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World Journal of Clinical Cases 2022年第24期10卷 8735-8741页

作者： Jeong A Yeom You Seon Song In Sook Lee In Ho han kyung Un Choi Department of Radiology Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Radiology Pusan National University HospitalBusan 49241South Korea Department of Neurosurgery Pusan National University HospitalBusan 49241South Korea Department of Pathology Pusan National University HospitalBusan 49241South Korea

BACKGROUND A malignant melanotic nerve sheath tumor(MMNST),previously known as a melanotic schwannoma,is a rare variant of a peripheral nerve sheath tumor composed of Schwann cells with melanotic *** a few reports of spinal MMNST have been *** SUMMARY In the first case,a 58-year-old woman presented with a history of low back pain and *** resonance imaging(MRI)and computed tomography(CT)of the lumbar spine revealed an intradural extramedullary mass lesion with amorphous linear *** tumor resection was performed and histological examination revealed a psammomatous melanotic *** the second case,a 72-year-old man presented with low back pain and *** of the thoracolumbar spine revealed an intramedullary mass lesion at the T11 vertebral body *** mass lesion was hypointense on T2WI and hyperintense on *** resection was performed and the histologic result was melanotic *** MMNST should be considered in the differential diagnosis when calcification or melanin is seen in an intradural spinal tumor.

关键词： Nerve sheath neoplasm Extramedullary Malignant Melanotic Magnetic resonance imaging Case reports

Mapping the Dementia Research Area at the Micro-Level Using Co-terms Analysis and Positioning for Traditional Herbal Medicine

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Chinese Journal of Integrative Medicine 2014年第9期20卷 706-711页

作者： Bu-Yeo Kim Jong Seok Kang ung-Soo han Won kyung Jeon Herbal Medicine Research Division Korea Institute of Oriental MedicineDaejeon 305-811Republic of Korea Information Analysis Center Korea Institute of S&T InformationSeoul 130-741Republic of Korea Department of Biological Science Konkuk UniversitySeoul 143-701Republic of Korea

Objective： To identify the position of traditional herbal medicine in dementia research field using mapping technology. Methods： Keywords for dementia and traditional herbal medicine for treating dementia were used to extract scientific articles from the Web of Science database from January 2000 to July 2010. A co- occurrence matrix was created based on the concurrent set of author＇s keywords occurring in each scientific article, and technology network maps were created from similarity index matrices. Results： Twenty specialized research areas were identified in the dementia field, and the relationship strength was 0.2-0.6. Many research fields were associated with diagnosis and risk factors for dementia. Additionally, the mechanism or cause of dementia is an actively studied field. Traditional herbal medicine for treating dementia was located on a map near the cortical dementia diagnosis and therapy, and frontotemporal dementia research field with a relationship strength of 0.53 and 0.31-0.33 respectively, which demonstrates that traditional herbal medicine for dementia occupies an independent research area with a relationship to existing scientific research fields. Conclusion： Traditional herbal medicine can provide an alternative and complementary approach for treating dementia as evidenced by a scientific mapping analysis.

关键词： dementia mapping positioning traditional herbal medicine

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Electro-optic tuning in ferroelectric capacitor with photonic crystal nanobeam cavity

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Science China(Information Sciences) 2025年

作者： Tongtong WANG Yong ZhanG Danyang YAO Zhi JIANG Dongxin TAN Jie WEN Qiyu YANG Xuetao GAN Yan LIU Yue HAO Genquan han State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian University Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information TechnologyShaanxi Key Laboratory of Optical Information Technology School of Physical Science and TechnologyNorthwestern Polytechnical University hangzhou Institute of Technology Xidian University

Silicon photonics has provided a platform for the convergency of photonic devices and electronic circuits, facilitating the development of optical telecommunications and optical interconnects on chip[1]. As the basic building block of optical communication systems, electro-optic tuning is expected to be more compact, high bandwidth, energy efficient, and allow for CMOS-compatible fabrication in the future[2]. Resonator-based electro-optic tuning has attracted more and more interest due to the small footprint, enhanced light-matter interactions and high energy efficiency. Compared with microring and microdisk resonators, photonic crystal nanobeam cavities （PCNBCs） realize higher quality factors, stronger light-matter interactions, ultrasmall mode volume and a much larger free spectral range （FSR）[3].

