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Injectable bone cements:What benefits the combination of calcium phosphates and bioactive glasses could bring?

Bioactive Materials 2023年第1期19卷 217-236页

作者： Öznur demir-Oguz Aldo R.Boccaccini Dagnija Loca Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU Institute of General Chemical EngineeringFaculty of Materials Science and Applied ChemistryRiga Technical UniversityPulka St 3RigaLV-1007Latvia Baltic Biomaterials Centre of Excellence Headquarters at Riga Technical UniversityRigaLatvia Institute of Biomaterials Department of Materials Science and EngineeringUniversity of Erlangen-Nuremberg91058ErlangenGermany

Out of the wide range of calcium phosphate(CaP)biomaterials,calcium phosphate bone cements(CPCs)have attracted increased attention since their discovery in the 1980s due to their valuable properties such as bioactivity,osteoconductivity,injectability,hardening ability through a low-temperature setting reaction and *** numerous researches have been performed to enhance the properties of ***,low mechanical performance of CPCs limits their clinical application in load bearing regions of ***,the in vivo resorption and replacement of CPC with new bone tissue is still controversial,thus further improvements of high clinical importance are *** glasses(BGs)are biocompatible and able to bond to bone,stimulating new bone growth while dissolving over *** the last decades extensive research has been performed analyzing the role of BGs in combination with different ***,the focal point of this review paper is to summarize the available research data on how injectable CPC properties could be improved or affected by the addition of BG as a secondary powder *** was found that despite the variances of setting time and compressive strength results,desirable injectable properties of bone cements can be achieved by the inclusion of BGs into *** published data also revealed that the degradation rate of CPCs is significantly improved by BG ***,the presence of BG in CPCs improves the in vitro osteogenic differentiation and cell response as well as the tissue-material interaction in vivo.

关键词： Calcium phosphate Bioactive glass Injectable bone cements Bone regeneration Calcium phosphate bone cements

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Ranking parameters in urban energy models for various building forms and climates using sensitivity analysis

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建筑模拟(英文) 2023年第9期16卷 1587-1600页

作者： Aysegul demir Dilsiz Kaitlynn Ng Jérôme Kämpf Zoltan Nagy Department of Civil and Architectural Engineering and Construction Management University of WyomingLaramie WYUSA Intelligent Environments Lab Department of CivilArchitectural and Environmental EngineeringThe University of Texas at AustinAustin TXUSA Energy Informatics Group Idiap Research Institute1920 MartignySwitzerland

Urban Building Energy Modelling(UBEM)allows us to simulate buildings’energy performances at a larger ***,creating a reliable urban-scale energy model of new or existing urban areas can be difficult since the model requires overly detailed input data,which is not necessarily publicly *** calibration is a necessary step to reduce the uncertainties and simulation results in order to develop a reliable and accurate *** to the concerns over computational resources and the time needed for calibration,a sensitivity analysis is often required to identify the key parameters with the most substantial impact before the calibration is deployed in ***,we study the sensitivity of uncertain input parameters that affect the annual heating and cooling energy demand by employing an urban-scale energy model,*** goal is to determine the relative influence of each set of input parameters and their interactions on heating and cooling loads for various building forms under different ***,we conduct a global sensitivity analysis for annual cooling and heating consumption under different climate *** upon this,we investigate the changes in input sensitivity to different building forms,focusing on the indices with the largest Total-order ***,we determine First-order indices and Total-order effects of each input parameter included in the urban building energy *** also provide tables,showing the important parameters on the annual cooling and heating demand for each climate and each building *** find that if the desired calibration process require to decrease the number of the inputs to save the computational time and cost,calibrating 5 parameters;temperature set-point,infiltration rate,floor U-value,*** U-value and roof U-value would impact the results over 55%for any climate and any building form.

