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Enhance Stability and in vitro Cell Response to a Bioinspired Coating on Zr Alloy with Increasing Chitosan Content

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Journal of Bionic Engineering 2017年第3期14卷 459-467页

作者： Daniela Ionita Maria Vardaki Miruna S. Stan Anca Dinischiotu ioana demetrescu Faculty of Applied Chemistry and Materials Science University Politehnica of Bucharest 1-7 Polizu 011061 Bucharest Romania Department of Biochemistry and Molecular Biology Faculty of Biology University of Bucharest 91-95 Splaiullndependentei 050095 Bucharest Romania Academy of Romanian Scientist Splaiullndependentei 54 050094 Bucharest Romania

The aim of the present paper is to characterize bioinspired chitosan （CS）＋ hydroxyapatite （HA） coatings with various components ratio on a zirconium alloy with titanium. The coatings were characterized by FT-IR, SEM, hydrophilic/hydrophobic balance, adherence, roughness, electrochemical stability and in vitro cell response. Electrochemical tests, including potentio- dynamic polarization curves and electrochemical impedance spectroscopy, were performed in normal saline physiological solution. Cell viability of MC3T3-E1 osteoblasts, lactate dehydrogenase, nitric oxide, and Reactive Oxygen Species （ROS） levels, as well as actin cytoskeleton morphology, were evaluated as biological in vitro tests. The results on in vitro cell response indicated good cell membrane integrity and viability for all samples, but an increased cell number, a decreased ROS level and a better cytoskeleton organization were noticed for the sample with a higher CS content. The coating with highest CS concen- tration indicated the best performance based on the experimental data. The highest hydrophilic character, highest resistance to corrosion and best biocompatibility as well recommend this coating for bioapplications in tissue engineering.

关键词： ZrTi alloy bioinspired coating cells response electrochemical stability

Determination of Metal Content in Soil and Wheat Plant by Inductively Coupled Plasma Mass Spectrometry

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Journal of Agricultural Chemistry and Environment 2024年第3期13卷 300-311页

作者： Iubu (Badea) Anişoara Ion V. Popescu Claudia Stihi ioana Daniela Dulama Doctoral School of Physics University of Bucharest Magurele Romania Faculty of Science and Arts Valahia University of Targoviste Targoviste Romania Academy of Romanian Scientists Bucharest Romania Institute of Multidisciplinary Research for Science and Technology Valahia University of Targoviste Targoviste Romania

This study aims to investigate the level of soil pollution and the grade of accumulation of metals and heavy metals by wheat plants from the soil in different parts of the crop: root, stem, leaf, spike and grain. Sampling campaigns took place in February, April and July when wheat plants were at different growth stages. A number of eight soil samples and eight wheat plant samples were collected. The sampled wheat plant was taken at the same time and from the same place as the soil. Concentrations of Al (aluminium), Cr (chromium), Mn (manganese), Fe (iron), Ni (nickel), Co (cobalt), Cu (copper), Zn (zinc), Sr (strontium), Cd (cadmium) and Pb (lead) were determined by inductively coupled plasma mass spectrometry. Bioconcentration and translocation factors were calculated for the samples analysed.

关键词： Soil Wheat Plant Heavy Metals Translocation Factor

The Impact of Sleep Patterns on Academic Performance and Social Integration among Medical Students

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Journal of Biosciences and Medicines 2024年第8期12卷 189-198页

作者： Livia-Ștefana Găgilă Tudor Cojocaru Giulia-Mihaela Pînzariu Daria Georgiana Sauciuc Diana Elena Lupașcu Livia Amira Sauciuc ioana Ilinca Ursachianu Elena Cojocaru Faculty of Medicine University of Medicine and Pharmacy Grigore T. Popa Iai Romania Morpho-Functional Sciences II Department Grigore T. Popa University of Medicine and Pharmacy Iasi Romania

Introduction: The impact of sleep on student life is crucial, particularly for those in demanding fields such as medicine. This study examines the relationships between sleep patterns, academic performance, and social integration among medical students, who often face irregular sleep cycles and sleep deprivation due to rigorous academic demands. Aim: This study aims to assess how sleep issues affect academic achievement and social relationships among medical students. Method: Data were collected from 215 medical students through surveys and academic records. Quantitative data provided insights into sleep quality and academic performance, while qualitative interviews explored the effects of sleep on social interactions. Results: The findings revealed a significant correlation between sleep quality and academic performance, with students reporting better sleep hygiene achieving higher grades. Qualitative data indicated that poor sleep negatively impacts social interactions, leading to feelings of isolation and reduced social participation. Conclusions: The study highlights the importance of promoting good sleep practices in medical schools to enhance academic success and social well-being. Interventions aimed at improving sleep quality may help reduce burnout and improve overall well-being among medical students. Future research should focus on longitudinal studies to better understand the long-term effects of sleep on academic and social outcomes in this population.