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Endoluminal closure of an unrecognized penetrating stab wound of the duodenum with endoscopic band ligation: A case report

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World Journal of Clinical Cases 2019年第20期7卷 3271-3275页

作者： Dae Hoon Kim hanlim Choi Ki Bae Kim hyo Yung Yun Joung-Ho han Department of Surgery Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644South Korea Department of Internal Medicine Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644South Korea

BACKGROUND A penetrating injury of a hollow viscus is an obvious indication for an exploratory laparotomy,but is not typically an indication for endoscopic *** SUMMARY A 27-year-old man visited the emergency department with a self-inflicted abdominal stab *** to the colon and ileum were detected,but an injury to the second portion of the duodenum was *** the day following admission to our institution,the patient became hemodynamically unstable with massive hematochezia,although there was no evidence of bleeding in the Levin tube or Jackson-Pratt *** thus performed an upper gastrointestinal endoscopy and discovered a missed duodenal injury that was actively *** endoscopic band ligation was performed for hemostasis and closure of the *** patient was subsequently discharged without any *** A penetrating injury of the duodenum can be overlooked,so careful abdominal exploration is very *** a missed duodenal injury is suspected,a cautious endoscopic approach may be helpful.

关键词： Penetrating abdominal injury Endoluminal treatment Unrecognized duodenal injury Case report

Preoperative CA 125 is significant indicator of curative resection in gastric cancer patients

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World Journal of Gastroenterology 2015年第4期21卷 1216-1221页

作者： Dae Hoon Kim hyo Yung Yun Dong Hee Ryu Hye-Suk han Joung-Ho han Soon Man Yoon Sei Jin Youn Department of Surgery Chungbuk National University College of MedicineCheongju 361-763South Korea Internal Medicine Chungbuk National University College of MedicineCheongju 361-763South Korea

AIM: To investigate the correlation among tumor markers, curative resection, and recurrence in gastric ***: The patients with preoperative tumormakers [Carcinoembryonic antigen, Carbohydrate antigen(CA) 19-9, and CA 125] and elective gastrectomy between January 2000 and December 2009 at Chungbuk National University Hospital were enrolled in this study. We analyzed the relationship among the tumor makers, curative resection and recurrence, ***: Among the 679 patients with gastric cancer, curative resection was 93.6%(n = 636) and noncurative resection was 6.4%(n = 43). The independent risk factors for the non-curative resection were tumor location and the positivity of preoperative serum CA 19-9 and CA 125 levels. After curative resection, the independent prognostic risk factors for recurrence in curative resection were gender, stage, and preoperative increased serum CA 125 level(HR = 2.431, P =0.020), in a multivariate analysis. CONCLUSION: Preoperative CA 125 is a useful predictive biomarker for curative resection and prognostic biomarker for recurrence in gastric cancer patients.

关键词： Gastric Cancer Tumor Marker Carcinoembryonic antig

Long-term survival after gastrectomy and metastasectomy for gastric cancer with synchronous bone metastasis

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World Journal of Gastroenterology 2018年第1期24卷 150-156页

作者： Young Jin Choi Dae Hoon Kim Hye Suk han Joung-Ho han Seung-Myoung Son Dong Soo Kim hyo Yung Yun Department of Surgery Chungbuk National University Hospital Chungbuk National University College of Medicine Department of Internal Medicine Chungbuk National University Hospital Chungbuk National University College of Medicine Department of Pathology Chungbuk National University Hospital Chungbuk National University College of Medicine Department of Orthopedics Chungbuk National University Hospital Chungbuk National University College of Medicine

Bone metastasis is a rare event in patients with gastric cancer, but pathologic fracture, paralysis, pain and hematological disorders associated with the bone metastasis may influence the quality of life. We report herein the case of a 53-year-old man who presented with primary remnant gastric cancer with bone metastasis. The patient requested further investigations after detection of a metastatic lesion in the 2 nd lumbar vertebra during evaluation for back pain that had persisted for 3 mo. No other metastatic lesions were detected. He underwent total gastrectomy and palliative metastasectomy to aid in reduction of symptoms, and he received combination chemotherapy with tegafur(S-1) and cisplatin. The patient survived for about 60 mo after surgery. Currently, there is no treatment guideline for gastric cancer with bone metastasis, and we believe that gastrectomy plus metastasectomy may be an effective therapeutic option for improving qualityof life and survival in patients with resectable primary gastric cancer and bone metastasis.

