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World Journal of Pediatrics 2020年第6期16卷 623-628页

作者： Yukari Atsumi Hiroshi Sakakibara Yoshihiko Morikawa Koichi Miyata Hiroyuki Yamagishi Masahiro Misawa masaru Miura Department of General Pediatrics Tokyo Metropolitan Children's Medical Center.TokyoJapan Clinical Research Support Center.Tokyo Metropolitan Children's Medical Center TokyoJapan Department of Cardiology.Tokyo Metropolitan Children's Medical Center.Tokyo Japan Department of Pediatrics Keio University School of MedicineTokyo.Japan Department of Pediatrics Tokyo Metropolitan Bokutoh HospitalTokyoJapan National Center for Global Health and Medicine.1-21-1.Toyama Shinjuku-kuTokyo 162-8655.Japan

Background Although Kawasaki disease(KD)is known to cause anemia,the relationship between its prognosis and hemoglobin level is less well *** We herein performed a secondary analysis of data from a previous study(Post-RAISE).Children aged 6 months to 2 years at the time of KD diagnosis were *** hemoglobin was defined as a decrease>10%on post-treatment day 2 compared with the level prior to the initial *** Of 1253 KD cases,treatment resistance was observed in 209(17%)and was significantly more frequent in the decreased hemoglobin group(37/167 vs.172/1086,P=0.041).Multivariable logistic regression analysis revealed that decreased hemoglobin was associated with resistance to the initial treatment(odds ratio 1.53;95%confidence interval 1.00-2.33;P=0.048).Conclusions Decreased hemoglobin was significantly associated with resistance to initial treatment in patients with KD.

关键词： Anemia Inflammation Hepcidin Kawasaki disease

Surgical techniques and postoperative management to prevent postoperative pancreatic fistula after pancreatic surgery

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World Journal of Gastroenterology 2019年第28期25卷 3722-3737页

作者： Hiromichi Kawaida Hiroshi Kono Naohiro Hosomura Hidetake Amemiya Jun Itakura Hideki Fujii Daisuke ichikawa First Department of Surgery Faculty of Medicine University of Yamanashi Yamanashi 409-3898 Japan Department of Surgery Kofu Manicipal Hospital Yamanashi 400-0832 Japan

Postoperative pancreatic fistula (POPF) is one of the most severe complications after pancreatic surgeries. POPF develops as a consequence of pancreatic juice leakage from a surgically exfoliated surface and/or anastomotic stump, which sometimes cause intraperitoneal abscesses and subsequent lethal hemorrhage. In recent years, various surgical and perioperative attempts have been examined to reduce the incidence of POPF. We reviewed several well-designed studies addressing POPF-related factors, such as reconstruction methods, anastomotic techniques, stent usage, prophylactic intra-abdominal drainage, and somatostatin analogs, after pancreaticoduodenectomy and distal pancreatectomy, and we assessed the current status of POPF. In addition, we also discussed the current status of POPF in minimally invasive surgeries, laparoscopic surgeries, and robotic surgeries.

关键词： Postoperative pancreatic fistula Pancreaticoduodenectomy Pancreatojejunostomy Pancreatogastrostomy Distal pancreatectomy Prophylactic drainage Somatostatin analogs

Clinicopathological features and prognosis of surgical resected cases of biliary cancer with pancreaticobiliary maljunction

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 97-100页

作者： Tsukasa Takayashiki Hideyuki Yoshitomi Katsunori Furukawa Satoshi Kuboki masaru Miyazaki Masayuki Ohtsuka Department of General Surgery Graduate School of MedicineChiba University Department of Gastroenterological Surgery Mita HospitalInternational University of Health and Welfare

To the Editor:Pancreaticobiliary maljunction(PBM)is a congenital anomaly in which the pancreatic and bile ducts join anatomically outside of the duodenal wall away from the Oddi’s *** condition causes the reflux of pancreatic juice into the bile duct under high pressure,resulting in various pathologic *** features of PBM patients are common bile duct dilatation,long common channel,and high amylase levels in bile *** them,one of the most significant problems is the development of biliary cancer,including extrahepatic bile duct and gallbladder cancers[1].A nationwide survey in Japan reported biliary cancer in 21.6%of adult patients with PBM concomitant with congenital biliary dilatation,32.1%and 62.3%extrahepatic bile duct and gallbladder cancers,respectively[2].

