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The effects of tannins-containing ground pine bark diet upon nutrient digestion,nitrogen balance,and mineral retention in meat goats

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Journal of Animal Science and Biotechnology 2015年第3期6卷 347-354页

作者： Byeng Ryel Min Sandra Solaiman Thomas Terrill Aina Ramsay irene Mueller-Harvey Department of Agricultural and Environmental Sciences Tuskegee University Agricultural Research Station Fort-Valley State University School of Agriculture Policy and DevelopmentUniversity of Reading

Background： Pine bark is a rich source of phytochemical compounds including tannins, phenolic acids, anthocyanins, and fatty acids. These phytochemicals have potential to significantly impact on animal health and animal production. The goal of this work is to measure the effects of tannins in ground pine bark as a partial feed replacement on feed intake, dietary apparent digestibility, nitrogen balance, and mineral retention in meat goats. Results： Eighteen Kiko cross goats （initial BW = 31.8 ± 1.49 kg） were randomly assigned to three treatment groups （n = 6）. Dietary treatments were tested： control （0 % pine bark powder （PB） and 30 % wheat straw （WS））; ] 5 % PB and 15 % WS, and 30 % PB and 0 % WS. Although dry matter （DM） intake and digestibility were not affected （P〉 0.10） by feeding PB, neutral detergent fiber （linear; P= 0.01）, acid detergent fiber （linear; P= 0.001） and lignin digestibility （linear; P= 0.01） decreased, and crude protein （CP） digestibility tended to decrease （P=0.09） as PB increased in the diet, apparent retention of Ca （P= 0.09）, P （P=0.03）, Mg （P= 0.01）, Mn （P= 0.01）, Zn （P= 0.01） and Fe （P= 0.09） also increased linearly. Nitrogen intake and fecal N excretion were not affected （P〉 0.05） by addition of PB in the diet, but N balance in the body was quadratically increased （P〈 0.01） in the 15 % PB diet compared to other diets. This may be due to more rumen escape protein and less excreted N in the urine with the 15 % PB diet. The study showed that a moderate level of tannin-containing pine bark supplementation could improve gastrointestinal nitrogen balance with the aim of improving animal performance. Conclusion： These results suggest that tannin-containing PB has negative impact on fiber, lignin, and protein digestibility, but positively impacted on N-balance.

关键词： Digestibility Goats Phytochemicals Tannins

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Therapeutic approaches for portal biliopathy: A systematic review

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World Journal of Gastroenterology 2016年第45期22卷 9909-9920页

作者： irene Franceschet Alberto Zanetto Alberto Ferrarese Patrizia Burra Marco Senzolo Gastroenterology Unit Department of Surgery Oncology and Gastroenterology University Hospital of Padua Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology University Hospital of Padua

Portal biliopathy(PB) is defined as the presence of biliary abnormalities in patients with non-cirrhotic/nonneoplastic extrahepatic portal vein obstruction(EHPVO) and portal cavernoma(PC). The pathogenesis of PB is due to ab extrinseco compression of bile ducts by PC and/or to ischemic damage secondary to an altered biliary vascularization in EHPVO and PC. Although asymptomatic biliary abnormalities can be frequently seen by magnetic resonance cholangiopancreatography in patients with PC(77%-100%), only a part of these(5%-38%) are symptomatic. Clinical presentation includes jaundice, cholangitis, cholecystitis, abdominal pain, and cholelithiasis. In this subset of patients is required a specific treatment. Different therapeutic approaches aimed to diminish portal hypertension and treat biliary strictures are available. In order to decompress PC, surgical porto-systemic shunt or transjugular intrahepatic porto-systemic shunt can be performed, and treatment on the biliary stenosis includes endoscopic(Endoscopic retrograde cholangiopancreatography with endoscopic sphincterotomy, balloon dilation, stone extraction, stent placement) and surgical(bilioenteric anastomosis, cholecystectomy) approaches. Definitive treatment of PB often requires multiple and combined interventions both on vascular and biliary system. Liver transplantation can be considered in patients with secondary biliary cirrhosis, recurrent cholangitis or unsuccessful control of portal hypertension.

