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Bile acid increases expression of the histamine-producing enzyme,histidine decarboxylase,in gastric cells

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World Journal of Gastroenterology 2014年第1期20卷 175-182页

作者： hye jin Ku hye Young Kim hyeong Hoe Kim Hee Ju Park Jae Hun Cheong Department of Pediatrics College of MedicinePusan National UniversityBusan 601-721South Korea Department of Molecular Biology College of Natural SciencesPusan National UniversityBusan 609-735South Korea Department of Experimental Medicine College of MedicinePusan National UniversityBusan 601-721South Korea

AIM: To investigate the effect of bile acid on the expression of histidine decarboxylase (HDC), which is a major enzyme involved in histamine production, and gene expression of gastric transcription factors upon coope... 详细信息

关键词： Histamine Histidine decarboxylase Bile acid Farnesoid X receptor

User Interface-Based Repeated Sequence Detection Method for Authentication

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Intelligent Automation & Soft Computing 2023年第3期35卷 2573-2588页

作者： shin jin Kang Soo Kyun Kim School of Games Hongik UniversitySejong30016Korea Department of Computer Engineering Jeju National UniversityJeju63243Korea

In this paper,we propose an authentication method that use mouse and keystroke dynamics to enhance online privacy and *** proposed method identiﬁes personalized repeated user interface(UI)sequences by analyzing mouse and keyboard *** this end,an Apriori algorithm based on the keystroke-level model(KLM)of the human–computer interface domain was *** proposed system can detect repeated UI sequences based on KLM for authentication in the *** effectiveness of the proposed method is veriﬁed through access test-ing using commercial applications that require intensive UI *** results show using our cognitive mouse-and-keystroke dynamics system can com-plement authentication at the application level.

关键词： Authentication keystroke-level model(KLM) keystroke mouse dynamics

Inhibitory potential of three Yin-tonification herbal formulas on the activities of human major cytochrome P450 and UDP-glucuronosyltransferases isozymes in vitro

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Journal of Traditional Chinese Medicine 2018年第4期38卷 511-522页

作者： Seong Eun jin hyeun-Kyoo shin hyekyung Ha K-herb Research Center Korea Institute of Oriental Medicine Daejeon 34054 Republic of Korea

OBJECTIVE:To investigate the influence of Yin-tonification herbal formulas Jaeumganghwa-tang(Ziyin Jianghuo Tang,JEGHT),Ssanghwa-tang(Shuanghe Tang,SHT) and Yukmijihwang-tang(Liuwei Di huang Tang,YMJHT) on the activities of human major cytochrome P450(CYP450 s) and UDP-glucuronosyltransferases isozymes(UGTs) in ***:The activities of CYP450 s(CYP1 A2,CYP3 A4,CYP2 B6,CYP2 C9,CYP2 C19,CYP2 D6 and CYP2 E1) and UGTs(UGT1 A1,UGT1 A4 and UGT2 B7)were assessed using in vitro fluorescence-and luminescence-based enzyme assays,*** effects of herbal formulas on the activities of CYP450 s and UGTs were presented as IC50 ***:JEGHT showed the potent inhibition of the CYP2 D6 activity,with weak inhibition on the activities of CYP1 A2,CYP2 B6,CYP2 C9,CYP2 C19,CYP2 E1,CYP3 A4,UGT1 A1,UGT1 A4 and UGT2 *** inhibited the activities of CYP1 A2 and CYP2 E1,whereas the negligible inhibition of the activities of CYP2 B6,CYP2 C9,CYP2 C19,CYP2 D6,CYP3 A4,UGT1 A1,UGT1 A4 and UGT2 B7 through SHT was *** inhibited CYP2 E1 activity,with a negligible inhibition on the activities of CYP1 A2,CYP2 B6,CYP2 C9,CYP2 C19,CYP2 D6,CYP3 A4,UGT1 A1,UGT1 A4 and UGT2 ***:These findings provide information about the potential interactions between three Yin-tonification herbal formulas and conventional drugs.

关键词： Yin reinforcing agents CytochromeP-450 enzyme system Uridine diphosphate gluc-uronic acid Transferases Herb-drug interactions

Image Translation Method for Game Character Sprite Drawing

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Computer Modeling in Engineering & Sciences 2022年第5期131卷 747-762页

作者： Jong-In Choi Soo-Kyun Kim shin-jin Kang Department of Digital Media Seoul Women’s UniversitySeoul01797Korea Computer Engineering Jeju National UniversityJeju63243Korea School of Games Hongik UniversitySejong30016Korea

Two-dimensional(2D)character animation is one of the most important visual elements on which users’interest is focused in the game ***,2D character animation works in the game field are mostly performed manually in two dimensions,thus generating high production *** study proposes a generative adversarial network based production tool that can easily and quickly generate the sprite images of 2D ***,we proposed a methodology to create a synthetic dataset for training using images from the real world in the game resource production field where machine learning datasets are *** addition,we have enabled effective sprite generation while minimizing user input in the process of using the *** this end,we proposed a mixed input method with a small number of segmentations and skeletal bone *** proposed image-to-image translation network effectively generated sprite images from the user input images using the skeletal *** conducted an experiment regarding the number of images required and showed that 2D sprite resources can be generated even with a small number of segmentation inputs and one skeletal bone drawing.

