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Protective effect of estradiol on hepatocytic oxidative damage

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World Journal of Gastroenterology 2002年第2期8卷 363-366页

作者： ichiro Shimizu Toshihiro Omoya Susumu Ito Second Department of Internal Medicine School of MedicineUniversity of TokushimaTokushima770-8503Japan

AIM: To examine the protective effect of estradiol on the cultured hepatocytes under oxidative stress. METHODS: Hepatocytes of rat were isolated by using perfusion method, and oxidative stress was induced by a serum-free medium and FeNTA. MDA level was determined with TBA method. Cell damage was assessed by LDH assay. Apoptosis of hepatocytes was assessed with cytoflowmetric analysis. Expression of Bcl-xl in cultured hepatocytes was detected by Western blot. The radical-scavenging activity of estradiol was valued by its ability to scavenge the stable free radical of DDPH. RESULTS: Oxidative stress increased LDH from 168 +/- 25 x 10(-6)***(-1) to 780 +/- 62 x 10(-6)***(-1) and MDA(from 0.28 +/- 0.07 x 10(-6)***(-1) to 1.35 +/- 0.12 x 10(-6)***(-1)) levels in cultured hepatocyte, and estradiol inhibited both LDH and MDA production in a dose dependent manner. In the presence of estradiol 10(-6)mol.L(-1), 10( -7 )mol.L(-1) and 10(-8)mol.L(-1),the LDH levels are 410 +/- 53 x 10(-6)***(-1) (P<0.01 vs oxidative group), 530 +/- 37 X 10(-6)***(-1 ) (P<0.01 vs oxidative group), 687+/-42 x 10(-6)***(-1) (P<0.05 vs oxidative group) respectively, and the MDA level are 0.71+/-0.12 x 10(-6)***(-1) (P<0.01 vs oxidative group),0.97+/-0.11 x 10(-6)***(-1 )(P<0.01 vs oxidative group) and 1.27+/-0.19 x 10(-6)***(-1) respectively. Estradiol suppressed apoptosis of hepatocytes induced by oxidative stress, administration of estradiol(10(-6)mol/L)decreased the apoptotic rate of hepatocytes under oxidative stress from 18.6 +/- 1.2% to 6.5 +/-2.5%, P<0.01. Bcl-xl expression was related to the degree of liver cell damage due to oxidative stress, and estradiol showed a protective action. CONCLUSION: Estradiol protects hepatocytes from oxidative damage by means of its antioxidant activity.

关键词： Oxidative Stress Animals Apoptosis Cells, Cultured Estradiol Female Flow Cytometry Hepatocytes L-Lactate Dehydrogenase Lipid Peroxidation Male Proto-Oncogene Proteins c-bcl-2 Rats Rats, Wistar Thiobarbituric Acid Reactive Substances bcl-X Protein

Comparison of dissimilarity measures for cluster analysis of X-ray diffraction data from combinatorial libraries

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npj Computational Materials 2017年第1期3卷 448-456页

作者： Yuma Iwasaki A.Gilad Kusne ichiro Takeuchi IoT Devices Research Laboratories NEC CorporationTsukuba 305-8501Japan Spin Quantum Rectification Project ERATOJapan Science and Technology AgencySendai 980-8577Japan National Institute of Standards and Technology GaithersburgMD 20899USA Department of Materials Science and Engineering University of MarylandCollege parkMD 20742USA

Machine learning techniques have proven invaluable to manage the ever growing volume of materials research data produced as developments continue in high-throughput materials simulation,fabrication,and *** particular,machine learning techniques have been demonstrated for their utility in rapidly and automatically identifying potential composition-phase maps from structural data characterization of composition spread libraries,enabling rapid materials fabrication-structure-property analysis and functional materials discovery.A key issue in development of an automated phase-diagram determination method is the choice of dissimilarity measure,or kernel *** desired measure reduces the impact of confounding structural data issues on analysis *** issues include peak height changes and peak shifting due to lattice constant change as a function of *** this work,we investigate the choice of dissimilarity measure in X-ray diffraction-based structure analysis and the choice of measure’s performance impact on automatic composition-phase map *** dissimilarity measures are investigated for their impact in analyzing X-ray diffraction patterns for a Fe-Co-Ni ternary alloy composition *** cosine,Pearson correlation coefficient,and Jensen-Shannon divergence measures are shown to provide the best performance in the presence of peak height change and peak shifting(due to lattice constant change)when the magnitude of peak shifting is *** prior knowledge of the maximum peak shifting,dynamic time warping in a normalized constrained mode provides the best *** work also serves to demonstrate a strategy for rapid analysis of a large number of X-ray diffraction patterns in general beyond data from combinatorial libraries.

