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Ethanol extract of Chondracanthus tenellus(Harvey)Hommersand attenuates lipopolysaccharide-induced inflammatory and oxidative response by blocking the NF-κB,MAPKs,and PI3K/Akt signaling pathways

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Asian Pacific Journal of Tropical Biomedicine 2021年第10期11卷 450-459页

作者： Da hye Kwon Cheol Park hyesook Lee Su Hyun Hong Gi-Young Kim Hee-Jae Cha Suhkmann Kim Heui-Soo Kim hye-jin hwang Yung Hyun Choi Anti-Aging Research Center Dong-eui UniversityBusan 47340Republic of Korea Department of Biochemistry College of Korean MedicineDong-eui UniversityBusan 47227Republic of Korea Division of Basic Sciences College of Liberal StudiesDong-eui UniversityBusan 47340Republic of Korea Department of Marine Life Sciences School of Marine Biomedical SciencesJeju National UniversityJeju 63243Republic of Korea Department of Parasitology and Genetics College of MedicineKosin UniversityBusan 49104Republic of Korea Department of Chemistry College of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Biological Sciences College of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Food and Nutrition College of NursingHealthcare Sciences&Human EcologyDong-eui UniversityBusan 47340Republic of Korea

Objective:To investigate whether the ethanol extract of Chondracanthus tenellus(Harvey)Hommersand,a type of red algae,could exhibit anti-inflammatory potential in lipopolysaccharide(LPS)-stimulated ***:The ethanol extract of Chondracanthus tenellus was applied to 100 ng/mL LPS-stimulated RAW 264.7 cells,and cell viability,phagocytic ability,levels of pro-inflammatory factors,and the production of reactive oxygen species were *** identify the underlying mechanism of the ethanol extract of Chondracanthus tenellus,the expression of inflammation-regulated genes was ***:The ethanol extract of Chondracanthus tenellus had no cytotoxic effect at concentrations below 300μg/mL,and reduced the LPS-induced production of inflammatory mediators including nitric oxide(NO)and prostaglandin ***,the extract markedly suppressed the expression of inducible NO synthase and cyclooxygenase-2,as well as the production of reactive oxygen *** LPS-induced up-regulation of pro-inflammatory cytokines was attenuated by treatment with the ethanol extract of Chondracanthus tenellus,reducing their extracellular *** Chondracanthus tenellus extract also inhibited LPS-mediated activation of nuclear factor-kappa B(NF-κB).In addition,the phosphorylation of mitogen activated protein kinases(MAPKs)and phosphatidylinositol 3 kinase(PI3K)/Akt was markedly increased by LPS,which was significantly abolished by the Chondracanthus tenellus ***:Our findings indicate that the ethanol extract of Chondracanthus tenellus exhibited potential anti-inflammatory and antioxidant effects through downregulating the NF-κB,MAPKs,and PI3K/Akt signaling pathways in LPS stimulated RAW 264.7 *** ***:Our findings indicate that the ethanol extract of Chondracanthus tenellus exhibited potential anti-inflammatory and antioxidant effects through downregulating the NF-κB,MAPKs,and PI3K/Akt signaling pathways in LPS stimu

关键词： Chondracanthus tenellus Inflammation ROS NF-κB RAW 264.7 cells

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Ethanol extracts of Hizikia fusiforme induce apoptosis in human prostate cancer PC3 cells via modulating a ROS-dependent pathway

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Asian Pacific Journal of Tropical Biomedicine 2020年第2期10卷 78-86页

