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Nano Research 2019年第10期12卷 2568-2575页

作者： jin Hee Lee Hack-Keun Lee Dong Hyun Chun Hyunkyung Choi Geun Bae Rhim Min hye Youn Heondo Jeong shin Wook Kang Jung-ll Yang Heon Jung Chui Sung Kim Ji Chan Park Clean Fuel Laboratory Korea Institute of Energy ResearchDaejeon 34129Republic of Korea Department of Chemical Engineering University of SeoulSeoul 02504Republic of Korea Advanced Energy and System Technology University of Science and TechnologyDaejeon 34113Republic of Korea Department of Physics Kookmin UniversitySeoul 02707Republic of Korea

Iron-based nan oparticles with un iform and high particle dispersi on,which are supported on carb on structures,have been used for various ***,their preparation still suffers from complicated synthesis involving multiple steps and from the high price of precursors and solve *** the prese nt work,a new carbon en capsulated iron-carbide nano particle supported on n itroge rvdoped porous carbon(Fe5C2@C/NPC)structure was *** was made using a simple solid-state reaction with sequential thermal ***5C2@C/NPC is a highly active and stable catalyst for the high-temperature Fischer-Tropsch synthesis *** showed very high hydrocarbon productivity(4.71 gHc gcat^-1·h^-1)with high CO conversions(up to 96%).

关键词： iron-carbide one-pot synthesis nitrogen-doped graphene Fischer-Tropsch synthesis Mdssbauer spectroscopy

Effect of ZnO Electrodeposited on Carbon Film and Decorated with Metal Nanoparticles for Solar Hydrogen Production

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Journal of Materials Science & Technology 2016年第10期32卷 1059-1065页

作者： Young Kwang Kim hye-jin Seo Soonhyun Kim Sung-Ho Hwang Hyunwoong Park Sang Kyoo Lim Division of Nano and Energy Convergence Research Daegu Gyeongbuk Institute of Science and Technology (DGIST) School of Energy Engineering Kyungpook National University

In this study, we prepared horn-like ZnO structures on carbon films（ZnO/CF） by electrodeposition and decorated the ZnO horns with different metals（Ag, Au, and Pt） via photodeposition（M-ZnO/CF）. Using M-ZnO/CF as photocatalysts, we examined ways to enhance solar hydrogen production from various points of view, such as modifying the intrinsic physical properties and thermodynamics of the materials, and varying the chemical environment during M-ZnO/CF fabrication. In particular, we focused on the effects of the carbon film and metals in M-ZnO/CF hybrid photocatalysts on solar hydrogen production. The type of metal nanoparticles is an important factor in solar hydrogen production because the deposition rate and electrical conductivity of each metal affect the proton-water reduction ability.

关键词： Solar hydrogen production ZnO horn Carbon film Metal nanoparticle Electrodeposition

Nusinersen for spinal muscular atrophy types Ⅱ and Ⅲ:a retrospective single-center study in South Korea

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World Journal of Pediatrics 2023年第5期19卷 450-459页

作者： Hui jin shin Ji-Hoon Na Hyunjoo Lee Young-Mock Lee Department of Pediatrics Gangnam Severance HospitalYonsei University College of Medicine211 Eonju-RoGangnam-GuSeoul135-720Korea

Background This study investigated the efficacy and safety of nusinersen,an antisense oligonucleotide,in patients with spinal muscular atrophy(SMA)types II(OMIM:253,550)or III(OMIM:253,400),including those with severe scoliosis or requiring respiratory support via mechanical *** Data from 40 patients with genetically confirmed SMA who were treated with nusinersen at our institute from March 2019 to April 2022 were retrospectively *** these,30 patients with an age of onset<3 years and not on permanent ventilation were *** and genetic characteristics were investigated,and motor function was evaluated based on the Hammersmith Functional Motor Scale-Expanded(HFMSE)*** The mean age of symptom onset was 1.2 *** patients were diagnosed with SMA type II(27/30,90%).Nusinersen was administered via computed tomography-guided or direct intrathecal injection in 87%(26/30)and 13%(4/30)of the patients,*** the 6-,14-,22-,and 26-month follow-ups,72%,71%,88%,and 86%of patients showed motor improvement,respectively,with mean changes in HFMSE scores of 2.10,2.88,4.21,and 5.29,*** analysis showed that the use of noninvasive ventilation was associated with poorer outcomes of motor *** Patients with SMA type II or III who received nusinersen treatment showed significant improvement in motor function.A longer treatment duration led to a higher number of patients with improved motor *** significant side effects of nusinersen were *** with SMA,even those with severe scoliosis or on respiratory support,can be safely treated using nusinersen.