关键词： Portal biliopathy Portal cavernoma Magnetic resonance cholangiopancreatography Endoscopic retrograde cholangiopancreatography Porto-systemic shunt

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Proteinase activated-receptors-associated signaling in the control of gastric cancer

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World Journal of Gastroenterology 2014年第34期20卷 11977-11984页

作者： Silvia Sedda irene Marafini Roberta Caruso Francesco Pallone Giovanni Monteleone Dipartimento di Medicina dei Sistemi Università Tor Vergata00133 RomeItaly

Gastric cancer(GC)is the fourth most common cancer in the world and the second cause of cancer-related *** carcinogenesis is a multifactorial process,in which environmental and genetic factors interact to activate multiple intracellular signals thus leading to uncontrolled growth and survival of GC *** such a pathway is regulated by proteinase activated-receptors(PARs),seven transmembrane-spanning domain G protein-coupled receptors,which comprise four receptors(i.e.,PAR-1,PAR-2,PAR-3,and PAR-4)activated by various *** PAR-1 and PAR-2 are over-expressed on GC cells and their activation triggers and/or amplifies intracellular pathways,which sustain gastric *** is also evidence that expression of either PAR-1 or PAR-2 correlates with depth of wall invasion and metastatic dissemination and inversely with the overall survival of ***,data emerging from experimental models of GC suggest that both these receptors can be important targets for therapeutic interventions in GC *** contrast,PAR-4levels are down-regulated in GC and correlate inversely with the aggressiveness of GC,thus suggesting a negative role of this receptor in the control of *** this article we review the available data on the expression and role of PARs in GC and discuss whether manipulation of PAR-driven signals may be useful for interfering with GC cell behavior.

关键词： Proteinase activated-receptors Gastric cancer Helicobacter pylori infection

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Viral integration detection strategies and a technical update on Virus-Clip

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BIOCELL 2021年第6期45卷 1495-1500页

作者： DANIEL WAI-HUNG HO XUEYING LYU irene OI-LIN NG Department of Pathology The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Oncovirus infection is crucial in human *** oncoviruses can lead to structural variations in the human genome known as viral genomic integration,which can contribute to *** viral integration detection tools differ in their underlying algorithms pinpointing different aspects or features of viral integration *** discuss about major procedures in performing viral integration *** importantly,we provide a technical update on Virus-Clip to facilitate its usage on the latest human genome builds(hg19 and hg38)and the adoption of multi-thread mode for faster initial read *** comparing the execution of Virus-Clip using single-thread and multi-thread modes of read alignment on targeted-panel sequencing data of HBV-associated hepatocellular carcinoma patients,we demonstrate the marked improvement of multi-thread mode in terms of significantly reduced execution time,while there is negligible difference in memory *** together,with the current update of Virus-Clip,it will continue supporting the in silico detection of oncoviral integration for better understanding of various human malignancies.

关键词： Oncovirus Viral genomic integration In silico detection Tumorigenesis Human malignancies

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Soil-transmitted helminths and plasmodium falciparum malaria among individuals living in different agroecosystems in two rural communities in the mount Cameroon area:a cross-sectional study

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Infectious Diseases of Poverty 2017年第1期6卷 573-587页

作者： irene Ule Ngole Sumbele Gladys Belanka Nkemnji Helen Kuokuo Kimbi Department of Zoology and Animal Physiology University of BueaBueaCameroon Department of Medical Laboratory Sciences University of BamendaBamendaCameroon

