检索结果-南通市图书馆

Je-Chun-Jun induced apoptosis of human cervical carcinoma HeLa cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2004年第10期 132-139页

作者： Han-jung CHAE,Kyung-mi park,Geun-youn LEE,Gi-seup JEONG,hyung-rae park,hyung-min KIM,Soo-wan CHAE,Shim-keun YOO,hyung-ryong KIM Department of Pharmacology and the Institute of Cardiovascular Research School of Medicine Chonbuk National University Jeonju Chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan Chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Pharmacology College of Oriental Medicine Kyung Hee University Seoul South Korea Department of Pharmacology and the Institute of Cardiovascular Research School of Medicine Chonbuk National University Jeonju Chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan Chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea

AIM: To study the mechanism of Je-Chun-Jun (JCJ)-inducing the apoptosis of the human cervical carcinoma, HeLa cells. METHODS: The cell viability was assessed using MTT assay. The optical density was measured at 570 nm. The caspase activity was measured using 50 mmol/L of fluorogenic substrate, AC-DEVD-AMC (caspase-3), AC-VEID-AMC (caspase-8) or AC-LEHD-AFC (caspase-9). To confirm the expression of proteins, Western blotting was performed. To detect the characteristic of apoptosis chromatin condensation, HeLa cells were stained with Hoechst 33258 in the presence of JCJ. For the cell cycle analysis, HeLa cells were incubated with Propidium iodide (PI) solution. Fluorescence intensity of cell cycle was measured using flow cytometry system. RESULTS: The loss of viability occurred following the exposure of 10 g/L JCJ. Cells treated with 10 g/L JCJ for 3 d exhibited the apoptotic morphology (brightly blue-fluorescent condensed nuclei by Hoechst 33258-staining) and the reduction of cell volume. Cells incubated

关键词： herbal medicine apoptosis p38 MAPK HeLa cells

Omni-functional simultaneous interfacial treatment for enhancing stability and outgassing suppression of lithium-ion batteries

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第7期94卷 677-687页

作者： Youbean Lee Chanjoo park Kyoungmin min Kwangjin park Department of Mechanical Engineering Gachon UniversityGyeonggi-do 13120Republic of Korea Department of Battery Engineering Gachon UniversityGyeonggi-do 13120Republic of Korea School of Mechanical Engineering Soongsil UniversitySeoul 06978Republic of Korea

Ni-rich layered oxides in lithium-ion batteries have problems with gas generation and electrochemical performance reduction due to residual lithium's reaction on the surface with the *** address this issue,in this study,the Acid solvent evaporation(AsE)method has been proposed as a potential method to remove residual lithium while promoting the formation of a new LiNO_(3)-derived coating layer on the cathode *** reduction of residual lithium using the ASE method and the construction of a LiNO_(3)-derived coating layer suppresses gas evolution caused by the side effects of the electrolyte,improves electrochemical performance,and improves thermal stability by facilitating the smooth movement of lithium ***,the structural stability and resistance change due to the LiNO_(3)-derived coating layer effects is guaranteed through cycling and DCIR of the pouch *** a result,compared to Pristine,the capacity retention of coin cells increased by 8%after 100 cycles,and pouch cells increased by 25%after 160 *** addition,after cycling the pouch cell,CO_(2) gas has significantly reduced by about 30%compared to Pristine using gas *** ASE method effectively forms a robust LiNO_(3)-derived coating layer on the cathode active material,which helps minimize electrolyte reactivity,suppress ,CO_(2) emissions,enhance surface structure stability,improve thermal stability,and improveoverallbatteryperformance.

