检索结果-南通市图书馆

Heat-Resistant Properties of a SiO<sub>2</sub>-Coated PET Film Prepared by Irradiating a Polysilazane-Coated Film with Excimer Light

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Materials Sciences and Applications 2020年第1期11卷 58-69页

作者： Tomoji Ohishi Kousei ichikawa Satoki Isono Department of Applied Chemistry Faculty of Engineering Shibaura Institute of Technology Toyosu Koto-ku Tokyo Japan

Flexible electronics have been recently paid much attention. A flexible substrate (Organic resin film) is indispensable component for flexible devices. Though PET film is low-cost organic film, low heat-resistance of PET film limits its application as a flexible device substrate. We have developed heat-resistant PET which does not deteriorate even at 190°C heat treatment for one hour. An excimer light was irradiated onto a polysi-lazane (PHPS: perhydropolysilane)-coated film to form a dense silicon-dioxide (SiO2) layer on a PET film, and the heat-resistance property of the formed film was examined. Changes of surface state and cross-sectional structure of the formed film due to heat treatment were investigated by scanning electron microscope (SEM) and transmission electron microscope (TEM). Compared to normal PET, which is deteriorated and whitened by heat treatment of about 110°C - 120°C, the SiO2-coated PET film maintains transparency and does not deteriorate after heat treatment at 180°C - 190°C for one hour. This high heat resistance is due to a dense SiO2 film formed on the surface that prevents surface precipitation and crystallization of low-molecular-weight oligomers (which are the cause of thermal degradation of PET). It is expected that enhancing the heat resistance of PET—which has high versatility and low cost—to about 180°C to 190°C will allow SiO2-film-coated PET to be developed as a film substrate for flexible devices.

关键词： Polysilazane Dense Silica Thin Film Photo-Irradiation Excimer Light Heat Resistance PET Film Flexible Electronics

Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第33期17卷 3802-3809页

作者： Tomohisa Takagi Yuji Naito Kazuhiko Uchiyama Toshimitsu Okuda Katsura Mizushima Takahiro Suzuki Osamu Handa Takeshi Ishikawa Nobuaki Yagi Satoshi Kokura Hiroshi ichikawa Toshikazu Yoshikawa Department of Molecular Gastroenterology and Hepatology Graduate School of Medical ScienceKyoto Prefectural University of Medicine6028566 KyotoJapan

AIM:To investigate the efficacy of rebamipide in a rat model of colitis and restitution of intestinal epithelial cells in ***:Acute colitis was induced with trinitrobenzene sulfonic acid(TNBS)in male Wistar *** received intrarectal rebamipide treatment daily starting on day 7 and were sacrificed on day 14 after TNBS *** distal colon was removed to evaluate the various parameters of ***,wound healing assays were used to determine the enhanced restitution of rat intestinal epithelial(RIE)cells treated with ***:Intracolonic administration of rebamipide accelerated TNBSinduced ulcer *** in the wet weight of the colon after TNBS administration were significantly inhibited by *** wound assay revealed that rebamipide enhanced the migration of RIE cells through phosphorylation of extracellular signalregulated kinase(ERK)and activation of Rho ***:Rebamipide enema healed intestinal injury by enhancing restitution of RIE cells,via ERK *** might be a novel therapeutic approach for inflammatory bowel disease.

关键词：肠上皮细胞伤口愈合结肠炎复原溃疡 Wistar大鼠灌肠治疗大鼠模型

Erratum to “Regardless of the Puncture Angle, a Tuohy Needle with Sand-Blasted Steel at the Tip of the Bevel Is a Valid Needle on the Ultrasonic Images”, [Open Journal of Anesthesiology, 2016, 6, 101-104]

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Anesthesiology 2021年第7期11卷 219-220页

作者： ichikawa Yuki Hironobu Ueshima Akira Kitamura Department of Anesthesiology Saitama Medical University International Medical Center Saitama Japan Department of Anesthesiology Showa University Hospital Tokyo Japan

The original online version of this article (ichikawa Yuki, Ueshima Hironobu, Hiroshi Otake, Akira Kitamura (2016) Regardless of the Puncture Angle, a Tuohy Needle with Sand-Blasted Steel at the Tip of the Bevel Is a Valid Needle on the Ultrasonic Images, 2016, 6, 101-104, https://***/Html/1-1920418_***) unfortunately contains some mistakes. The authors wish to correct the errors in co-authors, Table 1, and Table 2.