关键词： Student Medicine Sleep Quality Academic Performance

Neurological complications of hematopoietic cell transplantation in children and adults

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Neural Regeneration Research 2018年第6期13卷 945-954页

作者： Adriana Octaviana Dulamea ioana Gabriela Lupescu University of Medicine and Pharmacy Carol Davila Bucharest Romania Department of Neurology Fundeni Clinical Institute Bucharest Romania Radiology and Medical imaging Department Fundeni Clinical Institute Bucharest Romania

Hematopoietic cell transplantation（HCT） is widely performed for neoplastic and non-neoplastic diseases. HCT involves intravenous infusion of hematopoietic progenitor cells from human leukocyte antigen（HLA）-matched donor（allogeneic） or from the patient（autologous）. Before HCT, the patient is prepared with high dose chemotherapy and/or radiotherapy to destroy residual malignant cells and to reduce immunologic resistance. After HCT, chemotherapy is used to prevent graft rejection and graft versus host disease（Gv HD）. Neurological complications are related to the type of HCT, underlying disease, toxicity of the conditioning regimens, immunosuppression caused by conditioning regimens, vascular complications generated by thrombocytopenia and/or coagulopathy, Gv HD and inappropriate immune response. In this review, neurological complications are presented according to time of onset after HCT：（1） early complications（in the first month）-related to harvesting of stem cells, during conditioning（drug toxicity, posterior reversible encephalopathy syndrome）, related to pancytopenia,（2） intermediate phase complications（second to sixth month）-central nervous system infections caused by prolonged neutropenia and progressive multifocal leukoencephalopathy due to JC virus,（3） late phase complications（after sixth month）-neurological complications of Gv HD, second neoplasms and relapses of the original disease.

关键词： neurological complications hematopoietic cell transplantation posterior reversible encephalopathy syndrome central nervous system infections progressive multifocal leukoencephalopathy graft versus host disease second neoplasm immune reconstitution inflammatory syndrome post-transplant acute limbic encephalitis drug reaction with eosinophiIia and systemic symptoms

Spontaneous and antiviral-induced cutaneous lesions in chronic hepatitis B virus infection

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World Journal of Gastroenterology 2014年第42期20卷 15860-15866页

作者： ioana Grigorescu Dan Lucian Dumitrascu 2nd Department of Internal Medicine University of Medicine and Pharmacy "Iuliu Hatieganu"

AIM: To describe spontaneous, or interferon (IFN)- or immunization-induced skin lesions in hepatitis B virus (HBV) infection.

关键词： Hepatitis B Skin diseases Adverse effects Immunization

Mapping flood and flooding potential indices： a methodological approach to identifying areas susceptible to flood and flooding risk. Case study： the Prahova catchment （Romania）

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Frontiers of Earth Science 2017年第2期11卷 229-247页

作者： Liliana ZAHARIA Romulus COSTACHE Remus PRAVALIE Gabriela ioana-TOROIMAC Faculty of Geography University of Bucharest 1 Nieolae Balcescu Str. 010041 Bucharest Romania National Institute of Hydrology and Water Management 97 Bucuresti-Ploiesti Str. District 1 Bucharest Romania

Given that floods continue to cause yearly significant worldwide human and material damages, flood risk mitigation is a key issue and a permanent challenge in developing policies and strategies at various spatial scales. Therefore, a basic phase is elaborating hazard and flood risk maps, documents which are an essential support for flood risk management. The aim of this paper is to develop an approach that allows for the identification of flash-flood and flood-prone susceptible areas based on computing and mapping of two indices： FFPI （Flash-Flood Potential Index） and FPI （Flooding Potential Index）. These indices are obtained by integrating in a GIS environment several geographical variables which control runoff（in the case of the FFPI） and favour flooding （in the case of the FPI）. The methodology was applied in the upper （mountainous） and middle （hilly） catchment of the Prahova River, a densely populated and socioeconomically well-developed area which has been affected repeatedly by water-related hazards over the past decades. The resulting maps showing the spatialization of the FFPI and FPI allow for the identification of areas with high susceptibility to flash- floods and flooding. This approach can provide useful mapped information, especially for areas （generally large） where there are no flood/hazard risk maps. Moreover, the FFPI and FPI maps can constitute a preliminary step for flood risk and vulnerability assessment.

