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Long-term clinical outcomes of drug-eluting stents ***-metal stents in Chinese geriatric patients

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Journal of Geriatric Cardiology 2013年第4期10卷 330-335页

作者： Pak-Hei Chan Sha-Sha Liu hung-fat tse Wing-Hing Chow Man-Hong Jim Hee-Hwa HO Chung Wah Siu Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong 102 Pokfulam Rd Hong Kong China Cardiac Medical Unit Grantham Hospital 125 Wong Chuk Hang Rd Aberdeen Hong Kong China

BACKGROUND & OBJECTIVE: Little is known about the relative efficacies of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and bare-metal stents (BMS) in elderly patients。 The objective of this study was to evaluate the clinical outcome for geriatric patients who received either DES or BMS。 METHODS: From January 2002 to October 2005, 199 consecutive Chinese geriatric patients (≥ 75 years old) underwent PCI with coronary DES or BMS implantation at our institution。 We analyzed the major clinical end points that included all-cause mortality, cardiovascular death, myocardial infarction, target lesion revascularization (TLR), stent thrombosis, and bleeding complications。 RESULTS: The three-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (6.3%,3.6%,5.4%) compared with the BMS group (16.2%,11.5%,14.9%; P <0.05)。 No significant differences were found in the three-year cumulative rate for target lesion revascularization (6.3% vs4.6%, P =0.61) or stent thrombosis (3.6% vs2.3%, P =0.70)。 Likewise, there were no statistically significant differences in the cumulative rate for intracranial hemorrhage, or major and minor hemorrhage at three years。 CONCLUSIONS: DES-based PCI was associated with a significant reduction in the three-year cumulative rate of all-cause mortality, cardiovascular death, and myocardial infarction compared with BMS, without increased risk of TLR, stent thrombosis, or bleeding complications at three years in this group of Chinese geriatric patients。

关键词： Bare-metal stents Drug-eluting stents Geriatric patients Percutaneous coronary intervention

Multiple ion channel currents and their role in proliferation of human cardiac fibroblasts

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Multiple ion channel currents and their role in proliferatio...

第七届海峡两岸心血管科学研讨会

作者： hung-fat tse Chu-Pak Lau Departments of 1 Medicine and 2Physiology The University of Hong Kong

Objective:Electrophysiology is well established in cardiac contractile myocytes;however,information for ion channels is poorly understood in human cardiac fibroblasts,though cardiac fibroblasts play a crucial role in maintenance of the extra-cellular matrix in the normal heart,and in myocardial remodeling in the injured and failing *** present study was designed to investigate ion channel expression and function of ion channels in cultured human cardiac ***:Whole-cell patch voltage clamp and RT-PCR approaches were employed to determine ion channel expression,and cell proliferation assay was made to study the potential role of these channels in fibroblast ***:It was found that multiple ion channels were heterogeneously expressed in human cardiac *** include a big conductance calcium-activated potassium channel current(BKCa)in most(88%)human cardiac fibroblasts,a delayed rectifier potassium current(IKDR)and a transient outward potassium current(Ito)that is sensitive to 4-aminopyridine in a small population(15 and 14%,respectively)of cells,an inwardly-rectifying potassium current(IKir)in 24%of cells,and a chloride current(ICl)in 7%of *** addition,two types of voltage-gated sodium currents(INa)with distinct properties are present in most human (61%)cardiac *** is a slowly inactivated current,sensitive to tetrodotoxin(TTX)inhibition (***,IC=7.8 nmol/L),and another was a fast inactivated M).RT-PCR revealed current,relatively resistant to TTX(***,IC=1.8 the molecular identities(mRNAs)of these ion channels in human cardiac fibroblasts,including KCa.1.1(for BKCa),Kv1.5(likely responsible for IKDR),Kv4.2(likely responsible for Ito),Kir2.1(for IKir)and ClC2 and ClC3(likely responsible for ICl).NaV1.2,NaV1.3,NaV1.6,NaV1.7 (for ***),and NaV1.5(for ***),The proliferation assay with MTT and H-thymidine incorporation approaches demonstrated that inhibition of BKCa with paxilline or ICl with DID

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Predictive value of red cell distribution width on left atrial thrombus or left atrial spontaneous echo contrast in patients with non-valvular atrial fibrillation

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Journal of Geriatric Cardiology 2018年第6期15卷 408-412页

