Familial gastric cancers with Li-Fraumeni Syndrome: A case repast

作     者：Il-Jin Kim Hio Chung Kang Yong Shin Byong Chul Yoo Han-Kwang Yang Jae-Gahb Park 

作者机构：Korean Hereditary Tumor Registry Cancer Research Institute and Cancer Research CenterSeoul National UniversitySeoulSouth Korea Research Institute and Hospital National Cancer Center Goyang Gyeonggi South Korea 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2005年第11卷第26期

页      面：4124-4126页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Familial gastric cancers Li-Fraumeni syndrome TP53 mutation 

摘      要：TO THE EDITOR Although the incidence of gastric cancer has declined somewhat in recent years, it remains one of the most common cancers worldwide[1], and is the most common cancer in East Asian countries such as Korea and Japan[2].In terms of the genetics of gastric cancer, mutations in CDH1 (E-cadberin) have been associated with hereditary diffuse gastric cancer (HDGC). The first germline mutation in CDH1 was reported in a large Maori HDGC family[1],with subsequent corroborations in Western and Asian HDGC families[3-5], CDH1 mutations are believed to be associated with up to 50% of HDGC families[5], but have not been linked with sporadic or intestinal types of gastric cancer[5].