关键词： biliary cancer congenital

Is ERCP really necessary in case of suspected spontaneous passage of bile duct stones?

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World Journal of Gastroenterology 2009年第26期15卷 3283-3287页

作者： Yuji Sakai Toshio Tsuyuguchi Takeshi Ishihara Seigo Yukisawa Tadashi Ohara masaru Tsuboi Yoshihiko Ooka Kazuki Kato Kiyotake Katsuura Michio Kimura Makoto Takahashi Kazuhisa Nemoto masaru Miyazaki Osamu Yokosuka Department of Medicine and Clinical Oncology Graduate School of MedicineChiba University Department of Internal Medicine Funabashi Central Hospital Department of Surgery Funabashi Central Hospital Department of Radiology Funabashi Central Hospital Department of General Surgery Graduate School of MedicineChiba University

AIM:To investigate the usefulness of magnetic resonance cholangiopancreatography (MRCP) and the need for endoscopic retrograde cholangiopancreatography (ERCP) in cases of suspected spontaneous passage of stones into the common bile ***:Thirty-six patients with gallbladder stones were clinically suspected of spontaneous passage of stones into the common bile duct because they presented with clinical symptoms such as abdominal pain and fever,and showed signs of inflammatory reaction and marked rise of hepatobiliary *** symptoms resolved and they showed normalized values of blood biochemical parameters after conservative treatment without evidence of stones in the common bile duct on *** these patients were subjected to ERCP within 3 d of MRCP to check for the presence of ***:No stones were detected by ERCP in any patient,confi rming the results of ***:When clinical symptoms improve,blood biochemical parameters have normalized,and MRCP shows there are no stones in the common bile duct,it can be considered the stone has spontaneously passed and thus ERCP is not necessary.

关键词：胆囊结石检查表胆管血液生化指标临床症状炎症反应保守治疗正常化

Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis

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World Journal of Gastroenterology 2009年第5期15卷 615-621页

作者： Motoko Sasaki Ichiro Araki Toshiaki Yasui masaru Kinoshita Keita Itatsu Takayuki Nojima Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of Medicine Kanazawa 920-8640 Japan Department of Internal Medicine Asanogawa General Hospital Kanazawa 920-8621 Japan Department of Surgery Asanogawa General Hospital Kanazawa 920-8621 Japan Hanazono Medical Office Kanazawa 920-0293 Japan Department of Pathology Kanazawa Medical University Ishikawa 920-0293 Japan

We report a case of primary localized malignant biphasic mesothelioma of the liver in a 66-year-old man associated with asbestosis. The tumor was detected as a hepatic nodule, 4 cm in diameter, in the right lobe (S8 segment) on CT scan. Histopathological examination demonstrated an intrahepatic tumor with central necrosis consisting of a papillary epithelioid pattern on the surface of the liver, microcystic (microglandular or adenomatoid) pattern mainly in the subcapsular area and sarcomatoid pattern intermingled with microcystic pattern in the major part of the hepatic nodular tumor. Tumor cells, especially of epithelioid type, showed distinct immunoreactivity for mesothelial markers (WT-1, calretinin, D2-40, CK5/6, mesothelin, thrombomodulin) and no immunoreactivity for epithelial (adenocarcinoma) markers (CEA, CD15, BerEP4, BG8, MOC31). P53 immunoreactivity was detected focally in papillary epithelioid tumor cells and extensively in microcystic and sarcomatoid components, suggesting that the papillary epithelioid mesothelioma arose on the surface of the liver, and tumor cells showing microcystic and sarcomatoid patterns invaded and grew into the liver. To date, this is the first case of primary localized malignant biphasic mesothelioma of the liver, since all three primary hepatic mesotheliomas reported so far were epithelioid type.

