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Mucins in neoplasms of pancreas,ampulla of Vater and biliary system

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World Journal of Gastrointestinal Oncology 2016年第10期8卷 725-734页

作者： Dimitrios Moschovis Giorgos Bamias ioanna Delladetsima Department of Gastroenterology Agios Panteleimon General Hospital Academic Department of Gastroenterology Medical SchoolNational and Kapodistrian University of AthensLaikon Hospital First Department of Pathology Medical SchoolNational and Kapodistrian University of Athens

Tumors of the pancreas,the ampulla of Vater,and the extrahepatic and intrahepatic bile ducts have significant histological similarities due to the common embryonic origin of the pancreatobiliary *** obviates the need for discovery of biomarkers with diagnostic and prognostic value for these ***,especially MUC-1,-2,-4 and-5AC,are important candidates for developing into such reliable *** expression of MUC1 occurs in pancreatic ductal adenocarcinomas and is associated with increased degrees of dysplasia in pancreatic intraepithelial neoplasia(Pan IN).Positive expression of MUC2 in intraductal papillary mucinus neoplasms(IPMN) of the intestinal type indicates high potential progression to invasive carcinoma with de novo expression of MUC1,while absence of MUC2 expression in IPMNs of gastric type implies low potential to malignant *** novo MUC4 expression correlates to the severity of dysplasia in Pan IN and is associated with a poor prognosis in patients with pancreatic ductal *** biliary intraepithelial neoplasia(Bil IN),increased expression of MUC1 is associated with higher degrees of *** cholangiocarcinomas(ICC) are characterized by increased expression of all glycoforms of *** MUC2 expression in intraductal papillary neoplasm of the bile ducts(IPNB) of the intestinal type indicates high malignant potential with de novo expression of MUC1 in the invasive *** MUC2 expression in any degree of Bil IN may prove useful in differentiating them from *** novo expression of MUC4 is associated with poor prognosis in patients with ICC or carcinoma of the extrahepatic bile ducts(EHBDC).High de novo expression of MUC5 AC is found in all degrees of Bil IN and all types of IPNB and *** MUC5 AC is useful in the detection of neoplastic lesions of the bile duct at an early *** expression of mucin MUC1 in carcinoma of the ampulla of Vater associated with unfavorable b

关键词： Ampulla Vater neoplasms Biliary system neoplasms Mucins Pancreatic neoplasms

Arsenic speciation in fish from Greek coastal areas

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Journal of Environmental Sciences 2017年第6期29卷 300-312页

作者： ioanna Kalantzi Kyriaki Mylona Katerina Sofoulaki Manolis Tsapakis Spiros A.Pergantis Institute of Oceanography Hellenic Centre for Marine Science(HCMR)PO Box 2214Heraklion 71003CreteGreece Environmental Chemical Processes Laboratory Department of ChemistryUniuersity of CreteHeraklion 71003CreteGreece

Arsenic speciation analysis was conducted on fish samples （sardine and anchovy） collected from six areas along the Greek coastline, i.e. Artemisium Straits, Thermaikos Gulf, Amvrakikos Gulf, Strymonian Gulf, Thracian Sea, and Elefsina Gulf. Total arsenic levels ranging from 11.8 to 62.6 mg As/kg dry weight were determined. Arsenobetaine, a non-toxic form of arsenic, was found to be the main arsenic species, present at 8.6 to 58.8 mg As/kg dry weight, accounting for 67--95% of the total arsenic. Also detected in all fish samples was dimethylarsinic acid, although at considerably lower concentrations, ranging from 0.072-3.956 mg As/kg dry weight. Monomethylarsonic acid was detected at low levels in all anchovy samples, and only in sardines from one area. Finally, inorganic arsenic in the form of arsenate was detected only in fish at one area, indicating the possible effect of an environmental parameter on its presence at detectable amounts. Statistical analysis revealed the environmental variables, such as salinity, total organic carbon and nitrogen, ammonium, phosphate, total phosphorus, dissolved oxygen and pressure index, are potentially correlated to As species concentrations. Furthermore, based on factor analysis, the biological parameters, such as fish weight, lipids, protein and ash content, that are correlated to As species concentrations of fish were also identified. The interrelationship of arsenobetaine and dimethylarsinic acid concentrations within each fish species was evaluated.

