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Rising incidence of acute hepatitis A among adults and clinical characteristics in a tertiary care center of Pakistan

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World Journal of Virology 2025年第1期14卷 73-82页

作者： Yumna Shahid Amna Subhan Butt iqra Jamali Faisal Wasim Ismail Division of Gastroenterology Department of MedicineAga Khan University HospitalKarachi 74800Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan

BACKGROUND For decades,hepatitis A virus(HAV)has been a leading cause of acute hepatitis among children and was less prevalent among ***,recently a paradigm shift has been observed in the epidemiology of HAV,as evident by cases of acute hepatitis due to HAV among *** To estimate frequency of HAV in acute viral hepatitis and compare characteristics in HAV and hepatitis E virus(HEV)*** This was a trend analysis conducted at Aga Khan University Hospital Karachi(Sindh,Pakistan)from February 2024 to May *** aged 18 years and older diagnosed with acute viral hepatitis attributed to hepatotropic viruses in 2024 were *** compare the trend patients admitted with acute hepatitis during 2019-2023 were also *** regarding clinical and laboratory parameters were *** yearly trend of acute hepatitis due to HAV and HEV was analyzed,and comparative analysis was done between HAV and HEV cases among *** A total of 396 patients were found to have acute hepatitis during our study *** was diagnosed in 234 patients(59%)while 157 patients(39.6%)were found to have acute HEV ***,acute hepatitis B virus infection was identified in 3 patients(0.7%),whereas acute hepatitis C virus infection was found in 2(0.5%)cases of acute *** trends showed increasing occurrence of HAV infection among adults over last 5 *** patients with acute HAV were younger than patients with HEV(28 years±8 years vs 30 years±8 years;P<0.01).Higher levels of total bilirubin were seen in HEV infection,while higher levels of alanine transaminase were seen in HAV ***,a higher proportion of acute liver failure(ALF),coagulopathy,and mortality were observed in *** An increase in acute hepatitis A cases among adults shows less severity than hepatitis E,highlighting the need for better sanitation,hygiene,and adult hepatitis A vaccination programs.

关键词： Acute hepatitis Hepatitis A virus Hepatitis E virus Acute liver failure Hepatotropic virus Vaccination

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Expanding role of antibodies in kidney transplantation

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World Journal of Transplantation 2025年第1期15卷 57-71页

作者： Khawar abbas Muhammed Mubarak Department of Transplant Immunology Sindh Institute of Urology&TransplantationKarachi 74200SindhPakistan Javed I.Kazi Department of Histopathology Sindh Institute of Urology&TransplantationKarachi 74200SindhPakistan

The role of antibodies in kidney transplant(KT)has evolved significantly over the past few *** role of antibodies in KT is multifaceted,encompassing both the challenges they pose in terms of antibody-mediated rejection(AMR)and the opportunities for improving transplant outcomes through better detection,prevention,and treatment *** our understanding of the immunological mechanisms continues to evolve,so too will the approaches to managing and harnessing the power of antibodies in KT,ultimately leading to improved patient and graft *** narrative review explores the multifaceted roles of antibodies in KT,including their involvement in rejection mechanisms,advancements in desensitization protocols,AMR treatments,and their potential role in monitoring and improving graft survival.

关键词： Antibodies Humoral theory Kidney transplantation Rejection

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Interaction between tumor stage and age on survival outcomes of patients with anaplastic thyroid cancer

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World Journal of Experimental Medicine 2024年第3期14卷 90-100页

作者： Ayrton I Bangolo Auda Auda John Bukasa-Kakamba Nayan Bhakta Shraboni Dey Anupriya lilhori Gowry Reddy Budoor Alqinai Aman Sidiqui Imranjot Sekhon Barbare Khatiashvili iqra abbas Sandra Kunnel Amer Jarri Emelyn Martinez Deborah Daoud Ishita Gupta Harshini Gompa Silvanna Pender Dana Aljaberi Hamed Aljanaahi Sandra S Kunnel Yingxia Xiao Yoontae Jung Sneha Nagpaul Afshan Naz Tejaswee Mallela Phyo Maung Maung Ibtihal Y Khalaf Soobee Kim Roua Alrestom Aditya Gajera Hiba Alkealy Deepti Kansal Sonam Dhall Sanya Satheesha Simcha Weissman Pierre Fwelo Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Endocrine and Metabolic Disorders University of KinshasaKinshasa KinshasaCongo Department of Epidemiology Human Geneticsand Environmental SciencesUTHealth School of Public HealthHoustonTX 77030United States

