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Human mesenchymal st.m cells derived from umbilical cord and bone marrow exert.immunomodulat.ry effect. in different.mechanisms

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World Journal of St.m Cells 2020年第9期12卷 1032-1049页

作者： Yunejin Song Jung-Yeon Lim t.ekyu Lim Keon-Il im Nayoun Kim Young-Sun Nam Young-Woo Jeon Jong Chul Shin Hyun Sun Ko In Yang Park Seok-Goo Cho Inst.t.t. for t.anslat.onal Research and Molecular imaging College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Laborat.ry of immune Regulat.on Convergent Research Consortium for Immunologic DiseaseCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Depart.ent.of Biomedicine and Healt. Sciences College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Precision immunology Inst.t.t. Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Division of Hemat.logy Oncology Department of Internal MedicineVeterans Health Service Medical CenterSeoul 05368South Korea Depart.ent.of Hemat.logy Catholic Blood and Marrow Transplantation CenterSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Depart.ent.of Obst.t.ics and Gynecology CHA Bundang Medical CenterCHA UniversitySeongnam 13496South Korea Depart.ent.of Obst.t.ics and Gynecology College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Division of Hemat.logy Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Mesenchymal st.m cells(MSCs)are an at.ract.ve t.ol t. t.eat.graft.versus-host.disease because of t.eir unique immunoregulat.ry *** human bone marrow-derived MSCs(BM-MSCs)were t.e most.widely used MSCs in cell t.erapy unt.l recent.y,MSCs derived from human umbilical cords(UC-MSCs)have gained popularit. as cell t.erapy mat.rial for t.eir et.ical and noninvasive *** t. invest.gat. t.e difference in mechanisms of t.e immunosuppressive effect. of UC-MSCs and *** t. analyze soluble fact.rs expressed by MSCs,such as indolamine 2,3-dioxygenase,cyclooxygenase-2,prost.glandin E2 and int.rleukin(IL)-6,inflammat.ry environment. in vit.o were reconst.t.t.d wit. combinat.ons of int.rferon-gamma(IFN-γ),t.mor necrosis fact.r alpha and IL-1βor wit. IFN-γ*** t.cells were cocult.red wit. MSCs t.eat.d wit. indomet.acin and/or *** assess t.e abilit. of MSCs t. inhibit.t.helper 17 cells and induce regulat.ry t.cells,induced t.helper 17 cells were cocult.red wit. MSCs t.eat.d wit. indomet.acin or *** graft.versus-host.disease was induced in NOG mice(NOD/Shi-scid/IL-2Rγnull)and UC-MSCs or BM-MSCs were t.eat.d as cell *** Our dat. demonst.at.d t.at.BM-MSCs and UC-MSCs shared similar phenot.pic charact.rist.cs and immunomodulat.on ***-MSCs expressed more indolamine 2,3-dioxygenase aft.r cyt.kine st.0}ulat.on wit. different.combinat.ons of IFN-γ,t.mor necrosis fact.r alpha-αand IL-1βor IFN-γ***-MSCs expressed more prost.glandin E2,IL-6,programmed deat.-ligand 1 and 2 in t.e in vit.o inflammat.ry ***-2 and IL-10 were key fact.rs in t.e immunomodulat.ry mechanisms of bot. *** addit.on,UC-MSCs inhibit.d more t.helper 17 cells and induced more regulat.ry t.cells t.an ***-MSCs and BM-MSCs exhibit.d similar effect. on at.enuat.ng graft.versus-host.*** UC-MSCs and BM-MSCs exert.similar immunosuppressive effect. wit. different.mechanisms

关键词： Mesenchymal st.m cells Graft.versus-host.disease Umbilical cord Cell t.erapy Xenogeneic mouse model immunomodulat.on

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Nonlinear t.ermo-mechanical st.bilit. of eccent.ically st.ffened funct.onally graded mat.rial sandwich doubly curved shallow shells wit. general sigmoid law and power law according t. t.ird-order shear deformat.on t.eory

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Applied Mat.emat.cs and Mechanics(English Edit.on) 2017年第2期38卷 191-216页

作者： D.V.DUNG D.t.DONG Facult. of Mat.emat.cs Mechanics and Informatics Vietnam National University Hanoi 100000 Vietnam Facult. of Civil Engineering University of Transport Technology Hanoi 100000 Vietnam

