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Chinese Journal of Polymer Science 2014年第6期32卷 681-689页

作者： ignazio blanco Department of Industrial Engineering University of Catania

A long-term （about nine months） isothermal degradation experiment of two different commercial polylactide （PLA） samples used for food packaging was carried out at a relatively low temperature （423 K）. Thermooxidative degradations of the same polymers were carried out in a thermogravimetric （TG） analyser, at higher temperatures （453 K 〈 T 〈 523 K）, under isothermal heating conditions. The obtained set of experimental TG data was used to determine the apparent activation energy （Ea） of degradation through two isothermal kinetic methods. The results from long-term experiment evidenced considerable mass loss for both PLA samples in the investigated period, but the experimental data were not in agreement with those from the short-term degradations at higher temperatures, thus suggesting a different degradation kinetics, and, then a low reliability of the lifetime predictions for polymers in service or degradation forecasts for the end of their life based on experiments at higher temperatures.

关键词： Lifetime prediction Degradation activation energy Kinetics of polymer degradation Thermogravimetry.

The Doppelgänger phenomenon and death:a peculiar case of homicide by a subject with first-episode psychosis

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Forensic Sciences Research 2022年第4期7卷 798-802页

作者： Cristiano Barbieri Gabriele Rocca Caterina Bosco Lucia Tattoli ignazio Grattagliano Giancarlo Di Vella Section of Forensic Medicine and Forensic Sciences University of PaviaPaviaItaly Department of Health Sciences University of GenoaGenoaItaly S.C.Medicina Legale U A.O.U.Cittàdella Salute e della Scienza di TorinoTurinItaly Department of Education PsychologyCommunication University Aldo Moro of BariBariItaly Department of Public Health and Pediatric Sciences Legal Medicine UnitUniversity of TurinTurinItaly

The Doppelgänger phenomenon refers to the experience of a direct encounter with one’s self,characteriswed by:(i)the perception of a figure with one’s own identical physical features;or(ii)the apprehension that the perceived figure shares the same personality and identity.The Doppelgänger does not only look like the same person,it is his/her double.The perceptual element is usually a hallucination,although occasionally a false perception of an actual figure may be involved.This phenomenon has been described in individuals suffering from overwhelming fear,severe anxiety or intoxication,epilepsy,as well as in the sleep-wakefulness transition.It has also been reported in major psychoses.The fear of imminent death often precedes the Doppelgänger experience.This report presents the case of a 30-year-old man,Mr.Y,who was stabbed to death by Mr.X,his“double”.The aggressor and his victim,although not related,were truly doubles;remarkably,they shared the same name and surname,age,professional activity and place of work.Moreover,they attended the same sports center but barely knew each other.The forensic psychiatric evaluations in Mr.X,subsequent to the crime committed,were suggestive of a psychotic condition.This case is unique in the scientific literature.In the most serious psychotic forms,the issue of the“double”calls into question not only the dissociative processes involved in the etiopathogenesis of the disorder,but also bio-psycho-social elements,as well as personal data in this case,which made the victim and the aggressor“identical”.In the context of psychopathological functioning,the delusional mood(Wahnstimmung)that precedes the development of delirium is a sort of gateway to an impending psychotic illness,involving delusional awareness or mood(atmosphere).In psychosis,splitting is the main issue and this influence is seen as an evil,foreign,apocalyptic and unknown side no longer recognised as belonging to the self even in a physical sense.In such a situation,it is felt that the only way to survive is by suppress

关键词： Forensic sciences forensic psychiatry homicide first-episode psychosis Doppelgänger delusional disorder criminal responsibility

Operative management of a shear fracture of the bilateral capitellum： A case report and review of the literature

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Chinese Journal of Traumatology 2016年第4期19卷 231-234页

作者： Alessandro Are ignazio Tornatore Emmanouil Theodorakis Department of Orthopedics Policlinico Casilino Hospital Rome Italy Department of Orthopedics Aurelia Hospital Rome Italy

Fracture of bilateral capitulum humeri is a very rare injury. We present a case of a 38-year-old woman, affected by a shear fracture of bilateral capitellum after a motorcycle accident. Intervention was carried out through a lateral approach on both sides and direct fixation of the fragment with headless screws. Consolidation was achieved and no signs of avascular necrosis occurred at 24 months of follow-up. The patient returned to her previous activities with no functional limitations. To the best of our knowledge, only four cases are reported describing different types of treatment and postoperative period of cast immobilization. According to our review of the literature regarding capitellar fractures, we preferred an immediate postoperative rehabilitation of the elbow, following the stable osteosynthesis.