作者： Eun Ok Choi hyesook Lee Cheol Park Gi-Young Kim Hee-Jae Cha Suhkmann Kim Heui-Soo Kim You-jin Jeon hye jin hwang Yung Hyun Choi Anti-Aging Research Center Dong-eui UniversityBusan 47340Republic of Korea Department of Biochemistry College of Korean MedicineDong-eui UniversityBusan 47227Republic of Korea Department of Molecular Biology College of Natural SciencesDong-eui UniversityBusan 47340Republic of Korea Laboratory of Immunobiology Department of Marine Life SciencesJeju National UniversityJeju 63243Republic of Korea Department of Parasitology and Genetics Kosin University College of MedicineBusan 49267Republic of Korea Department of Chemistry College of Natural SciencesCenter for Proteome Biophysics and Chemistry Institute for Functional MaterialsPusan National UniversityBusan 46241Republic of Korea Department of Biological Sciences College of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Food and Nutrition College of NursingHealthcare Sciences&Human EcologyDong-eui UniversityBusan 47340Republic of Korea

Objective:To investigate whether ethanol extracts of Hizikia fusiforme could induce apoptosis in human prostate cancer PC3 ***:Cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium *** and mitochondrial membrane potential(MMP)were measured using flow cytometry in PC3 *** damage was assessed by nuclear staining and DNA fragmentation *** of apoptosis-associated proteins were determined by Western blotting *** of caspase-3,-8,and-9 were determined by colorimetric ***,intracellular reactive oxygen species(ROS)generation was detected using a flow cytometer and fluorescence ***:Treatment of PC3 cells with ethanol extracts of Hizikia fusiforme inhibited proliferation,which was associated with induction of apoptosis,and accompanied by increased expression of Fas,Fas-ligand(Fas L),Bax and t Bid,and decreased expression of *** addition,ethanol extracts of Hizikia fusiforme reduced c-Flip expression and activated caspase-8,-9 and-3,resulting in an increase in poly(ADP-ribose)polymerase(PARP)***,in the presence of a pan-caspase inhibitor,ethanol extracts of Hizikia fusiforme-mediated growth inhibition and apoptosis were significantly *** extracts of Hizikia fusiforme also destroyed the integrity of mitochondria due to the loss of MMP,leading to cytosolic release of cytochrome ***,the levels of ROS were markedly increased by treatment with ethanol extracts of Hizikia fusiforme,which was significantly suppressed by the ROS scavenger *** investigation of whether ethanol extracts of Hizikia fusiforme-induced apoptosis was related to the generation of ROS was conducted and the results showed that N-acetyl-L-cysteine fully blocked ethanol extracts of Hizikia fusiforme-induced apoptotic events including loss of MMP,activation of caspase-3,the cytosolic release of cytochrome c and ***:E

关键词： Hizikia fusiforme Apoptosis Prostate cancer cells Caspase Reactive oxygen species

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Immunostimulatory effect of ethanol extract of Chondracanthus tenellus in RAW 264.7 macrophages in vitro

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Asian Pacific Journal of Tropical Biomedicine 2021年第6期11卷 263-272页

作者： Cheol Park Da hye Kwon hyesook Lee Su Hyun Hong Gi-Young Kim Hee-Jae Cha Do-Hyung Kim Suhkmann Kim Heui-Soo Kim hye-jin hwang Yung Hyun Choi Division of Basic Sciences College of Liberal StudiesDong-eui UniversityBusan 47340Republic of Korea Anti-Aging Research Center Dong-eui UniversityBusan 47340Republic of Korea Department of Biochemistry College of Korean MedicineDong-eui UniversityBusan 47227Republic of Korea Department of Marine Life Sciences School of Marine Biomedical SciencesJeju National UniversityJeju 63243Republic of Korea Department of Parasitology and Genetics College of MedicineKosin UniversityBusan 49104Republic of Korea Department of Aquatic Life Medicine College of Fisheries SciencePukyong National UniversityBusan 48513Republic of Korea Department of Chemistry College of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Biological Sciences College of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Food and Nutrition College of NursingHealthcare Sciences&Human EcologyDong-eui UniversityBusan 47340Republic of Korea

