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droughts in Homogeneous Areas of South America and Associated Processes during the Months of Austral Spring and Summer

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Advances in Atmospheric Sciences 2024年第12期41卷 2337-2353页

作者： Mariah Sousa gomes iracema Fonseca de Albuquerque CAVALCANTI Gabriela V.MULLER General Coordination of Earth Science(CGCT) National Institute for Space Research(INPE)Avenida dos Astronautas1758CEP:12227-010Sao Josédos CamposSPBrasil National Scientific and Technical Research Council(CONICET) Argentina -Santa Fe Argentina

droughts that occurred in selected areas located in homogeneous regions of South America during the austral springs(SON)and summers(dJF)from 1982 to 2019 are identified using the Standard Precipitation Index(SPI).Four areas were analyzed for droughts in SON,and three areas were analyzed for droughts in *** areas in the Amazon suffered from the majority of their droughts during El Niño years,while most of the droughts in the areas of southern Brazil,Uruguay,and North Argentina occurred during La Niña *** southeastern and central-western parts of Brazil,droughts occurred during both phases of El Nino-Southern Oscillation(ENSO)and also during neutral ***,other processes besides ENSO are likely related to the observed *** droughts were investigated for each area and month,and composites of atmospheric and oceanic variables during both seasons were analyzed for the selected *** and large-scale field composites were examined to identify the main processes associated with dry conditions in the different *** features were related to the influence of high pressure over southern and southeastern areas and the divergence of moisture flux in all *** circulations contributed to subsidence over the dry *** large-scale influential features include SST anomalies,wavetrains over the South Pacific Ocean with centers of action over South America that produced subsidence in the study areas,and convection anomalies in the Maritime continent and surrounding ***,the droughts were associated with a combination of regional and large-scale features that produced subsidence over the analyzed regions.

关键词： droughts South America regional features large-scale features

Integrating vegetation indices and geo-environmental factors in GIS-based landslide-susceptibility mapping:using logistic regression

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Journal of Mountain Science 2022年第2期19卷 477-492页

作者： Himasha d.ABEYSIRIWARdANA Pattiyage I.A.gomes department of Civil Engineering Faculty of EngineeringSri Lanka Institute of Information TechnologyMalabe 101115Sri Lanka

This study aimed to assess the potential of in-situ measured soil and vegetation characteristics in landslide susceptibility ***,data for eight independent variables,i.e.,soil moisture content,soil organic content,compaction of soil(soil toughness),plant root strength,crop biomass,tree diameter at knee height,Shannon Wiener Index(SWI)for trees and herbs was assembled from field tests at two historic landslide locations:Aranayaka and Kurukudegama,Sri *** economical,finer resolution database was obtained as the field tests were not *** logistic regression(LR)analysis showed that soil moisture content,compaction of soil,SWI for trees and herbs were statistically significant at Pd to test for *** values(d the absence of multicollinearity between four independent variables in the LR *** Operating Characteristics(ROC)curve and Confusion Metrix(CM)methods were used to validate the *** ROC analysis,areas under the curve of Success Rate Curve and Prediction Rate Curve were 84.5% and 96.6%,respectively,demonstrating the model’s excellent compatibility and *** to the CM,the model demonstrated a 79.6% accuracy,63.6% precision,100% recall,and a F-measure of 77.8%.The model coefficients revealed that the vegetation cover has a more significant contribution to landslide susceptibility than soil ***,the susceptibility map,which was then classified as low,medium,and highly susceptible areas based on the natural breaks(Jenks)method,was generated using geographical information systems(GIS)*** the historic landslide locations fell into the high susceptibility ***,validation of the model and inspection of the susceptibility map indicated that the in-situ soil and vegetation characteristics used in the model could be employed to demarcate historical landslide patches and identify landslide susceptibl

关键词： Landslide Susceptibility Slope stability GIS Logistic regression Area under the curve Confusion Metrix

Combinatorial therapies for spinal cord injury: strategies to induce regeneration

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Neural Regeneration Research 2019年第1期14卷 69-71页

作者： Eduardo d.gomes Nuno A.Silva António J. Salgado Life and Health Sciences Research Institute (ICVS) School of Medicine University of Minho Campus de Gualtar ICVS/3B’s–PT Government Associate Laboratory

Spinal cord injury(SCI)is a condition without treatment,mainly characterized by the loss of motor and sensory function below the level of *** is accompanied by several complications such as cardiac and respiratory compromise,and often patients present psychological ailments associated with the drastic alteration of their normal *** pathophysiology derives from a massive damage to the spinal cord tissue,which is propagated

关键词：损害绳索新生治疗感觉功能生活方式星形细胞并发症

A geomechanics classification for the rating of railroad subgrade performance

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Railway Engineering Science 2022年第3期30卷 323-359页