关键词： Hammersmith Functional Motor Scale Expanded Motor function Nusinersen South Korea Spinal muscular atrophy

CD4＋VEGFR1HIGH T cell as a novel Treg subset regulates inflammatory bowel disease in lymphopenic mice

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Cellular & Molecular Immunology 2015年第5期12卷 592-603页

作者： jin-Young shin Department of Microbiology and Immunology Seoul National University College of Medicine Seoul South Korea Department of Biomedical Sciences Seoul National University College of Medicine Seoul South Korea Xenotransplantation Research Center Seoul National University College of Medicine Seoul South Korea Cancer Research Institute Seoul National University College of Medicine Seoul South Korea J.Y. shin's current address is Biopharmaceutical Quality Management Division Ministry of Food and Drug Safety 187 Osongsaengmyeong2-ro Osong-eup Heungduk-gu Cheungju-si Chungbuk 363-700 South Korea J.H. Lim's current address is Department of Clinical Pathobiochemistry Faculty of Medicine Technische UniversitSt Dresden Dresden 01307 Germany Y.H. Kim's current address is Department of Microbiology Kyungpook National University School of Medicine 680 Gukchaebosang-ro Jung-gu Daegu 700-842 South Korea H.S. Cho's current address is Department of Pathology University of Massachusetts Medical School MA 01655 USA S.H. Hong's current address is Division of Immunology and Rheumatology Emory University School of MedicineGA 30322 USA

Regulatory T cells （Tregs） are a specialized subpopulation of T cells that control the immune response and thereby maintain immune system homeostasis and tolerance to self-antigens. Many subsets of CD4＋ Tregs have been identified, including Foxp3~, Trl, Th3, and Foxp3neg iT（R）35 cells. In this study, we identified a new subset of CD4＋VEGFR1high Tregs that have immunosuppressive capacity. CD4＋VEGFRlhigh T cells, which constitute approximately 1.0% of CD4＋ T cells, are hyporesponsive to T-cell antigen receptor stimulation. Surface marker and FoxP3 expression analysis revealed that CD4＋VEGFR1high T cells are distinct from known Tregs. CD4＋VEGFR1high T cells suppressed the proliferation of CD4＋CD25- T cell as efficiently as CD4＋CD25high natural Tregs in a contact-independent manner. Furthermore, adoptive transfer of CD4＋VEGFR1＋ T cells from wild type to RAG-2-deficient C57BL/6 mice inhibited effector T-cell-mediated inflammatory bowel disease. Thus, we report CD4＋ VEGFR1high T cells as a novel subset of Tregs that regulate the inflammatory response in the intestinal tract.

关键词： inflammatory bowel disease regulatory T cells suppression vascular endothelial growth factor receptor 1

SPARC Local Workshop on “WCRP Grand Challenges and Regional Climate Change”

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Advances in Atmospheric Sciences 2018年第6期35卷 624-627页

作者： Joowan KIM Seok-Woo SON hye-jin KIM Baek-Min KIM Changhyun YOO Department of Atmospheric Sciences Kongju National University Gongju 32588 Republic of Korea School of Earth and Environmental Sciences Seoul National University Seoul 08826 Republic of Korea Korea Polar Research Institute Incheon 21990 Republic of Korea Department of Climate and Energy Systems Engineering Ewha Womans University Seoul 03760 Republic of Korea

*** SPARC（Stratosphere-Troposphere Processes and their Role in Climate）is one of the core projects of the World Climate Research Program（WCRP）,coordinating international efforts to address relevant issues in clima... 详细信息

关键词： SPARC Local Workshop on WCRP Grand Challenges and Regional Climate Change QBO