Objective:To investigate whether ethanol extracts of Chondracanthus tenellus(EECT)could improve immunomodulatory property of murine monocyte/macrophage RAW 264.7 ***:Cell viability,phagocytic ability,and nitric oxide were *** levels of prostaglandin E2 and cytokines were determined using enzyme-linked immunosorbent assay *** of immunoregulatory response protein was detected by Western blotting ***:As the concentration of EECT increased,the morphology of the cells changed to a typical active macrophage shape,and the phagocytic activity increased *** also effectively enhanced the production and secretion of immunomodulatory mediators,such as nitric oxide and prostaglandin E2,and *** addition,compared with the control group,EECT markedly stimulated the expression of Toll-like receptor 4(TLR4)and myeloid differentiation factor 88,one of the TLR4 adapter ***,EECT promoted the nucleus translocation of nuclear factor-kappa B(NF-κB)by increasing the phosphorylation and degradation of the inhibitor of NF-κB-α,indicating activation of the NF-κB signaling ***,similar trends were found in cells treated with lipopolysaccharide as a positive ***:Taken together,the results indicate that EECT has an immunomodulatory effect by increasing the production of immunomodulatory mediators and cytokines through activation of the TLR4/NF-κB signaling *** could be used as a potential candidate for medication or dietary supplements to increase immune activity.

关键词： Chondracanthus tenellus Immunomodulatory property TLR4 NF-κB

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Volatile Flavor Components and the Body Weights of Rats in the Green Tea Added Miner Ingredients

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茶叶 2013年第4期39卷 321-324页

作者： Sung-Hee Choi hye-jin hwang Department of Food Science and Nutrition Blue-Bio Industry RICDongeui-University

In order to change for the good flavor in green tea of middle or low grade,roast naked barley(miner ingredient) was added to *** make tea having functional property,mixed roast naked barley-green tea with one medicinal herb(MH,miner ingredient).This study was performed to investigate the effect of drinking extracts of naked barley- MH- green tea(A group) and adlay- Angelica gigas Nakai- green tea(B group) on the body weights of rats,and volatile flavor components of best effective extract on weight ***-eight male Sprague-Dawley rats divided into six groups were fed five different green tea extracts for 8 *** result obtained in the experiment indicated that the change of body weights of rats was affected by A group,B group and others.A group showed highest reduction rate of body weights(36.40%).Reduction rate of body weights on the B group(10.10%) was much lower than A group(36.40%).Aroma compounds were extracted by the SDE *** concentrated aroma extracts were analyzed and identified by GC and *** main aroma components of the green tea blended with naked barley and MH were 12 pyrazines having roasty note,methyl butanals having sweet note,hexanal having briskness greenish note,and nerolidol and β-ionone having floral note.

关键词：绿茶提取物挥发性成分 Sprague-Dawley 体重大鼠矿工 GC-MS分析挥发性香味成分

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Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee Lee Byoungjoon hwang Sojung Seo Ji‑Hun Seo Dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Bee Venom Acupuncture Induced Skin Patch Discoloration Persisting for More than 3 Years:A Case Report

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Chinese Journal of Integrative Medicine 2021年第10期27卷 774-777页

作者： Ji hye hwang Department of Acupuncture&Moxibustion Medicine College of Korean MedicineGachon UniversitySeongnam(13120)Republic of Korea

Bee venom(BV),one of the most commonly encountered types of animal venom,consists of a mixture of chemical agents that cause allergic reactions in the human body.⑴BV therapy,in which BV is exploited for medicinal purposes,is available worldwide,mainly used in Asia,Eastern Europe,and South America.(2)BV therapy has been applied to treat a diverse set of diseases including various musculoskeletal conditions such as arthritis and rheumatism,arthralgia,chronic recalcitrant neuralgia,(3-5)Parkinson's disease,(6,7)postherpetic neuralgia,(8)and morphea.(9)Although the therapeutic utility of BV has been demonstrated,extensive studies regarding the safety of BV as a therapeutic agent have identified potential side effects,ranging from minor skin reactions that typically resolve over several days to severe life-threatening immune responses such as anaphylaxis.

