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Bispectral index monitoring as an adjunct to nurse-administered combined sedation during endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2012年第43期18卷 6284-6289页

作者： Se Young Jang hyun Gu Park Min Kyu jung Chang Min Cho Soo Young Park Seong Woo Jeon Won Young Tak Young Oh Kweon Sung Kook Kim Young Hoon Jeon Department of Internal Medicine Kyungpook National University School of Medicine Daegu 700-721 South Korea Department of Anesthesiology and Pain Medicine Kyungpook National University School of Dentistry Daegu 700-721 South Korea

AIM:To determine whether bispectral index (BIS) monitoring is useful for propofol administration for deep sedation during endoscopic retrograde cholangiopancreatography (ERCP). METHODS:Fifty-nine consecutive patients with a variety of reasons for ERCP who underwent the procedure at least twice between 1 July 2010 and 30 November 2010. This was a randomized cross-over study, in which each patient underwent ERCP twice, once with BIS monitoring and once with control monitoring. Whether BIS monitoring was done during the first or second ERCP procedure was random. Patients were intermittently administered a mixed regimen including midazolam, pethidine, and propofol by trained nurses. The nurse used a routine practice to monitor sedation using the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale or the BIS monitoring. The total amount of midazolam and propofol used and serious side effects were compared between the BIS and control groups. RESULTS:The mean total propofol dose administered was 53.1 ± 32.2 mg in the BIS group and 54.9 ± 30.8 mg in the control group (P = 0.673). The individual propofol dose received per minute during the ERCP procedure was 2.90 ± 1.83 mg/min in the BIS group and 3.44 ± 2.04 mg in the control group (P = 0.103). The median value of the MOAA/S score during the maintenance phase of sedation was comparable for the two groups. The mean BIS values throughout the procedure (from insertion to removal of the endoscope) were 76.5 ± 8.7 for all 59 patients in using the BIS monitor. No significant differences in the frequency of < 80% oxygen saturation, hypotension (< 80 mmHg), or bradycardia (< 50 beats/min) were observed between the two study groups. Four cases of poor cooperation occurred, in which the procedure should be stopped to add the propofol dose. After adding the propofol, the procedure could be conducted successfully (one case in the BIS group, three cases in the control group). The endoscopist rated patient sedation as exc

关键词： Conscious sedation Bispectral index monitors Pancreatic neoplasm Endoscopic retrograde cholangiopancreatography

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Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis

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World Journal of Gastroenterology 2016年第41期22卷 9205-9213页

作者： Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong hyun Sinn Eileen L Yoon Young Kul jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 06591South Kerea Institute of Medical Science Hanyang UniversitySeoul 04763South Kerea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Kerea Department of Internal Medicine Inje University Sanggye Paik HospitalSeoul 01757South Kerea Department of Internal Medicine Korea University Ansan HospitalAnsan 15355South Korea Department of Internal Medicine Hallym University Chuncheon Sacred Heart HospitalChuncheon 24253South Kerea Department of Internal Medicine Gyeongsang National University HospitalJinju 52727South Kerea Department of Internal Medicine Catholic University of Daegu School of MedicineDaegu 42472South Kerea Department of Internal Medicine Ewha Womans University School of MedicineSeoul 07985South Kerea Department of Internal Medicine Konkuk University School of MedicineSeoul 05030South Kerea Department of Internal Medicine Hallym University Sacred Heart HospitalAnyang 14068South Kerea Department of Internal Medicine Yonsei University Wonju College of MedicineWonju 26426South Kerea Department of Internal Medicine Chungnam National UniversitySchool of MedicineDaejeon 35015South Kerea Department of Internal Medicine Soonchunhyang University College of MedicineSeoul 04401South Kerea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheon 14584South Kerea Department of Internal Medicine Hanyang University Guri HospitalGuri 11923South Kerea Department of Internal Medicine Yeungnam University College of MedicineDaegu 42415South Kerea Department of Internal Medicine Inje University Haeundae Paik-HospitalInje University College of MedicineBusan 48108South Kerea Institute of Lifestyle Medicine Yonsei University Wonju College of MedicineWonju 26426South Kerea 不详

AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic *** We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and *** Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d *** CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis.