关键词：石棉沉滞症间皮瘤恶性肿瘤患者诊断

Lithium ion conductivity of complex hydrides incorporating multiple closo–type complex anions

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Journal of Energy Chemistry 2019年第11期28卷 84-87页

作者： Naoki Toyama Sangryun Kim Hiroyuki Oguchi Toyoto Sato Shigeyuki Takagi masaru Tazawa Genki Nogami Shin-ichi Orimo Institute for Materials Research Tohoku UniversityKatahira 2-1-1Aoba-kuSendai 980-8577Japan WPI-Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversityKatahira 2-1-1Aoba-kuSendai 980-8577Japan Mitsubishi Gas Chemicals Co. Inc.182 Tayuhama ShinwariKita-kuNiigata 950-3112Japan

We report the lithium ionic conductivities of closo –type complex hydrides synthesized from various molar ratios of lithium borohydride(LiBH4) and decaborane(B10H14) as starting materials. The prepared closo –type complex hydrides comprised [B12H12]^2-, [B11H11]^2-, and [B10H10]^2- complex anions. In addition, increasing the LiBH4 content in the starting materials increased the amounts of [B11H11]^2- and [B10H10]^2-, leading to an improved ion conductivity of the prepared sample. The present study offers useful insights into strategies for controlling the complex anion composition in emerging solid electrolytes of closo-type complex hydrides at the molecular level, and improving their ionic conductivities.

关键词： Closo-type complex hydride Solid electrolyte Lithium ion conductivity Multiple complex anions

Optical mesoscopic membrane sensor layouts for waterfree and blood-free toxicants

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Nano Research 2015年第10期8卷 3150-3163页

作者： Sherif A. El-Safty Mohamed Khairy Mohamed A. Shenashen Emad Elshehy Wojciech Warkocki masaru Sakai NationalInstituteforMaterialsScience(NIMS) 1-2-1SengenTsukuba-shiIbaraki305-0047Japan GraduateSchoolforScienceandEngineering WasedaUniversity3-4-1OkuboShinjuku-kuTokyo169-8555Japan CenterforResearchinIsotopesandEnvironmentalDynamics TsukubaUniversity1-1-1TennodaiTsukubaIbaraki305-8572Japan

与阳极的氧化铝膜( AAM ) nanochannels 导致了的在内的唯一的结构和形态学在 mesoscopic 膜传感器的制造进展为检测，设想，吸附，过滤，并且恢复有毒的金属离子的极端踪迹的集中的各种各样的方法的发展，例如水和血里的 Hg 2+和 Pb 2+... 详细信息

与阳极的氧化铝膜( AAM ) nanochannels 导致了的在内的唯一的结构和形态学在 mesoscopic 膜传感器的制造进展为检测，设想，吸附，过滤，并且恢复有毒的金属离子的极端踪迹的集中的各种各样的方法的发展，例如水和血里的 Hg 2+和 Pb 2+,。这些经常，一个壶屏蔽方法在常规方法上提供优点因为他们不要求复杂仪器或勤劳样品准备。在现在的学习，我们在生物、环境的样品为 Hg 2+ 和 Pb 2+ 的裸体眼睛的察觉，识别，过滤，和恢复制作了二个 mesoscopic 膜传感器。这些传感器被器官的颜料的稠密的固定在作为脚手架用 AAM 的 nanochannels 被构造的硅石 nanotubes 的 mesopore 表面上描绘。我们证实 nanotubes 沿着 AAM nanochannels 的长轴是面向的，在两结束开，并且完全并且一致地充满了器官的颜料；另外，器官的颜料的稠密的固定没影响 ion-to-ligand 绑定事件的速度。我们使用了简单，台式，为 Hg 的察觉，移动，和过滤估计发达的膜传感器的适用性的流动彻底地试金关于再循环能力的 2+ 和 Pb 2+ 并且连续监视。从生物液体的目标离子的移动借助于流动 cytometric 分析被估计。我们的结果表明我们的膜传感器的潜力被用于阻止在环境和血与暴露联系到有毒的金属离子的健康风险。

关键词：膜传感器传感器布局介观无水有毒金属离子流式细胞仪分析检测评估毒物

Successful endoscopic procedures for intraductal papillary neoplasm of the bile duct:A case report

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World Journal of Gastroenterology 2010年第7期16卷 909-913页