关键词： Elbow joint Fracture of capitulum humeri Fracture fixation Internal Recovery of functional

Dynamic carbon 13 breath tests for the study of liver function and gastric emptying

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Gastroenterology Report 2015年第1期3卷 12-21页

作者： Leonilde Bonfrate ignazio Grattagliano Giuseppe Palasciano Piero Portincasa Department of Biomedical Sciences and Human Oncology Clinica Medica‘A.Murri’University of Bari Medical SchoolBariItaly Italian College of General Practitioners Florence and BariItaly

In gastroenterological practice,breath tests(BTs)are diagnostic tools used for indirect,non-invasive assessment of several pathophysiological metabolic processes,by monitoring the appearance in breath of a metabolite of a specific substrate.Labelled substrates originally employed radioactive carbon 14(^(14)C)and,more recently,the stable carbon 13 isotope(^(13)C)has been introduced to label specific substrates.The ingested^(13)C-substrate is metabolized,and exhaled^(13)CO_(2)is measured by mass spectrometry or infrared spectroscopy.Some^(13)C-BTs evaluate specific(microsomal,cytosolic,and mitochondrial)hepatic metabolic pathways and can be employed in liver diseases(i.***.simple liver steatosis,non-alcoholic steato-hepatitis,liver fibrosis,cirrhosis,hepatocellular carcinoma,drug and alcohol effects).Another field of clinical application for^(13)C-BTs is the assessment of gastric emptying kinetics in response to liquids(^(13)C-acetate)or solids(^(13)C-octanoic acid in egg yolk or in a pre-packed muffin or the^(13)C-Spirulina platensis given with a meal or a biscuit).Studies have shown that^(13)C-BTs,used for gastric emptying studies,yield results that are comparable to scintigraphy and can be useful in detecting either delayed-(gastroparesis)or accelerated gastric emptying or changes of gastric kinetics due to pharmacological effects.Thus,^(13)C-BTs represent an indirect,cost-effective and easy method of evaluating dynamic liver function and gastric kinetics in health and disease,and several other potential applications are being studied.

关键词： breath tests stable isotope hepatic metabolism gastric motility scintigraphy

REVIEW ON JOHN W. HEAD＇S WORKS： GREAT LEGAL TRADITIONS -- CIVIL LAW, COMMON LAW AND CHINESE LAW IN HISTORICAL AND OPERATIONAL PERSPECTIVE

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Frontiers of Law in China-Selected Publications from Chinese Universities 2012年第4期7卷 702-706页

作者： ignazio Castellucci at School of Law University of Trento Trento Italy

John W. Head is a Robert W. Wagstaff Distinguished Professor at School of Law, University of Kansas, USA; his involvement in comparative and historical legal research dates back decades, with specific experiences in China and Asia as a researcher, teacher and legal consultant. This handbook on comparative legal traditions follows other books of his on Chinese law and legal history, published by Carolina Academic Press in 2009 （China＇s Legal Soul -- the Modern Chinese Legal Identity in Historical Context） and 2005 （Law Codes in Dynastic China, co-authored with Yanping Wang）.

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Management of liver cirrhosis between primary care and specialists

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World Journal of Gastroenterology 2011年第18期17卷 2273-2282页

作者： ignazio Grattagliano Enzo Ubaldi Leonilde Bonfrate Piero Portincasa Italian College of General Practitioners (SIMG) Via del Pignoncino 9-11 50142 Firenze Italy Clinica Medica "A. Murri" Department of Internal and Public Medicine University Medical School of Bari

