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Bioactive properties of glycosaminoglycans extracted from Turkey (Meleagris gallopavo) by-products

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Food Bioscience 2022年第2期46卷 321-329页

作者： Evellin Balbinot-Alfaro Claudio R.Novello Elisˆangela Düsman Alexandre T.Alfaro Helyn P.O.Barddal igor v.Almeida veronica E.P.vicentini vil´asia G.Martins School of Chemistry and Food Federal University of Rio GrandeRio GrandeRSBrazil Department of Food Technology Federal University of TechnologyParan´aFrancisco Beltr˜aoPRBrazil Department of Biochemistry and Molecular Biology Federal University of Paran´aCuritibaPRBrazil Federal Rural University of Amazonia Capit˜ao PoçoPABrazil Department of Biotechnology State University of Maring´aMaring´aPRBrazil

Turkey wattle is a by-product generated during slaughter,which has a large amount of connective tissue and is a potential source of glycosaminoglycans(GAGs).This study aimed to extract GAGs from the turkey wattle(Meleagris gallopavos)and investigate its anticoagulant activity,and its cytotoxic and antiproliferative activity in tumor *** sulfate(CS-4 and CS-6)and dermatan sulfate(DS)present in the F-vII fraction and hyaluronic acid(HA)in the F-v fraction were *** HA showed a high molecular weight(1.0×10^(6) Da)and an apparent cytotoxic/antiproliferative effect against human hepatoma cells.F-vII fraction has an apparent cytotoxic/antiproliferative effect against renal adenoma cells and anticoagulant potential in *** results achieved in this study demonstrated that wattle,a by-product of turkey industrialization,has the potential to be valued as a raw material for the extraction of GAGs with bioactive properties.

关键词： Poultry By-products Hyaluronic acid Dermatan sulfate Chondroitin sulfate

GFAP expression in the optic nerve and increased Н2S generation in the integration centers of the rainbow trout（Oncorhynchus mykiss） brain after unilateral eye injury

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Neural Regeneration Research 2020年第10期15卷 1867-1886页

作者： Evgeniya v.Pushchina Anatoly A.varaksin Dmitry K.Obukhov igor M.Prudnikov A.v.Zhirmunsky National Scientific Center of Marine Biology Far Eastern BranchRussian Academy of SciencesVladivostokRussia A.A.Bogomoletz Institute of Physiology National Academy of Sciences of UkraineKievUkraine St.Petersburg State University St.PetersburgRussia

Hydrogen sulfide(H2S)is considered as a protective factor against cardiovascular ***,there are few reports on the effects of H2S in the central nervous system during stress or *** studies on goldfish have shown that astrocytic response occurs in the damaged and contralateral optic *** fibrillary acidic protein(GFAP)concentration in the optic nerves of rainbow trout has not been measured *** study further characterized the astrocytic response in the optic nerve and the brain of a rainbow trout(Oncorhynchus mykiss)after unilateral eye injury and estimated the amount of H2S-producing enzyme cystathionineβ-synthase(CBS)in the brain of the rainbow *** 1 week after unilateral eye injury,a protein band corresponding to a molecular weight of 50 kDa was identified in the ipsi-and contralateral optic nerves of the rainbow *** concentration of GFAP in the injured optic nerve increased compared to the protein concentration on the contralateral *** results of a quantitative analysis of GFAP+cell distribution in the contralateral optic nerve showed the largest number of GFAP+cells and fibers in the optic nerve *** the damaged optic nerve,patterns of GFAP+cell migration and large GFAP+bipolar activated astrocytes were detected at 1 week after unilateral eye *** study of H2S-producing system after unilateral eye injury in the rainbow trout was conducted using enzyme-linked immunosorbent assay,western blot analysis,and immunohistochemistry of polyclonal antibodies again st CBS in the integrative centers of the brain:telencephalon,optic tectum,and ***-linked immunosorbent assay results showed a 1.7-fold increase in CBS expression in the rainbow trout brain at 1 week after unilateral eye injury compared with that in intact *** the ventricular and subventricular regions of the rainbow trout telencephalon,CBS+radial glia and neuroepithelial cells were *** unilateral eye injury