关键词： Arsenic speciationArsenobetaineDimethylarsinic acidArsenateFishEnvironmental and biologicalparameters

Role of NLRP3 inflammasome in inflammatory bowel diseases

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World Journal of Gastroenterology 2019年第33期25卷 4796-4804页

作者： Evanthia Tourkochristou ioanna Aggeletopoulou Christos Konstantakis Christos Triantos Division of Gastroenterology Department of Internal Medicine Medical School University of Patras

Inflammasomes are multiprotein intracellular complexes which are responsible for the activation of inflammatory responses. Among various subtypes of inflammasomes, NLRP3 has been a subject of intensive investigation. NLRP3 is considered to be a sensor of microbial and other danger signals and plays a crucial role in mucosal immune responses, promoting the maturation of proinflammatory cytokines interleukin 1β(IL-1β) and IL-18. NLRP3 inflammasome has been associated with a variety of inflammatory and autoimmune conditions, including inflammatory bowel diseases(IBD). The role of NLRP3 in IBD is not yet fully elucidated as it seems to demonstrate both pathogenic and protective effects. Studies have shown a relationship between genetic variants and mutations in NLRP3 gene with IBD pathogenesis. A complex interaction between the NLRP3 inflammasome and the mucosal immune response has been reported. Activation of the inflammasome is a key function mediated by the innate immune response and in parallel the signaling through IL-1β and IL-18 is implicated in adaptive immunity. Further research is needed to delineate the precise mechanisms of NLRP3 function in regulating immune responses. Targeting NLRP3 inflammasome and its downstream signaling will provide new insights into the development of future therapeutic strategies.

关键词： NLRP3 inflammasome Inflammatory bowel diseases Mucosal immune system Interleukin 1β Interleukin 18 NLRP3 gene polymorphisms

An explainable AI model for power plant NOx emission control

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Energy and AI 2024年第1期15卷 171-180页

作者： Yuanye Zhou ioanna Aslanidou Mikael Karlsson Konstantinos Kyprianidis School of Business Society and EngineeringMälardalens UniversityUniversitetsplan 172220VästeråsSweden Future Energy Centre Mälardalens UniversityUniversitetsplan 172220VästeråsSweden School of Innovation Design and EngineeringMälardalens UniversityUniversitetsplan 172220VästeråsSweden

In recent years,developing Artificial Intelligence(AI)models for complex system has become a popular research *** have been several successful AI models for predicting the Selective Non-Catalytic Reduction(SNCR)system in power plants and large ***,all these models are in essence black box models and lack of explainability,which are not able to give new *** this study,a novel explainable AI(XAI)model that combines the polynomial kernel method with Sparse Identification of Nonlinear Dynamics(SINDy)model is proposed to find the governing equation of SNCR system based on 5-year operation data from a power *** proposed model identifies the system’s governing equation in a simple polynomial format with polynomial order of 1 and only 1 independent variable among original 68 input *** addition,the explainable AI model achieves a considerable accuracy with less than 21%deviation from base-line models of partial least squares model and artificial neural network model.

关键词： Explainable AI SINDy Kernel SNCR Power plant Boiler

Risk of hepatitis B reactivation in patients treated with direct-acting antivirals for hepatitis C

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World Journal of Gastroenterology 2017年第24期23卷 4317-4323页

作者： ioanna Aggeletopoulou Christos Konstantakis Spilios Manolakopoulos Christos Triantos Department of Gastroenterology University Hospital of Patras 2nd Department of Internal Medicine Hippokration General Hospital of Athens