Repeated ventricular bigeminy by trigeminocardiac reflex despite atropine administration during superficial upper lip surgery: A case report

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World Journal of Clinical Cases 2022年第32期10卷 11967-11973页

作者： Su-Yeon Cho Bo-Hyun Jang hye-jin Jeon Dong-Joon Kim Department of Anesthesiology and Pain Medicine Chosun University HospitalGwangju 61453South Korea

BACKGROUND The trigeminocardiac reflex(TCR)is usually caused by an increased parasympathetic tone when pressure or traction is applied to the surrounding tissue of the trigeminal ***,the inexperienced anesthesiologists may have challenges on the management of TCR *** SUMMARY This is the case of an 18-year-old woman diagnosed with hemangioma of the upper *** the operation,about 1 h after surgery started,a constant 1:1 premature ventricular complex was detected,and blood pressure was decreased when approaching the deeper part with more strong traction for exposure of the *** the management of arrhythmias,such as lidocaine and atropine,was injected,arrhythmia induced by surgical stimulation could not be eliminated *** the traction repeated,bradycardia was also repeated,despite injecting additional ***,the anesthesiologist and the surgeon decided to perform the operation only to the extent that the vascular tissue was selectively removed only at the site without the *** With TCR,anesthesiologists should perform appropriate *** addition to proper drug administration,surgeons should be consulted to cope with stopping the surgery and setting the scope of the surgery even if the site is superficial.

关键词： Trigeminocardiac reflex Bigeminy Arrhythmia Hypotension Atropine Case report

Enhanced Electrical Properties in Carbon Nanotube/Poly （3-hexylthiophene） Nanocomposites Formed Through Non-Covalent Functionalization

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Nano Research 2011年第11期4卷 1129-1135页

作者： Sung hye Park Sung Hwan jin Gwang Hoon Jun SeokwoO Jeon Soon Hyung Hong Department of Material Science and Engineering Korea Advanced Institutc of Science Technol0gy Daejeon 305＇701 Republic of Korea

Poly（3-hexylthiophene）（P3HT） has received much attention as a good candidate to replace inorganic semiconductors for flexible electronics due to its solution-processability. However, the low charge mobility of P3HT is an obstacle to its commercialization. To overcome this problem, we propose a new non-covalent functionalization method for carbon nanotubes （CNTs） for use in CNT/P3HT nanocomposites. By using modified pyrene molecules with hydrophobic long alkyl chains, the non-covalently functionalized CNTs can become well dispersed in hydrophobic solutions and organic semiconductor matrices. Fabrication of organic thin-film transistors （OTFTs） from the non-covalently functionalized CNT/organic semiconductor nanocomposites shows that our non-covalent functionalization method significantly reduces damage to CNTs during functionalization when compared with covalent functionalization by treatment with acids. The OTFTs show 15 times enhancement of field effect mobility （1.5 × 10^-2 cm^2/（V.s）） compared to the mobility of OTFTs made from pure P3HT. This enhancement is achieved by addition of only 0.25 wt% of CNTs to P3HT.

关键词： Carbon nanotubes conjugated polymers nanocomposites organic thin film transistors

Analysis of keto-enol tautomers of curcumin by liquid chromatography/mass spectrometry

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Chinese Chemical Letters 2013年第8期24卷 685-687页

作者： shin-ichi Kawano Yusuke Inohana Yuki Hashi jin-Ming Lin Department of Chemistry Beijing Key Laboratory of Microanalytical Methods and InstrumentationTsinghua University Shimadzu Global COE for Application & Technical Development Shimadzu(China) Co.Ltd. Global Application Development Center Shimadzu Corporation Department of Chemistry Beijing Key Laboratory of Microanalytical Methods and Instrumentation.Tsinghua University

Keto-enol tautomers of curcumin were confirmed by reversed-phase liquid chromatography（RPLC）/ hybrid quadrupole ion trap/time-of-flight mass spectrometry（QIT/TOFMS）.Tautomers gave different MS/MS spectra in negative *** mass spectra were also obtained by hydrogen/deuterium exchange LC/MS/MS in positive *** results suggest that enol form is the major form in the solution（water/acetonitrile）.

