Correlation of computed tomography findings and lung function in children and adolescents with cystic fibrosis
作者机构：School of MedicineNational and Kapodistrian University of AthensAthensGreece Department of PediatricsAthens Medical Center5-7 Distomou str15125 MarousiGreece Department of Cystic Fibrosis“Agia Sofia”Children’s HospitalAthensGreece
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2021年第17卷第3期
页 面：221-226页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Computed tomography Computed tomography score Cystic fibrosis Lung clearance index Lung function Spirometry
摘 要：Background The timely and appropriate monitoring of pulmonary status is of utmost importance for patients with cystic fibrosis(CF).Computed tomography(CT)has been used in clinical and research settings for tracking lung involvement in CF ***,as CT delivers a considerable amount of radiation,its sequential use in CF patients remains a *** application of CT,therefore,should take into account its potential *** review aims to understand whether and to what extent the CT findings correlate with the findings from other monitoring tools in CF lung *** sources PubMed was searched for articles about the correlation of chest CT findings with spirometric indices and with lung clearance index in children and adolescents with *** most relevant articles were reviewed and are presented *** Most studies have shown that forced expiratory volume in the first second(FEV,)and other spirometric indices correlate moderately with CT structural lung ***,at the individual level,there were patients with FEV,within the normal range and abnormal CT and vice ***,longitudinal studies have indicated that the deterioration of structural lung damage does not occur in parallel with the progression of lung *** clearance index is a better predictor of CT *** In general,the existing studies do not support the use of lung function tests as surrogates of chest CT.
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