检索结果-南通市图书馆

Open Journal of Respiratory Diseases 2014年第3期4卷 73-82页

作者： Ron Eccles ingo fietze Uwe-Bernd Rose Common Cold Centre and Healthcare Clinical Trials Cardiff School of BiosciencesCardiff UniversityCardiffUK Campus Charité Mitte—Schlafmedizinisches Zentrum BerlinGermany Burg Apotheke Konigstein/TaunusGermany

This up-to-date overview will look at the rationale for the recommendation of combination products for multi-symptom relief of common cold and flu. Common cold and flu are defined by their multi-symptom nature with data showing a variety of symptoms reported simultaneously each day over the first six days of illness. Multi-ingredient combination products for multi-symptom relief are formulated to safely, simply, and simultaneously treat multiple symptoms when used as directed. The rationale for the formulation combination products for common cold and flu is therefore practical, logical and reasonable. No evidence has been found that multi-symptom relief medicines are inherently less safe than single-active ingredient medicines. Multi-symptom relief combination products containing several active ingredients provide a safe, effective, cost-effective, and convenient way of treating the multiple symptoms of common cold and flu, when used as directed. This therapy requires some special information for the patient to be provided by the physician and the pharmacist.

关键词： Combination Products Multi-Symptom Relief Multi-Ingredient Common Cold Flu

Open-Label Real-World Pharmacy Purchaser Study of Two Fixed-Dose Combination OTC Cold Treatments;Wick MediNait, Wick DayMed Capsules or a Combination of Both

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Respiratory Diseases 2018年第3期8卷 43-62页

作者： Gillian Phillipson David Ramsey Sue Aspley ingo fietze Procter&Gamble International Operations Geneva Business CenterGenevaSwitzerland Procter&Gamble Health Care MasonOHUSA Procter&Gamble Technical Centres Ltd. SurreyUK Center of Sleep Medicine Charité—Universitatsmedizin BerlinBerlinGermany

Acute upper respiratory tract infections, i.e. common colds cause multiple symptoms and affect adults on average 2 - 4 times a year and children 6 - 8 times per year. Thousands of non-prescription, over-the-counter products are used by sufferers, aimed at relieving the various both er some symptoms such as cough, nasal congestion, sore throat, etc. This study evaluated real-world effectiveness of Wick MediNait or Wick DayMed medicines alone and together in a combination as a day and night treatment regimen. Adult cold sufferers were recruited in pharmacy by pharmacy staff following self-purchase of either Wick MediNait, Wick DayMed capsules, or the combination of DayMed and MediNait. Participants completed online questionnaires before and after product use (evening of the first day for DayMed and the morning after using MediNait at bedtime). For the primary endpoint “Wick MediNait was effective at relieving my symptoms”, there was a statistically significant difference (p < 0.0001) in the users who Strongly Agreed or Agreed vs. Neither Agreed or Disagreed, Disagreed or Strongly Disagreed. Further, all symptoms evaluated (cough, runny nose, nasal congestion, fever, headache, sore throat, muscle aches and pains, sneezing) were statistically improved after MediNait and DayMed alone and when both were used, and users were satisfied with both treatments. All treatments were well tolerated with minimal adverse event reporting. The diurnal use of DayMed capsules combined with the nocturnal use of MediNait allows cold sufferers to efficiently self-manage their symptom relief throughout the day and night.

关键词： Wick MediNait Real-World Use User Satisfaction Observational Cold Symptom Relief Sleep Quality

Multitarget Thiol-Activated Tetrapyridyl Gold(Ⅲ)Complexes for Hypoxic Cancer Therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第3期6卷 783-797页

作者： Xue-Quan Zhou Selda Abyar Imma Carbo-Bague Lan Wang Sebastian Türck Maxime ASiegler Uttara Basu ingo Ott Rongfang Liu Adriaan PIJzerman Sylvestre Bonnet Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School(SIGS)Tsinghua UniversityShenzhen 518055 Leiden Institute of Chemistry Leiden University2333 CC Leiden Department of Chemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6 Institute of Medicinal and Pharmaceutical Chemistry Technische Universität Braunschweig38106 Braunschweig Department of Chemistry Johns Hopkins UniversityBaltimoreMaryland 21218 Division of Drug Discovery&Safety Leiden Academic Centre for Drug ResearchLeiden University2333 CC Leiden

