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Perioperative topical ascorbic acid for the prevention of phacoemulsification-related corneal endothelial damage:Two case reports and review of literature

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World Journal of Clinical Cases 2019年第5期7卷 642-649页

作者： Chia-Yi Lee hung-ta chen Yi-Jen Hsueh hung-Chi chen Chieh-cheng Huang Yaa-Jyuhn James Meir Chao-Min cheng Wei-Chi Wu Department of Ophthalmology Show Chwan Memorial Hospital Department of Optometry College of Medicine and Life Science Chung Hwa University of Medical Technology Department of Internal Medicine Taipei City Hospital-Heping Branch Department of Ophthalmology Chang Gung Memorial Hospital Center for Tissue Engineering Chang Gung Memorial Hospital Department of Medicine College of Medicine Chang Gung University Institute of Biomedical Engineering National Tsing Hua University Department of Biomedical Sciences College of Medicine Chang Gung University

BACKGROUND The current case report describes successful phacoemulsification with the aid of perioperative topical ascorbic acid(AA) in two patients with corneal endothelial disorders to prevent postoperative corneal endothelial *** SUMMARY Two eyes of two patients underwent phacoemulsification with pre-existing corneal endothelial disorders including Fuchs corneal endothelial dystrophy(Patient 1) and endotheliitis(Patient 2). Topical AA was applied to both patients at least one month before and after with a frequency of four times per day. After the surgery, both eyes improved best-corrected visual acuity(BCVA) and there was limited human corneal endothelial cell loss without signs of corneal endothelial decompensation, such as deteriorated BCVA or persistent corneal edema during the follow-up of at least two *** Perioperative administration of topical AA may be an alternative therapy to the triple procedure in patients expecting to undergo cataract surgery.

关键词： Ascorbic acid Fuchs corneal endothelial dystrophy Endotheliitis Human corneal endothelial cell Phacoemulsification Case report

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Stercoral perforation of the cecum:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1189-1194页

作者： hung-Chun Yu ta-Wei Pu Jung-cheng Kang Chao-Yang chen Je-Ming Hu Ruei-Yu Su Department of Surgery Taichung Armed Forces General HospitalTaichung 411228Taiwan Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 325Taiwan

BACKGROUND With less than 90 reported cases to date,stercoral perforation of the colon is a rare *** ulceration is thought to occur due to ischemic pressure necrosis of the bowel wall,which is caused by the presence of a stercoraceous *** underscore this urgent surgical situation concerning clinical presentation,surgical treatment,and results,we present the case of a 66-year-old man with a stercoral *** SUMMARY A 66-year-old man with a history of hypertension,hyperlipidemia,and gout presented at the emergency department with lower abdominal pain and a low-grade fever lasting for a few *** computed tomography indicated a suspected bezoar(approximately 7.6 cm)in the dilated cecum,accompanied by pericolic fat stranding,mild proximal dilatation of the ileum,pneumoperitoneum,and minimal ***,feculent peritonitis with isolated cecal perforation were ***,a right hemicolectomy with peritoneal lavage was performed.A histopathological examination supported the intraoperative *** In stercoral perforations,a diagnosis should be diligently pursued,especially in older adults,and prompt surgical intervention should be implemented.

关键词： Acute abdomen Colectomy Peritoneal lavage Pneumoperitoneum Bezoars Case report

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Identifying Brand Consistency by Product Differentiation Using CNN

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 685-709页

作者： hung-Hsiang Wang Chih-Ping chen Department of Industrial Design National Taipei University of TechnologyTaipeiTaiwan Department of Product Design Ming Chuan UniversityTaoyuanTaiwan