关键词： alloy shifting analysis

Camera array calibration for light field acquisition

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Frontiers of Computer Science 2015年第5期9卷 691-702页

作者： Yichao XU Kazuki MAENO Hajime NAGAHARA Rin-ichiro TANIGUCHI Graduate School of Information Science and Electrical Engineering Kyushu University Fukuoka 819-0395 Japan

Light field cameras are becoming popular in com- puter vision and graphics, with many research and commercial applications already having been proposed. Various types of cameras have been developed with the camera array being one of the ways of acquiring a 4D light field image using multiple cameras. Camera calibration is essential, since each application requires the correct projection and ray geometry of the fight field. The calibrated parameters are used in the fight field image rectified from the images captured by multiple cameras. Various camera calibration approaches have been proposed for a single camera, multiple cameras, and a moving camera. However, although these approaches can be applied to calibrating camera arrays, they are not effective in terms of accuracy and computational cost. Moreover, less attention has been paid to camera calibration of a light field camera. In this paper, we propose a calibration method for a camera array and a rectification method for generating a light field image from the captured images. We propose a two-step algorithm consisting of closed form initialization and nonlinear refinement, which extends Zhang＇s well-known method to the camera array. More importantly, we introduce a rigid camera constraint whereby the array of cameras is rigidly aligned in the camera array and utilize this constraint in our calibration. Using this constraint, we obtained much faster and more accurate calibration results in the experiments.

关键词： light field camera array calibration rectification digital refocusing

Combination of Cyclamen persicum Mill. floral gene promoters and chimeric repressors for the modification of ornamental traits in Torenia fournieri Lind.

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Horticulture Research 2017年第1期4卷 324-334页

作者： ichiro Kasajima Norihiro Ohtsubo Katsutomo Sasaki Institute of Vegetable and Floriculture Science National Agriculture and Food Research Organization(NARO)Ibaraki305-8519Japan Department of Agriculture Iwate UniversityIwate 020-8550Japan Graduate School of Life and Environmental Sciences Kyoto Prefectural UniversityKyoto 606-8522Japan

Although chimeric repressors such as the Arabidopsis TCP3 repressor are known to have significant effects on flower morphology and color,their cellular-level effects on flower petals are not *** promoter sequences of the genes expressed in the flowers of cyclamen,a representative potted flower grown during the winter season,are also ***,we isolated eight promoters from cyclamen genes that are reportedly expressed in the *** promoters were then fused to four chimeric repressors and introduced into the model flower torenia to screen for effective combinations of promoters and repressors for flower *** expected,some of the constructs altered flower phenotypes upon *** further analyzed the effects of chimeric repressors at the cellular *** observed that complicated petal and leaf serrations were accompanied by excessive vascular *** in purple anthocyanin was inferred to result in bluish flowers,and imbalanced cell proliferation appeared to result in epinastic ***,the genetic constructs and phenotypic changes described in this report will benefit the future breeding and characterization of ornamental flowers.

关键词： traits flowers breeding

Effects of selenium-containing compounds on Cu^(2+)/Zn^(2+)-induced neuronal cell death and potential application as therapeutic agents for neurological diseases

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Neural Regeneration Research 2022年第2期17卷 311-312页

作者： Ken-ichiro Tanaka Mikako Shimoda Masahiro Kawahara Department of Bio-Analytical Chemistry Faculty of PharmacyMusashino UniversityShinmachiNishitokyoTokyoJapan

In many tissues, trace metals such as iron(Fe), zinc(Zn), and copper(Cu) are important for various physiological functions such as immune function, cell division, and enzyme function. However, it has been shown in humans and experimental animal models that excessive amounts of these trace metals in the body can induce various diseases in the central nervous system, liver.

关键词： metals potential copper

Biomimetic Drag Reduction Study on Herringbone Riblets of Bird Feather

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Journal of Bionic Engineering 2013年第3期10卷 341-349页

作者： Huawei Chen Fugang Rao Xiaopeng Shang Deyuan Zhang ichiro Hagiwara School of Mechanical Engineering and Automation Beihang University Beijing 100191 P. R. China Department of Mechanical Science and Engineering Tokyo Institute of Technology Tokyo 152-8550 Japan

Birds have gradually formed various excellent structures such as streamlined shape and hollow shaft of feather to improve their flying performance by millions of years of natural selection. As typical property of bird feather, herringbone riblets align along the shaft of each feather, which is caused by perfect link of barbs, especially for the primary and secondary feathers of wings. Such herringbone riblets of feather are assumed to have great impact on drag reduction. In this paper, microstructures of secondary feathers of adult pigeons are investigated by SEM, and their structural parameters are statistically obtained. Based on quantitative analysis of feather structure, novel biomimetic herringbone riblets with narrow smooth edge are proposed to reduce surface drag. In comparison with traditional microgroove riblets and other drag reduction structures, the drag reduction rate of the proposed biomimetic herringbone riblets is experimentally clarified up to 16%, much higher than others. Moreover, the drag reduction mechanism of herringbone riblets are also confirmed and exploited by CFD.

