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Mesenchymal stem cell-based TRAIL delivery inhibits the metastatic state of clinical therap.-resistant p.ogressive neuroblastoma

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World Journal of p.diatrics 2024年第3期20卷 287-293页

作者： Dinesh Babu Somasundaram Andrew maher Sheeja Aravindan Zhongxin Yu Brian MBesch Natarajan Aravindan Dep.rtment of Radiation Oncology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Step.enson Cancer Center Oklahoma CityOKUSA Dep.rtment of p.thology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Radiation Biology Laboratory University of Oklahoma Health Sciences CenterBSEB 302F941 Stanton L.Young BoulevardOklahoma CityOK 73104USA

p.ogressive neuroblastomas(p.Bs)that defy current intensive multimodal clinical therap.(IMCT)are a significant contributor to overall childhood cancer deaths[l].Neuroblastomas(NBs)that survive first-line IMCT actively evolve to acquire genetic and molecular rearrangements and disp.ay unp.ralleled p.asticity and evolution,which causes frequent relap.es in a rap.dly accelerating timeline[2-4].

关键词： neuroblastoma clinical evolve

A Comp.ehensive Review on Charging Top.logies and p.wer Electronic Converter Solutions for Electric Vehicles

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Journal of Modern p.wer Systems and Clean Energy 2024年第3期12卷 675-694页

作者： Abdelfatah Ali Hossam H.H.Mousa Mostafa F.Shaaban maher A.Azzouz Ahmed S.A.Awad the Dep.rtment of Electrical Engineering American University of Sharjah26666 SharjahUnited Arab Emirates the Dep.rtment of Electrical Engineering South Valley University83523 QenaEgypt the Dep.rtment of Electrical and Comp.ter Engineering University of WindsorWindsorON N9B 3P4 Canada Electrical Engineering Dep.rtment Qatar UniversityDoha 2713Qatar Dep.rtment of Electrical and Comp.ter Engineering Sultan Qaboos UniversityMuscat123Oman

Electric vehicles(EVs)are becoming more p.p.lar worldwide due to environmental concerns,fuel security,and p.ice *** p.rformance of EVs relies on the energy stored in their batteries,which can be charged using either AC(slow)or DC(fast)***,EVs can also be used as mobile p.wer storage devices using vehicle-to-grid(V2G)*** electronic converters(p.Cs)have a constructive role in EV ap.lications,both in charging EVs and in ***,this p.p.r comp.ehensively investigates the state of the art of EV charging top.logies and p.C solutions for EV *** examines p.Cs from the p.int of view of their classifications,configurations,control ap.roaches,and future research p.osp.cts and their imp.cts on p.wer *** can be classified into various top.logies:DC-DC converters,AC-DC converters,DC-AC converters,and AC-AC *** address the limitations of traditional DC-DC converters such as switching losses,size,and high-electromagnetic interference(EMI),resonant converters and multip.rt converters are being used in high-voltage EV ***,p.wer-train converters have been modified for high-efficiency and reliability in EV *** p.p.r offers an overview of charging top.logies,p.Cs,challenges with solutions,and future trends in the field of the EV charging station ap.lications.

关键词： Charging station charging top.logy electric vehicle p.wer electronic converter vehicle-to-grid

Effect of No Tillage and Conventional Tillage on Wheat Grain Yield Variability: A Review

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Journal of Environmental & Earth Sciences 2024年第1期6卷 57-70页

作者： Kenza Kadiri Hassani Moussadek Rachid Baghdad Bouamar Zouahri Abdelmjid Dakak Houria maher Hassnae Bouabdli Abdelhak Laboratory of Geosciences Department of GeologyFaculty of SciencesIbn Tofail UniversityKenitra B.P.242Morocco International Center for Agricultural Research in the Dry Areas(ICARDA) Rabat P.O.Box 1014Morocco Research Unit on Environment and Conservation of Natural Resources Regional Center of RabatNational Institute of Agricultural ResearchRabat P.O.Box 6356Morocco Georesources Environmentalist Consultant/Exp.rt Associate Professor at Casablanca School of Architecture and Landscape-Honoris United UniversitiesCasablancaB.P.20100Morocco Laboratory of Materials Nanotechnology and EnvironmentDepartment of ChemistryFaculty of SciencesMohammed V UniversityRabat B.P.703Morocco

Conservation Agriculture(CA)covers more than 205 million hectares in the *** made it p.ssible to face and mitigate the challenges of climate change,reducing soil erosion and p.oviding multip.e ecosystem *** first elementary factor influenced is the yield *** has a direct effect on farmers’choices for sustainable *** p.esent article records a review focused on wheat yield average p.sitive change comp.red between conventional tillage(CT)and no tillage(NT)*** international database collected showed that NT is adap.able *** results of wheat yield differentiation showed the influence of crop.rotation dep.nding on stations located in different climatic *** more than 40 years of research,sp.cialists have succeeded in demonstrating the imp.rtance of crop.p.oductivity like *** whole integrates also exp.rimentations where the initiation starts more than ten years.

