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Seven synchronous early gastric cancer with 28 lymph nodes metastasis

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World Journal of Gastroenterology 2013年第44期19卷 8141-8145页

作者： Hyeonjin Seong jin il kim Hyun Jeong Lee Hyun jin kim Hyung Joon Cho Hye Kang kim Dae Young Cheung Dong jin kim Wook kim Tae-Jung kim Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul 150-713 South Korea Department of Surgery College of Medicine The Catholic University of Korea Seoul 150-713South Korea Department of Hospital Pathology College of Medicine The Catholic University of Korea Seoul 150-713South Korea

An 85 year male patient complaining epigastric discomfort was *** the esophagogastroduodenoscopy,three early gastric cancer(EGCa)lesions had been identified and these were diagnosed as adenocarcinoma with poorly differentiated cell *** patient underwent *** the post-operative mapping,however,additional 4 EGCa lesions were found,and the patient was diagnosed with 7 synchronous *** of the 7 EGCa lesions,6 had shown invasion only to the mucosal layer and one had shown invasion into the 1/3layer of *** spite of such superficial invasions,28 of 48 lymph nodes had been identified as *** multiple lesions of EGCa do not increase the risk of lymph node metastasis,but if their differentiations are poor or if they have lympho-vascular invasion,multiple lymph node metastases could incur even if the depth of invasion is limited to the mucosal layer or the upper portion of the submucosal layer.

关键词： Early gastric cancer Synchronous Metastasis Lymph node Endoscopy

Concomitant therapy achieved the best eradication rate for Helicobacter pylori among various treatment strategies

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World Journal of Gastroenterology 2015年第1期21卷 351-359页

作者： Hyun Jeong Lee jin il kim jin Soo Lee Eun Jung Jun Jung-Hwan Oh Dae Young Cheung Woo Chul Chung Byung-Wook kim Sung Soo kim Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 150-713South Korea

AIM: To compare the Helicobacter pylori(***) eradication rate of clarithromycin-based triple therapy,metronidazole-based triple therapy,sequential therapy and concomitant ***: A total of 680 patients infected with *** were divided into 4 groups and each group was treated with a different eradication ***-based triple therapy was applied to the first group [rabeprazole,amoxicillin and clarithromycin(PAC) group: proton pump inhibitor(PPI),amoxicillin,clarithromycin],whereas the second group was treated with metronidazole-based triple therapy [rabeprazole,amoxicillin and metronidazole(PAM) group: PPI,amoxicillin,metronidazole].The third group was treated with rabeprazole and amoxicillin,followed by rabeprazole,clarithromycin and metronidazole(sequential group).The final group was simultaneously treated with rabeprazole,amoxicillin clarithromycin and metronidazole(concomitant therapy group).In the case of a failure to eradicate ***,second-line quadruple and third-line eradication therapies were ***: The per protocol(PP) analysis was performed on 143,139,141 and 143 patients in the PAC,PAM,sequential and concomitant groups,*** excluded patients who did not receive a C13-urea breath test(22,20,23 and 22 patients,respectively) and patients with less than an 80% compliance level(5,11,6 and 5 patients,respectively).The eradication rates were 76.2%(109/143) in the PAC group,84.2%(117/139) in the PAM group,84.4%(119/141) in the sequential group and 94.4%(135/143) in the concomitant group(P = 0.0002).All 14 patients who failed second-line therapy were treated with thirdline eradication *** these 14 patients,6 infections were successfully eradicated with the thirdline *** PP and intention-to-treat analysis showed an eradication rate of 42.9%(6/14).In the PAC group,3 of 4 patients were successfully cured(3/4,75%); 2 of 2 patients in the PAM group(2/2,100%) and 1 of 5 patients in the seque

关键词： Helicobacter pylori Eradication Drug resistance Co

Long-term follow up of endoscopic resection for type 3 gastric NET

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World Journal of Gastroenterology 2013年第46期19卷 8703-8708页

作者： Yong Hwan Kwon Seong Woo Jeon Gwang Ha kim jin il kim il-Kwun Chung Sam Ryong Jee Heung Up kim Geom Seog Seo Gwang Ho Baik Kee Don Choi Jeong Seop Moon Department of Internal Medicine Kyungpook National University Hospital Department of Internal Medicine Busan National University School of Medicine Department of Internal Medicine Catholic University of Korea College of Medicine Department of Internal Medicine Soonchunhyang University Department of Internal Medicine Inje University Pusan Paik Hospital Department of Internal Medicine Jeju National University School of Medicine Department of Internal Medicine Digestive Disease Research InstituteWonkwang University College of Medicine Department of Internal Medicine Hallym University College of Medicine Department of Internal Medicine University of Ulsan College of MedicineAsan Medical Center Department of Internal Medicine Inje University Seoul Paik Hospital