关键词： astrocyte-like cells glial fibrillary acidic protein hydrogen sulfide neuroepithelial cells neuroprotection radial glial cells rainbow trout(Oncorhynchus mykiss) reactive oxygen species unilateral eye injury

Mantle Transects in Africa According to Data of Mantle Xenocrysts and Diamond Inclusions

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Acta Geologica Sinica(English Edition) 2021年第S1期95卷 15-17页

作者： igor v.ASHCHEPKOv vladimir N.ZINCHENKO Alexandr S.IvANOv v.S.Sobolev Institute of Geology and Mineralogy SB RAS Novosibirsk 630090Russia CATOCA Mining Society СatocaMoscow 127473Russia ALROSA Ltd. Mirny 678174Russia

We designed the mantle transects using the PTXFO2 diagrams(Ashchepkov et al.,2010,2013,2017)constructed(Figs.1 a–c)for mantle columns beneath kimberlite and sections of the lithospheric mantle(SCLM)under the Kaapvaal... 详细信息

关键词： mantle lithosphere craton transect monomineral thermobarometry oxygen fugacity peridotite eclogite garnet clinopyroxene

Composition of the Diamond Indicator Minerals on the Mitchell Chart――Criteria of CLIPPIR Diamonds in Kimberlites and Conditions of their Mantle Crystallization

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Acta Geologica Sinica(English Edition) 2021年第S1期95卷 121-124页

作者： vladimir N.ZINCHENKO Alexandr S.IvANOv igor v.ASHCHEPKOv CATOCA Mining Society СatocaAngola ALROSA Ltd. MirnyRussia v.S.Sobolev Institute of Geology and Mineralogy SB RAS NovosibirskRussia

In the last decade,researchers have been particularly interested in IIa CLIPPIR type diamonds,which differ in composition and physical characteristics from diamonds of peridotite related"P"and eclogite related"E"***(Moore,2009)sought them as mantle kimberlite related megacrysts,but light C isotopy and chemical features needs special explanation.

关键词： CLIPPIR diamonds kimberlite mantle pyrope clinopiroxene chromite ilmenite

Atmospheric and Coupled Model Intercomparison in Terms of Amplitude—Phase Characteristics of Surface Air Temperature Annual Cycle

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Advances in Atmospheric Sciences 2004年第6期21卷 837-847页

作者： Alexey v. ELISEEv igor I. MOKHOv Konstantin G. RUBINSTEIN Maria S. GUSEvA A. M. Obukhov Institute of Atmospheric Physics RAS 3 Pyzhevsky 119017 Moscow RussiaA. M. Obukhov Institute of Atmospheric Physics RAS 3 Pyzhevsky 119017 Moscow RussiaRussian Hydrometcentre 9 Bol. Predtechensky 123242 Moscow RussiaRussian Hydrometcentre 9 Bol. Predtechensky 123242 Moscow Russia

A model intercomparison in terms of surface air temperature annual cycle amplitude-phase characteristics (SAT AC APC) is performed. The models included in the intercomparison belong to two groups: five atmospheric models with prescribed sea surface temperature and sea ice cover and four coupled models forced by the atmospheric abundances of anthropogenic constituents (in total six coupled model simulations). Over land, the models, simulating higher than observed time averaged SAT, also tend to simulate smaller than observed amplitude of its annual and semiannual harmonics and (outside the Tropics) later-than-observed spring and autumn moments. The models with larger (smaller) time averaged amplitudes of annual and semiannual harmonics also tend to simulate larger (smaller) interannual standard deviations. Over the oceans, the coupled models with larger interannual standard deviations of annual mean SAT tend to simulate larger interannual standard deviations of both annual and semiannual SAT harmonics amplitudes. Most model errors are located in the belts 60°–70°N and 60°–70°S and over Antarctica. These errors are larger for those coupled models which do not employ dynamical modules for sea ice. No systematic differences are found in the simulated time averaged fields of the surface air temperature annual cycle characteristics for atmospheric models on one hand and for the coupled models on the other. But the coupled models generally simulate interannual variability of SAT AC APC better than the atmospheric models (which tend to underestimate it). For the coupled models, the results are not very sensitive to the choice of the particular scenario of anthropogenic forcing. There is a strong linear positive relationship between the model simulated time averaged semiannual SAT harmonics amplitude and interannual standard deviation of annual mean SAT. It is stronger over the tropical oceans and is weaker in the extratropics. In the tropical oceanic areas, it is stronger f

关键词： annual cycle reanalysis data climate model intercomparison

Autoimmunity in acute ischemic stroke and the role of bloodbrain barrier: the dark side or the light one?