作者： Antonio gomes Correia Ana Ramos department of Civil Engineering ISISEUniversity of MinhoGuimara˜esPortugal

The type of subgrade of a railroad foundation is vital to the overall performance of the track *** the train speed and tonnage increase,as well as environmental changes,the evaluation and influence of subgrade are even more paramount in the railroad track structure performance.A geomechanics classification for subgrade is proposed coupling the stiffness(resilient modulus)and permanent deformation behaviour evaluated by means of repeated triaxial loading *** classification covers from fine-to coarse-grained soils,grouped by UIC and *** this achievement,we first summarize the main models for estimating resilient modulus and permanent deformation,including the evaluation of their robustness and their sensitivity to mechanical and environmental *** is followed by the procedure required to arrive at the geomechanical classification and rating,as well as a discussion of the influence of environmental *** work is the first attempt to obtain a new geomechanical classification that can be a useful tool in the evaluation and modelling of the foundation of railway structures.

关键词： Subgrade Resilient modulus Permanent deformation Geomechanical classification

Optimizing building retrofit through data analytics:A study of multi-objective optimization and surrogate models derived from energy performance certificates

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Energy and Built Environment

Energy and Built Environment 2024年第6期5卷 889-899页

作者： G.R.Araújo Ricardo gomes Paulo Ferrão M.Glória gomes IN+ DEMTécnico LisboaUniversidade de lisboaAv Rovisco PaisLisboa1049-001Portugal CERIS DECivilTécnico LisboaUniversidade de LisboaAv Rovisco PaisLisboa1049-001Portugal

The building stock is responsible for a large share of global energy consumption and greenhouse gas emissions,therefore,it is critical to promote building retrofit to achieve the proposed carbon and energy neutrality *** of the policies implemented in recent years was the Energy Performance Certificate(EPC)policy,which proposes building stock benchmarking to identify buildings that require ***,research shows that these mechanisms fail to engage stakeholders in the retrofit process because it is widely seen as a mandatory and complex *** study makes use of an EPC database to integrate machine learning techniques with multi-objective optimization and develop an interface capable of(1)predicting a building’s,or household’s,energy needs;and(2)providing the user with optimum retrofit solutions,costs,and return on *** goal is to provide an open-source,easy-to-use interface that guides the user in the building retrofit *** energy and EPC prediction models show a coefficient of determination(R2)of 0.84 and 0.79,and the optimization results for one case study EPC with a 2000€budget limit inÉvora,Portugal,show decreases of up to 60%in energy needs and return on investments of up to 7 in 3 years.

关键词： Building energy performance Building optimization Multi-Objective surrogate models Building retrofitting

Origami-Based design for 4d Printing of 3d Support-Free Hollow Structures

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Engineering 2022年第5期8卷 70-82页

作者： Bingcong Jian Frederic demoly Yicha Zhang H.Jerry Qi Jean-Claude Andre Samuel gomes Laboratoire Interdisciplinaire Carnot de Bourgogne UMR 6303 Centre National de la Recherche Scientifique&Universitede Technologie de Belfort-MontbeliardUniversite Bourgogne Franche-ComteBelfort 90400France George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Laboratoire Reactions et Genie des Procedes UMR 7274 Centre National de la Recherche Scientifique-Universitede LorraineNancy 54001France

The integration of additive manufacturing(AM)in design and engineering has prompted a wide spectrum of research efforts,involving topologically optimized solid/lattice structures,multimaterial structures,bioinspired organic structures,and multiscale structures,to name a ***,except for obvious cases,very little attention has been given to the design and printing of more complex three-dimensional(3d)hollow structures or folded/creased *** of the main reasons is that such complex open or closed 3d cavities and regular/freeform folds generally lead to printing difficulties from support-structure-related *** address this barrier,this paper aims to investigate four-dimensional(4d)printing as well as origami-based design as an original research direction to design and build 3d support-free hollow *** work consists of describing the rough 3d hollow structures in terms of two-dimensional(2d)printed origami precursor layouts without any support *** origami-based definitions are then embodied with folding functions that can be actuated and fulfilled by 3d printed smart *** desired 3d shape is then built once an external stimulus is applied to the active materials,therefore ensuring the transformation of the 2d origami layout to 3d *** demonstrate the relevance of the proposal,some illustrative cases are introduced.