关键词： flash-flood flooding Flash-flood/FloodingPotential Index Prahova River catchment Romania

Low fermentable oligosaccharides, disaccharides,monosaccharides, and polyols diet in children

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World Journal of Clinical Cases 2019年第18期7卷 2666-2674页

作者： ioana Fodor Sorin Claudiu Man Dan L Dumitrascu 3^rd Pediatric Department Iuliu Hatieganu University of Medicine and PharmacyCluj-Napoca 400006Romania 2^nd Medical Department Iuliu Hatieganu University of Medicine and PharmacyCluj-Napoca 400006Romania

Irritable bowel syndrome (IBS) is a lifelong condition with a high prevalence among children and adults. As the diet is a frequent factor that triggers the symptoms, it has been assumed that by avoiding the consumption of fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP), the symptoms might be improved. Therefore, in the past decade, low FODMAP diet has been intensively investigated in the management of IBS. The capacity of FODMAPs to trigger the symptoms in patients with IBS was related to the stimulation of mechanoreceptors in the small and large intestine. This stimulation appears as a response to a combination of increased luminal water (the osmotic effect) and the release of gases (carbon dioxide and hydrogen) due to the fermentation of oligosaccharides and malabsorption of fructose, lactose and polyols. Numerous studies have been published regarding the efficacy of a low FODMAP diet compared to a traditional diet in releasing the IBS symptoms in adults, but there are only a few studies in the juvenile population. The aim of this review is to analyze the current data on both low FODMAP diet in children with IBS and the effects on their nutritional status and physiological development, given the fact that it is a restrictive diet.

关键词： Low fermentable oligosaccharides Disaccharides Monosaccharides Polyols Diet Children Irritable bowel syndrome Symptom

Anomaly Detection in Textured Images with a Convolutional Neural Network for Quality Control of Micrometric Woven Meshes

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Fluid Dynamics & Materials Processing 2022年第6期18卷 1639-1648页

作者： Pierre-Frédéric Villard Maureen Boudart ioana Ilea Fabien Pierre Universitéde Lorraine CNRS Inria LORIA Nancy54000France IUT de Saint-DiéUniversitéde Lorraine Saint-Dié-des-Vosges88100France Technical University of Cluj-Napoca Cluj-Napoca400114Romania

Industrial woven meshes are composed of metal materials and are often used in construction,industrial and residential activities or *** objective of this work is defect detection in industrial fabrics in the quality control *** order to overcome the limitations of manual methods,which are often tedious and time-consuming,we propose a strategy that can automatically detect defects in micrometric steel meshes by means of a Convolutional Neural *** database used for such a purpose comes from real problem data for anomaly detection in micrometric woven *** detection is performed through supervised classification with a Convolutional Neural Network using a VGG19 *** define a pipeline and a strategy to tackle the related small amount of *** includes i)augmenting the database with translation,rotation and symmetry,ii)using pre-trained weights and iii)checking the learning curve behaviour through *** obtained results show that,despite the small size of our databases,detection accuracy of 96%was reached.

关键词： Industrial fabrics defects detection deep learning convolutional neural network VGG19

“Treat-Repair-Treat”:Management of Left Main Coronary Compression by a Pulmonary Artery Aneurysm in a Patient with Atrial Septal Defect and Significant Pulmonary Hypertension

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Congenital Heart Disease 2023年第1期18卷 67-72页

作者： Andrei George Iosifescu Roxana Enache ioana Marinică Corina Radu Vlad Anton Iliescu Carol Davila University of Medicine and Pharmacy Bucharest020021Romania Department of Cardiac Surgery C.C.Iliescu Emergency Institute for Cardiovascular DiseasesBucharest022322Romania Department of Cardiology C.C.Iliescu Emergency Institute for Cardiovascular DiseasesBucharest022322Romania Department of Cardiovascular Anesthesia and Intensive Care C.C.Iliescu Emergency Institute for Cardiovascular DiseasesBucharest022322Romania

Left main coronary compression syndrome(LMCS)may complicate pulmonary artery aneurysms(PAA),usually developed in the context of pulmonary arterial hypertension(PAH).We report the case of a 51-year-old female patient with an atrial septal defect(unsuitable for device closure)complicated by a PAA generating a 90%left main *** significant PAH held us back from immediate *** specific dual PAH-targeted therapy(sildenafil and bosentan),the atrial septal defect could be closed with a unidirectional valved patch;the PAAinduced LMCS was treated by reductive *** postoperative course was ***-up showed clinical improvement,but PAH treatment was still *** three months,coronary angiography showed only an insignificant residual left main stenosis,proving that reductive pulmonary arterioplasty was effective in treating *** PAA requires further evaluation for LMCS,a dangerous but treatable ***“treat-repair-treat”strategy and shunt-closure with a unidirectional valved patch can both improve surgical prospects of LMCS with shunt-related PAH.

关键词： Atrial septal defect pulmonary arterial hypertension pulmonary artery aneurysm left main coronary compression syndrome surgery unidirectional valved patch