咨询与建议

看过本文的还看了

相关文献

该作者的其他文献

文献详情 >Rescue of autoimmune hepatitis... 收藏

Rescue of autoimmune hepatitis by soluble MHC class II molecules in an altered concanavalin A-induced experimental model

Rescue of autoimmune hepatitis by soluble MHC class Ⅱ molecules in an altered concanavalin A-induced experimental model

作     者:Katerina Bakela Maria Georgia Dimitraki Evangelia Skoufa Irene Athanassakis Katerina Bakela;Maria Georgia Dimitraki;Evangelia Skoufa;Irene Athanassakis

作者机构:Laboratory of ImmunologyDepartment of BiologyUniversity of CreteHeraklionCreteGreece 

出 版 物:《Animal Models and Experimental Medicine》 (动物模型与实验医学(英文))

年 卷 期:2020年第3卷第3期

页      面:264-272页

核心收录:

学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基  金:the University of Crete(KA1226)for partially supporting this work through services to the private sector 

主  题:autoimmune hepatitis cytokines immunosuppression inflammation 

摘      要:Background:Soluble major histocompatibility complex class II(sMHCII)molecules have been described to maintain tolerance through the suppression of autoreactive T *** order to evaluate their ability to rescue autoimmune hepatitis(AIH)symptoms,the present work attempted to administer sMHCII molecules to an in vitro as well as in vivo concanavalin A(ConA)-induced AIH ***:The in vitro AIH model consisted of splenocyte stimulation with ConA in the presence or absence of serum-isolated sMHCII *** in vivo ConAmodified model with or without sMHCII treatment was *** cytokine profile in culture supernatants and serum was tested by *** markers were evaluated by immunofluorescence,while cell proliferation by tritiated thymidine *** symptoms were assessed by daily observations for the establishment of a disease severity scoring system and liver histology was evaluated using a biomolecular ***:The presence of sMHCII molecules in the ConA-stimulated cell cultures leads to a significant reduction of cell *** administration of sMHCII molecules to the ConA-treated animals showed a significant reduction in the levels of IL-2,IL-4,and IL-10,as well as a decrease in the number of spleen CD4+and CD8+*** development of a scoring system,it was shown that the sMHCII treatment was accompanied by a slower progression of the disease,while rescuing fibrotic liver ***:The results presented in this study confirm the ability of sMHCII proteins to alleviate autoimmune hepatitis,possibly highlighting new therapeutic approaches for autoimmune diseases.

读者评论 与其他读者分享你的观点

用户名:未登录
我的评分