关键词： Lithium-ion batteries Ni-rich NCM Acid solvent evaporation LiNO_(3)-derived coating Gasevolution

Real-Time Tunable Gas Sensing Platform Based on SnO_(2) Nanoparticles Activated by Blue Micro-Light-Emitting Diodes

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第12期16卷 103-119页

作者： Gi Baek Nam Jung-El Ryu Tae Hoon Eom Seung Ju Kim Jun min Suh Seungmin Lee Sungkyun Choi Cheon Woo Moon Seon Ju park Soo min Lee Byungsoo Kim Sung Hyuk park Jin Wook Yang Sangjin min Sohyeon park Sung Hwan Cho Hyuk Jin Kim Sang Eon Jun Tae hyung Lee Yeong Jae Kim Jae Young Kim Young Joon Hong Jong-In Shim hyung-Gi Byun Yongjo park Inkyu park Sang-Wan Ryu Ho Won Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Research Laboratory of Electronics Department of Mechanical EngineeringMassachusetts Institute of TechnologyCambridgeMA 02139USA ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Display Materials Engineering Soonchunhyang UniversityAsan 31538Republic of Korea Department of Photonics and Nanoelectronics BK21 FOUR ERICA-ACE CenterHanyang University ERICAAnsan 15588Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok 25913Republic of Korea Advance Institute of Convergence Technology Seoul National UniversitySuwon 16229Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Physics Chonnam National UniversityGwangju 500-757Republic of Korea

Micro-light-emitting diodes(μLEDs)have gained significant interest as an activation source for gas sensors owing to their advantages,including room temperature operation and low power ***,despite these benefits,challenges still exist such as a limited range of detectable gases and slow *** this study,we present a blueμLED-integrated light-activated gas sensor array based on SnO_(2)nanoparticles(NPs)that exhibit excellent sensitivity,tunable selectivity,and rapid detection with micro-watt level power *** optimal power forμLED is observed at the highest gas response,supported by finite-difference time-domain ***,we first report the visible light-activated selective detection of reducing gases using noble metal-decorated SnO_(2)*** noble metals induce catalytic interaction with reducing gases,clearly distinguishing NH3,H2,and ***-time gas monitoring based on a fully hardwareimplemented light-activated sensing array was demonstrated,opening up new avenues for advancements in light-activated electronic nose technologies.

关键词： Micro-LED Gas sensor array Low power consumption Metal decoration Real-time detection

Construction of a High‑Performance Composite Solid Electrolyte Through In‑Situ Polymerization within a Self‑Supported Porous Garnet Framework

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第5期16卷 56-70页

作者： An‑Giang Nguyen min‑Ho Lee Jaekook Kim Chan‑Jin park Department of Materials Science and Engineering Chonnam National University77 Yongbong‑roBuk‑guGwangju 61186South Korea

Composite solid electrolytes(CSEs)have emerged as promising candidates for safe and high-energy–density solid-state lithium metal batteries(SSLMBs).However,concurrently achieving exceptional ionic conductivity and interface compatibility between the electrolyte and electrode presents a significant challenge in the development of high-performance CSEs for *** overcome these challenges,we present a method involving the in-situ polymerization of a monomer within a self-supported porous Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZT)to produce the *** synergy of the continuous conductive LLZT network,well-organized polymer,and their interface can enhance the ionic conductivity of the CSE at room ***,the in-situ polymerization process can also con-struct the integration and compatibility of the solid electrolyte–solid electrode *** synthesized CSE exhibited a high ionic conductivity of 1.117 mS cm^(-1),a significant lithium transference number of 0.627,and exhibited electrochemical stability up to 5.06 V ***/Li+at 30℃.Moreover,the Li|CSE|LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cell delivered a discharge capacity of 105.1 mAh g^(-1) after 400 cycles at 0.5 C and 30℃,corresponding to a capacity retention of 61%.This methodology could be extended to a variety of ceramic,polymer electrolytes,or battery systems,thereby offering a viable strategy to improve the electrochemical properties of CSEs for high-energy–density SSLMBs.