Gold complexes have emerged as promising anticancer metallodrugs due to their efficient thioredoxin reductase(TrxR)inhibition,which disturbs the redox balance of cancer cells.However,in this model,the role of the ligand(s)coordinated to gold is often overlooked.In this work,we present a series of tetrapyridyl Au(Ⅲ)complexes that exhibit thiol-induced release of a Au(Ⅰ)ion and a tetrapyridyl ligand.The formation of a free Au(Ⅰ)center is responsible for the expected TrxR inhibition.Additionally,the released ligand,which was visible in cells due to its intense blue fluorescence,showed excellent binding properties to the hERG potassium channel.Moreover,these ligands ended up in the lysosomes,resulting in significant lysosome damage.Altogether,the Au(Ⅲ)complexes presented in this work showed broad-spectrum anticancer properties,both in hypoxic 2D monolayers and 3D tumor spheroids.We suggest that the interaction of the released Au(Ⅰ)center and the tetrapyridyl ligand with two different protein targets may combine into prodrugs that overcome hypoxia-induced drug deactivation.

关键词： anticancer Au(Ⅲ)complexes enzyme inhibtion potassium channel affinity lysosome damage cell imaging prodrug

The burden of diseases-Insomnia and OSA

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The burden of diseases-Insomnia and OSA

Sleep Medicine in Germany and China–Common Features and Differences

中国睡眠研究会第十届全国学术年会

作者： ingo fietze Thomas Penzel

＜正＞The worldwide challenge in medicine is the increase in obesity and suicide rate,as the medical economists say.The study?Global Burden of Disease"mentions the worldwide most common disorders and complaints,but this does not include sleep disorders.This is in contrast to the finding that every second adult person has some degree of sleep disordered

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Sleep Medicine in Germany and China–Common Features and Dif...

New technology to assess sleep apnea: wearables,smartphones,and accessories

中国睡眠研究会第十届全国学术年会

作者： ingo fietze Thomas Penzel

＜正＞Sleep medicine is not only in China but also in Germany a young medical discipline.In Germany,we have 312 accredited sleep centers and in China,we see about 2400 sleep centers.This is certainly not enough.Much bigger is the problem,that we have too few specialists.In China,every month,60.000 sleep medicine diagnoses were documented,in

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

New technology to assess sleep apnea: wearables,smartphones,...

Gallai-Ramsey Number for the Union of Stars

中国睡眠研究会第十届全国学术年会

作者： Thomas Penzel Christoph Sch?bel ingo fietze Interdisciplinary Sleep Medicine Center Charité – Universit?tsmedizin BerlinFreie Universit?t BerlinHumboldt-Universit?t zu Berlinand Berlin Institute of Health

＜正＞Sleep medicine has been an expanding discipline during the last decades.The prevalence of sleep disorders is increasing and sleep centers expand at hospitals and in the private care environment to meet the demands.Sleep medicine has evidence-based guidelines for diagnosis and therapy of sleep disorders.However,the number of sleep centers and

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2022年第8期38卷 1317-1332页

作者： Ya Ping MAO Zhao WANG Colton MAGNANT ingo SCHIERMEYER School of Mathematics and Statistics Qinghai Normal UniversityXining 810008P.R.China College of Science China Jiliang UniversityHangzhou 310018P.R.China Department of Mathematics Clayton State UniversityMorrowGA30260USA Technische Universit?t Bergakademie Freiberg Institut für Diskrete Mathematik und Algebra09596 FreibergGermany

Given a graph G and a positive integer k,define the Gallai–Ramsey number to be the minimum number of vertices n such that any k-edge coloring of Kn contains either a rainbow(all different colored)triangle or a monochromatic copy of G.In this paper,we obtain exact values of the Gallai–Ramsey numbers for the union of two stars in many cases and bounds in other cases.This work represents the first class of disconnected graphs to be considered as the desired monochromatic subgraph.