关键词： Acupuncture diseases Bee

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Effect of ZnO Electrodeposited on Carbon Film and Decorated with Metal Nanoparticles for Solar Hydrogen Production

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Journal of Materials Science & Technology 2016年第10期32卷 1059-1065页

作者： Young Kwang Kim hye-jin Seo Soonhyun Kim Sung-Ho hwang Hyunwoong Park Sang Kyoo Lim Division of Nano and Energy Convergence Research Daegu Gyeongbuk Institute of Science and Technology (DGIST) School of Energy Engineering Kyungpook National University

In this study, we prepared horn-like ZnO structures on carbon films（ZnO/CF） by electrodeposition and decorated the ZnO horns with different metals（Ag, Au, and Pt） via photodeposition（M-ZnO/CF）. Using M-ZnO/CF as photocatalysts, we examined ways to enhance solar hydrogen production from various points of view, such as modifying the intrinsic physical properties and thermodynamics of the materials, and varying the chemical environment during M-ZnO/CF fabrication. In particular, we focused on the effects of the carbon film and metals in M-ZnO/CF hybrid photocatalysts on solar hydrogen production. The type of metal nanoparticles is an important factor in solar hydrogen production because the deposition rate and electrical conductivity of each metal affect the proton-water reduction ability.

关键词： Solar hydrogen production ZnO horn Carbon film Metal nanoparticle Electrodeposition

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Effect of reduction in area per pass on strain distribution and microstructure during caliber rolling in twinning-induced plasticity steel

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Journal of Iron and Steel Research International 2020年第1期27卷 62-74页

作者： Joong-ki hwang Sung jin Kim School of Mechanical Engineering Tongmyong UniversityBusan 48520Republic of Korea Department of Advanced Materials Engineering Sunchon National UniversitySuncheon 57922Republic of Korea

The effects of reduction in area(RA)per pass during caliber rolling on microstructure and strain distribution of twinninginduced plasticity steel have been investigated to find solutions to make a more homogeneous material along the radial direction for wire rod *** steel wires subjected to an average RA per pass of 2.5%(skin pass caliber rolling)and 10.0%(conventional caliber rolling)were *** skin pass caliber-rolled wire was characterized as a duplex fiber texture of majorand minor.and the textures were almost same at/between center and surface area,which is totally different from those of conventional caliber rolling and wire *** skin pass caliber rolling led to more homogeneous microstructure and mechanical properties along the radial direction in comparison with the conventional caliber rolling and wire drawing due to the more homogeneous Hall-Petch hardening,dislocation hardening,and texture behavior with area,resulting in higher formability.

关键词： Twinning-induced plasticity steel Caliber rolling Deformation twin Reduction in area Skin pass

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Review on Tidal Energy Technologies and Research Subjects

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China Ocean Engineering 2020年第1期34卷 137-150页

作者： Chul Hee JO Su jin hwang Department of Naval Architecture and Ocean Engineering Inha University

Tidal current power is one of the promising and reliable renewable energies with the advantage of continuous and predictable resource. It can make stable electricity regardless of weather conditions or seasons all year around. The required technologies for tidal current power in the ocean have been developed for years and now recognized that it could be commercialized after intensive field tests and successful demonstrations. There are several tidal farm development projects in the world, such as the MeyGen project in UK with its commercialization at hand. However, various research subjects in the tidal current energy field are seeking improvements and industrialization of tidal current power in terms of economy and technical reliability. This paper introduces the resource assessment procedure of tidal energy that has been applied in Korea coastal regions. The key research subjects for tidal current power together with the interaction effect of multi-arrangement is described. Also, this paper is to introduce the research output of each subject such as turbine design, experimental validation, turbine interaction and wake, multi-array module, FSI (fluid-structure interaction), and duct application.

关键词： tidal current power resource assessment turbine design experimental validation turbine interaction multi arrangement FSI(fluid-structure interaction)

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