关键词： Acute-on-chronic liver failure Alcoholic hepatitis Mortality Prognosis Scoring system

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Positive regulation of cell proliferation by the miR-1290-EHHADH axis in hepatocellular carcinoma

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Cancer Communications 2024年第6期44卷 705-709页

作者： Jinkwon Lee Gyeonghwa Kim Tae-Su Han Eunsun jung Taesang Son Kwangho Kim Kiyoon Kwon Yuna Roh Tae Young Ryu In Hwan Tae Yunsang Kang Byungheon Lee Yu Rim Lee Soo Young Park Won Young Tak Dae-Soo Kim Mi-Young Son Keun Hur hyun-Soo Cho Stem Cell Convergence Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeonRepublic of Korea Department of Bioscience Korea University of Science and TechnologyDaejeonRepublic of Korea Department of Biochemistry and Cell Biology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Biological Science Sungkyunkwan UniversitySuwonRepublic of Korea Department of Internal Medicine School of MedicineKyungpook National University HospitalDaeguRepublic of Korea Department of Biomedical Convergence Science and Technology School of ConvergenceKyungpook National UniversityDaeguRepublic of Korea

Hepatocellular carcinoma(HCC)is the second most common cancer and the third leading cause of cancer-related death worldwide[1].Recently,HCC incidence and mortality rates have further increased due to changes in the global social environment and dietary habits[2].HCC is treated by surgical resection or combination chemotherapy,but the overall survival rate of HCC patients has not improved,and the recurrence rate is still high due to strong invasiveness and resistance to chemotherapy[3].

关键词： chemotherapy mortality cancer

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Analysis of Skin Parameters of Korean Men According to the Parts of the Body for Integumentary Physiotherapy Research

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Health 2018年第4期10卷 467-486页

作者： So-jung Kim Ju-hyun Kim Jeong-Uk Lee Mee-Young Kim Lim-Kyu Lee Byoung-Sun Park Seung-Min Yang Won-Deok Lee Ji-Woong Noh Yong-Sub Shin Doo-Ho Kim Il-hyun Kim junghwan Kim Laboratory of Health Science & Nanophysiotherapy Department of Physical Therapy Graduate School Yongin University Yongin South Korea Department of Physical Therapy College of Health Welfare Wonkwang Health Science University Iksan South Korea Department of Physical Therapy College of Health Science Honam University Gwangju South Korea The Team of Safety and Quality Management Yeongwol Combined Cycle Power Plant Division Korea Southern Power Plant Busan South Korea Department of Physical Therapy College of Public Health & Welfare Yongin University Yongin South Korea

Studies have demonstrated that some cutaneous biophysical properties vary with the part of the body. The results to date of skin conditions in human skin of multiple parts of the body have not yet been well established. In this study, we assessed the differences in the skin’s sebum, moisture, pores, wrinkles, pigmentation, and elasticity of each body part in Korean men in their 20s. A total of 34 healthy men were enrolled. A Skin Diagnosis Meter was used to measure the skin’s surface sebum, moisture, pores, wrinkles, pigmentation, and elasticity of each body part. The sebum content was significantly higher on the face than at other sites. Moisture was significantly high on the feet. Pores were significantly high on the face. Wrinkles were significantly high on the face. Pigmentation was high on the face and neck, but not significantly. Elasticity was significantly high on the hands. In the correlation analysis results, sebum and pore were positively correlated, but sebum and moisture and wrinkle and elasticity were negatively correlated. For nearly the first time, this study resulted in systematic reference values for standardized biophysical measuring methods and body parts reflecting the skin physiology of healthy South Korean men. The results show that skin’s surface sebum, moisture, pores, wrinkles, pigmentation, and elasticity vary with the part of the body.