关键词： Ramsey theory Gallai-Ramsey number union of stars

Tempering of exhausted T cells to comprehend their adaptive response for suitable clinical translation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2023年第12期20卷 1401-1402页

作者： Amit Sharma ingo G.H.Schmidt-Wolf Department of Integrated Oncology Center for Integrated Oncology(CIO)BonnUniversity Hospital BonnBonnGermany

Although cancer immunotherapy has taken center stage,exhaustion of T cells is undeniably one of the major problems preventing it from being fully successful[1].Certainly,reversal of T-cell exhaustion or dysfunction is of great importance for developing new strategies and restoring immune function.Nevertheless,counterarguments about the adverse effect of reversing T-cell exhaustion(leading to overactivation of T cells and cytotoxicity)and even their irreversible properties have been quite common in scientific debates.With more to be discovered about the reasons for T-cell failure,a better understanding of the molecular factors/determinants[2,3]that shape/remodel“heterogeneous”dysfunctional T cells in cancer makes clear sense.Indeed,two recent publications in Nature immunology have described the intriguing perspective of T-cell exhaustion[4,5].Of interest,Vignali et al.focused on the hypoxia-driven CD39-dependent suppressor function of exhausted T cells,whereas Saadey et al.emphasized restoring the epigenetic balance of TGFβ1/BMP signaling in exhausted T cells to unlock responsiveness to immune checkpoint blockade therapy.

关键词： irreversible exhaustion publications

Male mate choice in livebearing fishes： an overview

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2018年第3期64卷 393-403页

作者： ingo SCHLUPP Department of Biology University of Oklahoma 730 Van Vleet Oval Norman OK 73019 USA

Although the majority of studies on mate choice focus on female mate choice, there is growing recognition of the role of male mate choice too. Male mate choice is tightly linked to 2 other phenomena: female competition for males and ornamentation in females. In the current article, I review the existing literature on this in a group of fishes, Poeciliidae. In this group, male mate choice appears to be based on differences in female quality, especially female size, which is a proxy for fecundity. Some males also have to choose between heterospecific and conspecific females in the unusual mating system of the Amazon molly. In this case, they typically show a preference for conspecific females. Whereas male mate choice is relatively well documented for this family, female ornamentation and female competition are not.

关键词：配偶选择钓鱼交配系统女性亚马逊竞争装饰男性

Comparison of drug abuse in Germany and China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第10期28卷 1505-1518页

作者： ingo Ilja MICHELS Office of the Federal Drug Commissioner Federal Ministry of HealthBerlin 10117Germany

Drug abuse has a long,but also different history in Germany and China.TheOpium War largely influenced the history of China in 19th century;however,China was once recognized as a drug-free nation for 3 decades from the 1950s tothe 1980s.Drug abuse has spread quickly since re-emerging as a national problemin China in the late 1980s.The number of registered drug abusers increased from70 000 in 1990 to more than 1 million by the end of 2005.In past decades,illicit drugtrafficking and production have swept most provinces in China,and drug abusehas caused many problems for both abusers and the community.One major drug-related problem is the spread of HIV,which has caused major social and economicdamage in China.Germany,the largest developed European country,also facesthe drug and addiction problem.Germany has about 150 000 heroin addicts,forwhom HIV/AIDS has become a serious threat since the mid 1980s.To control thedrug problem,the German Government adopted the"Action Plan on Drugs andAddiction"in 2003;the China Central Government approved a similar regulationin the antidrug campaign in 2005.Germany has experience in reducing drug-re-lated harm.The methadone maintenance treatment (MMT) program has run formore than 20 years and the public has become more tolerant of addicts.In 2003,China began the MMT program for controlling the spread of HIV/AIDS.It isnecessary for China to learn from developed countries to acquire success in itsantidrug campaign.In this review,we will go over the differences and similaritiesin drug abuse between Germany and China.The differences are related to history,population and economics,drug policy context,drug laws,HIV/hepatitis C virusinfection,the MMT program and so on.These 2 nations have drug abuse prob-lems with different histories and currently use different approaches to handleillicit drug marketing and use.The legal penalties for illicit drug offences reflectthe social differences of these 2 nations with respect to the seriousness of particu-lar types of crimes.The characteristics of th

关键词： drug abuse methadone maintenance treatment heroin HIV/AIDS harm reduction comparison Germany China