The recent introduction of direct-acting antiviral drugs(DAAs) for treatment of the hepatitis C virus(HCV) has greatly improved the management of HCV for infected patients. These viral protein inhibitors act rapidly, allowing HCV clearance and increasing the sustained virological response rates. However, hepatitis B virus(HBV) reactivation has been reported in HCV/HBV co-infected patients. Hepatitis B reactivation refers to an abrupt increase in the HBV and is welldocumented in patients with previously undetected HBV DNA due to inactive or resolved HBV infection. Reactivation can occur spontaneously, but in most cases, it is triggered by various factors. Reactivation can be transient, without clinical symptoms; however, it usually causes a hepatitis flare. HBV reactivation may occur regardless of HCV genotype and type of DAA regimen. HBV screening is strongly recommended for co-infected HCV/HBV patients before initiation and during DAA therapy regardless of HBV status, HCV genotype and class of DAAs used. HBV reactivation can be prevented with pretreatment screening and prophylactic treatment when necessary. Additional data are required to evaluate the underlying mechanisms of HBV reactivation in this setting.

关键词： Hepatitis B Hepatitis C Hepatitis B virus reactivation Direct-acting antivirals Pretreatment screening

Role of band ligation for secondary prophylaxis of variceal bleeding

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World Journal of Gastroenterology 2018年第26期24卷 2902-2914页

作者： ioanna Aggeletopoulou Christos Konstantakis Spilios Manolakopoulos Christos Triantos Department of Gastroenterology University Hospital of Patras 2~(nd) Department of Internal Medicine Hippokration General Hospital of Athens

AIM To summarize and critically examine the role of band ligation in secondary prophylaxis of variceal bleeding in patients with cirrhosis. METHODS A literature review was performed using the MEDLINE and PubM ed databases. The search terms consisted of the words "endoscopic band ligation" OR "variceal band ligation" OR "ligation" AND "secondary prophylaxis" OR "secondary prevention" AND "variceal bleeding" OR "variceal hemorrhage" AND "liver cirrhosis". The data collected from relevant meta-analyses and from the most recent randomized studies that were not included in these meta-analyses were used to evaluate the role of endoscopic band ligation in an effort to demonstrate the most recent advances in the treatment of esophageal varices. RESULTS This study included 11 meta-analyses published from 2002 to 2017 and 10 randomized trials published from 2010 to 2017 that evaluated the efficacy of band ligation in the secondary prophylaxis of variceal bleeding. Overall, the results proved that band ligation was superior to endoscopic sclerotherapy. Moreover, the use of β-blockers in combination with band ligation increased the treatment effectiveness, supporting the current recommendations for secondary prophylaxis of variceal bleeding. The use of transjugular intrahepatic portosystemic shunt was superior to combination therapy regarding rebleeding prophylaxis, with no difference in the survival rates; however, the results concerning the hepatic encephalopathy incidence were conflicting. Recent advances in the management of secondary prophylaxis of variceal bleeding have targeted a decrease in portal pressure based on the pathophysiological mechanisms of portal *** This review suggests that future research should be conducted to enhance current interventions and/or to develop innovative treatment options with improved clinical endpoints.

关键词： Band ligation Variceal bleeding Rebleeding Liver cirrhosis Endoscopic therapy Variceal eradication Secondary prophylaxis Esophageal varices

Interleukin 12/interleukin 23 pathway: Biological basis and therapeutic effect in patients with Crohn's disease

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World Journal of Gastroenterology 2018年第36期24卷 4093-4103页

作者： ioanna Aggeletopoulou Stelios F Assimakopoulos Christos Konstantakis Christos Triantos Division of Gastroenterology Department of Internal MedicineMedical SchoolUniversity of Patras Department of Internal Medicine University Hospital of Patras

Considering that both innate and adaptive immune responses are involved in the pathogenesis of Crohn's disease(CD), novel therapeutic options have significantly been developed. Biological agents represent an important addition to the conventional treatments for immuno-inflammatory conditions, acting as antagonists of adhesion molecules or various inflammatory cytokines. The interleukin 12(IL-12)/IL-23 common pathway has been found to play a determinant role in the induction of inflammation in adaptive immune responses. In particular, IL-23 promotes the differentiation of na?ve T helper cells into Th17 phenotype with the concomitant secretion of several inflammatory cytokines such as IL-17 and IL-22, whereas IL-12 induces the Th1 polarization and production of critical cytokines such as interferon-γ and tumor necrosis factor. Nowadays, there is increased interest regarding the role of IL-23 as a therapeutic target of CD through the blockage of IL-23 mediated pathways. In this editorial, we focus on the role of IL-12/IL-23 pathway in the regulation of mucosal immunity and in the induction and maintenance of chronic inflammation. In parallel, we critically discuss the available data regarding the therapeutic effect of the IL-12/IL-23 inhibitors and especially of ustekinumab, a human monoclonal antibody which has been recently approved by the United States Food and Drug Administration for the management of moderateto-severe CD and its potential to be used as first-line therapy in everyday clinical practice.