关键词： Stomach neoplasms Gastrectomy Bone neoplasms Neoplasm metastasis Metastasectomy

On the Assimilation of Satellite Sounder Data in Cloudy Skies in Numerical Weather Prediction Models

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Journal of Meteorological Research 2016年第2期30卷 169-182页

作者：李俊王培 han hyojin 李金龙郑婧 Cooperative Institute for Meteorological Satellite Studies University of Wisconsin-Madison Department of Atmospheric & Oceanic Sciences University of Wisconsin-Madison National Satellite Meteorological Center China Meteorological Administration

Satellite measurements are an important source of global observations in support of numerical weather prediction（NWP）.The assimilation of satellite radiances under clear skies has greatly improved NWP forecast ***,the application of radiances in cloudy skies remains a significant *** order to better assimilate radiances in cloudy skies,it is very important to detect any clear field-of-view（FOV） accurately and assimilate cloudy radiances *** progress on both clear FOV detection methodologies and cloudy radiance assimilation techniques are reviewed in this *** on approaches being implemented in the operational centers and studied by the satellite data assimilation research community is *** and future directions for satellite sounder radiance assimilation in cloudy skies in NWP models are also discussed.

关键词： satellite sounder data assimilation cloudy region

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Bile-derived circulating extracellular mi R-30d-5p and mi R-92a-3p as potential biomarkers for cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 41-50页

作者： Hye Sook han Mi Jin Kim Joung-Ho han Jieun Yun Hee kyung Kim Yaewon Yang Ki Bae Kim Seon Mee Park Department of Internal Medicine Chungbuk National University HospitalCheongju 28644Korea Departments of Internal Medicine Chungbuk National University College of MedicineCheongju 28644Korea Department of Pharmaceutical Engineering College of Science EngineeringCheongju UniversityCheongju 28644Korea

Background: Cholangiocarcinoma (CCA) is from cholangiocytes, and therefore bile is a potentially rich source of biomarkers for CCA. The aim of the study was to identify and validate microRNAs (miRNAs) in bile samples that are differentially expressed between benign biliary disease (BBD) and CCA. Methods: Bile samples from 106 patients with obstructive biliary disease were allocated consecutively to a discovery set (10 patients with BBD and 11 with CCA) and then a validation set (48 patients with BBD and 37 with CCA). An miRNA microarray platform was used to screen 1209 miRNAs in the discovery set. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the pro ling results in the discovery and validation sets. In addition, the levels of carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) were determined from patient serum samples. Results: Microarray pro ling showed that miR-30d-5p and miR-92a-3p were signi cantly upregulated in bile from the CCA group compared with those from the BBD group. qRT-PCR results indicated that the expression levels of miR-30d-5p and of miR-92a-3p were signi cantly upregulated in the CCA group compared to the BBD group, validating the miRNA microarray results. Pathway analysis suggested that putative target genes of miR-30d-5p and of miR-92a-3p were involved in CCA-associated signalling path- ways, such as Hippo, Wnt, p53, MAPK, and EGFR. Receiver operating curve analysis revealed that the areas under the curve for bile miR-30d-5p, miR-92a-3p, serum CA19-9, and CEA were 0.730, 0.652, 0.675, and 0.603, respectively, and bile miR-30d-5p showed the best diagnostic performance with a sensitivity of 81.1% and a speci city of 60.5%. Conclusions: The levels of extracellular miR-30d-5p and miR-92a-3p in bile were signi cantly higher in patients with CCA than those in patients with BBD. Bile-derived circulating extracellular miR-30d-5p and miR-92a-3p are potential biomarkers for discr

