practiceoriented *** trajectories of land cover change characterized altitudinal zones of Andean cities and their surroundings over the last three decades?Are there similarities that allow for the formulation of more general hypotheses?Using the Peruvian cases of Cusco and Huaraz,and combining a traditional altitudinal zonation model of land use in Peru with direct field observations and GIS-based analyses of remotely sensed data from 1991,2001,2011,and 2021,this study identifies the main trajectories of land cover change in the Quechua(>2300–3500 m),Suni(>3500–4000 m),and Puna(>4000–4800 m)regions—and finds insightful similarities between Cusco and Huaraz:(1)an impressive area of built-up land substitutes grassland in the Quechua,which,following regional altitudinal zonation models,is characterized by irrigated and rain-fed cropland;(2)an unexpected expansion of irrigated cropland takes place in the Suni,which,in theory,often lacks irrigation infrastructure and is mostly used for rain-fed tuber cultivation;and(3)a clear change from“other land”to grassland occurs in the Puna—where grassland is thought to predominate,anyway,since pre-Hispanic *** that these changes reflect the interplay between speculative fallow,agricultural intensification,and ecological restoration,the results can be read as vertically complementary,local manifestations of concentrated and extended urba

关键词： Mountain cities Mountain agriculture Land use change Land cover change Rural-urban linkages Montology

The Farallon-Aluk ridge collision with South America:Implications for the geochemical changes of slab window magmas from fore- to back-arc

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Geoscience Frontiers 2013年第4期4卷 377-388页

作者： Eugenio Aragón Lucio Pinotti Fernando D'Eramo Antonio Castro Osvaldo Rabbia Jorge Coniglio Manuel Demartis irene Hernando Claudia E.Cavarozzi Yolanda E.aguilera Centro de Investigaciones Geologicas(UNLP-CONICET) 1 N°644(1900) La Plata.Buenos Aires.Argentina Facultad de Ciencias Naturales y Museo Universidad Nacional de la Plata122 y 60s/n.(1900).La PlataBuenos AiresArgentina Departamento de Geologia.Universidad Nacional de Rio Cuarto.(UNRC-CONICET).Ruta 36 km 601.Rio Cuarto.Cordoba.Argentina Departamento de Geologia.Universidad de Huelva.21071 Huelva.Spain Instituto de Geologia Economica Aplicada.Universidad de Concepcion.Concepcion.Chile Departamento de Geologia.Universidad Nacional de Rio Cuarto.(UNRC-CONICET) Ruta 36 km 601.Rio Cuarto.CordobaArgentina Centro de Investigaciones Geologicas(UNLP-CONICET).1 N°644.(1900) La Plata.Buenos Aires.Argentina Facultad de Ciencias Naturales y Museo.Universidad Nacional de la Plata.122 y 60 s/n.(1900).La PlataBuenos Aires.Argentina Facultad de Ciencias Naturales y Museo.Universidad National dela Plata.122 y 60 s/n(1900)La Plata.Buenos Aires.Argentina Direccion de Aplicacion de Imagenes Satelitarias(M.O.S.P.).58 e/ 7 y 8.piso 2.1900 La Plata.Buenos Aires.Argentina

The collision of a divergent ocean ridge may evolve into two end cases： in the continuity of ocean-floor subduction, or in the detachment of the subducted plate. The northern Patagonia active plate margin has the unique situation that in Cenozoic time it has been subjected to two divergent ridge collisions, each one representing one of the end members. The Neogene Antarctica-Nazca divergent ridge collision evolved as a continuous ocean-floor subduction system, promoting a magmatic hiatus at the arc axis, the obduction of part of the ridge ocean-floor in the fore-arc, and basaltic volcanism in the back-arc. In contrast, the Paleogene Farallon-Aluk divergent ridge collision evolved into a transform margin, with the detachment and sinking of the Aluk plate and the development of a large slab window. As in the previous case, this collision promoted a magmatic hiatus at the arc axis, but the tectono-magmatic scenario changed to postorogenic synextensional volcanism that spread to the former fore-arc （basalt, andesite, rhyolite） and former back-arc （bimodal ignimbrite flare-up, basalt）. Geochemistry of this slab window synextensional volcanism shows more MORB-like basalts towards the former fore-arc, and MORB-OIB-Iike basalts towards the former back-arc. Instead, an isolated undeformable crustal block in the former back-arc, with an ＂epeirogenic＂ response to the slab window and extensional regime, was covered by OIB-type basalts after uplift. Major elements show that slab window basalts reach TiO2 values up to 3 wt%, as compared with the top value of 1.5 wt% of arc magmas. Besides, the MgO with respect to （FeOt ＋ A1203） ratio helps to distinguish slab window magma changes from the former fore-arc to the former back-arc and also with respect to the ＂epeirogenic＂ block. Higher contents of HFS elements such as Nb and Ta also help to distinguish this slab window from arc magmas and also, to distinguish slab window magma changes from the former fore-arc to the former back-arc