BACKGROUND Anaplastic thyroid cancer(ATC)is an aggressive,rare malignancy associated with rapid growth and metastasis,and a very poor *** investigated the clinical characteristics,survival outcomes and independent prognostic factors associated with anaplastic thyroid *** To assess to what extent the interaction between age and tumor stage affects *** A total of 622 patients diagnosed with anaplastic thyroid cancer,between 2010 and 2017 were enrolled in our study by retrieving data from the Surveillance,Epidemiology and End Results(SEER)*** analyzed demographics,clinical characteristics,overall mortality(OM)and cancer specific mortality(CSM)of *** with a P value<0.1 were incorporated into the multivariate cox model to determine the independent prognostic ***,we analyzed the interaction between age and tumor stage on *** In the multivariate analyses,the divorced/separated population had a lower OM[hazard ratio(HR)=0.63,95%CI:0.42-0.94,P<0.05]and CSM(HR=0.61,95%CI:0.40-0.92,P<0.05).OM was higher in tumors with direct extension only(HR=6.26,95%CI:1.29-30.42,P<0.05)and tumors with distant spread(HR=5.73,95%CI:1.34-24.51,P<0.05).CSM was also higher in tumors with direct extension(HR=5.05,95%CI:1.05-24.19,P<0.05)and tumors with distant spread(HR=4.57,95%CI:1.08-19.29,P<0.05).Mortality was not adversely affected by lymph node *** was lower in patients who received radiation(HR=0.66,95%CI:0.53-0.83,P<0.01),chemotherapy(HR=0.63,95%CI:0.50-0.79,P<0.01)or surgery(HR=0.53,95%CI:0.43-0.66,P<0.01).CSM was also lower in patient who received radiation(HR=0.64,95%CI:0.51-0.81,P<0.01),chemotherapy(HR=0.62,95%CI:0.50-0.78,P<0.01)or surgery(HR=0.51,95%CI:0.41-0.63,P<0.01).There was no significant interaction between age and tumor stage that affected *** In this large US SEER database retrospective study,we found the mortality to be higher in advanced stage tumors with direct extensi

关键词： Undifferentiated thyroid cancer Survival outcome Prognosis Metastasis Clinical trials Interaction

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Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN T.ASGHAR Z.abbas Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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Mathematical Analysis for Peristaltic Flow of Two Phase Nanofluid in a Curved Channel

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Communications in Theoretical Physics 2015年第11期64卷 547-554页

作者： S.Nadeem iqra Shahzadi Department of Mathematics Quaid-i-Azam University

This paper describes the theoretical analysis for peristaltic motion of water base nanoBuid containing distinct types of the nanoparticles like Cu,TiO_2,and Al_2O_*** of nano Quid are modelled and simplified by constructing the suppositions of low Reynolds number as well as long wave *** reduced equations are solved *** are represented through *** for the velocity,temperature,pressure rise and stream lines are analyzed *** work presented here is based on the fictitious values,however some other values can be tested experimentally.

关键词： peristaltic flow nanofluid curved channel exact so

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Role of Inclined Magnetic Field and Copper Nanoparticles on Peristaltic Flow of Nanofluid through Inclined Annulus: Application of the Clot Model

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Communications in Theoretical Physics 2017年第6期67卷 704-716页

作者： iqra Shahzadi S.Nadeem Department of Mathematics Quaid-i-Azam University

A genuine neurotic condition is experienced when some blood constituents accumulate on the wall of the artery get withdrew from the wall, again join the circulatory system and coagulation occur. Role of copper nanoparticles and inclined magnetic field on the peristaltic flow of a nanofluid in an annular region of inclined annulus is *** represent the clot model by considering the small artery as an annulus whose outer tube has a wave of sinusoidal nature and inner tube has a clot on its walls. Lubrication approach is used to simplify the problem. Close form solutions are determined for temperature and velocity profile. Impact of related parameters on pressure rise, pressure gradient,velocity and streamlines are interpreted graphically. Comparison among the pure blood and copper blood is presented and analyzed. One main finding of the considered analysis is that the inclusion of copper nanoparticles enlarges the amplitude of the velocity. Therefore, the considered study plays a dominant role in biomedical applications.

关键词： inclined magnetic field copper nanoparticles inclined annulus clot model exact solution

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EMMS mixture model with size distribution for two-fluid simulation of riser flows

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Particuology 2018年第3期16卷 165-173页

作者： Atta Ullah iqra Jamil Adnan Hamid Kun Hong Department of Chemical Engineering Pakistan Institute of Engineering and Applied Sciences Istamabad 45650 Pakistan Jiangsu Provincial Engineering Laboratory for Biomass Conversion and Process Integration Jiangsu Provincial Engineering Laboratory for Advanced Materials of Salt Chemical Industry Huaiyin Institute of Technology Huaian 223003 China

Further development of an energy-minimization multiscale modeling approach to simulating two-phase flow under turbulent conditions that considers the size distribution of mesoscale structures, i.e. bubbles and clusters, is presented. User-defined values of minimum and maximum cluster or bubble diame- ters were specified. A uniform size distribution was first considered as a test case, in which the drag force comprised contributions from each size group. The mathematical form of the objective function describing the energy for suspension and transport was not altered. The heterogeneity index of this new drag modification was then used to simulate pilot-scale circulating fluidized-bed risers involving Geldart group A particles. The results were validated against available experimental data. The model is capable of capturing both axial and radial profiles of flow-field variables.