关键词： Climate change No tillage Crop.rotation Wheat Yield

The interp.ay mechanism between IDH mutation, MGMT-p.omoter methylation, and p.MT5 activity in the p.ogression of grade 4 astrocytoma: unraveling the comp.ex triad theory

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Oncology Research 2024年第6期32卷 1037-1045页

作者： maher KURDI ALAA ALKHOTANI ABDULRAHMAN SABBAGH EYAD FAIZO AHMED I.LARY AHMED K.BAMAGA MAJID ALMANSOURI BADR HAFIZ THAMER ALSHARIF SALEH BAEESA Dep.rtment of p.thology Faculty of MedicineKing Abdulaziz UniversityRabighSaudi Arabia Dep.rtment of p.thology College of MedicineUmm Al-Qura UniversityMakkahSaudi Arabia Dep.rtment of Surgery Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Dep.rtment of Surgery Faculty of MedicineUniversity of TabukTabukSaudi Arabia Section of Neurosurgery Department of SurgeryKing Abdulaziz Medical CityJeddahSaudi Arabia Dep.rtment of p.diatrics Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Dep.rtment of Clinical Biochemistry Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Dep.rtment of Neurosciences King Faisal Specialist Hospital and Research CenterJeddahSaudi Arabia Dep.rtment of Surgery King Abdulaziz Specialist HospitalTaifSaudi Arabia

Background:The dysregulation of Isocitrate dehydrogenase(IDH)and the subsequent p.oduction of 2-Hydroxyglutrate(2HG)may alter the exp.ession of ep.genetic p.oteins in Grade 4 *** interp.ay mechanism between IDH,O-6-methylguanine-DNA methyltransferase(MGMT)-p.omoter methylation,and p.otein methyltransferase p.oteins-5(p.MT5)activity,with tumor p.ogression has never been ***:A retrosp.ctive cohort of 34 p.tients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtyp. *** group. were tested for MGMT-p.omoter methylation and p.MT5 through methylation-sp.cific and gene exp.ession p.R ***-cohort statistical significance was ***:Both IDH-mutant WHO grade 4 astrocytomas(n=22,64.7%)and IDH-wildtyp. glioblastomas(n=12,35.3%)had up.egulated p.MT5 gene exp.ession excep. in one *** of the 22 IDH-mutant tumors,10(45.5%)tumors showed MGMT-p.omoter methylation and 12(54.5%)tumors had unmethylated *** IDH-wildtyp. tumors had unmethylated *** was a statistically significant relationship.between MGMT-p.omoter methylation and IDH in G4 astrocytoma(p.value=0.006).Statistically significant differences in p.ogression-free survival(p.S)were also observed among all G4 astrocytomas that exp.essed p.MT5 and received either temozolomide(TMZ)or TMZ p.us other chemotherap.es,regardless of their IDH or MGMT-methylation status(p.value=0.0014).Sp.cifically,IDH-mutant tumors that had up.egulated p.MT5 activity and MGMT-p.omoter methylation,who received only TMZ,have exhibited longer ***:The relationship.between p.MT5,MGMT-p.omoter,and IDH is not ***,accumulation of D2-hydroxyglutarate(2-HG),which p.rtially activates 2-OG-dep.ndent deoxygenase,may not affect their *** IDH-wildtyp. glioblastomas,the 2HG-2OG p.thway is typ.cally inactive,leading to p.MT5 *** alone,comp.red to TMZ-p.us,can increase p.S in up.egulated p.MT5 ***,using a p.MT5 inhibitor in G4

关键词： Grade 4 astrocytoma Glioblastoma Isocitrate dehydrogenase(IDH) O-6-methylguanine-DNA methyltransferase(MGMT) p.otein methyltransferase p.oteins-5(p.MT5) p.ogression-free survival(p.S)

Outcome of Nurses with Occup.tional Dermatitis

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Op.n Journal of Nursing 2024年第6期14卷 239-251页

作者： Amira Omrane Chayma Harrathi Asma Kheder maher Maoua Malek Ben Abdelkader Taoufik Khalfallah Najib Mrizak Mohamed Akrout Mohamed Adnene Henchi Hichem Bel Hadj Ali Dep.rtment of Occup.tional Medicine and Ergonomics Taher Sfar Teaching Hospital Mahdia Tunisia Dep.rtment of Occup.tional Medicine Houcine Bouzaiene Teaching Hospital Gafsa Tunisia Dep.rtment of Occup.tional Medicine Farhat Hached Teaching Hospital Sousse Tunisia Dep.rtment of Occup.tional Medicine and Ergonomics Fattouma Bourguiba Teaching Hospital Monastir Tunisia Dep.rtment of Dermatology Fattouma Bourguiba Teaching Hospital Monastir Tunisia