This article discusses a practical, evidence-based approach to the diagnosis and management of liver cirrhosis by focusing on etiology, severity, presence of complications, and potential home-managed treatments. Relevant literature from 1985 to 2010 (PubMed) was reviewed. The search criteria were peer-reviewed full papers published in English using the following MESH headings alone or in combination: "ascites", "liver fibrosis", "cirrhosis", "chronic hepatitis", "chronic liver disease", "decompensated cirrhosis", "hepatic encephalopathy", "hypertransaminasemia", "liver transplantation" and "portal hypertension". Forty-nine papers were selected based on the highest quality of evidence for each section and type (original, randomized controlled trial, guideline, and review article), with respect to specialist setting (Gastroenterology, Hepatology, and Internal Medicine) and primary care. Liver cirrhosis from any cause represents an emerging health issue due to the increasing prevalence of the disease and its complications worldwide. Primary care physicians play a key role in early identification of risk factors, in the management of patients for improving quality and length of life, and for preventing complications. Specialists, by contrast, should guide specific treatments, especially in the case of complications and for selecting patient candidates for liver transplantation. An integrated approach between specialists and primary care physicians is essential for providing better outcomes and appropriate home care for patients with liver cirrhosis.

关键词：卫生保健肝硬化管理专家随机对照试验研究论文慢性肝炎家庭护理

Smart biomaterials: Surfaces functionalized with proteolytically stable osteoblast-adhesive peptides

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Bioactive Materials 2017年第3期2卷 121-130页

作者： Annj Zamuner Paola Brun Michele Scorzeto Giuseppe Sica ignazio Castagliuolo Monica Dettin Department of Industrial Engineering University of PadovaVia F.Marzolo 935131PadovaItaly Department of Molecular Medicine University of PadovaVia A.Gabelli 6335121PadovaItaly Department of Biomedical Sciences University of PadovaVia U.Bassi 58/B35131PadovaItaly

Engineered scaffolds for bone tissue regeneration are designed to promote cell adhesion,growth,proliferation and differentiation.Recently,covalent and selective functionalization of glass and titanium surfaces with an adhesive peptide(HVP)mapped on[351e359]sequence of human Vitronectin allowed to selectively increase osteoblast attachment and adhesion strength in in vitro assays,and to promote osseointegration in in vivo studies.For the first time to our knowledge,in this study we investigated the resistance of adhesion sequences to proteolytic digestion:HVP was completely cleaved after 5 h.In order to overcome the enzymatic degradation of the native peptide under physiological conditions we synthetized three analogues of HVP sequence.A retro-inverted peptide D-2HVP,composed of D amino acids,was completely stable in serum-containing medium.In addition,glass surfaces functionalized with D-2HVP increased human osteoblast adhesion as compared to the native peptide and maintained deposition of calcium.Interestingly,D-2HVP increased expression of IBSP,VTN and SPP1 genes as compared to HVP functionalized surfaces.Total internal reflection fluorescence microscope analysis showed cells with numerous filopodia spread on D-2HVP-functionalized surfaces.Therefore,the D-2HVP sequence is proposed as new osteoblast adhesive peptide with increased bioactivity and high proteolytic resistance.

关键词： Adhesive sequences Retro-inverso peptides Surface grafting Proteolytic degradation Osteoblast TIRF

Biochemical mechanisms in drug-induced liver injury:Certainties and doubts

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World Journal of Gastroenterology 2009年第39期15卷 4865-4876页

作者： ignazio Grattagliano Leonilde Bonfrate Catia V Diogo Helen H Wang David QH Wang Piero Portincasa Clinica Medica "A.Murri" Dipartimento di Medicina Interna e Medicina PubblicaUniversity of Bari Medical School Department of Zoology Center for Neurosciences and Cell BiologyUniversity of Coimbra Department of Medicine Liver Center and Gastroenterology DivisionBeth Israel Deaconess Medical CenterHarvard Medical School and Harvard Digestive Diseases Center

