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Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

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Research 2024年第1期2023卷 637-649页

作者： Hyun-Kyung So Hyebeen Kim Jinwoo Lee Chang-Lim You Chae-Eun Yun hyeon-ju jeong Eun-ju Jin Yunju Jo Dongryeol Ryu Gyu-Un Bae Jong-Sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

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Novel fabrication techniques for ultra-thin silicon based flexible electronics

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International Journal of Extreme Manufacturing 2024年第4期6卷 116-149页

作者： ju Young Lee jeong Eun ju Chanwoo Lee Sang Min Won Ki jun Yu School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeodaemunguSeoul 03722Republic of Korea Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea YU-Korea Institute of Science and Technology(KIST)Institute Yonsei University50Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Flexible electronics offer a multitude of advantages,such as flexibility,lightweight property,portability,and high *** unique properties allow for seamless applications to curved and soft surfaces,leading to extensive utilization across a wide range of fields in consumer *** applications,for example,span integrated circuits,solar cells,batteries,wearable devices,bio-implants,soft robotics,and biomimetic ***,flexible electronic devices have been developed using a variety of materials such as organic,carbon-based,and inorganic semiconducting ***(Si)owing to its mature fabrication process,excellent electrical,optical,thermal properties,and cost efficiency,remains a compelling material choice for flexible ***,the research on ultra-thin Si in the context of flexible electronics is studied rigorously *** thinning of Si is crucially important for flexible electronics as it reduces its bending stiffness and the resultant bending strain,thereby enhancing flexibility while preserving its exceptional *** review provides a comprehensive overview of the recent efforts in the fabrication techniques for forming ultra-thin Si using top-down and bottom-up approaches and explores their utilization in flexible electronics and their applications.

关键词： flexible electronics silicon fabrication technique top-down approach bottom-up approach

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Machine learning for CO_(2) capture and conversion:A review

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Energy and AI 2024年第2期16卷 512-527页

作者： Sung Eun Jerng Yang jeong Park ju Li Department of Environmental and Energy Engineering The University of Suwon17Wauan-gilBongdam-eupHwaseong-si18323Gyeonggi-doRepublic of Korea Department of Materials Science and Engineering Massachusetts Institute of Technology77 Massachusetts AveCambridge02139MAUnited States of America Department of Nuclear Science and Engineering Massachusetts Institute of Technology77 Massachusetts AveCambridge02139MAUnited States of America MIT-IBM Watson AI Lab 75 Binney StreetCambridge02142MAUnited States of America

Coupled electrochemical systems for the direct capture and conversion of CO have garnered significant attention owing to their potential to enhance energy-and cost-efficiency by circumventing the amine regeneration ***,optimizing the coupled system is more challenging than handling separated systems because of its complexity,caused by the incorporation of solvent and heterogeneous ***,the deployment of machine learning can be immensely beneficial,reducing both time and cost owing to its ability to simulate and describe complex systems with numerous parameters *** this review,we summarized the machine learning techniques employed in the development of CO_(2)capture solvents such as amine and ionic liquids,as well as electrochemical CO_(2)conversion *** optimize a coupled electrochemical system,these two separately developed systems will need to be combined via machine learning techniques in the future.

关键词： Machine learning CO_(2)conversion CO_(2)capture Amine Ionic liquids Single-atom alloys High-entropy catalysts

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Combined Insights from Leachate Structure and Microstructure Characteristics for Eating Quality of Convenience Rice Processed by Super-Heated and Pressurized Steam Technologies

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Rice science 2024年第4期31卷 475-488,I0035,I0036页

作者： Mingyo HA Hyo-Young jeong ju Hun LEE Hyun-jung CHUNG Division of Food and Nutrition Chonnam National UniversityGwangju 61186South Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul 02841South Korea Division of Food Science&Culinary Arts Shinhan UniversityGyeonggi 11644South Korea