作者： Xian-Zhang ZHAN Wei-Dong LIN Fang-Zhou LIU Yu-Mei XUE Hong-Tao LIAO Xin LI Xian-Hong FANG Hai DENG Jun HUANG Yang-Qiu LI Jo-Jo HAI hung-fat tse Shu-Lin WU Department of Hematology the First Affiliated Hospital Jinan University Guangzhou China Department of Cardiology Atrial Fibrillation Center Guangdong Cardiovascular Institute Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou China Cardiology Division Department of Medicine Queen Mary Hospital the University of Hong Kong Hong Kong China Division of Cardiology Department of Medicine the University of Hong Kong Shenzhen Hospital Shenzhen China

Objective To evaluate the predictive value of red cell distribution width （RDW） on left atrial thrombus （LAT） or left atrial spontane- ous echo contrast （LASEC） in patients with non-valvular atrial fibrillation （AF）. Methods We reviewed 692 patients who were diagnosed as non-valvular AF and underwent transesophageal echocardiography （TEE） in Guangdong Cardiovascular Institute from April 2014 to December 2015. The baseline clinical characteristics, laboratory test of blood routine, electrocardiograph measurements were analyzed. Results Eighty-four patients were examined with LAT/LASEC under TEE. The mean RDW level was significantly higher in LAT/LASEC patients compared with the non-LAT/LASEC patients （13.59% ± 1.07% ws. 14.34% ± 1.34%; P 〈 0.001）. Receiver-operating characteristic curve analysis was performed and indicated the best RDW cut point was 13.16%. Furthermore, multivariate logistic regression analysis indicated that RDW level 〉 13.16% could be an independent risk factor for LAT/LASEC in patients with AF. Conclusion Elevated RDW level is associated with the presence of LAT/LASEC and could be with moderate predictive value for LAT/LASEC in patients with non-valvular AF.

关键词： Atrial fibrillation Left atrial spontaneous echo contrast Left atrial thrombus Red cell distribution width

Nutrient supplemented serum-free medium increases cardiomyogenesis efficiency of human pluripotent stem cells

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World Journal of Stem Cells 2013年第3期5卷 86-97页

作者： Sherwin Ting Marti Lecina Yau-Chi Chan hung fat tse Shaul Reuveny Steve KW Oh Bioprocessing Technology Institute A*STAR (Agency for Science Technology and Research) Cardiology Division Department of Medicine The University of Hong KongQueen Mary Hospital

AIM: To development of an improved p38 MAPK inhibitor-based serum-free medium for embryoid body cardiomyocyte differentiation of human pluripotent stem cells. METHODS: Human embryonic stem cells (hESC) differentiated to cardiomyocytes (CM) using a p38 MAPK inhibitor (SB203580) based serum-free medium (SB media). Nutrient supplements known to increase cell viability were added to SB medium. The ability of these supplements to improve cardiomyogenesis was evaluated by measurements of cell viability, total cell count, and the expression of cardiac markers via flow cytometry. An improved medium containing Soy hydrolysate (HySoy) and bovine serum albumin (BSA) (SupSB media) was developed and tested on 2 additional cell lines (H1 and Siu-hiPSC). Characterization of the cardiomyocytes was done by immunohistochemistry, electrophysiology and quantitative real-time reverse transcriptionpolymerase chain reaction. RESULTS: hESC cell line, HES-3, differentiating in SB medium for 16 d resulted in a cardiomyocyte yield of 0.07 ± 0.03 CM/hESC. A new medium (SupSB media) was developed with the addition of HySoy and BSA to SB medium. This medium resulted in 2.6 fold increase in cardiomyocyte yield (0.21 ± 0.08 CM/hESC). The robustness of SupSB medium was further demonstrated using two additional pluripotent cell lines (H1, hESC and Siu1, hiPSC), showing a 15 and 9 fold increase in cardiomyocyte yield respectively. The age (passage number) of the pluripotent cells did not affect the cardiomyocyte yields. Embryoid body (EB) cardiomyocytes formed in SupSB medium expressed canonical cardiac markers (sarcomeric α-actinin, myosin heavy chain and troponin-T) and demonstrated all three major phenotypes: nodal-, atrial- and ventricular-like. Electrophysiological characteristics (maximum diastolic potentials and action potential durations) of cardiomyocytes derived from SB and SupSB media were similar. CONCLUSION: The nutrient supplementation (HySoy and BSA) leads to increase in cell viability

关键词： Soy hydrolysate Bovine serum albumin Differentiation Cardiomyocyte Human embryonic stem cells Human induced pluripotent stem cells

Impact of Atrial Fibrillation on Preserved Left Ventricular Systolic Function of Congestive Heart Failure Patients

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Impact of Atrial Fibrillation on Preserved Left Ventricular ...