关键词： Sprite generation body segmentation pose estimation generative adversarial network deep learning

Effects of Traditional Herbal Formulae on Human CYP450 Isozymes

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Chinese Journal of Integrative Medicine 2017年第1期23卷 62-69页

作者： Seong Eun jin hyekyung Ha hyeun-Kyoo shin K-Herb Research Center Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea

Objective：To assess the effects of traditional herbal formulae Sijunzi Decoction（四君子汤,Sagunja-tang,SJZD）,Siwu Decoction（四物汤,Samul-tang,SWD）,Bawu Decoction（八物汤,Palmul-tang,BWD）and Shiquan Dabu Decoction（十全大补汤,Sipjeondaebo-tang,SDD）on the activities of human cytochrome P450（CYP450）,a drug-metabolizing ***：Herbal formula water extracts were filtered and lyophilized after the powder extracts were dissolved in distilled *** activities of major human CYP450isozymes（CYP3A4,CYP2C19,CYP2D6 and CYP2E1）were measured using in vitro fluorescence-based enzyme *** inhibitory effects of the herbal formulas on the activities of CYP450 were characterized as half maximal inhibition concentration（IC50）***：All the tested herbal formulae inhibited CYP2C19activity（IC50：SJZD,83.28μg/m L;SWD,235.54μg/m L;BWD,166.82μg/m L;SDD,178.19μg/m L）;SJZD（IC50=196.46μg/m L）,SWD（IC50=333.42μg/m L）and SDD（IC50=163.42μg/m L）inhibited CYP2E1-mediated metabolism;whereas BWD exhibited comparatively weak inhibition of CYP2E1（IC50=501.78μg/m L）.None of the four herbal formulas significantly affected CYP3A4 or ***：These results suggest that SJZD,SWD,BWD and SDD could potentially inhibit the metabolism of co-administered synthetic drugs whose primary route of elimination is via *** addition,clinically relevant pharmacokinetic interactions could occur when SJZD,SWD or SDD is co-administered with drugs metabolized by *** findings provide information for the safety and effective clinical use of these four classic herbal formulas.

关键词： cytochrome P450 Sijunzi Decoction Siwu decoction Bawu Decoction Shiquan Dabu Decoction,herb-drug interactions

Subcarrier BD with Cooperative Communication for MIMO-NOMA System

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Computers, Materials & Continua 2022年第9期72卷 5807-5821页

作者： Jung-In Baik Ji-Hwan Kim Beom-Sik shin Ji-hye Oh Hyoung-Kyu Song Department of Information and Communication Engineering and Convergence for Intelligent DroneSejong UniversitySeoul05006Korea

With the rapid evolution of Internet of things(IoT),many edge devices require simultaneous connection in 5G communication *** afford massive data of IoT devices,multiple input multiple output non-orthogonal multiple access(MIMO-NOMA)method has been considered as a promising ***,there are numerous drawbacks due to error propagation and inter-user ***,proposed scheme aims to improve the reliability of the MIMO-NOMA system with digital beamforming and intracluster cooperative multi point(CoMP)to efficiently support IoT *** the conventional MIMO-NOMA system,user entities are grouped into *** diagonalization(BD)is applied to efficiently eliminate the inter-cluster interference of the MIMO-NOMA ***,since the channel path of the data stream from a single antenna to a single cluster doesn’t hold other cluster’s data,the system can’t fully utilize the selective subcarrier channel *** indicates that there can be better channel paths for a data stream at a certain subcarrier ***,proposed scheme allocates data streams to antennas adaptively considering selective channel ***,intra-cluster CoMP method is adjusted to enhance the reliability of the system in the *** simulation results show that the proposed scheme improves BER and throughput performance compared to the conventional MIMO-NOMA system.

关键词： 5G MIMO-NOMA CoMP BD interference

Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites

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World Journal of Gastroenterology 2008年第24期14卷 3884-3890页

作者： Soong Lee Seung-Cheol Son Moon-Jong Han Woo-jin Kim Soo-Hyun Kim hye-Ran Kim Woo-Kyu Jeon Ki-Hong Park Myung-Geun shin Department of Internal Medicine College of MedicineSeonam University and Seonam University Hospital Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National University Hwasun Hospital Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National University Medical School Department of Internal Medicine Kangbuk Samsung HospitalSungkyunkwan University School of Medicine Korea Polymer Testing & Research Institute Ltd.