This paper presents a new method of using a convolutional neural network(CNN)in machine learning to identify brand consistency by product appearance *** Experiment 1,we collected fifty mouse devices from the past thirty-five years from a renowned company to build a dataset consisting of product pictures with pre-defined design features of their appearance and *** show that it is a challenge to distinguish periods for the subtle evolution of themouse devices with such traditionalmethods as time series analysis and principal component analysis(PCA).In Experiment 2,we applied deep learning to predict the extent to which the product appearance variation ofmouse devices of various *** investigation collected 6,042 images ofmouse devices and divided theminto the Early Stage and the Late *** show the highest accuracy of 81.4%with the CNNmodel,and the evaluation score of brand style consistency is 0.36,implying that the brand consistency score converted by the CNN accuracy rate is not always perfect in the real *** relationship between product appearance variation,brand style consistency,and evaluation score is beneficial for predicting new product styles and future product style *** addition,the CNN heat maps highlight the critical areas of design features of different styles,providing alternative clues related to the blurred *** study provides insights into practical problems for designers,manufacturers,and marketers in product *** not only contributes to the scientific understanding of design development,but also provides industry professionals with practical tools and methods to improve the design process and maintain brand *** can use these techniques to find features that influence brand ***,capture these features as innovative design elements and maintain core brand values.

关键词： Machine learning product differentiation brand consistency principal component analysis convolutional neural network computer mouse

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Heterogeneous decentralised machine unlearning with seed model distillation

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 608-619页

作者： Guanhua Ye Tong chen Quoc Viet hung Nguyen Hongzhi Yin School of Information Technology and Electrical Engineering The University of QueenslandSt LuciaQueenslandAustralia School of Information and Communication Technology Griffith UniversityBrisbaneQueenslandAustralia

As some recent information security legislation endowed users with unconditional rights to be forgotten by any trained machine learning model,personalised IoT service pro-viders have to put unlearning functionality into their *** most straight-forward method to unlearn users'contribution is to retrain the model from the initial state,which is not realistic in high throughput applications with frequent unlearning *** some machine unlearning frameworks have been proposed to speed up the retraining process,they fail to match decentralised learning scenarios.A decentralised unlearning framework called heterogeneous decentralised unlearning framework with seed(HDUS)is designed,which uses distilled seed models to construct erasable en-sembles for all ***,the framework is compatible with heterogeneous on-device models,representing stronger scalability in real-world *** experiments on three real-world datasets show that our HDUS achieves state-of-the-art performance.

关键词： data mining data privacy machine learning

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Highly Accurate Golden Section Search Algorithms and Fictitious Time Integration Method for Solving Nonlinear Eigenvalue Problems

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1317-1335页

作者： Chein-Shan Liu Jian-hung Shen Chung-Lun Kuo Yung-Wei chen Center of Excellence for Ocean Engineering Taiwan Ocean UniversityKeelung202301TaiwanChina Department of Marine Engineering Taiwan Ocean UniversityKeelung202301TaiwanChina

This study sets up two new merit functions,which are minimized for the detection of real eigenvalue and complex eigenvalue to address nonlinear eigenvalue *** each eigen-parameter the vector variable is solved from a nonhomogeneous linear system obtained by reducing the number of eigen-equation one less,where one of the nonzero components of the eigenvector is normalized to the unit and moves the column containing that component to the right-hand side as a nonzero input vector.1D and 2D golden section search algorithms are employed to minimize the merit functions to locate real and complex ***,the real and complex eigenvectors can be computed very accurately.A simpler approach to the nonlinear eigenvalue problems is proposed,which implements a normalization condition for the uniqueness of the eigenvector into the eigenequation *** real eigenvalues can be computed by the fictitious time integration method(FTIM),which saves computational costs compared to the one-dimensional golden section search algorithm(1D GSSA).The simpler method is also combined with the Newton iterationmethod,which is convergent very *** the proposed methods are easily programmed to compute the eigenvalue and eigenvector with high accuracy and efficiency.

关键词： Nonlinear eigenvalue problem quadratic eigenvalue problem two new merit functions golden section search algorithm fictitious time integration method

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Treatment of benign rectal stricture caused by repeated anal insertion by endoscopy and balloon dilation:A case report

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World Journal of Gastrointestinal Endoscopy 2024年第2期16卷 91-97页

作者： Shih-hung Liu Jung-cheng Kang Je-Ming Hu Chao-Yang chen Kuan-Hsun Lin ta-Wei Pu Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgerySongshan BranchTri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan

BACKGROUND Benign rectal strictures can be categorized as primary(disease-related)and secondary(surgical anastomosis-related).Secondary strictures arise from surgical complications,whereas primary strictures have diverse etiologies,including various inflammatory *** strictures are usually managed by surgery and *** present an unusual etiology of benign rectal stricture caused by the repeated insertion of foreign objects into the rectum for sexual purposes,resulting in rectal injury and subsequent chronic *** SUMMARY A 53-year-old man presented to the outpatient clinic of the Colorectal Surgery Department with symptoms of chronic constipation and bloody *** patient previously experienced rectal injury due to foreign object insertion for sexual *** revealed benign circumferential narrowing of the *** underwent treatment by endoscopic argon plasma coagulation and balloon dilation and follow-up as an outpatient for 4 months.A colonoscopy at the end of the follow-up period revealed no evidence of rectal stricture *** A history of rectal injury,followed by chronic inflammation,should be considered in patients with benign rectal *** with endoscopic argon plasma coagulation and balloon dilation can prevent the need for surgical resection of benign rectal strictures.

关键词： Chronic rectal inflammation Colonoscopy Benign rectal stricture Foreign body insertion Rectal injury Case report

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Automatic fovea detection and choroid segmentation for choroidal thickness assessment in optical coherence tomography

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1763-1771页

作者： chen Yu Lin hung Ju chen Yi Kit Chan Wei Ping Hsia Yu Len Huang Chia Jen Chang Department of Ophthalmology Taichung Veterans General HospitalTaichung 407TaiwanChina Department of Computer Science Tunghai UniversityTaichung 407TaiwanChina

AIM:To develop an automated model for subfoveal choroidal thickness(SFCT)detection in optical coherence tomography(OCT)images,addressing manual fovea location and choroidal contour ***:Two procedures were proposed:defining the fovea and segmenting the *** localization from B-scan OCT image sequence with three-dimensional reconstruction(LocBscan-3D)predicted fovea location using central foveal depression features,and fovea localization from two-dimensional en-face OCT(LocEN-2D)used a mask region-based convolutional neural network(Mask R-CNN)model for optic disc detection,and determined the fovea location based on optic disc relative *** segmentation also employed Mask ***:For 53 eyes in 28 healthy subjects,LocBscan-3D’s mean difference between manual and predicted fovea locations was 170.0μm,LocEN-2D yielded 675.9μ***-2D performed better in non-high myopia group(P=0.02).SFCT measurements from Mask R-CNN aligned with manual ***:Our models accurately predict SFCT in OCT ***-3D excels in precise fovea localization even with high ***-2D shows high detection rates but lower accuracy especially in the high myopia *** both models offers a robust SFCT assessment approach,promising efficiency and accuracy for large-scale studies and clinical use.

关键词： subfoveal choroidal thickness optical coherence tomography automatic foveal detection automatic choroid segmentation

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Extended finite element-based cohesive zone method for modeling simultaneous hydraulic fracture height growth in layered reservoirs

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 2960-2981页

作者： Lei Yang Baixi chen Hopkins Extreme Materials Institute Johns Hopkins UniversityBaltimoreMD21218USA School of Civil Engineering The University of SydneyNSW2006Australia Department of Mechanical Engineering University of Wisconsin-Madison1513 University AvenueMadisonWI53706-1572USA Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

In this study,a fully coupled hydromechanical model within the extended finite element method(XFEM)-based cohesive zone method(CZM)is employed to investigate the simultaneous height growth behavior of multi-cluster hydraulic fractures in layered porous reservoirs with modulus *** coupled hydromechanical model is first verified against an analytical solution and a laboratory ***,the fracture geometry(***,aperture,and area)and fluid pressure evolutions of multiple hydraulic fractures placed in a porous reservoir interbedded with alternating stiff and soft layers are investigated using the *** stress and pore pressure distributions within the layered reservoir during fluid injection are also *** simulation results reveal that stress umbrellas are easily to form among multiple hydraulic fractures’tips when propagating in soft layers,which impedes the simultaneous height *** is also observed that the impediment effect of soft layer is much more significant in the fractures suppressed by the preferential growth of adjoining *** that,the combined effect of in situ stress ratio and fracturing spacing on the multi-fracture height growth is presented,and the results elucidate the influence of in situ stress ratio on the height growth behavior depending on the fracture ***,it is found that the inclusion of soft layers changes the aperture distribution of outmost and interior hydraulic *** results obtained from this study may provide some insights on the understanding of hydraulic fracture height containment observed in filed.