关键词： Sebum Moisture Pores Wrinkles Pigmentation Elasticity Total Body

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Characteristic Dermatologic Changes in the Condition of Skin after Ultrasonic Stimulation in Healthy Korean Men

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Journal of Cosmetics, Dermatological Sciences and Applications 2018年第4期8卷 195-206页

作者： So-jung Kim Seung-Min Yang Ju-hyun Kim Jeong-Uk Lee Mee-Young Kim Lim-Kyu Lee Byoung-Sun Park Won-Deok Lee Ji-Woong Noh Yong-Sub Shin Doo-Ho Kim Il-hyun Kim junghwan Kim Laboratory of Health Science & Nanophysiotherapy Department of Physical Therapy Graduate School Yongin University Yongin Republic of Korea Department of Physical Therapy College of Health Welfare Wonkwang Health Science University Iksan Republic of Korea Department of Physical Therapy College of Health Science Honam University Gwangsan-gu Republic of Korea The Team of Safety and Quality Management Yeongwol Combined Cycle Power Plant Division Korea Southern Power Plant Yeongwol-gun Republic of Korea Department of Physical Therapy College of Public Health & Welfare Yongin University Yongin Republic of Korea

The aim of our study was to recognize different skin conditions of the face and neck using six biophysical parameters and to show the changes after the application of ultrasonic stimulation (US). We assessed the differences in the sebum, moisture, pores, wrinkles, pigmentation, and elasticity of the skin in the face and neck regions. A total of 30 healthy men in their 20s were enrolled. We used a skin diagnosis meter to assess the state of the skin. The sebum and pores of the face were more significant than in the neck. The amount of moisture in the U-zone was significantly higher than in other areas. Statistical differences were found between the pre-and post-measure-ment values in the sebum, moisture, wrinkles and pigmentation. Wrinkles and pigmentation were positively correlated. Our data showed that the changes in skin condition are associated with external stimulants. The effect of US on skin may differ depending on the part of the body, and some biophysical properties of skin vary depending on the location on the body.

关键词： Ultrasonic Stimulation Korean Men Skin

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Association of chronic viral hepatitis B with insulin resistance

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World Journal of Gastroenterology 2012年第42期18卷 6120-6126页

作者： Jeong Gyu Lee Sangyeoup Lee Yun Jin Kim Byung Mann Cho Joo Sung Park hyung Hoi Kim JaeHun Cheong Dong Wook Jeong Yu hyun Lee Young Hye Cho Mi Jin Bae Eun jung Choi Department of Family Medicine Pusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Family Medicine Medical Research InstitutePusan National University HospitalBusan 602-739South Korea Medical Education Unit Pusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Family Medicine Clinic Yangsan Pusan National University HospitalBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Preventive Medicine and Occupational Medicine Pusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Family Medicine Dong-A University Medical CenterBusan 602-715South Korea Department of Laboratory Medicine Biomedical Informatics UnitPusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Molecular Biology College of Natural SciencesPusan National UniversityBusan 602-739South Korea

AIM:To investigate the relationship between chronic viral hepatitis B(CVHB) and insulin resistance(IR) in Korean ***:A total of 7880 adults(3851 men,4029 women) who underwent a comprehensive medical examination were enrolled in this *** diagnosed with either diabetes mellitus,or any other disorder that could influence their insulin sensitivity,were ***,metabolic risk factors,hepatitis B surface antigen,hepatitis B surface antibody,hepatitis B core antibody,fasting plasma glucose and insulin were measured for all *** model assessment(HOMA),quantitative insulin check index(QUICKI),and Mf fm index were used for determining insulin *** participant was categorized into a negative,recovery,or CVHB *** compare variables between groups,a t-test and/or one-way analysis of variance were *** correlation coefficients were computed to present the association between insulin resistance and other *** logistic regression analysis was used to assess the independent association between CVHB and ***:The mean age of men and women were 48.9 and 48.6 years,*** in the CVHB group had significantly higher waist circumference [(86.0 ± 7.7 cm vs 87.3 ± 7.8 cm,P = 0.004 in men),(78.3 ± 8.6 cm vs 80.5 ± 8.5 cm,P < 0.001 in women)],cystatin C [(0.96 ± 0.15 mg/dL vs 1.02 ± 0.22 mg/dL,P < 0.001 in men),(0.84 ± 0.15 mg/dL vs 0.90 ± 0.16 mg/dL,P < 0.001 in women)],fasting insulin [(5.47 ± 3.38 U/mL vs 6.12 ± 4.62 U/mL,P < 0.001 in men),(4.57 ± 2.82 U/mL vs 5.06 ± 3.10 U/mL,P < 0.001 in women)] and HOMA index [(1.24 ± 0.86 vs 1.43 ± 1.24,P < 0.001 in men),(1.02 ± 0.76 vs 1.13 ± 0.87,P = 0.033 in women)] compared to control *** HOMA index revealed a positive correlation with body mass index(BMI)(r = 0.378,P < 0.001),waist circumference(r =0.356,P < 0.001),percent body fat(r = 0.296,P < 0.001),systolic blood pressure(r = 0.202,P < 0.001),total cholesterol(r = 0.134,P < 0.00