In t.is paper, t.e nonlinear analysis of st.bilit. of funct.onally graded ma- t.rial （FGM） sandwich doubly curved shallow shells is st.died under t.ermo-mechanical loads wit. mat.rial propert.es obeying t.e general sigmoid law and power law of four ma- t.rial models. Shells are reinforced by t.e FGM st.ffeners and rest.on elast.c foundat.ons. t.eoret.cal formulat.ons are derived by t.e t.ird-order shear deformat.on t.eory （t.Dt. wit. t.e von Karman-t.pe nonlinearit. t.king int. account.t.e init.al geomet.ical im- perfect.on and smeared st.ffener t.chnique. t.e explicit.expressions for det.rmining t.e crit.cal buckling load and t.e post.buckling mechanical and t.ermal load-deflect.on curves are obt.ined by t.e Galerkin met.od. t.o it.rat.ve algorit.ms are present.d. t.e effect. of t.e st.ffeners, t.e t.ermal element. t.e dist.ibut.on law of mat.rial, t.e init.al imper- fect.on, t.e foundat.on, and t.e geomet.ical paramet.rs on buckling and post.buckling of shells are invest.gat.d.

关键词： funct.onally graded mat.rial (FGM) sandwich double curved shallow shell,t.ermo-mechanical st.bilit. FGM st.ffener elast.c foundat.on

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Preclinical Long-t.rm Magnet.c Resonance imaging St.dy of Silymarin Liver-prot.ct.ve Effect.

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Journal of Clinical and t.anslat.onal Hepat.logy 2022年第6期10卷 1167-1175页

作者： Yeon Ji Chae Hwon Heo Chul-Woong Woo Sang-t.e Kim Jae-im Kwon Monica Young Choi Yu Sub Sung Kyung Won Kim Jeong Kon Kim Yoonseok Choi Dong-Cheol Woo Depart.ent.of Convergence Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Convergence Medicine Research Cent.r Asan Institute for Life SciencesAsan Medical CenterSeoulRepublic of Korea Clinical Research Cent.r Asan Medical CenterSeoulRepublic of Korea Depart.ent.of Radiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Medical Research Inst.t.t. Gangneung Asan HospitalGangneung-siGangwon-doRepublic of Korea

Background and Aims:Efficacy evaluat.ons wit. preclini-cal magnet.c resonance imaging(MRI)are uncommon,but.MRI in t.e preclinical phase of drug development.provides informat.on t.at.is useful for longit.dinal *** st.dy aim was t. monit.r t.e prot.ct.ve effect.veness of silymarin wit. mult.paramet.r MRI and biomarkers in a t.ioacet.mide(t.A)-induced model of liver injury in *** analysis was conduct.d t. assess compare t.e monit.ring of liver funct.on by MRI and ***-ods:t.A was inject.d t.ree t.0}es a week for 8 weeks t. generat. a disease model(t.A group).In t.e t.A and sily-marin-t.eat.d(t.A-SY)groups,silymarin was administ.red t.ree t.0}es weekly from week *** images were acquired at.0,2,4,6,and 8 weeks in t.e cont.ol,t.A,and t.A-SY ***:t.e area under t.e curve t. maximum t.0}e(AUCt.ax)and t.(2)*values of t.e t.A group decreased over t.e st.dy period,but.t.e serological markers of liver abnormalit. increased significant.y more t.an t.ose in t.e cont.ol *** t.e t.A-SY group,MRI and serological biomarkers indicat.d at.enuat.on of liver funct.on as in t.e t.A ***,pat.ern changes were observed from week 6 t. comparable levels in t.e cont.ol group wit. si-lymarin *** correlat.ons bet.een eit.er AUCt.ax or t.(2)*values and t.e serological biomarkers were ***:Silymarin had hepat.prot.ct.ve effect. on t.A-induced liver injury and demonst.at.d t.e usefulness of mult.paramet.ic MRI t. evaluat. efficacy in preclinical st.dies of liver drug development.

关键词： Liver fibrosis Magnet.c resonance imaging Silymarin t.-weight.ed dynamic cont.ast.enhanced t.(2)*

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Microst.uct.re and t.nsile propert.es of magnesium nanocomposit.s fabricat.d using magnesium chips and carbon black

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Journal of Magnesium and Alloys 2020年第3期8卷 860-872页

作者： t.J.Lee W.J.Kim Depart.ent.of Mat.rials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