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Frontiers of Medicine 2019年第4期13卷 420-426页

作者： Nikolay v. Tsygan Alexandr P. Trashkov igor v. Litvinenko viktoriya A. Yakovleva Alexandr v. Ryabtsev Andrey G. vasiliev Leonid P. Churilov Department of Molecular and Radiation Biophysics B.P. Konstantinov Petersburg Nuclear Physics Institute Gatchina Leningrad Region 188300 Russian Federation Department of Nervous Diseases S.M. Kirov Military Medical Academy Saint Petersburg 194044 Russian Federation Department of Experimental Pharmacology I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry Saint Petersburg 194223 Russian Federation Department of Pathological Physiology with the Course of Immunopathology Saint Petersburg State Pediatric Medical University Saint Petersburg Russian Federation Department of Pathology Laboratory of the Mosaic of Autoimmunity Saint Petersburg State University Saint Petersburg 199034 Russian Federation

This article presents a synopsis of the current data on the mechanisms of blood-brain barrier (BBB) alteration and autoimmune response in acute ischemic stroke. Most researchers confirm the relationship between the severity of immunobiochemical changes and clinical outcome of acute ischemic stroke. Ischemic stroke is accompanied by aseptic inflammation, which alters the brain tissue and exposes the co-stimulatory molecules of the immune system and the neuronal antigens. To date, BBB is not considered the border between the immune system and central nervous system, and the local immune subsystems are found within and behind the BBB. BBB disruption contributes to the leakage of brain autoantigens and induction of secondary autoimmune response to neuronal antigens and long-term inflammation. Glymphatic system function is altered and jeopardized both in hemorrhagic and ischemic stroke types. The receptors of innate immunity (toll-like receptor-2 and toll-like receptor-4) are also involved in acute ischemia-reperfusion injury. Immune response is related to the key processes of blood clotting and fibrinolysis. At the same time, the stroke-induced immune activation may promote reparation phenomena in the brain. Subsequent research on the reduction of the acute ischemic brain injury through the target regulation of the immune response is promising.

关键词： stroke blood-brain barrier autoimmunity innate immunity inflammation cell death

Fe Nanoclusters on the Ge（001） Surface Studied by Scanning Tunneling Microscopy, Density Functional Theory Calculations and X-Ray Magnetic Circular Dichroism

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Nano Research 2011年第10期4卷 971-978页

作者： Olaf LUbben Sergey A. Krasnikov Alexei B. Preobrajenski Barry E. Murphy igor v. Shvets Centre for Research on Adaptive Nanostructures and Nanodevices （CRANN） School of Physics Trinity College Dublin Dublin 2 Ireland MAX-lab Lund University Box 118. 22100 Lund Sweden

Ge (001 ) 表面上的 Fe nanoclusters 的生长用低温度的扫描通道显微镜学(STM ) 和密度被学习了功能的理论(DFT ) 计算。STM 结果显示 Fe 在 Ge (001 ) 表面上起核心作用，形成一致尺寸的秩序井然的 nanoclusters。取决于准备条件， nan... 详细信息

Ge (001 ) 表面上的 Fe nanoclusters 的生长用低温度的扫描通道显微镜学(STM ) 和密度被学习了功能的理论(DFT ) 计算。STM 结果显示 Fe 在 Ge (001 ) 表面上起核心作用，形成一致尺寸的秩序井然的 nanoclusters。取决于准备条件， nanoclusters 的二种类型被观察在 nanocluster 以内有四或十六个 Fe 原子。结果被 DFT 计算证实。退火在 420 K 的 nanoclusters 导致 nanorow 结构的形成，由于在如此的温度的簇活动性。在 Ge (001 ) 表面上形成的 Fe nanoclusters 和 nanorow 结构显示出由 X 光检查磁性的圆形的二色性测量了的 superparamagnetic 行为。