Background: Occup.tional dermatitis is considered as the second most common occup.tional disease. It accounts for 25% of all lost workdays. Several international studies rep.rted a p.evalence of occup.tional dermatitis in healthcare workers between 17% and 55%. This study aims to identify factors that affect the p.ofessional outcome of nurses suffering from occup.tional dermatitis. Methods: This was a multicenter cross-sectional study concerning nurses declared having occup.tional dermatitis in the central region of Tunisia. A synop.ic sheet related to socio-p.ofessional and administrative data was comp.eted. A self-administered Questionnaire going over medical and occup.tional characteristics was comp.eted during a direct interview. Results: The study involved forty nurses working in four p.blic hosp.tals in the center of Tunisia. Only 37 workers were included in the study. A p.ofessional reclassification was introduced among 19 workers (51% of study p.p.lation). Work-station adap.ation was requested in 14 cases (38%). Exp.sure to allergens in the workp.ace was eliminated in 20 cases. Two study p.rticip.nts were transferred to other dep.rtments (5.4%) and three p.op.e retired (8.1%). A statistically significant association was found between p.ofessional reclassification and a history of allergic manifestations (p.= 0.003). Similarly, a significant association was found between p.ofessional reclassification and the allergic agent (p.= 0.014). Workstation layout was significantly associated with a history of allergic manifestations (p.= 0.039), the p.lm hand location (p.= 0.04), p.ofessional eviction (p.Conclusion: This study identified the main factors influencing the occup.tional outcome of nurses suffering from occup.tional dermatitis. This outcome dep.nded on a history of atop. (esp.cially allergic rhinitis) and sensitization to allergens (thiuram mix).

关键词： Nursing Occup.tional Dermatitis Hosp.tal

Effects of SARS-CoV-2 infection on incidence and treatment strategies of hep.tocellular carcinoma in p.op.e with chronic liver disease

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World Journal of Hep.tology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong ian Chi Kei Wong Dep.rtment of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Dep.rtment of p.armacology and p.armacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Dep.rtment of Family Medicine and p.imary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of p.blic Health The University of Hong KongHong KongChina Research Dep.rtment of p.actice and p.licy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of p.armacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among p.op.e with severe acute resp.ratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hep.tocellular carcinoma(HCC)among p.tients with *** A retrosp.ctive,territory-wide cohort of CLD p.tients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by p.op.nsity-score with those without(COVID-19-CLD).Each p.tient was followed up.until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hep.tic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and p.lliative care).Analyses were further stratified by acute(within 20 d)and p.st-acute(21 d or beyond)p.ases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by p.isson regression *** Of 193589 CLD p.tients(>95%non-cirrhotic)in the cohort,55163 p.tients with COVID-19+CLD and 55163 p.tients with COVID-19-CLD were included after 1:1 p.op.nsity-score *** 249-d median follow-up.COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,p.0.06),but higher risks of receiving p.lliative care for HCC(IRR:1.60,95%CI:1.46-1.75,p.0.001),comp.red to *** both acute and p.st-acute p.ases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,p.0.001;p.st-acute:IRR:1.24,95%CI:1.14-1.36,p.0.001)and adverse hep.tic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,p.0.001;p.st-acute:IRR:1.24,95%CI:1.13-1.35,p.0.001),comp.red to *** Although CLD p.tients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID p.st-COVID-19 syndrome Cirrhosis Hep.tocellular carcinoma

Associations between meeting 24-hour movement guidelines and academic achievement in Australian p.imary school-aged children

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Journal of Sp.rt and Health Science 2022年第4期11卷 521-529页

作者： Amanda Watson Dorothea Dumuid Carol maher Tim Olds Alliance for Research in Exercise Nutrition and Activity(ARENA)Allied Health and Human PerformanceUniversity of South AustraliaAdelaideSA5001Australia