AIM： To determine intestinal permeability, the serum tumor necrosis factor （TNF）-α level and urine nitric oxide （NO） metabolites are altered in liver cirrhosis （LC） with or without ascites. METHODS： Fifty-three patients with LC and 26 healthy control subjects were enrolled in the study. The intestinal permeability value is expressed as the percentage of polyethylene glycol （PEG） 400 and 3350 retrieval in 8-h urine samples as determined by high performance liquid chromatography. Serum TNF-α concentrations and urine NO metabolites were determined using an enzyme-linked immunosorbent assay （ELISA） and Greiss reaction method, respectively. RESULTS： The intestinal permeability index wassignificantly higher in patients with LC with ascites than in healthy control subjects or patients with LC without ascites （0.88 ± 0.12 vs 0.52 ± 0.05 or 0.53 ± 0.03, P 〈 0.05） and correlated with urine nitrite excretion （r = 0.98）. Interestingly, the serum TNF-α concentration was significantly higher in LC without ascites than in control subjects or in LC with ascites （198.9 ± 55.8 pg/mL vs 40.9 ± 12.3 pg/mL or 32.1 ± 13.3 pg/mL, P 〈 0.05）. Urine nitrite excretion was significantly higher in LC with ascites than in the control subjects or in LC without ascites（ 1170.9± 28.7 μmol/L vs 903.1 ± 55.1 μmol/L or 956.7 ± 47.7 μmol/L, P 〈 0.05）. COMCLUSIOM： Increased intestinal macromolecular permeability and NO is probably of importance in the pathophysiology and progression of LC with ascites, but the serum TNF-α concentration was not related to LC with ascites.

关键词： Intestinal permeability Tumor necrosisfactor-R Nitric oxide Liver cirrhosis Ascites

Selective conversion of N_(2) to NH_(3) on highly dispersed RuO_(2) using amphiphilic ionic liquid-anchored fibrous carbon structure

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Journal of Energy Chemistry 2022年第4期31卷 474-482页

作者： Kahyun Ham Muhammad Salman Sunki Chung Minjun Choi HyungKuk Ju hye jin Lee Jaeyoung Lee School of Earth Sciences and Environmental Engineering Gwangju Institute of Science and Technology(GIST)123 Cheomdangwagi-RoGwangju 61005South Korea International Future Research Center of Chemical Energy Storage and Conversion Processes GIST123 Cheomdangwagi-RoGwangju 61005South Korea Ertl Center for Electrochemical and Catalysis GIST123 Cheomdangwagi-RoGwangju 61005South Korea Department of Chemistry and Green-Nano Materials Research Center Kyungpook National University80 Daehak-RoDaegu-city 41566South Korea Hydrogen Research Department Korea Institute of Energy Research152 Gajeong-RoYuseong-guDaejeon 34129South Korea

Ammonia (NH_(3)) plays a key role in the agricultural fertilizer and commodity chemical industries and is useful for exploring hydrogen storage *** electrochemical nitrogen reduction reaction (NRR) is receiving attention as an environmentally sustainable NH_(3) synthesis replacement for the traditional Haber–Bosch process owing to its near ambient reaction conditions (<100℃ and 1 atm).However,its NH_(3) yield and faradaic efficiency are extremely low because of the sluggish kinetics of N≡N bond dissociation and the hindrance from competitive hydrogen *** overcome these challenges,we herein introduce a dual-functionalized ionic liquid (1-(4-hydroxybutyl)-3-methylimidazolium hydroxide[HOBIM]OH) for a highly dispersed ruthenium oxide electrocatalyst to achieve a biased *** observed uniform distribution of RuO_(2) on the carbon fiber and increase in the surface area for N_(2) adsorption by limiting proton access can be attributed to the presence of imidazolium ***,extensive N_(2) adsorption contributes to enhanced NRR selectivity with an NH_(3) yield of 3.0×10^(-10)mol cm^(-2)s^(-1)(91.8μg h^(-1)mg^(-1)) and a faradaic efficiency of 2.2%at-0.20 V_(RHE).We expect our observations to provide new insights into the design of effective electrode structures for electrochemical NH;synthesis.

关键词： Ammonia synthesis Nitrogen reduction reaction Imidazolium-based ionic liquid Ruthenium oxide

Gold nanoparticle-assisted delivery of brain-derived neurotrophic factor to cerebral organoids

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Nano Research 2022年第4期15卷 3099-3105页

作者： Sung Bum Park hye-jin Cho Sang Rin Moon Kyoung jin Choi Won Hoon Jung Ki Young Kim Byumseok Koh Therapeutics and Biotechnology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea Chemical Platform Technology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea

Gold nanoparticle(AuNP)-assisted delivery of proteins/drugs to cells or in vivo systems has long been ***,their interaction with in vivo mimicking organoids is still largely ***,we conjugated brain-derived neurotropic factor(BDNF)to the AuNP surface and monitored how AuNP-BDNF interacts with cerebral *** suggest that AuNP-BDNF can successfully enter cerebral organoids and can be found up to 15.21μm inside cerebral ***-BDNF does not induce significant cytotoxicity to cerebral organoids at concentrations up to 2 nM and increases the expression of 75 genes compared to control cerebral *** data suggest the successful delivery of BDNF through AuNP-BDNF conjugation in cerebral organoids,and the conjugation can affect its differentiation.

关键词： gold nanoparticles cerebral organoids delivery penetration differentiation viability