关键词： Hepatitis B Insulin resistance Diabetes mellitus type 2 Metabolic syndrome

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Analysis of Interferential Current Therapy-Induced Skin Changes in Healthy Korean Men

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Natural Science 2018年第11期10卷 436-447页

作者： So-jung Kim Seung-Min Yang Ju-hyun Kim Jeong-Uk Lee Mee-Young Kim Lim-Kyu Lee Byoung-Sun Park Won-Deok Lee Ji-Woong Noh Yong-Sub Shin Doo-Ho Kim Il-hyun Kim Kong-Sook Noh junghwan Kim Laboratory of Health Science & Nanophysiotherapy Department of Physical Therapy Graduate School Yongin Uni-versity Yongin-si Republic of Korea Department of Physical Therapy College of Health Welfare Wonkwang Health Science University Iksan-si Republic of Korea Department of Physical Therapy College of Health Science Honam University Gwangju-si Republic of Korea The Team of Safety and Quality Management Yeongwol Combined Cycle Power Plant Division Korea Southern Pow-er Plant Yeongwol-gun Republic of Korea Department of Physical Therapy College of Public Health & Welfare Yongin University Yongin-si Republic of Korea

We examined the changes in numerous skin conditions before and after the ap-plication of interferential current therapy to various regions of healthy male bodies. In this study, we assessed the differences in the skin’s sebum, moisture levels, pores, wrinkles, pigmentation, and elasticity on the shoulders, lower back, and the knees of Korean males in their 20s. A total of 30 healthy males were in-cluded in the study. We used a skin diagnosis meter as a device for measuring the state of the skin. A statistical difference was found when comparing the pre- and post-measurement values in regards to the moisture levels, wrinkles, and pig-mentation. In the correlation analysis results, the sebum and pigmentation, moisture levels and wrinkles, moisture levels and pigmentation, and moisture levels and elasticity were all positively correlated, respectively. The results of this study partially suggest that a change in skin condition is associated with ex-ternal stimulation. The study also found that the effects of the application of in-terferential current therapy on the various skin conditions may differ depending on the region of the body that the application is conducted as well.

关键词： Interferential Current Therapy Korean Men Skin

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疏水链接枝的PHEA在水溶液中形成的多种自组装体

疏水链接枝的PHEA在水溶液中形成的多种自组装体

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2008（第十届）国际表面活性剂和洗涤剂会议

作者： hyun Jin Lee Eun jung Ahn Kwangsuk Jang Jong-Duk Kim Department of Chemical and Biomolecular Engineering（BK21 Graduate Program） and Center for Ultramicrochemical Process SystemsKAISTDaejeon 305-701Republic of Korea

本研究合成了一系列具有不同亲液侧链接枝率的聚（2-羟乙基天冬酰氨）两亲接枝共聚物,它们直接溶解于水中时可以形成多种形貌的分子自组装体。TEM 观察结果显示球形胶束、蠕虫状胶束、管状网络和囊泡各种聚集体结构的转变与疏水侧链接...