关键词： Hydraulic fracturing Layered reservoir Simultaneous height growth In situ stress Fracture spacing Extended finite element method(XFEM) Cohesive zone method(CZM)

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Prognostic factors of early recurrence after complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

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World Journal of Clinical Cases 2024年第27期12卷 6057-6069页

作者： Chao-Yu chen Tzu-Hao Huang Li-Wen Lee Jrhau Lung Yu-Che Ou Chien-Hui hung Huei-Chieh Chuang Min-Chi chen Ting-Yao Wang Department of Obstetrics and Gynecology Chang Gung Memorial HospitalChiayi 613Taiwan Graduate Institute of Clinical Medical Sciences College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Early Childhood Care and Education Shu-Zen Junior College of Medicine and ManagementKaohsiung 821Taiwan Division of General Surgery Department of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Department of Diagnostic Radiology Chang Gung Memorial HospitalChiayi 613Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Research and Development Chang Gung Memorial HospitalChiayi 613Taiwan Department of Obstetrics and Gynecology Kaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalChiayi 613Taiwan Department of Public Health Chang Gung UniversityTaoyuan 333Taiwan Division of Hematology and Oncology Department of Internal MedicineChang Gung Memorial HospitalChiayi 613Taiwan

BACKGROUND Although cytoreductive surgery(CRS)and hyperthermic intraperitoneal chemotherapy(HIPEC)offer the potential for long-term survival in peritoneal carcinomatosis,outcomes following CRS/HIPEC vary *** To identify the clinical factors associated with progression-free survival(PFS)after complete CRS/HIPEC in patients with colorectal/high-grade appendiceal,ovarian,and gastric *** We retrospectively evaluated the risk of recurrence within 1 year after CRS/HIPEC and its impact on overall survival(OS)in patients recruited between 2015 and *** regression models were used to assess the prognostic factors for the risk of recurrence within 1 ***–Meier survival curves and Cox proportional hazards models were used to evaluate the association between recurrence and *** Of the 80 enrolled patients,39 had an unfavorable PFS(12 was associated with a lower rate of achieving CC-0(P=0.027).The favorable PFS group had a significantly longer OS(median 81.7 mo vs 17.0 mo,Ptance of selecting appropriate candidates for CRS/HIPEC to manage peritoneal carcinomatosis.

关键词： Peritoneal metastasis Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Predictor Recurrence

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Re-evaluating the role of pelvic radiation in the age of modern precision medicine and systemic therapy

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World Journal of Clinical Oncology 2024年第1期15卷 1-4页

作者： tao-Wei Ke Yu-Min Liao Sheng-Chi Chang Che-hung Lin William Tzu-Liang chen Ji-An Liang Chun-Ru Chien Department of Colorectal Surgery China Medical University HospitalTaichung 40402Taiwan School of Chinese Medicine College of Chinese MedicineChina Medical UniversityTaichung 40402Taiwan Division of Hematology and Oncology Department of Internal MedicineChina Medical University HospitalTaichung 40402Taiwan Department of Colorectal Surgery China Medical University Hsinchu HospitalHsinchu 30272Taiwan School of Medicine College of MedicineChina Medical UniversityTaichung 40402Taiwan Department of Radiation Oncology China Medical University HospitalTaichung 40402Taiwan

The efficacy of pelvic radiation in the management of locally advanced stage rectal cancer has come under scrutiny in the context of modern precision medicine and systemic therapy as evidenced by recent clinical trials such as FOWARC(J Clin Oncol 2019;37:3223-3233),NCT04165772(N Engl J Med 2022;386:2363-2376),and PROSPECT(N Engl J Med 2023;389:322-334).In this review,we comprehensively assess these pivotal trials and offer additional insights into the evolving role of pelvic radiation in contemporary oncology.

关键词： Radiotherapy Locally advanced stage rectal cancer Precision medicine Systemic therapy Clinical trial

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