Prognostic factors of early recurrence after complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
作者机构：Department of Obstetrics and GynecologyChang Gung Memorial HospitalChiayi 613Taiwan Graduate Institute of Clinical Medical SciencesCollege of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Early Childhood Care and EducationShu-Zen Junior College of Medicine and ManagementKaohsiung 821Taiwan Division of General SurgeryDepartment of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Department of Diagnostic RadiologyChang Gung Memorial HospitalChiayi 613Taiwan College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Medical Research and DevelopmentChang Gung Memorial HospitalChiayi 613Taiwan Department of Obstetrics and GynecologyKaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Department of Anatomic PathologyChang Gung Memorial HospitalChiayi 613Taiwan Department of Public HealthChang Gung UniversityTaoyuan 333Taiwan Division of Hematology and OncologyDepartment of Internal MedicineChang Gung Memorial HospitalChiayi 613Taiwan
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2024年第12卷第27期
页 面：6057-6069页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the Chang Gung Medical Foundation No.CMRPG6L0091 No.CMRPG6L0092 and No.CMRPG6L0093
主 题：Peritoneal metastasis Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Predictor Recurrence
摘 要：BACKGROUND Although cytoreductive surgery(CRS)and hyperthermic intraperitoneal chemotherapy(HIPEC)offer the potential for long-term survival in peritoneal carcinomatosis,outcomes following CRS/HIPEC vary *** To identify the clinical factors associated with progression-free survival(PFS)after complete CRS/HIPEC in patients with colorectal/high-grade appendiceal,ovarian,and gastric *** We retrospectively evaluated the risk of recurrence within 1 year after CRS/HIPEC and its impact on overall survival(OS)in patients recruited between 2015 and *** regression models were used to assess the prognostic factors for the risk of recurrence within 1 ***–Meier survival curves and Cox proportional hazards models were used to evaluate the association between recurrence and *** Of the 80 enrolled patients,39 had an unfavorable PFS(12 was associated with a lower rate of achieving CC-0(P=0.027).The favorable PFS group had a significantly longer OS(median 81.7 mo vs 17.0 mo,P0.001).CONCLUSION Achieving CC-0 was associated with a lower early recurrence rate and improved long-term *** study underscores the importance of selecting appropriate candidates for CRS/HIPEC to manage peritoneal carcinomatosis.
维普期刊数据库