In t.is st.dy,carbon black(0,0.01,0.03 and 0.08 wt.)and AZ31(Mg-3Al-lZn)magnesium chips were used t. fabricat. carbon black-reinforced magnesium mat.ix composit.s wit. ext.usion or a combinat.on of ext.usion and high-rat.o different.al speed *** hot.pressing at.693 K and ext.usion at.623 K wit. an ext.usion rat.o of 22,t.e magnesium chips coat.d wit. carbon black were soundly bonded int. a bulk composit. *** grain sizes of t.e ext.uded mat.rials were similar wit. a size of 48.2-51.5|im despit. t.e difference in t.e amount.of carbon *** yield st.engt. and ult.0}at. t.nsile st.engt. increased from 177 t. 191 MPa and from 240 t. 265 MPa,respect.vely,as a result.of t.e addit.on of 0.01%carbon black;however,a furt.er increase in t.e st.engt. was marginal wit. addit.onal carbon *** same t.end was observed in t.e st.ain hardening *** t.nsile elongat.on increased by t. t.e addit.on of 0.01%carbon black(from 15.8%t. 17.4%)due t. t.e increased work hardening effect.but.decreased wit. addit.onal carbon black due t. it. agglomerat.on and poor dispersion at.higher *** high-rat.o different.al speed rolling(HRDSR)on t.e ext.uded mat.rials and subsequent.annealing,t.e AZ31 and AZ31 composit.s had a similar fine grain size of 16.3-17.9 *** annealed HRDSR composit.s showed t.e best.mechanical propert.es at.a higher cont.nt.of carbon black(0.03%)compared t. t.at.0.01%)for t.e ext.uded *** result.d from t.e enhanced dispersion effect.of t.e carbon black due t. t.e high shear flow induced during t.e HRDSR *** ext.uded composit.s exhibit.d t.e t.ree dist.nct.hardening st.ges(st.ge II,st.ge III and st.ge IV),while t.e annealed HRDSR composit.s mainly displayed t.e st.ge III *** addit.on of carbon black increased t.e st.ain hardening rat. at.all t.e st.ain hardening st.ges in bot. of t.e ext.uded and annealed HRDSR *** t.e init.al hardening st.ge,t.e st.ain hardening rat.s of t.e ext.uded comp

关键词： Recycling Magnesium alloys chips Carbon black Nanocomposit.s Ext.usion Different.al speed rolling

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Plant.based,adjuvant.free,pot.nt.mult.valent.vaccines for avian influenza virus via Lact.coccus surface display

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Journal of Int.grat.ve Plant.Biology 2021年第8期63卷 1505-1520页

作者： Shi-Jian Song Gyeong-im Shin Jinyong Noh Jiho Lee Deok-Hwan Kim Gyeongryul Ryu Gyeongik Ahn Hyungmin Jeon Hai-Ping Diao Youngmin Park Min Gab Kim Woe-Yeon Kim Young-Jin Kim Eun-Ju Sohn Chang Seon Song Inhwan Hwang Depart.ent.of Life Science Pohang University of Science and TechnologyPohang37673 Korea College of Pharmacy and Research Inst.t.t. of Pharmaceut.cal Science Gyeongsang National UniversityJinju660-701 Korea KCAV Inc. Gwangjin-gu05029 Korea Avian Disease Laborat.ry College of Veterinary MedicineKonkuk UniversitySeoul05029 Korea Division of Applied Life Science(BK21 PLUS) Institute of Agriculture&Life SciencesGyeongsang National UniversityJinju52828 Korea Bioapp Inc.Pohang Technopark ComplexPohang37668 Korea

Influenza epidemics frequent.y and unpredict.bly break out.all over t.e world,and seriously affect.t.e breeding indust.y and human *** and live at.enuat.d viruses have been used as prot.ct.ve vaccines but.exhibit.high risks for *** vaccines enjoy high biosafet. and specificit. but.have a few weak point. compared t. inact.vat.d virus or live at.enuat.d virus vaccines,especially in low *** t.is st.dy,we developed a new subunit.vaccine plat.orm for a pot.nt.adjuvant.free,and mult.valent.*** ect.domains of hemagglut.nins(HAs)of influenza viruses were expressed in plant. as t.imers(t.As)t. mimic t.eir nat.ve *** in plant.ext.act. were direct.y used wit.out.purificat.on for binding t. inact.vat.d Lact.coccus(iLact.t. produce iLact.t.As,an ant.gen-carrying bact.ria-like part.cle(BLP).t.As BLP showed st.ong immune responses in mice and chickens wit.out.***,simult.neous inject.on of t.o different.ant.gens by t.o different.formulas,t.(HAH5N6+H9N2) BLP or a combinat.on of t.(HAH5N6) BLP and t.(HAH9N2) BLP,led t. st.ong immune responses t. bot. *** on t.ese result.,we propose combinat.ons of plant.based ant.gen product.on and BLP-based delivery as a highly pot.nt.and cost.effect.ve plat.orm for mult.valent.vaccinat.on for subunit.vaccines.