关键词： Bile Biomarkers Cholangiocarcinoma MicroRNA

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A dry-electrode enabled ECG-on-Chip with arrhythmia-aware data transmission

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Science China(Information Sciences) 2025年

作者： Xinzi XU Yanxing SUO Yang ZHAO Peiyi ZHOU Xiao han Qiao CAI Min WANG Jiajun YUAN Liebin ZHAO Yongfu LI Guoxing WANG Yong LIAN Department of Micro-Nano Electronics and MoE Key Lab of Artificial Intelligence Shanghai Jiao Tong University Pediatric AI Clinical Application and Research Center Shanghai Engineering Research Center of Intelligence Pediatrics (SERCIP) Child Health Advocacy Institute Shanghai Children's Medical Center School of MedicineShanghai Jiao Tong University Shanghai Engineering Research Center of Intelligence Pediatrics (SERCIP) Xin Hua Hospital Affiliate to Shanghai Jiao Tong University School of Medicine

Early detection and treatment of cardiovascular diseases (CVDs) can be significantly enhanced through the use of flexible wearable electrocardiogram (ECG) sensors, potentially reducing CVD-related mortality. This paper introduces an ECG-on-Chip (EoC) solution tailored for flexible ECG sensors, incorporating novel features to address common challenges in wearable ECG technology. The EoC integrates a chopper-stabilized capacitively-coupled instrumentation amplifier (CS-CCIA),ensuring a high common-mode rejection ratio (CMRR) and low noise performance. Performance is further boosted via a positive feedback loop (PFL) and a programmable gain amplifier (PGA) with shared on-chip calibration logic, which enhances input impedance and minimizes gain variability to ensure consistent algorithm performance. Additionally, a secondary chopping technique is employed to further reduce noise, achieving an input-referred noise level of 454 nVrms. The embedded algorithm within the EoC is designed to extract clinically meaningful features, facilitating robust real-time arrhythmia analysis. Fabricated using a 0.18μm CMOS process, the EoC consumes 14.9μW with a supply voltage of 1.2 V. The algorithm’s efficacy has been validated over 0.4 million heartbeats, demonstrating a sensitivity of over 99.7%for R-peak detection and 98.3%for arrhythmia analysis. To demonstrate practical application, the EoC has been integrated with a commercial Bluetooth low energy (BLE)transceiver, forming a wireless arrhythmia monitoring sensor equipped with dry electrodes. This system consumes 292.04μW in arrhythmia-aware transmission mode, supporting 13 days of operation with a 30 mAh thin-film battery.

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领导倾听内涵及其多层次效应

心理科学进展 2025年第1期33卷 25-41页

作者：刘庚韩翼卢俊阳江西农业大学经济管理学院南昌330045 中南财经政法大学工商管理学院武汉430073 江西师范大学历史文化与旅游学院南昌330022

面对错综复杂和快速变化的商业环境,组织要想做出快速响应,领导者的有效倾听显得非常重要。通过文献综述发现,现有研究尚未对领导倾听的概念形成统一界定,且理论视角和研究层次较为单一,这不利于我们深入理解领导倾听的内涵及其多层次... 详细信息

面对错综复杂和快速变化的商业环境,组织要想做出快速响应,领导者的有效倾听显得非常重要。通过文献综述发现,现有研究尚未对领导倾听的概念形成统一界定,且理论视角和研究层次较为单一,这不利于我们深入理解领导倾听的内涵及其多层次效应。事实上,作为一种领导行为,领导倾听不仅会对领导者自身产生影响,而且会给团队及其下属带来影响。因此,本研究基于二元互动情境,从沟通信息和支持员工两方面对领导倾听的内涵进行探索性研究,并从领导力效能的评价对象(领导者、团队、员工)出发,结合多层次、多理论、多研究方法的全景研究范式逐步揭示领导倾听对不同对象的不同效应、黑箱机制及边界条件。本研究不仅开拓了倾听研究的新思路和新视角,而且为企业增强领导倾听的积极效能提供了管理启示。

关键词：领导倾听领导力效能领导工作绩效团队追随行为员工建言

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