关键词： Mesoscale Bubble Cluster EMMS CFD Riser

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Applying the spectral stochastic finite element method in multiple-random field RC structures

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Frontiers of Structural and Civil Engineering 2022年第4期16卷 434-447页

作者： abbas YAZDANI Civil Engineering Department University of Sistan and BaluchestanZahedan 98167-45845Iran

This paper uses the spectral stochastic finite element method(SSFEM)for analyzing reinforced concrete(RC)beam/slab *** doing so,it presents a new framework to study how the correlation length of a random field(RF)with uncertain parameters will affect modeling uncertainties and reliability *** considers:1)different correlation lengths for uncertainty parameters,and 2)dead and live loads as well as the elasticity moduli of concrete and steel as a multi-dimensional RF in concrete *** show the SSFEM’s efficiency in the study of concrete structures and to evaluate the sensitivity of the correlation length effects in evaluating the reliability,two examples of RC beams and slabs have been *** to the results,the RF correlation length is effective in modeling uncertainties and evaluating reliabilities;the longer the correlation length,the greater the dispersion range of the structure response and the higher the failure probability.

关键词： uncertainty spectral stochastic finite element method correlation length reliability assessment reinforced concrete beam/slab

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Characteristics of settling of dilute suspension of particles with different density at high Reynolds numbers

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Particuology 2021年第3期19卷 62-74页

作者： Ali abbas Zaidi Department of Mechanical and Process Engineering ETH Zurich8092 ZurichSwitzerland

Dilute suspension of particles with same density and size develops clusters when settle at high Reynolds number(≥250).It is due to particles entrapment in the wakes produced by upstream *** this work,this phenomenon is studied for suspension having particles with different densities by numerical *** particle-fluid interactions are modelled using immersed boundary method and inter-particle collisions are modelled using discrete element *** simulations,settling Reynolds number is always kept above 250 and the suspension solid volume fraction is nearly 0.1 *** particle density ratios(*** of heavy particles to lighter particles)equal to 4:1 and 2:1 and particles with same density are *** each density ratio,the percentage volume fraction of each particle density is nearly varied from 0.8 to *** characteristics such as microstructures of settling particle,average settling velocity and velocity fluctuations of settling particles are *** show that for different density particles settling characteristics of suspension is largely dominated by heavy *** the end of paper,the underlying physics is explained for the anomalies observed in simulation.

关键词： Particle clustering at high reynolds number Suspension with different density particles Particle microstructure due to settling Immersed boundary method

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Photocatalytic degradation evaluation of N–Fe codoped aligned TiO2 nanorods based on the effect of annealing temperature

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Journal of Advanced Ceramics 2020年第1期9卷 107-122页

作者： abbas Sadeghzadeh-Attar Department of Metallurgy and Materials Engineering University of KashanP.O.Box.87317-53153Ghotb Ravandi Blvd.KashanIran

In this paper,a comparative study on the photocatalytic degradation of the Rhodamine B(Rh B)dye as a model compound using N–Fe codoped Ti O2 nanorods under UV and visible-light(λ≥420 nm)irradiations has been *** O2 photocatalysts were fabricated as aligned nanorod arrays by liquid-phase deposition process,annealed at different temperatures from 400 to 800℃.The effects of annealing temperature on the phase structure,crystallinity,BET surface area,and resulting photocatalytic activity of N–Fe codoped Ti O2 nanorods were also *** degradation studies confirmed that the nanorods annealed at 600℃composed of both anatase(79%)and rutile phases(21%)and offered the highest activity and stability among the series of nanorods,as it degraded 94.8%and 87.2%Rh B in 120 min irradiation under UV and visible-light,*** 600℃,the photocatalytic performance of nanorods decreased owning to a phase change,decreased surface area and bandgap,and growth of Ti O2 crystallites induced by the annealing *** is hoped that this work could provide precious information on the design of 1 D catalyst materials with more superior photodegradation properties especially under visible-light for the further industrial applications.

关键词： N–Fe codoped TiO2 nanorods liquid-phase deposition annealing temperature photocatalytic degradation

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