关键词： Crohn’s disease Interleukin 12 Interleukin 23 Monoclonal antibodies Ustekinumab Biological agents Interleukin 12/interleukin 23 blockade

Synthesis of carbon nanotubes loaded hydroxyapatite: Potential for controlled drug release from bone implants

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Journal of Advanced Ceramics 2016年第3期5卷 232-243页

作者： Lisa COSTANTINI Nikolaos BOUROPOULOS Dimitrios G.FATOUROS ioanna KONTOPOULOU Marta ROLDO School of Pharmacy and Biomedical Science University of Portsmouth St Michael's BuildingWhite Swan Road Portsmouth UK Department of Materials Science University of Patras 26504 Rio Patras GreeceFoundation for Research and Technology Hellas-Institute of Chemical Engineering and High Temperature Chemical Processes—FORTH/ICEHT P.O.Box 1414 GR 26504 Patras Greece Department of Pharmaceutical Technology School of Pharmacy Aristotle University of ThessalonikiGR-54124 Thessaloniki Greece Department of Materials Science University of Patras 26504 Rio Patras Greece

Carbon nanotubes (CNTs) can support the building of flexible and porous scaffolds for bone regeneration. Various studies have looked at the mixing of CNTs with hydroxyapaptite for the formulation of bone implants. In the present work, we report the one step preparation and characterisation of chitosan/hydroxyapatite/CNTs composite materials obtained by wet precipitation of hydroxyapatite (HA) in the presence of chitosan or its amphiphilic derivative N-octyl-O-sulphate chitosan and CNTs. The in situ precipitation of HA assured inclusion of the polysaccharide and the CNTs in the HA structure and provided materials with the ability to control the release of different model drugs.

关键词： carbon nanotubes (CNTs) hydroxyapatite (HA) composites bone regeneration chitosan

Correlation of computed tomography findings and lung function in children and adolescents with cystic fibrosis

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World Journal of Pediatrics 2021年第3期17卷 221-226页

作者： Andrew Fretzayas ioanna Loukou Maria Moustaki Konstantinos Douros School of Medicine National and Kapodistrian University of AthensAthensGreece Department of Pediatrics Athens Medical Center5-7 Distomou str15125 MarousiGreece Department of Cystic Fibrosis “Agia Sofia”Children’s HospitalAthensGreece

Background The timely and appropriate monitoring of pulmonary status is of utmost importance for patients with cystic fibrosis(CF).Computed tomography(CT)has been used in clinical and research settings for tracking lung involvement in CF ***,as CT delivers a considerable amount of radiation,its sequential use in CF patients remains a *** application of CT,therefore,should take into account its potential *** review aims to understand whether and to what extent the CT findings correlate with the findings from other monitoring tools in CF lung *** sources PubMed was searched for articles about the correlation of chest CT findings with spirometric indices and with lung clearance index in children and adolescents with *** most relevant articles were reviewed and are presented *** Most studies have shown that forced expiratory volume in the first second(FEV,)and other spirometric indices correlate moderately with CT structural lung ***,at the individual level,there were patients with FEV,within the normal range and abnormal CT and vice ***,longitudinal studies have indicated that the deterioration of structural lung damage does not occur in parallel with the progression of lung *** clearance index is a better predictor of CT *** In general,the existing studies do not support the use of lung function tests as surrogates of chest CT.

关键词： Computed tomography Computed tomography score Cystic fibrosis Lung clearance index Lung function Spirometry