Drug-induced liver injury is a significant and still unresolved clinical problem.Limitations to knowledge about the mechanisms of toxicity render incomplete the detection of hepatotoxic potential during preclinical development.Several xenobiotics are lipophilic substances and their transformation into hydrophilic compounds by the cytochrome P-450 system results in production of toxic metabolites.Aging,preexisting liver disease,enzyme induction or inhibition,genetic variances,local O2 supply and,above all,the intrinsic molecular properties of the drug may affect this process.Necrotic death follows antioxidant consumption and oxidation of intracellular proteins,which determine increased permeability of mitochondrial membranes,loss of potential,decreased ATP synthesis,inhibition of Ca2+-dependent ATPase,reduced capability to sequester Ca2+ within mitochondria,and membrane bleb formation.Conversely,activation of nucleases and energetic participation of mitochondria are the main intracellular mechanisms that lead to apoptosis.Non-parenchymal hepatic cells are inducers of hepatocellular injury and targets for damage.Activation of the immune system promotes idiosyncratic reactions that result in hepatic necrosis or cholestasis,in which different HLA genotypes might play a major role.This review focuses on current knowledge of the mechanisms of drug-induced liver injury and recent advances on newly discovered mechanisms of liver damage.Future perspectives including new frontiers for research are discussed.

关键词：生化机制肝损伤药物性免疫系统激活肝细胞损伤毒性机制肝脏疾病抗氧化剂

Resin foraging dynamics in Varroa destructor-infested hives: a case of medication of kin?

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Insect Science 2019年第2期26卷 297-310页

作者： Michelina Pusceddu Giannella Piluzza Panagiotis Theodorou Franco Buffa Luca Ruiu Simonetta Bullitta ignazio Floris Alberto Satta Dipartimento di Agraria sezione di Patologia vegetate ed Entomologia Universita di Sassari Sassari Italy lstituto per il Sistema Produzione Animate in Ambiente Mediterraneo (ISPAAM uos Sassari) Consiglio Nazionale delle Ricerche (CNR) Baldinca-Li Punti Sassari Italy General Zoology Institute for Biology Martin Luther University Halle-Wittenberg Halle (Saale) Germany German Centre for integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig Leipzig Germany

t Social insects have evolved colony behavioral, physiological, and organiza. tional adaptations (social immunity) to reduce the risks of parasitization and/or disease transmission. The collection of resin from various plants and its use in the hive as propolis is a clear example of behavioral defense. For Apis mellifera, an increased propolis content in the hive may correspond to variations in the microbial load of the colony and to a downregulation of an individual bee's immune response. However, many aspects of such antimicrobial mechanism still need to be clarified. Assuming that bacterial and fungal infection mechanisms differ from the action of a parasite, we studied the resin collection dynamics in Varroa destructor-infested honeybee colonies. Comparative experiments involving hives with different mite infestation levels were conducted in order to assess the amount of resin collected and propolis quality within the hive, over a 2-year period (2014 and 2015). Our study demonstrates that when A. mellifera colonies are under stress because of Varroa infestation, an increase in the number of resin foragers is recorded, even if a general intensification of the foraging activity is not observed. A reduction in the total polyphenolic content in propolis produced in infested versus uninfested hives was also noticed. Considering that different propolis types show varying levels of inhibition against a variety of honey bee pathogens in vitro, it would be very important to study the effects against Varroa of two diverse types of propolis: from Varroa-free and from Varroa-infested hives.

关键词： Apis mellifera host-parasite interaction polyphenols propolis selfmedication social immunity

Characterization of artificial spherical particles for DEM validation studies

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Particuology 2012年第2期10卷 209-220页

作者： ignazio Cavarretta Catherine O'Sullivan Erdin Ibraim Martin Lings Simon Hamlin David Muir Wood Division of Civil Chemical and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Department of Civil and Environmental Engineering Imperial College LondonLondon SW72AZUK Department of Civil Engineering University of BristolBristol BS81TRUK

This paper describes a study in which advanced particle-scale characterization was carried out on spherical particles that can be used in experimental tests to validate discrete element method （DEM） simulations. Two types of particle, alkaline and borosilicate glass beads, made from two different materials, were con- sidered. The particle shape, stiffness, contact friction properties and surface roughness were measured. The influences of hardness and roughness on the mechanical response of the particles were carefully considered. Compared to the alkaline beads, the borosilicate beads were more spherical and more uniform in size, and they exhibited mechanical characteristics closer to natural quartz sand. While only two material types were studied, the work has the broader implication as a methodology for selecting particles suitable for use in DEM studies and the key parameters that should be considered in the selection process are highlighted.

关键词： Particle characterizationGlass beadsDEM