AIM:To clarify the short and long-term results and to prove the usefulness of endoscopic resection in type 3gastric neuroendocrine tumors(NETs).METHODS:Of the 119 type 3 gastric NETs diagnosed from January 1996 to September 2011,50 patients treated with endoscopic resection were enrolled in this *** endoscopic resection,endoscopic mucosal resection(EMR)or endoscopic submucosal dissection(ESD)was *** efficacy,complications,and follow-up results were evaluated ***:EMR was performed in 41 cases and ESD in 9 *** complete resection was performed in 40 cases(80.0%)and incomplete resection specimens were observed in 10 cases(7 vs 3 patients in the EMR vs ESD group,P=0.249).Upon analysis of the incomplete resection group,lateral or vertical margin invasion was found in six cases(14.6%)in the EMR group and in one case in the ESD group(11.1%).Lymphovascular invasions were observed in two cases(22.2%)in the ESD group and in one case(2.4%)in the EMR group(P=0.080).During the follow-up period(43.73;13-60 mo),there was no evidence of tumor recurrence in either the pathologically complete resection group or the incomplete resection *** recurrence was reported during *** addition,no mortality was reported in either the complete resection group or the incomplete resection group for the duration of the follow-up ***:Less than 2 cm sized confined submucosal layer type 3 gastric NET with no evidence of lymphovascular invasion,endoscopic treatment could be considered at initial treatment.

关键词： Stomach Neuroendocrine tumor Endo-scopic resection Treatment Carcinoid

Dual-priming oligonucleotide-based multiplex PCR using tissue samples in rapid urease test in the detection of Helicobacter pylori infection

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World Journal of Gastroenterology 2014年第21期20卷 6547-6553页

作者： Woo Chul Chung Sung Hoon Jung Jung Hwan Oh Tae Ho kim Dae Young Cheung Byung Wook kim Sung Soo kim jin il kim Eun Young Sin Department of Internal Medicine the Catholic University of KoreaSeoul 130-709South Korea The Research Institute of St. Vincent Hospital the Catholic University of KoreaSuwon 442-723South Korea

AIM: To investigate whether tissue samples processed by the rapid urease test (RUT) kit are suitable for dual-priming oligonucleotide-based multiplex polymerase chain reaction (DPO-PCR) to detect Helicobacter pylori (... 详细信息

关键词： Helicobacter pylori Diagnosis Dual-priming oligonucleotide-based multiplex polymerase chain reaction

Endoscopic submucosal dissection for early gastric cancer:Quo vadis?

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World Journal of Gastroenterology 2011年第21期17卷 2623-2625页

作者： Won Young Cho Joo Young Cho il Kwun Chung jin il kim jin Seok Jang Jae Hak kim Institute for Digestive Research Digestive Disease CenterSoonchunhyang University College of Medicine Department of Internal Medicine Soonchunhyang University College of Medicine Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul Department of Internal Medicine Dong-A University College of Medicine Department of Internal Medicine Dongguk University College of Medicine

The diagnosis of early gastric cancer(EGC) is of great interest because its endoscopic and surgical treatment presents the best chance for a *** technical development,endoscopic submucosal dissection(ESD) has been widely performed for the curative treatment of EGC in *** studies of ESD for EGC will be the next missions that overcome these limitations and global guidelines will be processed for ESD for EGC.

关键词： Endoscopic submucosal dissection Early gastric cancer

Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues

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World Journal of Gastroenterology 2006年第35期12卷 5651-5657页

作者： Kyung-Hee kim jin-Sung Choi il-jin kim Ja-Lok Ku Jae-Gahb Park Laboratory of Cell Biology Korean Cell Line Bank Cancer Research Institute Seoul National University College of Medicine Seoul 110-744 Korea Laboratory of Cell Biology Korean Cell Line Bank Cancer Research Institute Seoul National University College of Medicine Seoul 110-744

AIM： To verify the expression and methylation status of the MAGE-A1 and MAGE-A3 genes in colorectal cancer tissues and cancer cell lines. METHODS： We evaluated promoter demethylation status of the MAGE-A1 and MAGE-A3 genes by RT-PCR analysis and methylation-specific PCR （MS-PCR）, as well as sequencing analysis, after sodium bisulfite modification in 32 colorectal cancer cell lines and 87 cancer tissues. RESULTS： Of the 32 cell lines, MAGE-A1 and MAGE-A3 expressions were observed in 59% and 66%, respectively. Subsequent to sodium bisulfite modification and MSPCR analysis, the promoter hypomethylation of MAGE-A1 and MAGE-A3 was confirmed in both at 81% each. Promoter hypomethylation of MAGE-A1 and MAGE-A3 in colorectal cancer tissues was observed in 43% and 77%, respectively. Hypomethylation of MAGE-A1 and MAGE-A3 genes in corresponding normal tissues were observed in 2% and 6%, respectively. CONCLUSION： The promoter hypomethylation of MAGE genes up-regulates its expression in colorectal carcinomas as well as in gastric cancers and might play a significant role in the development and progression of human colorectal carcinomas.