本研究合成了一系列具有不同亲液侧链接枝率的聚（2-羟乙基天冬酰氨）两亲接枝共聚物,它们直接溶解于水中时可以形成多种形貌的分子自组装体。TEM 观察结果显示球形胶束、蠕虫状胶束、管状网络和囊泡各种聚集体结构的转变与疏水侧链接枝率有关,并且这些自组装纳米结构的形成可以用界面自由能和堆积参数理论解释。这是关于梳型两亲接枝共聚物体系自组装体形貌的首次报道。本研究显示了梳型两亲接枝共聚物体系自组装体在生物医药领域的诱人应用前景和直接溶解于水大规模制备分子自组装体的可能。

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Preliminary results of pre-radiation neck dissection in head ＆ neck cancer patients undergoing organ preservation treatment

Preliminary results of pre-radiation neck dissection in head...

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2005国际暨第八届全国头颈肿瘤大会

作者： Kwang hyun Kim J.Hun Hah Woo-Jin Jeong Young-Ho jung Seong Keun Kwon Dae Seog Heo Hong-Gyun Wu Myung-Whun Sung Departments of Otolaryngology-Head ＆ Neck Surgery Departments of Otolaryngology-Head ＆ Neck Surgery Departments of Otolaryngology-Head ＆ Neck Surgery Departments of Otolaryngology-Head ＆ Neck Surgery Departments of Otolaryngology-Head ＆ Neck Surgery Internal Medicine and Radiation Oncology Seoul National University College of MedicineSeoulKorea Departments of Otolaryngology-Head ＆ Neck Surgery

＜正＞ Aim of study:Establish the role of pre-radiation neck dissection in undergoing organ preservation treatment for patients with head ＆ neck squamous cell *** ＆ methods:Thirty-two patients treated at two tertiary referral centersbetween July 1997 and March 2005 were *** had histologically confirmedadvanced head ＆ neck squamous cell carcinoma with proven regional *** treated with organ preservation intent with or without pre-radiation *** induction chemotherapy,15 patients with less than completeresponse in the neck underwent neck dissection prior to definitive radiotherapy,and 17 patients proceded in conventional *** medical record

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The prognostic nutritional index on postoperative day one is associated with one-year mortality after burn surgery in elderly patients

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Burns & Trauma 2021年第1期9卷 603-612页

作者： Young Joo Seo Yu-Gyeong Kong Jihion Yu Ji hyun Park Su-Jin Kim Hee Yeong Kim Young-Kug Kim Department of Anesthesiology and Pain Medicine Hangang Sacred Heart HospitalHallym University College of Medicine12Beodeunaru-ro 7-gilYeongdeungpo-guSeoul 07247Republic of Korea Department of Anesthesiology and Pain Medicine Asan Medical CenterUniversity of Ulsan College of Medicine88Olympic-ro 43-gilSongpa-guSeoul 05505Republic of Korea Department of Anesthesiology and Pain Medicine National Medical Center245EuljiroJung-guSeoul 04564Republic of Korea

Background:Burn injury in elderly patients can result in poor *** nutritional index(PNI)can predict the perioperative nutritional status and postoperative *** aim to evaluate the risk factors,including PNI,for one-year mortality after burn surgery in elderly ***:Burn patients aged≥65 years were retrospectively *** calculated using the following equation:10×serum albumin level(g/dL)+0.005×total lymphocyte count(per mm3).Cox regression,receiver operating characteristic curve and Kaplan–Meier survival analyses were performed to evaluate the risk factors for postoperative one-year ***:Postoperative one-year mortality occurred in 71(37.6%)of the 189 elderly burn *** factors for one-year mortality were PNI on postoperative day one(hazard ratio(HR)=0.872;95%CI=0.812–0.936;p25.5(32.1%vs 75.9%,p*** findings indicate the importance of identifying elderly burn patients with low PNI,thereby reducing the mortality after burn surgery.

关键词： Burn Elderly patients Prognostic nutritional index Mortality Nutrition Geriatric patients

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