Interaction between tumor stage and age on survival outcomes of patients with anaplastic thyroid cancer

作     者：Ayrton I Bangolo Auda Auda John Bukasa-Kakamba Nayan Bhakta Shraboni Dey Anupriya lilhori Gowry Reddy Budoor Alqinai Aman Sidiqui Imranjot Sekhon Barbare Khatiashvili Iqra Abbas Sandra Kunnel Amer Jarri Emelyn Martinez Deborah Daoud Ishita Gupta Harshini Gompa Silvanna Pender Dana Aljaberi Hamed Aljanaahi Sandra S Kunnel Yingxia Xiao Yoontae Jung Sneha Nagpaul Afshan Naz Tejaswee Mallela Phyo Maung Maung Ibtihal Y Khalaf Soobee Kim Roua Alrestom Aditya Gajera Hiba Alkealy Deepti Kansal Sonam Dhall Sanya Satheesha Simcha Weissman Pierre Fwelo 

作者机构：Department of Internal MedicinePalisades Medical CenterNorth BergenNJ 07047United States Department of MedicinePalisades Medical CenterNorth BergenNJ 07047United States Department of Endocrine and Metabolic DisordersUniversity of KinshasaKinshasa KinshasaCongo Department of EpidemiologyHuman Geneticsand Environmental SciencesUTHealth School of Public HealthHoustonTX 77030United States 

出 版 物：《World Journal of Experimental Medicine》 (世界实验医学杂志)

年 卷 期：2024年第14卷第3期

页      面：90-100页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Undifferentiated thyroid cancer Survival outcome Prognosis Metastasis Clinical trials Interaction 

摘      要：BACKGROUND Anaplastic thyroid cancer(ATC)is an aggressive,rare malignancy associated with rapid growth and metastasis,and a very poor *** investigated the clinical characteristics,survival outcomes and independent prognostic factors associated with anaplastic thyroid *** To assess to what extent the interaction between age and tumor stage affects *** A total of 622 patients diagnosed with anaplastic thyroid cancer,between 2010 and 2017 were enrolled in our study by retrieving data from the Surveillance,Epidemiology and End Results(SEER)*** analyzed demographics,clinical characteristics,overall mortality(OM)and cancer specific mortality(CSM)of *** with a P value0.1 were incorporated into the multivariate cox model to determine the independent prognostic ***,we analyzed the interaction between age and tumor stage on *** In the multivariate analyses,the divorced/separated population had a lower OM[hazard ratio(HR)=0.63,95%CI:0.42-0.94,P0.05]and CSM(HR=0.61,95%CI:0.40-0.92,P0.05).OM was higher in tumors with direct extension only(HR=6.26,95%CI:1.29-30.42,P0.05)and tumors with distant spread(HR=5.73,95%CI:1.34-24.51,P0.05).CSM was also higher in tumors with direct extension(HR=5.05,95%CI:1.05-24.19,P0.05)and tumors with distant spread(HR=4.57,95%CI:1.08-19.29,P0.05).Mortality was not adversely affected by lymph node *** was lower in patients who received radiation(HR=0.66,95%CI:0.53-0.83,P0.01),chemotherapy(HR=0.63,95%CI:0.50-0.79,P0.01)or surgery(HR=0.53,95%CI:0.43-0.66,P0.01).CSM was also lower in patient who received radiation(HR=0.64,95%CI:0.51-0.81,P0.01),chemotherapy(HR=0.62,95%CI:0.50-0.78,P0.01)or surgery(HR=0.51,95%CI:0.41-0.63,P0.01).There was no significant interaction between age and tumor stage that affected *** In this large US SEER database retrospective study,we found the mortality to be higher in advanced stage tumors with direct extensi