Background:Soil-transmitted helminths(STHs)and Plasmodium falciparum infections remain public health problems in Cameroon.A cross-sectional study was carried out in the Mount Cameroon area to determine the prevalence and intensity of STHs and *** infections in individuals living in different agroecosystems;to assess the influence of these infections on haematological parameters;and to identify the risk factors associated with STH ***:STH and malaria parasites were detected using the Kato-Katz method and Giemsa staining of blood films,*** blood count values were obtained using an automatic haematology *** samples were analysed using the sucrose floatation sedimentation *** and continuous variables were compared as required and logistic regression models were used to assess the risk factors for STH infections and ***:Of the 450 participants examined,STHs,*** and mixed co-infections were detected in 14.0,33.3 and 5.6%of participants,*** higher prevalences of Ascaris(18.8%)and Trichuris(7.9%)infections were observed in participants from tea plantation areas compared to those from banana and palm plantation areas,with similar trends in egg *** prevalence and parasite density were comparable between the different *** overall prevalence of anaemia was 64.2%.The prevalence of haematological manifestations such as moderate(48.0%)and severe(8.0%)anaemia,leucopenia(26.9%)and microcytosis(30.8%)was significantly higher among Plasmodium-STH co-infected *** samples from plantations showed the highest prevalences of STH eggs compared to soil samples from areas around pit toilets and public water *** in a tea plantation area(OR=3.07),age(AOR=1.49)and lack of access to potable water(OR=2.25)were identified as risk factors for STH infections,while the age groups 15-25 years(OR=2.928)and 26-35 years(OR=2.832),and being fem

关键词： Soil-transmitted helminths Plasmodium falciparum malaria Co-infection Anaemia Agroecosystem Haematological values Environmental contamination Cameroon

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TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma

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Frontiers of Medicine 2015年第3期9卷 322-330页

作者： Daniel Wai-Hung Ho Alan Ka-Lun Kai irene Oi-Lin Ng Department of Pathology and State Key Laboratory for Liver Research The University of Hong Kong ttong Kong SAR China

This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular carcinoma （HCC） by comparing the global gene expression profiles between tumors and their corresponding non- tumorous liver tissue. Based on the differential gene expression analysis, we identified a number of novel dysregulated genes, in addition to those previously reported. Top-listing upregulated （CENPF and FOXM1） and downregulated （CLEC4G, CRHBP, and CLEC1B） genes were successfully validated using qPCR on our cohort of 65 pairs of human HCCs. Further examination for the mechanistic overview by subjecting significantly upregulated and downregulated genes to gene set enrichment analysis showed that different cellular pathways were involved. This study provides useful information on the transcriptomic landscape and molecular mechanism of hepatocarcinogenesis for development of new biomarkers and further in-depth characterization.

关键词： TCGA whole-transcriptome sequencing HCC liver cancer

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The impact of hypoxia in hepatocellular carcinoma metastasis

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Frontiers of Medicine 2014年第1期8卷 33-41页

作者： Carmen Chak-Lui Wong Alan Ka-Lun Kai irene Oi-Lin Ng The State Key Laboratory for Liver Research and Department of Pathology The Universi(v of Hong Kong Hong Kong China

Hypoxia is a common phenomenon in hepatocellular carcinoma （HCC）. Hypoxia stabilizes transcription factor, hypoxia-inducible factor （HIF）, to activate gene transcription. Expression of HIF is closely associated with metastasis and poor prognosis in HCC. HIF mediates expression of genes that are involved in every step of HCC metastasis including epithelial-mesenchymal transition, invasion of the extracellular matrix, intravasation, extravasation, and secondary growth of the metastases. Because HIF is the central regulator of HCC metastasis, HIF inhibitors are attractive tools when used alone or as combined treatment to curb HCC metastasis. This review will summarize the current findings on the impact of hypoxia/HIF in HCC, with a particular focus on cancer metastasis.

关键词： hypoxia hepatocellular carcinoma (HCC) metastasis hypoxia-inducible factor (HIF)

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Electroconvulsive therapy,catatonia,deep vein thrombosis and anticoagulant treatment:a case report

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General Psychiatry 2021年第6期34卷 73-76,I0008,I0009页

作者： Ana Pérez-Balaguer irene Sánchez-Rivero Department of Psychiatry Hospital Universitario Puerta de Hierro MajadahondaMajadahondaSpain