2012中国中西医结合学会急救医学专业委员会学术年会

作者： ZHAN HONG hung-fat tse JING-MING CAO CHU-PAK LAU Department of Cardiology Kung Ming Medical College Department of Emergency The 1~(st) Affiliated Hospital of Zhong Shan University Division of Cardiology Department of MedicineQueen Mary HospitalThe University of Hong Kong

Objective To explore the prevalence、distribution and prognosis of Atrial fibrillation on preserved left ventricular systolic function of congestive heart failure(CHF) in hospitalized *** We reviewed the medical records of 346 unselected consecutive patients with heart failure,patients were categorized as having either normal left ventricular systolic function or systolic dysfunction based on the results of *** compared the 1 years clinical outcomes(stroke,myocardial infarction,unstable angina and cardiovascular death).Results AF was documented in 105 patients(65%),including 49 patients(30%) at baseline and 56 patients(35%) during subsequent follow-up with preserved left ventricular systolic function of *** occurrence of AF in patients of heart failure with LVEF≧50%was associated with an increase numbers of hospitalization and shorter time interval for readmission for CHF(P<0.05).Conclusion AF occurred in up to 2/3 patients with preserved left ventricular systolic function of *** occurrence of AF did not affect the 1 year outcomes in these patients,but increased their numbers of hospitalization for *** treatment and prevention of AF have important implication in the management of patients with preserved left ventricular systolic function of CHF.

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Proteomic Identification of Calcium-binding Chaperone Calreticulin as a Potential Mediator for The Neuroprotective and Neuritogenic Activities of Botanical Drug Amygdalin

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Proteomic Identification of Calcium-binding Chaperone Calret...

第十四届全国中药和天然药物学术研讨会

作者： Yuanyuan Cheng Chuanbin Yang Jia Zhao hung fat tse Jianhui Rong The University of Hong Kong

＜正＞Amygdalin is a potent botanical glycoside with multiple bioactivities,such as anti-cancers,hypertension and chronic *** is known about the effect of amygdalin on neurogenesis and *** the present study,we initially demonstrated that amygdalin profoundly enhanced nerve growth factor（NGF）-induced neuritogenesis and

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Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease

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World Journal of Gastroenterology 2006年第18期12卷 2923-2927页

作者： William Ng Wai-Man Wong Wai-Hong Chen hung-fat tse Pui-Yin Lee Kam-Chuen Lai Sheung-Wai Li Matthew Ng Kwok-Fai Lam Xi Cheng Chu-Pak Lau Division of Cardiology University Department of Medicine Queen Mary Hospital Hong Kong SAR China Division of Gastroenterology University Department of Medicine Queen Mary Hospital Hong Kong SAR China Division of Rehabilitation Medicine University Department of Medicine Queen Mary Hospital Hong Kong SAR China Department of Statistics and Actuarial Science University of Hong Kong Hong Kong SAR China

AIM： The use of low-dose aspirin to prevent cardiovascular disease events is well established. However, the incidence and predictors of upper gastrointestinal bleeding （UGIB） with its use are unknown. We studied prospectively the incidence and outcome of peptic ulceration in low-dose aspirin users. METHODS： A total of 991 patients with coronary artery disease （CAD） on low-dose aspirin were prospectively followed-up for two years for the occurrence and clinical features of first hospitalized episode of UGIB. RESULTS： UGIB had a bimodal presentation with 45% occurring within four months of aspirin initiation and had an overall prevalence of 1.5% per year. There was no UGIB-related death. Hypertension （OR = 4.6, 95%CI 1.5 - 14.7, P = 0.009）, history of peptic ulceration （OR = 3.1, 95%CI 1.1 - 9.0, P = 0.039）, tertiary education （OR = 3.08, 95%CI 1.1 - 9.0, P = 0.039） and higher lean body mass （P = 0.016） were independent factors associated with UGIB. Use of nitrate did not reduce UGIB. CONCLUSION： The incidence of UGIB in patients with CAD on long-term low-dose aspirin is low, but is accompanied with significant morbidity. With prolonged use of aspirin, UGIB continues to be a problem for those with risk factors and especially in patients with a history of peptic ulcers, in which UGIB tends to occur early after aspirin therapy.