关键词： Erratum

Role of the Na^+/K^+/2Cl^- cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第22期20卷 6844-6859页

作者： Atsushi Shiozaki Yoshito Nako Daisuke ichikawa Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Yoshinori Marunaka Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Pathology Kyoto PrefecturalUniversity of MedicineKyoto 602-8566Japan Departments of Molecular Cell Physiology and Bio-Ionomics Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 602-8566Japan Japan Institute for Food Education and Health St. Agnes’ UniversityKyoto 602-8013Japan

AIM:To investigate the role of Na+/K+/2Cl-cotransporter 1(NKCC1)in the regulation of genes involved in cell cycle progression and the clinicopathological significance of its expression in esophageal squamous cell carcinoma(ESCC).METHODS:An immunohistochemical analysis was performed on 68 primary tumor samples obtained from ESCC patients that underwent ***1expression in human ESCC cell lines was analyzed by Western *** experiments were conducted using NKCC1 small interfering RNA,and the effects on cell cycle progression were *** gene expression profiles of cells were analyzed by microarray ***:Immunohistochemical staining showed that NKCC1 was primarily found in the cytoplasm of carcinoma cells and that its expression was related to the histological degree of differentiation of ***1 was highly expressed in KYSE170 *** of NKCC1in these cells inhibited cell proliferation via G2/M phase *** analysis identified 2527 genes with altered expression levels in NKCC1depleted *** analysis showed that the top-ranked canonical pathway was the G2/M DNA damage checkpoint regulation pathway,which involves MAD2L1,DTL,BLM,CDC20,BRCA1,and ***:These results suggest that the expression of NKCC1 in ESCC may affect the G2/M checkpoint and may be related to the degree of histological differentiation of *** have provided a deeper understanding of the role of NKCC1 as a mediator and/or a biomarker in ESCC.

关键词： Na+/K+/2Cl-cotransporter 1 Esophageal cancer Cell

Deep-learning-based quality filtering of mechanically exfoliated 2D crystals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2019年第1期5卷 57-62页

作者： Yu Saito Kento Shin Kei Terayama Shaan Desai masaru Onga Yuji Nakagawa Yuki M.Itahashi Yoshihiro Iwasa Makoto Yamada Koji Tsuda RIKEN Center for Advanced Intelligence Project(AIP) Tokyo 103-0027Japan Department of Computational Biology and Medical Sciences Graduate School of Frontier SciencesThe University of TokyoKashiwa 277-8561Japan Graduate School of Medicine Kyoto UniversityKyoto 606-8501Japan Quantum-Phase Electronics Center(QPEC)and Department of Applied Physics The University of TokyoTokyo 113-8656Japan RIKEN Center for Emergent Matter Science(CEMS) Wako 351-0198Japan Department of Intelligence Science and Technology Kyoto UniversityKyoto 606-8501Japan PRESTO Japan Science and Technology Agency(JST)4-1-8HonchoKawaguchi-shiSaitama 332-0012Japan National Institute for Materials Science(NIMS) Center for Materials Research by Information IntegrationTsukuba 305-0047Japan California NanoSystems Institute University of California at Santa BarbaraSanta BarbaraCA 93106USA

Two-dimensional(2D)crystals are attracting growing interest in various research fields such as engineering,physics,chemistry,pharmacy,and biology owing to their low dimensionality and dramatic change of properties compared to the bulk counter *** the various techniques used to manufacture 2D crystals,mechanical exfoliation has been essential to practical applications and fundamental ***,mechanically exfoliated crystals on substrates contain relatively thick flakes that must be found and removed manually,limiting high-throughput manufacturing of atomic 2D crystals and van der Waals ***,we present a deep-learning-based method to segment and identify the thickness of atomic layer flakes from optical microscopy *** carefully designing a neural network based on U-Net,we found that our neural network based on Unet trained only with the data based on realistically small number of images successfully distinguish monolayer and bilayer MoS2 and graphene with a success rate of 70–80%,which is a practical value in the first screening process for choosing monolayer and bilayer flakes of all flakes on substrates without human *** remarkable results highlight the possibility that a large fraction of manual laboratory work can be replaced by AI-based systems,boosting productivity.