关键词：扫描隧道显微镜 DFT计算密度泛函理论纳米团簇磁性圆二色 X射线铁团簇表面

Epitaxial thin-film Pd_(1-x)Fe_(x) alloy: a tunable ferromagnet for superconducting spintronics

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Science China Materials 2021年第5期64卷 1246-1255页

作者： Alireza Esmaeili igor v.Yanilkin Amir I.Gumarov Iskander R.vakhitov Bulat F.Gabbasov Roman v.Yusupov Dmitriy A.Tatarsky Lenar R.Tagirov Institute of Physics Kazan Federal UniversityKazan 420008Russia Institute for Physics of Microstructures of RAS Nizhny Novgorod 603950Russia Zavoisky Physical-Technical Institute FRC Kazan Scientific Center of RASKazan 420029Russia

Thin epitaxial films of the palladium-rich Pd_(1-x)Fe_(x) alloy were synthesized and extensively studied as a tunable ferromagnetic material for superconducting spintronics. The(001)-oriented Mg O single-crystal substrate and the composition range of x = 0.01–0.07 were chosen to support the epitaxial growth and provide the films with magnetic properties spanning from very soft ferromagnet for memory applications to intermediately soft and moderately hard for the programmable logic and circuit biasing, respectively. Dependences of the saturation magnetization, Curie temperature and three magnetic anisotropy constants on the iron content x were obtained for the first time from the analyses of the magnetometry and ferromagnetic resonance data. The experimental results were discussed based on existing theories of dilute ferromagnetic alloys. Simulation of the hysteresis loops within the Stoner-Wohlfarth model indicates the predominant coherent magnetic moment rotation at cryogenic temperatures. The obtained results were compiled in a database of magnetic properties of a palladium-iron alloy in a single-crystal thin-film form considered as a material for superconducting spintronics.

关键词： alloy ferromagnetic palladium

Identifying ecological corridors for Amur tigers(Panthera tigris altaica)and Amur leopards(Panthera pardus orientalis)

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Integrative Zoology 2015年第4期10卷 389-402页

作者： Dale G.MIQUELLE vyachaslav v.ROZHNOv victor ERMOSHIN Andre A.MURZIN igor G.NIKOLAEv Jose A.HERNANDEZ-BLANCO Sergie v.NAIDENKO Wildlife Conservation Society BronxNew YorkUSA A.N.Severtsov Institute of Ecology and Evolution Russian Academy of SciencesMoscowRussia Pacific Institute of Geography Far Eastern Branch of the Russian Academy of SciencesVladivostokRussia The Institute of Biology and Soils Far Eastern Branch of the Russian Academy of SciencesVladivostokRussia

The rapid explosion of human populations and the associated development of human-dominated landscapes have drastically reduced and fragmented habitat for tigers(Panthera tigris)and leopards(Panthera pardus)across Asia,resulting in multiple small ***,Amur tiger(Panthera tigris altaica)habitat in Russia has remained largely interconnected,except for a break between tigers in southwest Primorye and the southern Sikhote-Alin *** habitat patch in southwest Primorye also retains the last population of Amur leopards(Panthera pardus orientalis).Genetic differentiation of tigers in southwest Primorye and the Sikhote-Alin Mountains along with survey data suggest that habitat fragmentation is limiting movement of tigers and leopards across the Razdolnaya River *** looked at historical and recent survey data on tigers and leopards and mapped existing cover types to examine land-use patterns of both large felids and humans in the development strip along the Razdolnaya *** then used least-cost distance analyses to identify the most effective potential corridor to retain connectivity for large felids between Land of the Leopard National Park and Ussuriskii Zapovednik(Reserve).We identified a single potential corridor that still exists with a total distance of 62.5 km from Land of the Leopard National Park to Ussuriskii Zapovednik,mostly(93%)through forested *** recommend formal recognition of a Razdolnaya ecological corridor and provide specific recommendations for each of 3 proposed management sections.

关键词： Amur tiger ecological corridor Sikhote-Alin Mountains