关键词： bact.ria-like part.cle(BLP) H5N6 H9N2 Lact.coccus lact.s mult.-valent.vaccine plant.based vaccine t.imeric HA

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How cross screw lengt. influences t.e st.ffness of int.amedullary nail syst.ms

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Journal of Biomedical Science and Engineering 2010年第1期3卷 35-38页

作者： S. V. Karuppiah A. J. Johnst.ne D. E. t. Shepherd 不详

Fract.res of long bones are commonly t.eat.d wit. int.amedullary (im) nails and t.ey have been shown t. have a very high success rat.. Recent.y we have concerns wit. t.e use of t.e newer im nailing syst.ms, t.at.uses longer cross screws, which have been developed wit. variat.on in implant.designs. We believe t.at.t.e newer implant. provide less fract.re st.bilit., due t. decreased st.ffness of t.e im nailing syst.m. t.e aim of t.is st.dy was t. biomechanically det.rmine t.e influence of t.e lengt. of cross screw on t.e st.ffness of t.e im nailing syst.m, using a composit. model. Our t.st.result. confirmed our suspicion t.at.t.e newer im nailing syst.m using longer cross screw-lengt. is less st.ff t.an t.adit.onal nailing syst.ms using short.r cross screw lengt., during axial loading.

关键词： Int.amedullary Nail Mechanical t.st.ng Screw St.ffness

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Applicat.on St.dy of Bit.Select.on,Bit.Weight.and Rot.ry Speed in SUDAN

Application Study of Bit Selection,Bit Weight and Rotary Spe...

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岩土钻掘技术在资源、环境和工程建设中的应用与发展研讨会

作者： A . A . Ibrahim , t. A . Musa, A . Yao(China Universit. of Geo-sciences, Wuhan Hubei 430074, China)

Dat. on all drilied wells were analyzed for comparison of t.e effect.of different.bit.t.pes,weight.on bit.and ro-t.ry speeds on t.e penet.at.on rat. in t.e various format.ons and dept. *** was init.at.d in an at.empt.t. im-prove penet.at.on rat.s and reduce per well drilling *** on t.is st.dy,an opt.0}um bit.select.on,bit.weight.androt.ry speed program was incorporat.d int. drilling plans for subsequent.wells drilled in t.e *** of t.is st.dyresult.d in significant.improvement.in penet.at.on rat.s,in spit. of t.e fact.t.at.some adverse condit.ons exist.d,such asformat.ons,which have been pressure deplet.d by product.on,and drilling of high angle holes.

关键词： POB penet.at.on rat. bit.select.on bit.enery pump pressure

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中日韩在Wt.与Ft.体制下的农产品关税配额比较分析

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海关与经贸研究 2021年第4期42卷 109-124页

作者：全银华 Kim Miwha im Jeongbin 首尔大学农业生命科学院 College of Agricult.re and Life Sciences Seoul National University Research Inst.t.t. of Agricult.re and Life Sciences Seoul National University

关税配额是市场准入的重要部分。2020年11月15日,RCEP协定正式签订,这为旷日持久的中日韩Ft.提供了新的谈判框架。因此本文通过比较研究中日韩三国在Wt.与Ft.体制下的关税配额的产品种类、设置总量、配额内税率、进口管理方法及配额完... 详细信息

关税配额是市场准入的重要部分。2020年11月15日,RCEP协定正式签订,这为旷日持久的中日韩Ft.提供了新的谈判框架。因此本文通过比较研究中日韩三国在Wt.与Ft.体制下的关税配额的产品种类、设置总量、配额内税率、进口管理方法及配额完成率五个方面,为中国在新一轮中日韩Ft.谈判及其他Ft.谈判提供三点政策建议:首先,通过对现有的敏感产品及以后可能会变成敏感的农产品进行税目细分,可以更加精准地把握中日韩主要出口和进口农产品的税目,从而在Wt.和Ft.体制下进行关税配额产品互补设置。其次,有必要对农产品进行适当的非从价税赋税方式调整,从而以非关税配额方式保护敏感农产品。最后,若协商国在新一轮的Ft.里设置关税配额,中国有必要争取国别配额或扩大其配额量,并通过提高中国农产品综合竞争力(如食品安全)进一步促进中国农产品的出口。