Convenience rice has become widely popular due to its easy availability for cooking. This study investigated the starch structure and composition of leachate and the microstructure of reheated convenience rice using novel processing technologies: super-heated steaming(SHS), auto-electric cooking(AEC), and pressurized-steam cooking(PSC). Additionally, the effect of two different target water contents(58% and 63%) was also evaluated. The PSC_63% sample had the highest total solids and amylopectin amount in the leachate. The amylopectin amount in the leachate differed significantly based on the targeted water content. Morphological characterization revealed that the swelling of starch and the coated layer on the surface of rice grains were most pronounced in the PSC_63% sample due to the pressure processing. The textural hardness of the AEC_58% sample was much higher than that of the other samples. The PSC_63% sample had the highest textural adhesiveness value, which can be attributed to the highest amylopectin amount in the leachate. Sensory characterization showed that the PSC_63% sample had the highest glossiness, whiteness, moistness, and overall acceptability. The principal component analysis score plots presented substantial differences in the leachate and textural and sensory characteristics of reheated convenience rice among the different processing technologies.

关键词： reheated convenience rice starch structure leachate multi-scale structure eating quality processing technology

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Understanding acute kidney injury (AKI) in liver cirrhosis from the acute-on-chronic liver failure (ACLF) perspective

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 715-717页

作者： jeong-ju Yoo Sang Gyune Kim Division of Gastroenterology and Hepatology Department of Internal MedicineSoonchunhyang University School of Medicine Bucheon HospitalBucheonKorea

In the field of hepatology,managing complications in patients with liver diseases is of paramount *** these,acute kidney injury(AKI)in patients with acute-on-chronic liver failure(ACLF)stands out due to its prevalence and significant impact on patient outcomes(1,2).AKI in ACLF differs substantially from AKI in simple liver cirrhosis in its clinical significance(3).AKI developed in ACLF is a manifestation of a multi-organ failure syndrome and is closely associated with a high mortality rate and severe complications.

关键词： Acute kidney injury(AKI) acute-on-chronic liver failure(ACLF) biomarker

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Transparent high-performance piezoceramics through pressureless sintering

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Journal of Advanced Ceramics 2024年第5期13卷 561-567页

作者： Hye-Lim Yu Woo-Seok Kang ju-hyeon Lee Temesgen Tadeyos Zate Young-Jin Lee Bo-Kun Koo Dong-Jin Shin Min-Soo Kim Soon-Jong jeong Young Ghyu Ahn Wook Jo Department of Material Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Energy Conversion Research Center Korea Electrotechnology Research InstituteChangwon 51543Republic of Korea MLCC Development Team Component Biz.UnitSamsung Electro-Mechanics Co.Ltd.Suwon 16674Republic of Korea

Piezoelectricity offers an electromechanical coupling that is widely utilized in transducer *** has been a consistent demand for transparent piezoelectric materials for optoelectrical ***,despite the inherent tradeoff between the transparency and the piezoelectricity,numerous strategies have been explored to develop the transparent piezoelectric ***,the most transparent piezoelectric materials developed to date is either a single crystal or materials that achieve transparency via hot-press sintering,limiting its industrial ***,we introduce a novel piezoelectric material that ensures transparency through co-doping and pressureless sintering of polycrystalline *** this study,we employed a compositional optimization approach to enhance the synergistic effect between the transparency and the piezoelectric properties of 0.71Pb(Mg_(1/3)Nb_(2/3))O_(3)–0.29PbTiO_(3)(PMN–0.29PT)*** utilizing the tape casting process for mass production and large-area manufacturing,our Pb_(0.913)La_(0.0145)Sm_(0.0145)(Mg_(1/3)Nb_(2/3))_(0.71)Ti_(0.29)O_(3)(TP2.9)ceramics exhibited over 60%transparency and large piezoelectric coefficient(d33)of 1104 pC/*** material holds considerable promise for a wide range of industrial applications in both the optical and electronic domains.