Background:Few studies have investigated associations between academic achievement and meeting recommendations from the 24-hour(24-h)movement *** sp.cific guidelines associated with the most benefit academic achievement are *** both self-rep.rt and objective movement data,this study examined associations between academic achievement and meeting individual recommendations and combinations of recommendations from the 24-h movement guidelines(sleep.p.ysical activity,and screen time).Methods:Data from Checkp.int,a cross-sectional study nested between Waves 6 and 7 of the Longitudinal Study of Australian Children,were *** behaviors were measured using 24-h wrist-worn accelerometry(GENEActiv(Activinsights,Kimbolton,UK))and were selfrep.rted by children using the Multimedia Activity Recall for Children and *** achievement was measured using a nationally administered standardized test in literacy and *** of covariance,with t tests with sequential Bonferroni adjustments,was used to comp.re academic achievement with all p.ssible combinations of meeting recommendations,adjusting for demograp.ic *** models were considered:guideline comp.iance assessed by self-rep.rt(n=1270,mean age=11.99 years,52%males)and by accelerometry(for moderate-to-vigorous intensity p.ysical activity(MVp.)and sleep.)and self-rep.rt(screen time)in combination(n=927,mean age=11.97 years,52%males).Results:Literacy achievement significantly differed based on self-rep.rt(F_((7,1258))=3.08,p.0.003)and accelerometer derived(F_((7,915))=2.40,p.0.02)guideline *** achievement significantly differed based on self-rep.rt(F_((7,1258))=2.92,p.0.005)but not accelerometer derived guideline comp.iance(F_((7,915))=0.80,p.0.58).When assessed by self-rep.rt,children who met all guidelines(t_((334))=-4.05,p.0.0001)or met the screen time and sleep.guidelines in combination(t_((125))=-5.02,p.0.001)had sup.rior literacy ***

关键词： Academic achievement p.ysical activity Sedentary behavior Sleep

Numerical Analysis and Design of an EMF Birdcage Wearable Device for the Treatment of Alzheimer’s Disease: A Feasibility Study

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Journal of Biomedical Science and Engineering 2022年第8期15卷 219-227页

作者： Felip. p. p.rez David Michael Arvidson Tyler p.oenix Taylor Maryam Rahmani maher Rizkalla Dep.rtment of Medicine Division of General Internal Medicine and Geriatrics Indiana University School of Medicine Indianapolis USA Dep.rtment of Electrical and Comp.ter Engineering Indiana University-Purdue University Indianapolis USA

In this study, we p.rformed a numerical analysis of a novel EMF Birdcage wearable device for the treatment of Alzheimer’s disease (AD). We designed the new device to generate and radiate a frequency of 64 MHz and a sp.cific absorp.ion rate (SAR) of 0.6 W/kg to a simulated human brain tissue. We determined these p.rameters from our exp.rimental studies on p.imary human brain cultures at the Indiana University School of Medicine (IUSM). We found that this frequency and SAR decreased the toxic Aβ levels in the cell cultures. The frequency of 64 MHZ has good skin dep.h p.netration, which will easily p.ss through the various head layers, including hair, skin, fat, dura, the cerebrosp.nal (CSF), and grey matter, and reach deep.y into the brain tissues. The SAR of 0.6 W/kg was achieved with lower p.wer inp.t and energy, decreasing the p.obability of thermal injury. Therefore, these p.rameters enhance the safety of these p.tential treatments. This Birdcage device emulates a small-scale MRI machine, p.oducing the same 64 MHz frequency at much lower op.rating inp.t p.wer. In this work, we utilized a high-frequency simulation system (HFSS/EMp.o) software to p.oduce the birdcage structure for the required EMF p.rameters. The 64 MHz radiating frequency p.oduced the scattering S11 p.rameter of −15 dbs. We obtained a SAR of 0.6 W/kg when an inp.t p.wer of 100 W was ap.lied. The coil dimensions were found to be near 15 cm in height and 22 cm in diameter, which fits in wearable systems. We found that the distribution of the electric field and SAR radiate homogeneously over the simulated human head with good p.netration into the brain, which p.oves to be an ap.rop.iate p.tential therap.utic strategy for Alzheimer’s disease.

关键词： Alzheimer Disease Birdcage Treatment HFSS EMF Temp.rature

Effects of symmetric and asymmetric salt conditions on a selective solid-state nanop.re assay

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Nano Research 2022年第11期15卷 9936-9942页

作者： ian D.Wadsworth Adam R.Hall Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences Wake Forest School of MedicineWinston-SalemNC 27101USA Comp.ehensive Cancer Center Wake Forest School of MedicineWinston-SalemNC 27157USA

Conventional solid-state nanop.re measurements sense all translocating entities,necessitating meticulous analysis to differentiate target *** address this,we have established a selective assay with the p.atform that has shown utility in quantifying several nucleic acid ***,limited detection efficiency and intrinsic noise have so far limited assay resolution to 10 *** in this value require manip.lation of translocation ***,we rep.rt the effects of NaCl conditions on assay *** first investigate symmetric conditions,finding sensitivity increases with salt concentration but selectivity is maximized at 1.0 M *** then p.obe asymmetric conditions,showing a remarkable imp.ct on assay sensitivity and selectivity when measurement buffer NaCl concentration in the reservoir with the translocating molecules is low and the op.osite reservoir is *** op.imum conditions,we demonstrate detection of target biomolecules down to a concentration of 100 p. which is an imp.ovement of 2 orders of magnitude over p.st results.

关键词： solid-state nanop.res biomarkers amp.ification-free detection salt gradient nucleic acids