关键词： biomimetic surface drag reduction herringbone riblets bird feather

Prevention of aspiration of gastric contents during attempt in tracheal intubation in the semi-lateral and lateral positions

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World Journal of Emergency Medicine 2016年第4期7卷 285-289页

作者： ichiro Takenaka Kazuyoshi Aoyama Department of Anesthesia Kyushu Rosai Hospital Department of Anesthesia Kitakyushu General Hospital

BACKGROUND:Pulmonary aspiration of gastric contents during tracheal intubation is a lifethreatening complication in emergency *** sequence intubation is commonly performed to prevent aspiration but is not associated with low risk of intubation related *** it has been considered that aspiration can be prevented in the lateral position,few studies have evaluated the ability to prevent ***,this position is not always a favorable position for tracheal *** aspiration can be prevented in a clinically relevant semi-lateral position,it may be *** assessed the ability to prevent aspiration in the lateral position and various degrees of the semi-lateral position using a vomiting-regurgitation manikin ***:A manikin's head was placed in the neutral,simple extension,or sniffing *** amount of aspirated saline into the bronchi during simulated vomiting was measured at semilateral position angles of 0°to 90° in 10° *** difference in the vertical height between the mouth corner and the inferior border of the vocal cord was measured radiologically at each semilateral position in the three head-neck ***:Pulmonary aspiration was prevented at the ≥70°,≥80°,and 90° semi-lateral positions in the neutral,simple extension,and sniffing positions,*** mouth was lower than the vocal cord in the semi-lateral position in which aspiration was ***:The lateral or excessive semi-lateral position was necessary to protect the lung from aspiration in the head-neck positions commonly used for tracheal *** of aspiration was difficult within clinically relevant semi-lateral positions.

关键词： Pulmonary aspiration Lateral position Semi-lateral position

Self-excited oscillation of spinning solar sails utilizing solar radiation pressure

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Astrodynamics 2020年第3期4卷 177-192页

作者： Yuki Takao Osamu Mori Jun'ichiro Kawaguchi Department of Aeronautics and A stronautics The University of TokyoTokyo 113-8654Japan Institute of Space and Astronartical Science Japan Aerospace Exploration AgencySagamihara 252-5210Japan

The present paper proposes a control method to excite spinning solar sail membranes for three-dimensional *** optical property switching,the input is given as the change in magnitude of the solar radiation *** resonance point of this system varies with the vibration state due to its nonlinearity and the change in equilibrium *** deal with this,a state feedback control law that automatically tracks the resonance point is developed in the present *** proposed method enables decentralized control of the actuators on the sail,each of which determines the control input independently using only the information of vibration *** proposed method is validated using numerical *** results show that the nonlinear system behaves differently from the linear system,and the vibration grows using the decentralized control regardless of resonance point variation.

关键词： solar sail solar radiation pressure vibration mode self-excited oscillation mechanical resonance decentralized control

Certification Criteria in Type I Ecolabelling Related to Metals for Sustainable Materials Management

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Journal of Shanghai Jiaotong university(Science) 2012年第3期17卷 377-379页

作者： ichiro Daigo KENICHI Nakajima TAKASHI Fujisaki Graduate School of Engineering The University of TokyoTokyo 113-8656Japan National Institute for Environmental Studies Tsukuba 305-8506Japan Japan Environment Association Tokyo 103-0002Japan

A sustainable materials management for metals should be achieved to conserve resources of metal *** the sustainable materials management,material flows through the whole life cycle of materials have been recognized by material flow analysis(MFA) *** MFA studies pointed out that cyclic use of metals could be enhanced not only by increasing quantity of recovered scrap but also by upgrading quality of the *** general,the quality is degraded by contaminants which commingle at disassembling *** mixture of contaminants depends on usage of materials in ***,Type I ecolabelling has a potential to convey messages for avoiding mixture of contaminants to the producers of finished *** this study,on the basis of a survey on existing certification criteria related to metals in the world,a general concept of certification criteria on sustainable materials management for metals in Type I ecolabelling system is ***,we propose six criteria in the form of certification criteria in Type I ecolabelling system.

关键词： ecolabelling metal recycling certification criteria life cycle thinking design for environment