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insect Science 2011年第3期18卷 282-288页

作者： Jaehyun kim Yonggyun kim Department of Bioresource Sciences Andong National University Andong Korea

An entomopathogenic bacterium, Xenorhabdus nematophila, has been known to induce significant immunosuppression of target insects by inhibiting immune-associated phospholipase A2 （PLA2）, which subsequently shuts down biosynthesis of eicosanoids that are critical in immune mediation in insects. Some metabolites originated from the bacterial culture broth have been identified and include benzylideneacetone, proline-tyrosine and acetylated phenylalanine-glycine-valine, which are known to inhibit enzyme activity of PLA2 extracted from hemocyte and fat body. This study tested their effects on digestive PLA2 of the beet armyworm, Spodoptera exigua. Young larvae fed different concentrations of the three metabolites resulted in significant adverse effects on larval development even at doses below 100 #g/mL. in particular, they induced significant reduction in digestive efficiency of ingested food. All three metabolites significantly inhibited catalytic activity of digestive PLA2 extracted from midgut lumen of the fifth instar larvae at a low micromolar range. These results suggest that the inhibitory activities of the three bacterial metabolites on digestive PLA2 of S. exigua midgut may explain some of their oral toxic effects.

关键词： digestion midgut phospholipase A2 Spodoptera exigua Xenorhabdus nematophila

Review of the current targeted therapies for non-small-cell lung cancer

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world Journal of Clinical Oncology 2014年第4期5卷 576-587页

作者： kim-Son H Nguyen Joel w Neal Heather wakelee Division of Oncology Department of Medicine Stanford University School of MedicineStanford CA 94305 United States Division of Oncology Department of Medicine Stanford University School of Medicine StanfordCA 94305 United States

The last decade has witnessed the development of oncogene-directed targeted therapies that have significantly changed the treatment of non-small-cell lung cancer(NSCLC). in this paper we review the data demonstrating efficacy of gefitinib, erlotinib, and afatinib, which target the epidermal growth factor receptor(EGFR), and crizotinib which targets anaplastic lymphoma kinase(ALK). we discuss the challenge of acquired resistance to these small-molecular tyrosine kinase inhibitors and review promising agents which may overcome resistance, including the EGFR T790 Mtargeted agents CO-1686 and AZD9291, and the ALKtargeted agents ceritinib(LDK378), AP26113, alectinib(CH/RO5424802), and others. Emerging therapies directed against other driver oncogenes in NSCLC including ROS1, HER2, and BRAF are covered as well. The identification of specific molecular targets in a significant fraction of NSCLC has led to the personalized deployment of many effective targeted therapies, with more to come.

关键词： Lung cancer Non-small cell lung cancer Targeted therapies Epidermal growth factor receptor Epidermal growth factor receptor Anaplastic lymphoma kinase Anaplastic lymphoma kinase Acquired resistance

Rapid synthesis of MoS_(2)-Ag nanocomposites via photoreduction for optical tuning and surface-enhanced Raman scattering applications

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Journal of Materiomics 2023年第2期9卷 229-234页

作者： Yoonkyung Lee Eunpa kim Hyeongkeun kim Kyunghoon kim School of Mechanical Engineering Sungkyunkwan UniversitySuwon16419Republic of Korea Samsung Electronics Semiconductor R&DAdvanced Manufacturing Engineering TeamPyeongtaek17786Republic of Korea Korea Electronics Technology institute Seongnam13509Republic of Korea

Semiconductoremetal nanocomposites have been widely investigated to modify the intrinsic properties of materials used for optoelectronic devices and sensing *** this study,a method for rapid synthesis of MoS_(2)-Ag nanocomposites via laser-assisted photoreduction was *** the photoreduction process,we used AgNO_(3)solution as a metal *** laser irradiation,Ag ions were easily reduced on MoS_(2)by photo-generated electrons from MoS_(2).The optical properties of MoS_(2)-Ag nanocomposites were easily controlled by simple adjustment of the photoreduction *** investigate the surface-enhanced Raman scattering(SERS)effect of the MoS_(2)-Ag nanocomposites,the SERS spectra of methylene blue(MB)on MoS_(2)-Ag nanocomposites were measured,and the nanocomposites were found to enhance the Raman scattering intensity of MB up to~***,the laser-assisted photoreduction method has great potential for rapid synthesis and optical tuning of semiconductoremetal nanocomposites.