关键词： Keto-enol tautomer Curcumin Liquid chromatography/mass spectrometry

Aqueous levels of erythropoietin in acute retinal vein occlusion with macular edema

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 501-506页

作者： Hyun jin shin Hyung Chan Kim Jun Woong Moon Department of Ophthalmology Konkuk University Medical Center Konkuk University School of Medicine Gongdeok Seoul Eye Clinic

AIM:To investigate the aqueous erythropoietin(EPO)levels and associated factors in patients with acute retinal vein occlusion(RVO).METHODS:The aqueous EPO level was measured in patients with macular edema(ME)secondary to acute branched retinal vein occlusion(BRVO)or central retinal vein occlusion(CRVO).Aqueous fluid from cataract patients served as the *** also evaluated whether aqueous level of EPO was associated with factors such as serum EPO level,non-perfusion area,central macular thickness(CMT),and arterio-venous(AV)transit timeRESULTS:Twenty-seven RVO patients(16 BRVO,11CRVO)and 9 control subjects were enrolled in the *** aqueous EPO level(mU/mL)was higher in RVO(68.2±54.3)than that in the control subjects(12.9±5.9).More specifically,the aqueous EPO level was higher in CRVO(118.9±52.1)than that in BRVO(33.3±10.8).However,no differences were found in serum EPO levels among three *** in RVO patients had a positive correlation with the aqueous EPO level(r=0.66).Also,in terms of non-perfusion area,the aqueous EPO levels were more elevated in the ischemic subgroup than in the non-ischemic subgroup in both BRVO and ***:Aqueous EPO levels are elevated in patients with macular edema secondary to recent onset *** with CRVO have higher EPO levels than those with *** aqueous EPO level in RVO has a positive correlation with CMT and is associated with non-perfusion *** results suggest that the aqueous EPO level could be associated with retinal ischemia and may be involved in the pathogenesis of macular edema secondary to RVO.

关键词： aqueous level of erythropoietin acute retinal vein occlusion retinal ischemia macular edema

Simultaneous laparoscopic multi-organ resection combined with colorectal cancer:Comparison with non-combined surgery

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World Journal of Gastroenterology 2012年第8期18卷 806-813页

作者： hye jin Kim Gyu-Seog Choi Jun Seok Park Soo Yeun Park Soo Han Jun Department of Surgery Kyungpook National University Hospital School of Medicine Kyungpook National University Department of Surgery Daegu Catholic Medical Center Catholic University of Daegu

AIM: To access the short-term outcomes of simultaneous laparoscopic surgery combined with resection for synchronous lesions in patients with colorectal cancer. METHODS: Between March 1996 and April 2010 prospectively collected data were reviewed from 93 consecutive patients who had colorectal cancer and underwent simultaneous multiple organ resection (combined group) and 1090 patients who underwent conventional laparoscopic right hemicolectomy or laparoscopic low/ anterior resection for colorectal cancer (non-combined group). In the combined group, there were nine gastric resections, three nephrectomies, nine adrenalectomies, 56 cholecystectomies, and 21 gynecologic resections. In addition, f ive patients underwent simultaneous laparoscopic resection for three organs. The patient demographics, intra-operative outcomes, surgical morbidity, and short-term outcomes were compared between thetwo groups (the combined and non-combined groups). RESULTS: There were no signifi cant differences in the clinicopathological variables between the two groups. The operating time was signifi cantly longer in the combined group than in the non-combined group, regardless of tumor location (laparoscopic right hemicolectomy and laparoscopic low/anterior resection groups; P = 0.048 and P < 0.001, respectively). The other intraoperative outcomes, such as the complications and open conversion rate, were similar in both groups. The rate of post-operative morbidity in the combined group was similar to the non-combined group (combined vs non-combined, 15.1% vs 13.5%, P = 0.667). Oncological safety for the colon and synchronous lesions were obtained in the combined group. CONCLUSION: Simultaneous laparoscopic multiple organ resection combined with colorectal cancer is a safe and feasible option in selected patients.

关键词： Laparoscopic combined resection Colorectal cancer Laparoscopic surgery