关键词： crystals filtering attracting

OTOTOXIC MODEL OF OXALIPLATIN AND PROTECTION FROM NICOTINAMIDE ADENINE DINUCLEOTIDE

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Otology 2013年第1期8卷 63-71页

作者： DING Dalian JIANG Haiyan FU Yong LI Yongqi Richard Salvi Shinichi Someya masaru Tanokura Center for Hearing and Deafness State University of New York at Buffalo Sixth People’s Hospital Shanghai Oriental Otolaryngology InstituteShanghai Jiao Tong University Xiangya Hospital Central South University Department of Applied Biological Chemistry University of Tokyo The First Officiated Hospital College of MedicineZhejiang University The Third Affiliated Hospital of Sun Yat-Sen University University of Florida

Oxaliplatin, an anticancer drug commonly used to treat colorectal cancer and other tumors, has a number of serious side effects, most notably neuropathy and ototoxicity. To gain insights into its ototoxic profile, oxaliplatin was applied to rat cochlear organ cultures. Consistent with it neurotoxic propensity, oxaliplatin selectively damaged nerve fibers at a very low dose 1 μM. In contrast, the dose required to damage hair cells and spiral ganglion neurons was 50 fold higher (50 μM). Oxailiplatin-induced cochlear lesions initial-ly increased with dose, but unexpectedly decreased at very high doses. This non-linear dose response could be related to depressed oxaliplatin uptake via active transport mechanisms. Previous studies have demon-strated that axonal degeneration involves biologically active processes which can be greatly attenuated by nicotinamide adenine dinucleotide (NAD+). To determine if NAD+would protect spiral ganglion axons and the hair cells from oxaliplatin damage, cochlear cultures were treated with oxaliplatin alone at doses of 10 μM or 50 μM respectively as controls or combined with 20 mM NAD+. Treatment with 10 μM oxaliplatin for 48 hours resulted in minor damage to auditory nerve fibers, but spared cochlear hair cells. However, when cochlear cultures were treated with 10 μM oxaliplatin plus 20 mM NAD+, most auditory nerve fibers were intact. 50 μM oxaliplatin destroyed most of spiral ganglion neurons and cochlear hair cells with apop-totic characteristics of cell fragmentations. However, 50 μM oxaliplatin plus 20 mM NAD+treatment great-ly reduced neuronal degenerations and hair cell missing. The results suggested that NAD+provides signifi-cant protection against oxaliplatin-induced neurotoxicity and ototoxicity, which may be due to its actions of antioxidant, antiapoptosis, and energy supply.

关键词： oxaliplatin apoptosis copper transporter nicotinamide adenine dinucleotide

Prospective real-time evaluation of diagnostic performance using endocytoscopy in differentiating neoplasia from nonneoplasia for colorectal diminutive polyps(≤ 5 mm)

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2018年第4期10卷 96-102页

作者： Takahiro Utsumi Yasushi Sano Mineo Iwatate Hironori Sunakawa Akira Teramoto Daizen Hirata Santa Hattori Wataru Sano Noriaki Hasuike Kazuhito ichikawa Takahiro Fujimori Gastrointestinal Center and Institute of Minimally Invasive Endoscopic Care (iMEC) Sano Hospital Department of Pathology Shinko Hospital

AIM To clarify the diagnostic performance of endocytoscopy for differentiation between neoplastic and nonneoplastic colorectal diminutive *** Patients who underwent endocytoscopy between October and December 2016 at Sano Hospital were prospectively recruited. When diminutive polyps(≤5 mm) were detected, the lesions were evaluated by endocytoscopy after being stained with 0.05% crystal violet and 1% methylene blue. The diminutivepolyps were classified into five categories(EC 1 a, 1 b, 2, 3 a, and 3 b). Endoscopists were asked to take a biopsy from any lesion diagnosed as EC1 b(indicator of hyperplastic polyp) or EC2(indicator of adenoma). We have assessed the diagnostic performance of endocytoscopy for EC2 and EC1 b lesions by comparison with the histopathology of the biopsy specimen. RESULTS A total of 39 patients with 63 diminutive polyps were analyzed. All polyps were evaluated by endocytoscopy. The mean polyp size was 3.3 ± 0.9 mm. Among the 63 diminutive polyps, 60 were flat and 3 were pedunculated. The mean time required for EC observation, including the time for staining with crystal violet and methylene blue, was 3.0 ± 1.9 min. Histopathologic evaluation showed that 13 polyps were hyperplastic and 50 were adenomas. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of EC2 for adenoma compared with EC1 b for hyperplastic polyp were 98.0%, 92.3%, 96.8%, 98.0% and 92.3%, respectively. There were only two cases of disagreement between the endoscopic diagnosis made by endocytoscopy and the corresponding histopathological *** Endocytoscopy showed a high diagnostic performance for differentiating between neoplastic and non-neoplastic colorectal diminutive polyps, and therefore has the potential to be used for "real-time histopathology".