作者： Kohei Tsuchida Michiko Yamagata Yasuyuki Saifuku Dan ichikawa Kazunari Kanke Toshimitsu Murohisa Masaya Tamano Makoto Iijima Yukiko Nemoto Wataru Shimoda Toshiaki Komori Hirokazu Fukui Kazuhito ichikawa Hitoshi Sugaya Kazuhito Miyachi Takahiro Fujimori Hideyuki Hiraishi Department of Gastroenterology Dokkyo Medical UniversityTochigi 321-0293Japan First Department of Surgery Dokkyo Medical UniversityTochigi 321-0293Japan Department of Surgical and Molecular Pathology Dokkyo Medical UniversityTochigi 321-0293Japan

Attention has recently been focused on biliary papillary tumors as the novel disease entity intraductal papillary neoplasm of the bile duct(IPNB),which consists of papillary proliferation of dysplastic biliary *** even benign papillary tumors are considered as premalignant,some investigators recommend aggressive surgical therapy for IPNB,although no guidelines are available to manage this *** reports have described long-term follow-up of patients with benign IPNB without radical *** patients with IPNB who are treated only with endoscopic procedures are noted,clinical profiles and alternative therapies other than resection may be *** report the case of a patient who experienced repetitive cholangitis for 10 years and was finally diagnosed with *** resection could not be recommended because of the age of the patient,therefore,endoscopic sphincterotomy was *** an endoscopic retrograde biliary drainage catheter was placed several times for repetitive cholangitis,the patient has done well during *** case may offer insights into the natural course and management decisions for the novel disease entity of IPNB.

关键词： Biliary tract neoplasms Papilloma Endoscopic sphincterotomy Endoscopic retrograde biliary drainage

Characteristics and outcomes of avoidant/restrictive food intake disorder in Japanese elementary-school students on total parenteral nutrition

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Pediatric Investigation 2021年第4期5卷 293-298页

作者： Akira Tamura Koichi Minami Yuko Tsuda Hiroshi Tsujimoto Takayuki ichikawa Kazuhiro Mizumoto Hiroyuki Suzuki Department of Pediatrics Wakayama Medical UniversityWakayama CityWakayamaJapan Department of Medical Safety Promotion Wakayama Medical UniversityWakayama CityWakayamaJapan

The clinical outcomes of adolescents with avoidant/restrictive food intake disorder(ARFID)remain ***,no report has compared the characteristics of ARFID and restricting-type anorexia nervosa(R-AN)in elementary-school students on total parenteral nutrition(TPN).This study retrospectively reviewed inpatients diagnosed with ARFID or R-AN between 2005 and *** with ARFID(two boys and seven girls)and R-AN(13 girls)were hospitalized because of rapid physical deterioration,and nutrition therapy was continued without *** ARFID group exhibited significantly lower body weights at admission than the R-AN group and gained an average of 6.5 kg during hospitalization;furthermore,the monthly weight gain during hospitalization was significantly higher,and no relapse was *** physical improvement in ARFID resulted in good *** conclusion,TPN can be easily introduced to patients with ARFID,in whom aversive eating is a concern,and is a suitable treatment for ARFID.

关键词： Adolescent Anorexia nervosa Avoidant/restrictive food intake disorder Eating disorder Total parenteral nutrition

Plasmodium vivax cerebral malaria complicated with venous sinus thrombosis in Colombia

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Asian Pacific Journal of Tropical Medicine 2013年第5期6卷 413-415页

作者： Miguel A Pinzon Juan C Pineda Fernando Rosso masaru Shinchi Fabio Bonilla-Abadia Department of Infectious Diseases Hospital San Vicente de PaulMedellinColombia Department of Internal Medicine Fundacion Clinica Valle del LiliICESI UniversityCaliColombia Department of Infectious Diseases Fundacion Clinica Valle del LiliCaliColombia Department of Neurology Fundacion Clinica Valle del LiliCuliColombia Department of Rheumatology Fundacion Clinica Valle del LiliICESI UniversityCaliColombia

Complicated malaria is usually due to Plasmodium ***,Plasmodium vivax is infrequently related with life-threatening *** cases have been reported of severe Plasmodium vivax infection,and most of them from Southeast Asia and *** report the first case of cerebral malaria due to Plasmodium vivax in Latin America,complicated with sagittal sinus thrombosis and confirmed by a molecular method.

关键词： Cerebral malaria Vivax malaria Plasmodium vivax Intracranial sinus thrombosis