关键词： MAGE-A1 MAGE-A3 Promoter Hypomethylation Colorectal cancer

Prolapse gastropathy syndrome may be a predictor of pathologic acid reflux

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World Journal of Gastroenterology 2008年第36期14卷 5601-5605页

作者： jin-Soo kim Hyung-Keun kim Young-Seok Cho Hiun-Suk Chae Byung-Wook kim jin-il kim Sok-Won Han Kyu-Yong Choi Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary's Hospital Gyeonggi-do 480-717 South Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary’s Hospital Gyeonggi-do 480-717 South Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Our Lady of Mercy Hospital Gyeonggi-do 403-720 South Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Yeoeuido St. Mary’s Hospital Seoul 150-713 South Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Holy Family Hospital Gyeonggi-do 420-717 South Korea

AIM： To assess the occurrence of gastric acid reflux into the esophagus in endoscopically confirmed prolapse gastropathy syndrome （PGS）. METHODS： Using ambulatory esophageal pH measurement （BRAVOTM wireless esophageal pH monitoring system）, twenty-six patients with PGS were compared with twenty-one patients with erosive esophagitis （EE） as controls. We assessed several reflux parameters, including the percentage of total time at pH 〈 4, and the DeMeester score. RESULTS： There were no statistical differences between the PGS group and the EE group as to mean age, sex ratio and pH recording time. The EE group showed more severe reflux than the PGS group, as evaluated in terms of the longest duration of reflux, the number of reflux episodes, the number of reflux episodes lasting 〉 5 min, the total time with pH 〈 4 during acid reflux episodes, and the DeMeester score, but none of these parameters showed statistically significant difference. Although 53.8% （14/26） of the PGS group and 76.2% （16/22） of the EE group demonstrated pathologic acid reflux （DeMeester score 〉 14.72）, there was no statistically significant difference between the two groups in the incidence of pathologic acid reflux （P = 0.11）. CONCLUSION： There was no statistically significant difference in pathologic acid reflux between the PGS and EE group. These data suggest that endoscopically diagnosed PGS might be a predictor of pathologic acid reflux.

关键词： Prolapse gastropathy syndrome Pathologic acid reflux Erosive esophagitis Ambulatory esophageal pH monitoring Retching

Familial gastric cancers with Li-Fraumeni Syndrome: A case repast

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World Journal of Gastroenterology 2005年第26期11卷 4124-4126页

作者： il-jin kim Hio Chung Kang Yong Shin Byong Chul Yoo Han-Kwang Yang Jae-Gahb Park Korean Hereditary Tumor Registry Cancer Research Institute and Cancer Research Center Seoul National UniversitySeoulSouth Korea Research Institute and Hospital National Cancer Center Goyang Gyeonggi South Korea

TO THE EDITORAlthough the incidence of gastric cancer has declined somewhat in recent years, it remains one of the most common cancers worldwide[1], and is the most common cancer in East Asian countries such as Korea and Japan[2].In terms of the genetics of gastric cancer, mutations in CDH1 (E-cadberin) have been associated with hereditary diffuse gastric cancer (HDGC). The first germline mutation in CDH1 was reported in a large Maori HDGC family[1],with subsequent corroborations in Western and Asian HDGC families[3-5], CDH1 mutations are believed to be associated with up to 50% of HDGC families[5], but have not been linked with sporadic or intestinal types of gastric cancer[5].

关键词： Familial gastric cancers Li-Fraumeni syndrome TP53 mutation

Clinical outcome of Fitz-Hugh-Curtis syndrome mimicking acute biliary disease

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World Journal of Gastroenterology 2008年第45期14卷 6975-6980页

作者： Seong Yong Woo jin il kim Dae Young Cheung Se Hyun Cho Soo-Heon Park Joon-Yeol Han Jae Kwang kim Division of Gastroenterology and Hepatology Department of Internal Medicine the Catholic University of Korea

AIM: To analyze the clinical characteristics of patients diagnosed with Fitz-Hugh-Curtis ***: The clinical courses of patients that visited St. Mary's Hospital with abdominal pain from January 2005 to December 2006 and were diagnosed with Fitz-Hugh-Curtis syndrome were ***: Fitz-Hugh-Curtis syndrome was identified in 22 female patients of childbearing age; their mean age was 31.0 ± 8.1 years. Fourteen of these cases presented with pain in the upper right abdomen alone or together with pain in the lower abdomen, and six patients presented with pain only in the lower abdomen. The first impression at the time of visit was acute cholecystitis or cholangitis in 10 patients and acute appendicitis or pelvic inflammatory disease in eight patients. Twenty-one patients were diagnosed by abdominal computer tomograghy (CT), and the results of abdominal sonography were normal for 10 of these patients. Chlamydia trichomatis was isolated from 18 patients. Two patients underwent laparoscopic adhesiotomy and 20 patients were completely cured by antibiotic ***: For women of childbearing age with acute pain in the upper right abdomen alone or together with pain in the lower abdomen, Fitz-Hugh-Curtis syndrome should be considered during differential diagnosis. Moreover, in cases suspected to be Fitz-Hugh-Curtis syndrome, abdominal CT, rather than abdominal sonography, assists in the diagnosis.

关键词： Chlamydia trichomatis Abdominal pain Fitz-Hugh-Curtis syndrome