关键词： piezoelectric ceramics transparency pressureless sintering co-doping tape casting

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Metabolic relationships between marine red algae and algae‑associated bacteria

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Marine Life Science & Technology 2024年第2期6卷 298-314页

作者： Kyung Hyun Kim jeong Min Kim ju Hye Baek Sang Eun jeong Hocheol Kim Hwan Su Yoon Che Ok Jeon Department of Biological Sciences and Biotechnology Hannam UniversityDaejon 34054Republic of Korea Department of Life Science Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biological Sciences Sungkyunkwan UniversitySuwon 16419Republic of Korea

Mutualistic interactions between marine phototrophs and associated bacteria are an important strategy for their success-ful survival in the ocean,but little is known about their metabolic ***,bacterial communities in the algal sphere(AS)and bulk solution(BS)of nine marine red algal cultures were analyzed,and Roseibium and Phycisphaera were identified significantly more abundantly in AS than in *** metabolic features of Roseibium RMAR6-6(isolated and genome-sequenced),Phycisphaera MAG 12(obtained by metagenomic sequencing),and a marine red alga,Porphyridium purpureum CCMP1328(from GenBank),were analyzed ***6-6 has the genetic capability to fix nitrogen and produce B vitamins(B1,B2,B5,B6,B9,and B12),bacterioferritin,dimethylsulfoniopropionate(DMSP),and phenylacetate that may enhance algal growth,whereas MAG 12 may have a limited metabolic capability,not producing vitamins B9 and B12,DMSP,phenylacetate,and siderophores,but with the ability to produce bacitracin,possibly modulating algal *** CCMP1328 lacks the genetic capability to fix nitrogen and produce vitamin B12,DMSP,phenylacetate,and *** was shown that the nitrogen-fixing ability of RMAR6-6 promoted the growth of ***-pureum,and DMSP reduced the oxidative stress of *** metabolic interactions between strain RMAR6-6 and *** CCMP1328 were also investigated by the transcriptomic analyses of their monoculture and *** together,potential metabolic relationships between Roseibium and *** were *** study provides a bet-ter understanding of the metabolic relationships between marine algae and algae-associated bacteria for successful growth.

关键词： Metabolic relationship Marine red algae Symbiotic bacteria Roseibium Phycisphaera Porphyridium

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Can ChatGPT be used to generate scientific hypotheses?

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Journal of Materiomics 2024年第3期10卷 578-584页

作者： Yang jeong Park Daniel Kaplan Zhichu Ren Chia-Wei Hsu Changhao Li Haowei Xu Sipei Li ju Li Department of Nuclear Science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA02139USA Institute of New Media and Communications Seoul National University1 Gwanak-roGwanak-guSeoul08826Republic of Korea Department of Condensed Matter Physics Weizmann Institute of ScienceRehovot7610001Israel Department of Materials Science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA02139USA Global Technology Applied Research JPMorgan Chase237 Park AveNew YorkNY10017USA

We investigate whether large language models can perform the creative hypothesis generation that human researchers regularly *** the error rate is high,generative AI seems to be able to effectively structure vast amounts of scientific knowledge and provide interesting and testable *** future scientific enterprise may include synergistic efforts with a swarm of“hypothesis machines”,challenged by automated experimentation and adversarial peer reviews.

关键词： large language models scientific hypothesis generation generative AI GPT-4

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Enhancement of porcine in vitro embryonic development through luteolin‑mediated activation of the Nrf2/Keap1 signaling pathway

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Journal of Animal Science and Biotechnology 2024年第2期15卷 600-613页

作者： Se-Been Jeon Pil-Soo jeong Min ju Kim Hyo-Gu Kang Bong-Seok Song Sun-Uk Kim Seong-Keun Cho Bo-Woong Sim Futuristic Animal Resource&Research Center(FARRC) Korea Research Institute of Bioscience and Biotechnology(KRIBB)Cheongju 28116Republic of Korea Department of Animal Science College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea Department of Animal Science and Biotechnology College of Agriculture and Life ScienceChungnam National UniversityDaejeon 34134Republic of Korea Department of Functional Genomics University of Science and TechnologyDaejeon 34113Republic of Korea Department of Animal Science Life and Industry Convergence Research Institute(RICRI)College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea

Background Oxidative stress,caused by an imbalance in the production and elimination of intracellular reactive oxygen species(ROS),has been recognized for its detrimental effects on mammalian embryonic ***(Lut)has been documented for its protective effects against oxidative stress in various ***,its specific role in embryonic development remains *** study aims to investigate the influence of Lut on porcine embryonic development and to elucidate the underlying *** After undergoing parthenogenetic activation(PA)or in vitro fertilization,embryos supplemented with 0.5μmol/L Lut displayed a significant enhancement in cleavage and blastocyst formation rates,with an increase in total cell numbers and a decrease in the apoptosis rate compared to the *** on D2 and D6 revealed that embryos with Lut supplementation had lower ROS levels and higher glutathione levels compared to the ***,Lut supplementation significantly augmented mitochondrial content and membrane ***,activation of the Nrf2/Keap1 signaling pathway was observed in embryos supplemented with Lut,leading to the upregulation of antioxidant-related gene transcription *** further validate the relationship between the Nrf2/Keap1 signaling pathway and effects of Lut in porcine embryonic development,we cultured PA embryos in a medium supplemented with brusatol,with or without the inclusion of *** positive effects of Lut on developmental competence were negated by brusatol *** Our findings indicate that Lut-mediated activation of the Nrf2/Keap1 signaling pathway contributes to the enhanced production of porcine embryos with high developmental competence,and offers insight into the mechanisms regulating early embryonic development.

关键词： Luteolin Mitochondrial function Nrf2/Keap1 signaling pathway Oxidative stress Porcine embryo development

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Prevalence of nonalcoholic fatty liver disease in pediatrics and adolescents:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第6期20卷 569-580页

作者： Eun Joo Lee Miyoung Choi Sang Bong Ahn jeong-ju Yoo Seong Hee Kang Yuri Cho Do Seon Song Hong Koh Dae Won Jeon Hye Won Lee Department of Pediatrics Yonsei University College of MedicineSeoulKorea Clinical Evidence Research National Evidence-Based Healthcare Collaborating Agency(NECA)SeoulKorea Department of Internal Medicine Nowon Eulji Medical CenterEulji University College of MedicineSeoulKorea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheonKorea Department of Internal Medicine Sangkye Paek HospitalInje University College of MedicineSeoulKorea Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyangKorea Department of Internal Medicine College of MedicineSt.Vincent's HospitalThe Catholic University of KoreaSuwonKorea Department of Internal Medicine Hanyang University College of MedicineSeoulKorea Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background As childhood obesity escalates worldwide,the prevalence of nonalcoholic fatty liver disease(NAFLD)in pediatric and adolescent populations is also ***,systematic studies and meta-analyses evaluating the prevalence of pediatric NAFLD remain *** The MEDLINE,Korean Medical Database(KMBASE),Embase,Global Health,and Cochrane Library databases were searched from January 1997 to April *** terms included NAFLD or steatosis;nonalcoholic or steatohepatitis;child(ren),adolescent,or teenager;and prevalence,incidence,or epidemiology.A random-effects meta-analysis model was used to estimate the prevalence of pediatric *** A total of 2116 publications were found,of which 62 were included in the *** them,27 reported the prevalence in the general population and 39 in the obese *** worldwide pooled prevalence of pediatric NAFLD was 13%[95%confidence interval(CI)9-18%]in the general population and 47%(95%CI 41%–53%)in the obese *** 16 studies in the general population and 18 in the obese population,NAFLD prevalence varied by *** the general population,the prevalence of NAFLD was 15%(95%CI 8%–23%)in males and 10%(95%CI 6%–15%)in *** the obese population,it was 54%(95%CI 46%–61%)in males and 39%(95%CI 30%–49%)in *** The global prevalence of pediatric NAFLD is rising in both the general and obese *** the increasing rates of childhood obesity,epidemiological studies on the prevalence and incidence of NAFLD are needed.

关键词： Meta-analysis Nonalcoholic fatty liver disease Pediatric Prevalence

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