关键词： Coronary artery disease, Aspidn Gastrointestinal bleeding

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健康人运动时诱发的心脏停搏

健康人运动时诱发的心脏停搏

作者： hung-fat tse Chu-Pak Lau 胡清甘肃长庆油田职工医院

阻塞性心脏病变和运动诱发的快速型心律失常是体育运动中致命性和非致命性虚脱的常见原因。然而,运动诱发的心脏停搏(EACA)鲜有报道。本文报道2例无器质性心脏病患者在踏车运动试验中伴发心脏停搏和血液动力学衰竭,旨在探讨EACA与恶性...

阻塞性心脏病变和运动诱发的快速型心律失常是体育运动中致命性和非致命性虚脱的常见原因。然而,运动诱发的心脏停搏(EACA)鲜有报道。本文报道2例无器质性心脏病患者在踏车运动试验中伴发心脏停搏和血液动力学衰竭,旨在探讨EACA与恶性血管迷走神经综合症的关系。病例报告例1,男性,41岁。常规体检做踏车运动试验。尽管罹患过3次腹痛或排尿性晕厥,但并无心脏病的症状。多年来经常打网球。体格检查、静息12导联心电图(ECG)、胸片、常

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不同左心室射血分数老年充血性心力衰竭患者药物治疗的临床研究

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中国危重病急救医学 2006年第4期18卷 210-215页

作者：詹红 tse hung-fat 曹晶茗 Lau Cpu-pak 中山大学第一附属医院急诊科广州510080 香港大学玛丽医院心脏内科昆明医学院第一附属医院心内科

目的探讨充血性心力衰竭(心衰)患者的临床特征和药物治疗情况以及不同左心室射血分数(LVEF)心衰患者的并发症与药物治疗情况。方法连续调查2001年1月—2002年1月香港大学玛丽医院收住60岁以上的老年充血性心衰患者,符合ICD9CM诊断标准,... 详细信息

目的探讨充血性心力衰竭(心衰)患者的临床特征和药物治疗情况以及不同左心室射血分数(LVEF)心衰患者的并发症与药物治疗情况。方法连续调查2001年1月—2002年1月香港大学玛丽医院收住60岁以上的老年充血性心衰患者,符合ICD9CM诊断标准,并用弗明翰研究标准确诊,共计1074例次,收集入院时及入院3d内的超声心动图、心电图、X线胸片等检查结果以及患者出院时转归、出院带药情况。结果1女性充血性心衰患者几乎为男性患者的2倍,年龄≥65岁者占95.5%,≥80岁者占50.6%,按美国纽约心脏协会(NYHA)心功能分级,和级占70.2%,521例(占48.5%)入院治疗1次。2充血性心衰的主要并发症为糖尿病和高血压。3399例次行超声心动图检查者中,208例次(占52.1%)LVEF<0.50,191例次(占47.9%)LVEF≥0.50的患者更倾向于女性,年龄≥80岁,而冠心病及糖尿病较少发生,心房颤动84例次(占44.0%)占多数(P<0.05)。糖尿病、完全性左束支传导阻滞及心肌梗死病史常伴随LVEF<0.50的患者(P<0.05)。4大部分患者均接受利尿剂治疗,LVEF<0.50的患者中使用血管紧张素转换酶抑制剂(ACEI)131例次(占63.0%),地高辛47例次(占22.6%),β受体阻滞剂25例次(占12.0%),钙阻滞剂29例次(占13.9%),而LVEF≥0.50的患者分别有119例次(62.3%)、67例次(35.1%)、18例次(占9.4%)和35例次(占18.3%)使用上述药物,地高辛多用在LVEF≥0.50的患者(P<0.05)。结论1LVEF<0.50与≥0.50的充血性心衰患者单从临床症状和体征上较难区别,目前强调对每个心衰患者尽可能进行早期超声心动图检查,这是区别两类心衰的重要手段。2ACEI、β受体阻滞剂的使用与治疗指南还有一定距离。3尽早地区分LVEF<0.50与≥0.50充血性心衰患者将有利于抗心衰治疗。

关键词：心力衰竭,充血性左心室射血分数诊断药物疗效