Electroconvulsive therapy(ECT)is considered an effective treatment for pharmacotherapy-resistant severe mental *** is a complex syndrome characterised by important psychomotor *** vein thrombosis(DVT)and pulmonary embolism(PE)are frequent side effects of prolonged immobility in catatonic ***,it is important to resolve the catatonia as soon as *** is the most effective therapy available and is generally considered a safe ***,its use in patients with DVT or PE and anticoagulant treatment remains *** describe a case of a woman in her 40s with a previous diagnosis of bipolar disorder and dysfunctional personality *** was hospitalised with persecutory and reference delusions,high emotional lability,anxiety,somatisation and regressive *** later developed catatonic *** progress was achieved after a month of hospitalisation,despite several pharmacological *** suffered multiple complications of prolonged bedding,such as an extensive DVT of the left common femoral,the external iliac and the common iliac *** was conducted under treatment with *** the third administration,she showed *** major bleeding or PE was *** safety of ECT while receiving anticoagulant therapy has been documented,though dosage and type of anticoagulant must be *** of DVT(proximal or distal)may be an important topic to take into *** report provides further evidence about the efficacy and safety of undergoing ECT in the context of concomitant serious medical conditions,such as DVT and anticoagulant therapy administration.

关键词： dosage treatment diagnosis

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Antiglutamatergic agents for obsessive-compulsive disorder:Where are we now and what are possible future prospects?

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World Journal of Psychiatry 2021年第9期11卷 568-580页

作者： Annalisa Maraone Lorenzo Tarsitani irene Pinucci Massimo Pasquini Department of Human Neurosciences Sapienza University of RomeRome 00185LazioItaly

Recent data suggest that obsessive-compulsive disorder(OCD)is driven by an imbalance among the habit learning system and the goal-directed *** frontostriatal loop termed cortico-striatal-thalamo-cortical(CSTC)circuitry loop is involved in habits and their dysfunction plays an important role in *** neurotransmission is the principal neurotransmitter implicated in the CSTC model of *** in the CSTC loop implies a high level of glutamate in the cortical-striatal pathways as well as a dysregulation of GABA ergic transmission,and could represent the pathophysiology of ***,the dysregulation of glutamate levels can lead to neurotoxicity,acting as a neuronal *** hypothesis of a role of neurotoxicity in the pathophysiology of OCD clinically correlates to the importance of an early intervention for ***,some studies have shown that a reduction of duration of untreated illness is related to an earlier onset of *** robust data supporting a progression of such brain changes are not available so far,an early intervention could help interrupt damage from ***,agents targeting glutamate neurotransmission may represent promising therapeutical option in OCD patients.

关键词： Obsessive-compulsive disorder Antiglutamatergic agents Glutammate Early intervention Neurophysiopathology Duration of untreated illness

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Rescue of autoimmune hepatitis by soluble MHC class II molecules in an altered concanavalin A-induced experimental model

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Animal Models and Experimental Medicine 2020年第3期3卷 264-272页

作者： Katerina Bakela Maria Georgia Dimitraki Evangelia Skoufa irene Athanassakis Laboratory of Immunology Department of BiologyUniversity of CreteHeraklionCreteGreece

Background:Soluble major histocompatibility complex class II(sMHCII)molecules have been described to maintain tolerance through the suppression of autoreactive T *** order to evaluate their ability to rescue autoimmune hepatitis(AIH)symptoms,the present work attempted to administer sMHCII molecules to an in vitro as well as in vivo concanavalin A(ConA)-induced AIH ***:The in vitro AIH model consisted of splenocyte stimulation with ConA in the presence or absence of serum-isolated sMHCII *** in vivo ConAmodified model with or without sMHCII treatment was *** cytokine profile in culture supernatants and serum was tested by *** markers were evaluated by immunofluorescence,while cell proliferation by tritiated thymidine *** symptoms were assessed by daily observations for the establishment of a disease severity scoring system and liver histology was evaluated using a biomolecular ***:The presence of sMHCII molecules in the ConA-stimulated cell cultures leads to a significant reduction of cell *** administration of sMHCII molecules to the ConA-treated animals showed a significant reduction in the levels of IL-2,IL-4,and IL-10,as well as a decrease in the number of spleen CD4+and CD8+*** development of a scoring system,it was shown that the sMHCII treatment was accompanied by a slower progression of the disease,while rescuing fibrotic liver ***:The results presented in this study confirm the ability of sMHCII proteins to alleviate autoimmune hepatitis,possibly highlighting new therapeutic approaches for autoimmune diseases.

关键词： autoimmune hepatitis cytokines immunosuppression inflammation

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