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Enhanced axonal regeneration and functional recovery of the injured sciatic nerve in a rat model by lithium-loaded electrospun nanofibrous scaffolds

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Bio-Design and Manufacturing 2024年第5期7卷 701-720页

作者： Banafsheh Dolatyar Bahman Zeynali iman Shabani Azita Parvaneh Tafreshi Reza karimi-Soflou Developmental Biology Laboratory School of BiologyCollege of ScienceUniversity of TehranTehran ***Iran Department of Biomedical Engineering Amirkabir University of Technology(Tehran Polytechnic)Tehran ***Iran Department of Molecular Medicine Faculty of Medical BiotechnologyNational Institute of Genetic Engineering and BiotechnologyTehran ***Iran 123

Increasing evidence indicates that engineered nerve grafts have great potential for the regeneration of peripheral nerve injuries(PNIs).While most studies have focused only on the topographical features of the grafts,we have considered both the biophysical and biochemical manipulations in our applied *** achieve this,we fabricated an electrospun nanofibrous scaffold(ENS)containing polylactide nanofibers loaded with lithium(Li)ions,a Wnt/β-catenin signaling *** addition,we seeded human adipose-derived mesenchymal stem cells(hADMSCs)onto this engineered scaffold to examine if their differentiation toward Schwann-like cells was *** further examined the efficacy of the scaffolds for nerve regeneration in vivo via grafting in a PNI rat *** results showed that Li-loaded ENSs gradually released Li within 11 d,at concentrations ranging from 0.02 to(3.64±0.10)mmol/L,and upregulated the expression of Wnt/β-catenin target genes(cyclinD1 and c-Myc)as well as those of Schwann cell markers(growth-associated protein 43(GAP43),S100 calcium binding protein B(S100B),glial fibrillary acidic protein(GFAP),and SRY-box transcription factor 10(SOX10))in differentiated *** the PNI rat model,implantation of Li-loaded ENSs with/without cells improved behavioral features such as sensory and motor functions as well as the electrophysiological characteristics of the injured *** improved function was further validated by histological analysis of sciatic nerves grafted with Li-loaded ENSs,which showed no fibrous connective tissue but enhanced organized myelinated *** potential of Li-loaded ENSs in promoting Schwann cell differentiation of hADMSCs and axonal regeneration of injured sciatic nerves suggests their potential for application in peripheral nerve tissue engineering.

关键词： Stem cell Schwann cell differentiation Electrospun nanofibrous scaffold Lithium ion Nerve regeneration

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A New Fault Detection and Diagnosis Approach for a Distillation Column based on a Combined PCA and ANFIS Scheme

A New Fault Detection and Diagnosis Approach for a Distillat...

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第24届中国控制与决策会议

作者： iman karimi Karim Salahshoor South Tehran Branch of Islamic Azad University-Department of Graduate Studies Petroleum University of Technology-Department of Instrumentation and Automation

In this paper, a new approach is introduced for fault detection and diagnostic. The method uses integration of PCA （Principal Component Analysis） and ANFIS （Adaptive Neuro -Fuzzy Inference System）. PCA is employed to reduce the recorded data dimension and yet extract informative features for fault detection purpose. The reduced data is then fed to ANFIS to discriminate the occurred fault. Resolution of the multiple ANFISs is enhanced through adequate selection of the utilized membership function （MF） numbers to compensate for the large number of possible created rules. This approach naturally removes extra pressure on each ANFIS to yield good responses only on close neighborhood of faulty data in training process. The combination of boundary models in the extra number of MFs provides fault isolation of the faulty plant section even when novel faults. The key point of this approach is the ability to detect and diagnose any novel fault with the same time-response pattern but different severities. The efficacy of the proposed FDD approach has been demonstrated via extensive conducted tests in a distillation column benchmark.

关键词： Fault Detection and Diagnosis PCA ANFIS Dimension Reduction Residual Analysis Distillation Column

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Practical Design and Implementation of a Control Loop Performance Assessment Package in an Industrial Plant

Practical Design and Implementation of a Control Loop Perfor...

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第三十届中国控制会议

作者： Karim Salahshoor iman karimi Erfan Nazari Fazel Hosein Beitari Department of Automation and Instrumentation Petroleum University of TechnologyTehranIran Islamic Azad University South-Tehran branchTehranIran

Practical design and implementation of a customized control loop performance assessment(CLPA) software package has been addressed in this *** assessment algorithms are developed in MATLAB software environment to provide an easy way to devise the required calculation *** developed algorithms are embedded in an integrated CLPA package to execute the target diagnostic performance *** designed CLPA package is then implemented in an industrial simulated propylene glycol plant to assess performances of two flow and one temperature controllers using Aspen-HYSYS simulator in MATLAB *** this purpose,an interactive interface has been developed and realized in the designed CLPA package to allow communication between MATLAB runtime and Aspen-HYSYS using Microsoft OLE (Object Linking Embedding) local automation *** test scenarios have been organized to carry out the simulation environment to validate the capabilities of the designed CLPA package in detecting loop oscillation,valve stiction and loop *** simulation results clearly demonstrate promising outcomes.

