Tempering of exhausted T cells to comprehend their adaptive response for suitable clinical translation

作     者：Amit Sharma Ingo G.H.Schmidt-Wolf 

作者机构：Department of Integrated OncologyCenter for Integrated Oncology(CIO)BonnUniversity Hospital BonnBonnGermany 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2023年第20卷第12期

页      面：1401-1402页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：Projekt DEAL 

主　　题：irreversible exhaustion publications 

摘      要：Although cancer immunotherapy has taken center stage,exhaustion of T cells is undeniably one of the major problems preventing it from being fully successful[1].Certainly,reversal of T-cell exhaustion or dysfunction is of great importance for developing new strategies and restoring immune ***,counterarguments about the adverse effect of reversing T-cell exhaustion(leading to overactivation of T cells and cytotoxicity)and even their irreversible properties have been quite common in scientific *** more to be discovered about the reasons for T-cell failure,a better understanding of the molecular factors/determinants[2,3]that shape/remodel“heterogeneousdysfunctional T cells in cancer makes clear ***,two recent publications in Nature immunology have described the intriguing perspective of T-cell exhaustion[4,5].Of interest,Vignali et *** on the hypoxia-driven CD39-dependent suppressor function of exhausted T cells,whereas Saadey et *** restoring the epigenetic balance of TGFβ1/BMP signaling in exhausted T cells to unlock responsiveness to immune checkpoint blockade therapy.