关键词： Scalable tape-casting method Self-supported porous Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12) Composite solid electrolyte LiF-and B-rich interphase layers

M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： Ha Eun Shin Jun-Hyeok Han Seungyong Shin Ga-Hyun Bae Boram Son Tae-hyung Kim Hee Ho park Chun Gwon park Wooram park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor Tumor microenvironment(TME)

Long-term outcomes of very low birth weight infants with intraventricular hemorrhage:a nationwide population study from 2011 to 2019

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第7期20卷 692-700页

作者： Joonsik park Sook-Hyun park Yu-ra Kwon So Jin Yoon Joo Hee Lim Jung Ho Han Jeong Eun Shin Ho Seon Eun min Soo park Soon min Lee Department of Pediatrics Yonsei University College of Medicine211 Eonjuro GangnamguSeoul 06273Republic of Korea

Background Advancements in neonatal care have increased preterm infant survival but paradoxically raised intraventricular hemorrhage(IVH)*** study explores IVH prevalence and long-term outcomes of very low birth weight(VLBW)infants in Korea over a *** Using Korean National Health Insurance data(NHIS,2010-2019),we identified 3372 VLBW infants with IVH among 4,129,808 live ***-related claims data,encompassing diagnostic codes,diagnostic test costs,and administered procedures were sourced from the NHIS *** results of the developmental assessments are categorized into four groups based on standard deviation(SD)*** characteristics and complications were compared among the *** regression models were employed to identify significant changes in the incidence of complications and to calculate odds ratios with corresponding 95%confidence intervals for each risk factor associated with mortality and morbidity in ***-term growth and development were compared between the two groups(years 2010-2013 and 2014-2017).Results IVH prevalence was 12%in VLBW and 16%in extremely low birth weight(ELBW)*** the past decade,IVH rates increased significantly in ELBW infants(P=0.0113),while mortality decreased(P=0.0225).Major improvements in certain neurodevelopmental outcomes and reductions in early morbidities have been observed among VLBW infants with *** percent of the population received surgical treatments such as external ventricular drainage(EVD)or a ventriculoperitoneal(VP)shunt,with the choice of treatment methods remaining consistent over *** IVH with surgical intervention group exhibited higher incidences of delayed development,cerebral palsy,seizure disorder,and growth failure(height,weight,and head circumference)up to 72 months of age(P<0.0001).Surgical treatments were also significantly associated with abnormal developmental screening test *** The neurodevelopmental outcomes of infa

关键词： Cerebral intraventricular hemorrhage Developmental Hydrocephalus Mortality Posthemorrhagic ventricular dilatation Surgery

Validity of fatty liver prediction scores for diagnosis of fatty liver by Fibroscan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 353-360页

作者： Seogsong Jeong Sun Jae park Seong Kyun Na Sang min park Byung-Cheol Song Yun Hwan Oh Department of Biomedical Sciences Seoul National University Graduate SchoolSeoul 03080Korea Department of Biomedical Informatics CHA University School of MedicineCHA UniversitySeongnam 13488Korea Department of Internal Medicine Inje University College of MedicineSeoul 50834Korea Department of Family Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 03080Korea Department of Internal Medicine Jeju National University HospitalJeju National University College of MedicineJeju 63241Korea Department of Family Medicine Jeju National University HospitalJeju National University College of MedicineJeju 63241Korea Department of Family Medicine Chung-Ang University Gwangmyeong HospitalChung-Ang University College of MedicineGwangmyeong 14353Korea

Background:The Korea National Health and Nutrition Examination Survey nonalcoholic fatty liver disease(K-NAFLD)score was recently developed with the intent to operationally define nonalcoholic fatty liver disease(NAFLD).However,there remained an external validation that confirmed its diagnostic performance,especially in patients with alcohol consumption or hepatitis virus ***:Diagnostic accuracy of the K-NAFLD score was evaluated in a hospital-based cohort consisting of 1388 participants who received Fibroscan®.Multivariate-adjusted logistic regression models and the contrast estimation of receiver operating characteristic curves were used for validation of the K-NAFLD score,fatty liver index(FLI),and hepatic steatosis index(HSI).Results:K-NAFLD-moderate[adjusted odds ratio(aOR)=2.53,95%confidence interval(CI):1.13-5.65]and K-NAFLD-high(aOR=4.14,95%CI:1.69-10.13)groups showed higher risks of fatty liver compared to the K-NAFLD-low group after adjustments for demographic and clinical characteristics,and FLI-moderate and FLI-high groups revealed aORs of 2.05(95%CI:1.22-3.43)and 1.51(95%CI:0.78-2.90),*** addition,the HSI was less predictive for Fibroscan®-defined fatty *** K-NAFLD and FLI also demonstrated high accuracy in the prediction of fatty liver in patients with alcohol consumption and chronic hepatitis virus infection,and the adjusted area under curve values were comparable between K-NAFLD and ***:Externally validation of the K-NAFLD and FLI showed that these scores may be a useful,noninvasive,and non-imaging modality for the identification of fatty *** addition,these scores also predicted fatty liver in patients with alcohol consumption and chronic hepatitis virus infection.