关键词： Control Loop Performance Assessment(CLPA) MATLAB and HYSYS interfacing loop interaction PV-OP plot

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Decentralized Adaptive Control for a Class of Large-Scale Nonlinear Systems with Unknown Interactions

Decentralized Adaptive Control for a Class of Large-Scale No...

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2010 Chinese Control and Decision Conference

作者： Bahram karimi Fatemeh Jahangiri Mohammad B.Menhaj iman Saboori Center of Advanced Computational Intelligence Amirkabir University of TechnologyTehranIran Amirkabir University of Technology TehranIran

＜正＞This paper presents a decentralized adaptive controller for a class of large-scale nonlinear systems with unknown subsystems and interactions.A direct adaptive controller is devised based on Lyapunov stability analysis so that the stability of the closed loop system is guaranteed by introducing a suitably driven adaptive *** adaptive controller proposed in this paper can guarantee the stability of the closed-loop system without knowing the sign of the controller *** show the effectiveness of the proposed decentralized adaptive controller,a nonlinear system is chosen as a case *** results are very promising.

关键词： Adaptive control and Decentralized nonlinear system

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MRI tracking of human Wharton’s jelly stem cells seeded onto acellular dermal matrix labeled with superparamagnetic iron oxide nanoparticles in burn wounds

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Burns & Trauma 2022年第1期10卷 129-141页

作者： Davood Mehrabani Mehra Nazempour Rouhollah Mehdinavaz-Aghdam Seyedeh-Sara Hashemi Reza Jalli Mahdi Saeedi Moghadam Shahrokh Zare iman Jamhiri Javad Moayedi Feridoun karimi-Busheri Stem Cell Technology Research Center Shiraz University of Medical SciencesShirazFars T6G 2E171348-14336Iran Burn and Wound Healing Research Center Shiraz University of Medical SciencesShirazFars 71987-74731Iran Comparative and Experimental Medicine Center Shiraz University of Medical SciencesShirazFars 71348-14336Iran Li Ka Shing Center for Health Research and Innovation University of AlbertaEdmontonAlbertaCanada Department of Biomedical and Tissue Engineering Science and Research BranchIslamic Azad UniversityTehranIran School of Metallurgy and Materials Engineering College of EngineeringUniversity of TehranTehran ***Iran Medical Imaging Research Center Department of RadiologyShiraz University of Medical SciencesShirazFars 71348-14336Iran Department of Biochemistry School of Biotechnology and AgricultureShiraz BranchIslamic Azad UniversityShirazFars 71987-74731Iran Department of Oncology Faculty of MedicineUniversity of AlbertaEdmontonAlbertaT6G 1Z2Canada

Background:In vivo cell tracking after transplantation in regenerative medicine remains an unmet challenge and limits current understanding of the wound healing mechanism through cell-based *** study investigated tracking of human Wharton’s jelly stem cells(hWJSCs)seeded onto an acellular dermal matrix(ADM)and labeled with superparamagnetic iron oxide nanoparti-cles(SPIONs)by magnetic resonance imaging(MRI)in burn ***:The hWJSCs were characterized and assessed for growth kinetics.A total of 30 rats were enrolled in three equal *** 1 underwent scald burn injury left without treatment,the group 2 was treated by an ADM that was prepared from cosmetic surgery skin samples and the group 3 received hWJSCs labeled with SPIONs seeded onto an *** strength was evaluated before and after interventions,real time PCR assessed apoptosis,and Prussian blue staining,scanning electron microscopy(SEM)and MRI were used for the tracking of labeled ***:The hWJSCs exhibited mesenchymal stem cell *** doubling time was 40.1 *** did not show any toxic *** hWJSCs seeded onto an ADM decreased Bax and increased Bcl-2 gene *** of SPIONs within hWJSCs was confirmed by Prussian blue staining,SEM and MRI until day *** was a significant difference between the Young’s moduli of normal skin and the group receiving hWJSCs seeded onto an *** observations and SEM imaging confirmed that MRI is an accurate method to track SPION-labeled hWJSCs in ***:This study showed that SPION labeling coupled with MRI can be used to further understand the fate of stem cells after transplantation in a burn model.

关键词： Wharton’s jelly stem cells Superparamagnetic iron oxide nanoparticles Acellular dermal matrix Magnetic resonance imaging Healing Burn

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