关键词： Endocytoscopy Diagnostic performance Diminutive polyp Endocytoscopic classification Realtime histopathology

Relationship between ghrelin, Helicobacter pylori and gastric mucosal atrophy in hemodialysis patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第47期22卷 10440-10449页

作者： Hitomi ichikawa Mitsushige Sugimoto Yukitoshi Sakao Shu Sahara Naro Ohashi Akihiko Kato Ken Sugimoto Takahisa Furuta Akira Andoh Tadashi Sakao Hideo Yasuda First Department of Medicine Hamamatsu University School of Medicine Hamamastsu Shizuoka 431-3192 Japan Division of Digestive Endoscopy Shiga University of Medical Science Hospital Otsu Shiga 520-2192 Japan Hamana Clinic Hamana Clinic Hamamatsu Shizuoka 434-0037 Japan Blood Purification Unit Hamamatsu University School of Medicine Hamamastsu Shizuoka 431-3192 Japan Center for Clinical Research Hamamatsu University School of Medicine Hamamastsu Shizuoka 431-3192 Japan Department of Gastroenterology Shiga University of Medical Science HospitalOtsu Shiga 520-2192 Japan

AIM To investigate the relationship between plasma ghrelin level, Helicobacter pylori(H. pylori) infection status and the severity of atrophy in hemodialysis *** One hundred eights patients who received hemodialysis and 13 non-hemodialysis H. pylori-negative controlsunderwent gastroduodenoscopy to evaluate the severity of gastric atrophy. Serum levels of pepsinogen(PG) were measured as serum markers of gastric atrophy. H. pylori infection was evaluated by anti-H. pylori IgG antibody, rapid urease test and culture test. We classified H. pylori infection status as non-infection, present infection and past infection. In addition, plasma acyl-ghrelin and desacyl-ghrelin levels were measured by enzyme-linked immunosorbent assay. RESULTS Infection rate of H. pylori was 45.4%(49/108). Acylghrelin level in the non-infection group(39.4 ± 23.0 fmol/ml) was significantly higher than in the past(23.4 ± 19.9 fmol/ml, P = 0.005) and present infection groups(19.5 ± 14.0 fmol/ml, P < 0.001). Furthermore, desacyl-ghrelin level in the non-infection group(353.2 ± 190.2 fmol/ml) was significantly higher than those in the past(234.9 ± 137.5 fmol/ml, P = 0.008) and present infection groups(211.8 ± 124.2 fmol/ml, P < 0.001). Acyl-ghrelin was positively correlated with the PG Ⅰ level and PG Ⅰ/Ⅱ ratio(|R| = 0.484, P < 0.001 and |R| = 0.403, P < 0.001, respectively). Both ghrelins were significantly decreased in accordance with the progress of endoscopic atrophy(both P < 0.001) and acyl-ghrelin was significantly lower in patients with mild, moderate and severe atrophy(24.5 ± 23.1 fmol/ml, 20.2 ± 14.9 fmol/ml and 18.3 ± 11.8 fmol/ml) than in those with non-atrophy(39.4 ± 22.2 fmol/ml, P = 0.039, P = 0.002 and P < 0.001, respectively).CONCLUSION In hemodialysis patients, plasma ghrelin level was associated with the endoscopic and serological severity of atrophy related to H. pylori infection.

关键词： Acyl-ghrelin Desacyl-ghrelin Helicobacter pylori Hemodialysis Pepsinogen

Analysis of Bactericidal Components in Japanese Honeys

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Analytical Chemistry 2020年第8期11卷 309-321页

作者： Koji Karasawa masaru Kato Hidetoshi Arakawa Department of Bioanalytical Chemistry School of Pharmacy Showa University Tokyo Japan

It is known that the factors identified as contributing to the bactericidal activity of honeys are the high sugar concentration, hydrogen peroxide (H2O2) and low pH, and its bactericidal components depend on honey plant and natural environment. Manuka honey has been studied a lot about bactericidal effect. However, since Japanese honeys are mainly used as food, detailed analyzes of bactericidal components and its actions have not been reported. Therefore, we analyzed bactericidal components contained in nine Japanese honeys using Lucigenin-CL-HPLC. As our results, four species components of H2O2, glucose, fructose and methylglyoxal were detected from nine Japanese honeys. The H2O2 concentrations were 4.1 × 10-5 - 1.8 × 10-4 mol/L, the glucose concentrations were 1.4 - 2.8 mol/L, the fructose concentrations were 1.9 - 2.4 mol/L, the methylglyoxal concentrations were 4.0 × 10-3 - 1.6 × 10-2 mol/L. In this study, we confirmed that methylglyoxal is also contained in Japanese honeys, although it is a bactericidal component which is reported to be characteristic of manuka honey. It is considered that the further study of Japanese honeys is useful for more safe use, quality control, and clinical application.

关键词： Japanese Honey Bactericidal Components Hydrogen Peroxide Methylglyoxal Lucigenin-CL-HPLC