关键词： Nonalcoholic fatty liver disease Fatty liver index Hepatic steatosis index

Indolocarbazole-Based Small Molecule Cathode-Active Material Exhibiting Double Redox for High-Voltage Li-Organic Batteries

在线全文

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第5期7卷 90-98页

作者： Hyunji park Hyojin Kye Jong-Sung Lee Young-Chang Joo Dong Joo min Bong-Gi Kim Soo Young park Ji Eon Kwon Laboratory for Supramolecular Optoelectronic Materials (LSOM) Department of Materials Science and Engineering Research Institute of Advanced Materials (RIAM) Seoul National University Functional Composite Materials Research Center Jeonbuk Institute of Advanced Composite Materials Korea Institute of Science and Technology (KIST) Department of Organic and Nano System Engineering Konkuk University Department of Materials Science and Engineering Seoul National University Department of JBNU-KIST Industry Academia Convergence Research Jeonbuk National University

Most organic electrode materials （OEMs） for rechargeable batteries employ n-type redox centers, whose redox potentials are intrinsically limited <3.0 V versus Li+/Li. However, p-type materials possessing high redox ... 详细信息

Most organic electrode materials （OEMs） for rechargeable batteries employ n-type redox centers, whose redox potentials are intrinsically limited ming well at 100-C rate.

关键词： composite electrodes flexible batteries indolocarbazoles organic rechargeable batteries p-type

Driving inward growth of lithium metal in hollow microcapsule hosts by heteroatom‐controlled nucleation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Carbon Energy 2024年第8期6卷 262-272页

作者： Siwon Kim Hong Rim Shin Ki Jae Kim min‐Sik park Jong‐Won Lee Division of Materials Science and Engineering Hanyang UniversitySeoulRepublic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of Energy Science Sungkyunkwan UniversitySuwonRepublic of Korea Department of Advanced Materials Engineering for Information and Electronics Integrated Education for Frontier Science and Technology(BK21 Four)Kyung Hee UniversityYonginRepublic of Korea

The application of Li metal anodes in rechargeable batteries is impeded by safety issues arising from the severe volume changes and formation of dendritic Li ***‐dimensional hollow carbon is receiving increasing attention as a host material capable of accommodating Li metal inside its cavity;however,uncontrollable and nonuniform deposition of Li remains a *** this study,we synthesize metal–organic framework‐derived carbon microcapsules with heteroatom clusters(Zn and Ag)on the capsule walls and it is demonstrated that Ag‐assisted nucleation of Li metal alters the outward‐to‐inward growth in the microcapsule ***‐incorporated microcapsules are prepared via chemical etching of zeolitic imidazole framework‐8 polyhedra and are subsequently decorated with Ag by a galvanic displacement reaction between Ag^(+)and metallic *** introduced Ag significantly reduces the energy barrier and increases the reaction rate for Li nucleation in the microcapsule host upon Li *** combined electrochemical,microstructural,and computational studies,we verify the beneficial role of Ag‐assisted Li nucleation in facilitating inward growth inside the cavity of the microcapsule host and,in turn,enhancing electrochemical *** study provides new insights into the design of reversible host materials for practical Li metal batteries.

关键词： hollow carbon hosts lithium metal batteries lithium plating metal-organic frameworks nucleation