关键词： AndesActive ridge collisionSubduction-transform transitionSlab window volcanismSynextensional calc-alkalineBimodal volcanism

Resveratrol as an inductor of autophagy: is there a unique pathway of activation?

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Neural Regeneration Research 2021年第1期16卷 101-103页

作者： Narayana Pineda-Ramírez Penélope aguilera Laboratorio de Patología Vascular Cerebral.Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez Ciudad de MéxicoMéxico

Autophagy is a process of cellular degradation for the removal of damaged components and eventual recycling of the resulting molecules that help to the maintenance of cellular *** this pathway,proteins with relatively long half-life and whole organelles(e.g.,mitochondria,peroxisomes,and ribosomes)are degraded in the cytoplasm for the continuous turnover of cellular structures to facilitate their ***,the beneficial effect of autophagy goes beyond cellular“cleaning”and resides to a large extent on its ability to recycle cell components back into the ***,autophagy is a fundamental mechanism to regulate cellular functions,including DNA repair,proliferation,differentiation,embryonic development,and the immune response.

关键词： homeostasis activation autophagy

Inconsistencies in four-dimensional Einstein-Gauss-Bonnet gravity

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Chinese Physics C 2021年第1期45卷 89-96页

作者： Julio Arrechea Adria Delhom Alejandro Jimenez-cano Instituto de Astrofisica de Andalucia(IAA-CSIC) Glorieta de la AstronomiaGranadaSpain Departamento de Fisica Teorica and IFIC Centro Mixto Universidad de Valencia-CSIC.Universidad de ValenciaBuijassot-46100ValenciaSpain Departamento de Fisica Teorica y del Cosmos and CAFPE Universidad de Granada18071 GranadaSpain

We attempt to clarify several aspects concemi ng the recently presented four-dimensional Ein stein-Gauss-Bonnet *** argue that the limiting procedure outlined in[***.124,081301(2020)]generally involves ill-defined terms in the four dimensional field *** ways to circumvent this issue are discussed,alongside remarks regarding specific solutions of the *** prove that,although linear perturbations are well behaved around maximally symmetric backgrounds,the equations for second-order perturbations are illdefined even around a Minkowskia n *** on ally,we perform a detailed analysis of the spherically symmetric solutions and find that the central curvature singularity can be reached within a finite proper time.

关键词： alternative theories of gravity singularities Einstein・Gauss-Bonnet

Semantic framework of event detection in emergency situations for smart buildings

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Digital Communications and Networks 2022年第1期8卷 64-79页

作者： Yudith Cardinale Gabriel Freites Edgar Valderrama Ana aguilera Chinnapong Angsuchotmetee Departamento de Computacidn Universidad Simon BolivarCaracasVenezuela Escuela de Ingenieria Informatica Universidad de ValparaisoValparaisoChile Faculty of Science Prince of Songkla University Thailand

Multimedia Sensor Networks(MSNs)have enhanced the ability to analyze the environment and provide responses based on its current ***,MSNs are composed of scalar and multimedia sensors that have fixed ***,given the advancement of smart mobile device technologies,it is currently possible to dynamically integrate mobile sensors into *** this paper,we propose a formal platform to manage MSNs and the data gathered from them to detect complex *** main contributions include:M^(2)SSN-Onto,a Mobile and Multimedia Semantic Sensor Networks Ontology;Py-CEMiD,an engine for detecting complex events and generate reactions to them;a mobile device location engine to locate mobile sensors;and a proof-of-concept in the context of detecting emergency situations in smart *** scenarios are validated for emergency events,combining simulated sensor measurements with real measurements of mobile *** show complex events can be detected in near real time(less than 1 s).

关键词： Multimedia sensor network Semantic web Event processing Ontology Geolocalisation