关键词： Molybdenum disulfide(MoS2) Silver(Ag) Photoreduction Optical tuning Surface-enhanced Raman scattering(SERS)

A review on technologies with electricity generation potentials using liquified natural gas regasification cold energy

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Frontiers in Energy 2023年第3期17卷 332-379页

作者： Muhammad Tauseef NASiR Mirae kim Jaehwa LEE Seungho kim Kyung Chun kim School of Mechanical Engineering Eco-friendly Smart Ship Parts Technology Innovation CenterPusan National UniversityBusan 46241South Korea School of Mechanical Engineering Pusan National UniversityBusan 46241South Korea Korea Gas Corporation Daegu 41062South Korea

in modern times,worldwide requirements to curb greenhouse gas emissions,and increment in energy demand due to the progress of humanity,have become a serious *** such scenarios,the effective and efficient utilization of the liquified natural gas(LNG)regasification cold energy(RCE),in the economically and environmentally viable methods,could present a great opportunity in tackling the core issues related to global warming across the *** this paper,the technologies that are widely used to harness the LNG RCE for electrical power have been *** systems incorporating,the Rankine cycles,Stirling engines,Kalina cycles,Brayton cycles,Allam cycles,and fuel cells have been ***,the economic and environmental studies apart from the thermal studies have also been ***,the discussion regarding the systems with respect to the regassification pressure of the LNG has also been *** aim of this paper is to provide guidelines for the prospective researchers and policy makers in their decision making.

关键词： liquified natural gas cold energy power generation

Re-visiting supersymmetric Janus solutions: a perturbative construction

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Chinese Physics C 2020年第7期44卷 43-54页

作者： Nakwoo kim Se-Jin kim Department of Physics and Research institute of Basic Science Kyung Hee UniversitySeoul 02447Republic of Korea

we construct holographic Janus solutions,which describe a conformal interface in the theory of M2-branes,in four-dimensional gauged supergravities using a perturbative *** particular,we study three Einsteinscalar systems and their BPS equations,which are derived by Bobev,Pilch,and warner(2014).The actions of our interest are all consistent truncations of D=11 supergravity,chosen to be invariant under SO(4)×SO(4),SU(3)×U(1)×U(1),and G2 symmetry subgroups of SO(8).The utility of our semi-analytic result is illustrated by the calculation of minimal area surface and the associated holographic entanglement entropy.

关键词： holography Janus solutions supergravity entanglement entropy

in-situ electrochemical functionalization of carbon materials for high-performance Li–O2 batteries

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Journal of Energy Chemistry 2020年第9期29卷 7-13,I0001页

作者： Jungwon Kang Jin Min kim Do Youb kim Jungdon Suk Jaekook kim Dong wook kim Yongku Kang Department of Advanced Materials Science and Engineering Mokpo National University61 dorim-ri1666 Yeongsan-roCheonggye-myeonMuan-gunJeonnamSouth Korea Center for Advanced Battery Materials Advanced Materials DivisionKorea Research Institute of Chemical Technology(KRICT)141 Gajeong-RoYuseong-GuDaejeon 305-600South Korea Department of Materials Science and Engineering Chonnam National University300 Yongbong-dongBukguGwangju 500-757South Korea

The development of effective synthetic routes is important to manifest proper nature of specific ***-situ electrochemical functionalization possesses great advantages over conventional routes,especially facile way and leading to reaching elaborate sites of functional ***,we demonstrate the preparation of functionalized carbons by in-situ electrochemical reduction in an argon atmosphere for application in low-cost,environmentally benign,and high-performance oxygen-electrodes for non-aqueous Li-O2 batteries.A Li-O2 battery with functionalized carbon shows a high discharge capacity(100 times that of pristine carbon),high power and cycling *** outstanding performance is attributed to the high O2 affinity of the functionalized carbon surface that facilitates the formation of soluble and diffusible superoxide intermediates by the reduction of the remaining O2 competing with surface growth for Li2O2 formation.

关键词： Lithium-oxygen battery High areal capacity Functionalization of carbon Electrochemistry

investigation of operation and degradation mechanisms in ZnTeSe blue quantum-dot light-emitting diodes by identifying recombination zone

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Nano Research 2024年第7期17卷 6527-6533页

作者： Oul Cho Sujin Park Hogeun Chang Jiwhan kim Jaekwon kim Sungwoo kim Taehyung kim Jeonghun Kwak Department of Electrical and Computer Engineering Inter-university Semiconductor Research Centerand Soft Foundry InstituteSeoul National UniversitySeoul 08826Republic of Korea Material Research Center Samsung Advanced Institute of TechnologySuwonGyeonggi-do 16419Republic of Korea

ZnTeSe quantum dots(QDs),recognized as promising eco-friendly blue electroluminescent emitters,remain under-explored in light-emitting diode(LED)***,to elucidate the operation and degradation mechanisms of ZnTeSe blue QD-LEDs,stacked ZnTeSe QD layers with discernable luminescence are designed by varying Te doping concentrations,and the recombination zones(RZs)of the blue QD-LEDs are *** RZs are identified near the hole-transport layer(HTL),confirmed by angular-dependent electroluminescence measurements and optical *** addition,in order to investigate carrier dynamics in the process of recombination,the transient electroluminescence(tr-EL)signals of the dichromatic QD-LEDs are *** a result,it is inferred that the RZ initially formed near the electron-transport layer(ETL)due to the high injection barriers of ***,due to the fast electron mobility,the RZ shifts toward the HTL as the operating current *** the device lifetime tests,the RZ remains stationary while the photoluminescence(PL)corresponding to the RZ undergoes a substantial decrease,indicating that the degradation is accelerated by the concentrated *** this study contributes to a deeper understanding of the operational mechanisms of ZnTeSe blue QD-LEDs.