关键词： Origami-based design 4d printing Smart material Hollow 3d structures Additive manufacturing

Combination approaches in hepatocellular carcinoma:How systemic treatment can benefit candidates to locoregional modalities

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World Journal of Gastroenterology 2022年第28期28卷 3573-3585页

作者： Leonardo gomes da Fonseca Raphael L C Araujo department of Medical Oncology Instituto do Cancer do Estado de Sao PauloUniversity of Sao PauloSão Paulo 01246-000São PauloBrazil Hospital e Maternidade Brasil-Rede d'Or São Luiz Santo André09030-590São PauloBrazil department of digestive Surgery Escola Paulista de Medicina-UNIFESPSão Paulo 04023-062São PauloBrazil

The management of hepatocellular carcinoma(HCC)is challenging because most patients have underlying cirrhosis,and the treatment provides,historically,a limited impact on the natural history of patients with advanced-stage ***,recurrence rates are high for those patients who receive local and locoregional modalities,such as surgical(resection and transplantation)or imageguided(ablation and intra-arterial)*** research has led to new concepts that are reshaping the current clinical *** advancements were achieved in the understanding of the hallmarks that drive *** has primed a successful incorporation of novel agents with different targets,such as anti-angiogenic drugs,targeted-therapies,and immune-checkpoint *** clinical trials have proven efficacy of systemic agents in advanced stage disease,there is no conclusive evidence to support their use in combination with loco-regional *** novel local modalities are being incorporated(e.g.,radioembolization,microwave ablation,and irreversible electroporation),emerging data indicate that locoregional treatments may induce tumor microenvironment changes,such as hyperexpression of growth factors,release of tumor antigens,infiltration of cytotoxic lymphocytes,and modulation of adaptative and innate immune *** trials that evaluated the use of antiangiogenic drugs in the adjuvant setting after ablation or chemoembolization fail to demonstrate a substantial *** efforts are directed to investigate the role of immunotherapy-based regimens in this *** present review aims to describe the current landscape of systemic and locoregional treatments for HCC,present evidence to support combination approaches,and address future perspectives.

关键词： Liver cancer Hepatocellular carcinoma Immunotherapy Systemic therapy Ablation Embolization

Engineering carbon quantum dots for photomediated theranostics

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Nano Research 2018年第1期11卷 1-41页

作者： Mahbub Hassan Vincent G. gomes Alireza dehghani Sara M. Ardekani School of Chemical and Biomolecular Engineering The University of Sydney NSW 2006 Australia

Carbon quantum dots （CQds） have emerged as potential alternatives to classical metal-based semiconductor quantum dots （Qds） due to the abundance of their precursors, their ease of synthesis, high biocompatibility, low cost, and particularly their strong photoresponsiveness, tunability, and stability. Light is a versatile, tunable stimulus that can provide spatiotemporal control. Its interaction with CQds elicits interesting responses such as wavelength-dependent optical emissions, charge/electron transfer, and heat generation, processes that are suitable for a range of photomediated bioapplications. The carbogenic core and surface characteristics of CQds can be tuned through versatile engineering strategies to endow specific optical and physicochemical properties, while conjugation with specific moieties can enable the design of targeted probes. Fundamental approaches to tune the responses of CQds to photo-interactions and the design of bionanoprobes are presented, which enable biomedical applications involving diagnostics and therapeutics. These strategies represent comprehensive platforms for engineering multifunctional probes for nanomedicine, and the design of Qd probes with a range of metal-free and emer^in~ 2d materials.

关键词： carbon quantum dots nanobiophotonics therapeutics diagnostics nanomedicine

Influence of train speed and its mitigation measures in the short-and long-term performance of a ballastless transition zone

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Railway Engineering Science 2023年第4期31卷 309-324页

作者： Ana Ramos Rui Calçada António gomes Correia department of Civil Engineering Faculty of EngineeringUniversity of PortoCONSTRUCT-LESEPortoPortugal department of Civil Engineering University of MinhoISISEGuimarãesPortugal

The ballastless track is nowadays the most popular railway system due to the required low number of maintenance opera-tions and costs,despite the high *** gradual change from ballasted to ballastless tracks has been occurring in Asia,but also in Europe,increasing the number of transition *** transition zones are a special area of the railway networks where there is an accelerated process of track degradation,which is a major concern of the railway infrastructure ***,the accurate prediction of the short-and long-term performance of ballastless tracks in transition zones is an important topic in the current paradigm of building/rehabilitating high-speed *** work purposes the development of an advanced 3d model to study the global performance of a ballastless track in an embankment-tunnel transition zone considering the influence of the train speed(220,360,500,and 600 km/h).Moreover,a mitigation measure is also adopted to reduce the stress and displacements levels of the track in the transition.A resilient mat placed in the tunnel and embank-ment aims to soften the *** behaviour of the track with the resilient mat is evaluated considering the influence of the train speed,with special attention regarding the critical *** used methodology is a novel and hybrid approach that allows including short-term and long-term performance,through the development of a powerful 3d model combined with the implementation of a calibrated empirical permanent deformation model.

关键词： Ballastless track Train speed Numerical modelling Transition zone Critical speed