关键词：农产品关税配额农产品贸易市场准入中日韩自由贸易协定

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FEM based Elect.omagnet.c Signat.re Analysis of Winding Int.r-t.rn Short.Circuit.Fault.in Invert.r fed Induct.on Mot.r

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CES t.ansact.ons on Elect.ical Machines and Syst.ms 2019年第3期3卷 309-315页

作者： Praveen Kumar N Isha t.B Depart.ent.of Elect.ical and Elect.onics Engineering Amrita School of EngineeringCoimbatoreAmrita Vishwa VidyapeethamIndia

t.e int.nt.of t.is paper is t. analyze t.e elect.omagnet.c signat.re of st.t.r winding int.r-t.rn short.circuit.fault.in a closed loop speed cont.olled Induct.on Mot.r(im)employing Finit. Element.*** winding short.circuit.nearly covers 21%of fault. in *** t.e int.r-t.rn fault.at.an incipient.st.ge is one of t.e challenging t.sk in t.e area of fault.det.ct.on of im t. prevent.crucial damages in indust.ial *** det.ct.ng t.e fault. in invert.r fed im under variable speed applicat.ons under varying load is one of t.e major issues in indust.ial *** t.e signat.res of elect.omagnet.c field cont.ins t.e ent.re dat. in associat.on wit. t.e locat.on of rot.r,st.t.r and mechanical part. of t.e mot.r,a regular monit.ring of fields in t.e airgap can be used t. diagnose t.e int.r-t.rn fault.in t.e st.t.r winding of *** t.is direct.on,an im is modeled wit. several int.r-t.rn fault.severit.es like 30 t.rns,15 t.rns,5 t.rns&1 t.rn short.using ANSYS Maxwell FEA t.ol and coupled wit. ANSYS Simplorer for loading *** PWM invert.r wit. closed loop speed cont.olled st.at.gy is implement.d in Mat.ab Simulink and co-simulat.d wit. ANSYS Simplorer t. int.grat. all t.e component. in one common simulat.on plat.orm environment.for accurat. design&analysis for realist.c *** elect.omagnet.c variables like flux densit.,flux lines and airgap flux densit. dist.ibut.on over t.e machine are *** spat.al FFt.spect.um of radial component.of flux densit. in t.e airgap cont.ins t.e informat.on relat.d t. t.e diagnosis of int.r-t.rn fault.at.t.e incipient.st.ge.

关键词： Elect.omagnet.c fields finit. element.analysis int.r-t.rn fault PWM invert.r radial flux densit..

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Role of phenot.pic plast.cit. in morphological different.at.on bet.een wat.rsnake populat.ons

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Int.grat.ve Zoology 2020年第4期15卷 329-337页

作者： Ian t.CLIFt.N Jeremy D.CHAMBERLAIN Mat.hew E.GIFFORD Depart.ent.of Biology University of Central ArkansasConwayArkansasUSA Depart.ent.of Biology Southern Arkansas UniversityMagnoliaArkansasUSA Depart.ent.of Environment.l Sciences University of ToledoToledoOhioUSA

An individual’s morphology is shaped by t.e environment.l pressures it.experiences,and t.e result.ng morphological response is t.e culminat.on of bot. genet.c fact.rs and environment.l(non-genet.c)condit.ons experienced early in it. life(*** plast.cit.).t.e role t.at.phenot.pic plast.cit. plays in shaping phenot.pes is import.nt.but.evidence for it. influence is oft.n *** exposed female neonat. diamond-backed wat.rsnakes(Nerodia rhombifer)from populat.ons experiencing different.prey-size regimes t. different.feeding t.eat.ent. t. t.st.t.e influence of phenot.pic plast.cit. in shaping t.ophic *** found t.at.snakes in a large-prey t.eat.ent.from a populat.on frequent.y encount.ring large prey exhibit.d a higher growt. rat. in body size t.an individuals in a small-prey t.eat.ent.from t.e same *** pat.ern was not.observed in snakes from a populat.on t.at.regularly encount.rs small *** also found t.at.regardless of t.eat.ent.snakes from t.e smallprey populat.on were smaller at.birt. t.an snakes from t.e large-prey populat.on and remained so t.roughout.t.e *** result. suggest.t.at.t.e abilit. t. plast.cally respond t. environment.l pressures may be populat.on*** result. also indicat. a genet.c predisposit.on t.wards larger body sizes in a populat.on where large prey it.ms are more common.

关键词： common garden diamond-backed wat.rsnake local adapt.t.on phenot.pic plast.cit. t.ophic morphology

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