关键词： quantum dots light-emitting diodes degradation recombination zones carrier dynamics

innovative confocal laser method for exact dioptric power measurement of intraocular lens implants invited Paper

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Chinese Optics Letters 2008年第12期6卷 876-878页

作者： ilko K.ilev Robert w.Faaland Do-Hyun kim Robert H.James Don Calogero Office of Science and Engineering Laboratories Center for Devices and Radiological Health U.S.Food and Drug Administration10903 New Hampshire AvenueSilver Spring Office of Device Evaluation Center for Devices and Radiological Health U.S.Food and Drug Administration9200 Corporate BoulevardRockville

we present a novel confocal laser method （CLM） for precise testing of the dioptric power of both positive and negative intraocular lens （iOL） implants. The CLM principle is based on a simple fiber-optic confocal laser design including a single-mode fiber coupler that serves simultaneously as a point light source used for formation of a collimated Gaussian laser beam, and as a highly sensitive confocal point receiver. The CLM approach provides an accurate, repeatable, objective, and fast method for iOL dioptric power measurement over the range from 0 D to greater than ±30 D under both dry and in-situ simulated conditions.

关键词： Crystalline lens Fiber optic couplers Gaussian beams intraocular lenses Laser beams Single mode fibers

Using relief texture for interactive and tangible virtual environments

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第12期9卷 1656-1665页

作者： Junae kim Seonhyung SHiN Gerard Jounghyun kim Digital Contents Division Electronic and Telecommunications Research InstituteDaejon 305-700 Korea Department of Computer Science and Engineering Korea UniversitySeoul 136-713 Korea

This paper first introduces a way to improve interactivity with high polygon count virtual objects through the "mixed" use of image-based representation within one object. That is, both 3D polygonal and image-based representations are maintained for an object, and switched for rendering depending on the functional requirement of the object. Furthermore, in order to reduce the popping effect and provide smooth and gradual transition during the object representation switch, the object is subdivided with the subdivided parts possibly represented differently, i.e., using 3D models or images. As for the image-based representation, the relief texture (RT) method is used. in particular, through the use of the mixed representation, a new way called TangibleScreen is pro-posed to provide object tangibility by associating the image-based representation with a physical prop (projecting the RTs) in a selective and flexible way. Overall, the proposed method provides a way to maintain an interactive frame rate with selective perceptual details in a large-scale virtual environment, while allowing the user to interact with virtual objects in a tangible way.

关键词： Relief texture (RT) image-based modeling Tangible interaction Virtual environment

Boosting overall water splitting by incorporating sulfur into NiFe(oxy)hydroxide

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Journal of Energy Chemistry 2022年第1期31卷 364-371,I0010页

作者： Chiho kim Seong Hyun kim Seunghun Lee ilyeong Kwon Seong Hyun kim Shinho kim Changgyu Seok Yoo Sei Park Yangdo kim Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea BK21 Four Innovative Graduate Education Program for Global High-tech Materials&PartsPusan National UniversityBusan 46241Republic of Korea Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH).Pohang 37673Republic of Korea

Developing highly active and cost-effective electrocatalysts for enhancing the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)is a significant challenge for overall water ***-incorporated nickel iron(oxy)hydroxide(S-NiFeOOH)nanosheets were directly grown on commercial nickel foam using a galvanic corrosion method and a hydrothermal *** incorporation of sulfur into NiFeOOH enhanced the catalytic activity for the HER and OER in 1 M KOH *** enhanced catalytic activity is attributed to the change in the local structure and chemical states due to the incorporation of *** performance for overall water splitting was achieved with an alkaline water *** was realized by employing S-NiFeOOH as a bifunctional electrocatalyst,thereby outperforming a water electrolyzer that requires the usage of precious metal electrocatalysts(i.e.,Pt/C as the HER electrocatalyst and irO_(2) as the OER electrocatalyst).Moreover,when driven by a commercial silicon solar cell,an alkaline water electrolyzer that uses S-NiFeOOH as a bifunctional electrocatalyst generated hydrogen under natural *** study shows that S-NiFeOOH is a promising candidate for a large-scale industrial implementation of hydrogen production for overall water splitting because of its low cost,high activity,and *** addition,the solar-driven water electrolyzer using S-NiFeOOH as a bifunctional electrocatalyst affords the opportunity for developing effective and feasible solar power systems in the future.

关键词： Overall water splitting Hydrogen production Sulfur incorporated NiFe(oxy)hydroxide Electrocatalysts Solar-driven water splitting