关键词： global sensitivity analysis Sobol’method urban energy modeling building stocks energy modelling parameter screening Sobol’indices sustainable urban planning

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Mucosa-associated microbiota alterations in primary sclerosing cholangitis(PSC)before and after liver transplantation-who is calling the shots?

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 795-797页

作者： Münevver demir Michael Sigal Department of Hepatology and Gastroenterology Campus Virchow-Klinikum and Campus CharitéMitteCharitéUniversitätsmedizin BerlinBerlinGermany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular MedicineBerlinGermany

Primary sclerosing cholangitis(PSC)is an immune-related chronic cholangiopathy associated with high rates of progression to liver cirrhosis and the need for liver *** PSC is frequently associated with inflammatory bowel disease(IBD),several studies have investigated the role of the gut-liver axis in PSC and emerging evidence indicates that gut and bile microbiota are associated with the onset and progression of PSC[reviewed in(1)].

关键词： Primary sclerosing cholangitis(PSC) liver transplantation Klebsiella microbiota mucosal microbiota

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Developments in 4D-printing:a review on current smart materials,technologies,and applications

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International Journal of Smart and Nano Materials 2019年第3期10卷 205-224页

作者： Zhizhou Zhang Kahraman G.demir Grace X.Gu Department of Mechanical Engineering University of CaliforniaBerkeleyCAUSA

Recent advances in additive manufacturing(AM),commonly known as three-dimensional(3D)-printing,have allowed researchers to create complex shapes previously impossible using traditional fabrication methods.A research branch that originated from 3D-printing called four-dimensional(4D)-printing involves printing with smart materials that can respond to external stimuli.4Dprinting permits the creation of on-demand dynamically controllable shapes by integrating the dimension of *** achievements in synthetic smart materials,novel printers,deformation mechanism,and mathematical modeling have greatly expanded the feasibility of *** this paper,progress in the 4Dprinting field is reviewed with a focus on its practical *** discuss smart materials developed using 4D-printing with explanations of their morphing ***,case studies are presented on self-constructing structures,medical devices,and soft *** conclude with challenges and future opportunities in the field of 4D-printing.

关键词： 3D-printing 4D-printing smart materials multifunctional soft robotics

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Prognostic significance of primary tumor localization in stage Ⅱ and Ⅲ colon cancer

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World Journal of Gastrointestinal Oncology 2018年第11期10卷 410-420页

作者： Abdullah Sakin Serdar Arici Saban Secmeler Orcun Can Caglayan Geredeli Nurgul Yasar Cumhur demir Osman Gokhan demir Sener Cihan Department of Medical Oncology Yuzuncu Yil University Medical SchoolVan 65090Turkey Department of Medical Oncology University of Health SciencesOkmeydani Training and Research HospitalIstanbul 34384Turkey Department of Medical Oncology Aciadem UniversityIstanbul 34396Turkey

AIM To investigate the effects of tumor localization on disease free survival(DFS) and overall survival(OS) in patients with stage Ⅱ-Ⅲ colon *** This retrospective study included 942 patients with stage Ⅱ and Ⅲ colon cancer, which were followed up in our clinics between 1995 and 2017. The tumors from the caecum to splenic flexure were defined as right colon cancer(RCC) and those from splenic flexure to the sigmoid colon as left colon cancer(LCC).RESULTS The median age of the patients was 58 years(range: 19-94 years). Male patients constituted 54.2%. The rates of RCC and LCC were 48.4%(n = 456) and 51.6%(n = 486), respectively. During the median follow-up of 90 mo(range: 6-252 mo), 14.6% of patients developed recurrence and 9.1% of patients died. In patients with stage Ⅱ and Ⅲ disease with or without adjuvant therapy, DFS was similar in terms of primary tumor localization(stage Ⅱ; P = 0.547 and P = 0.481, respectively; stage Ⅲ; P = 0.976 and P = 0.978, respectively). In patients with stage Ⅱ and Ⅲ disease with or without adjuvant therapy, OS was not statistically significant with respect to primary tumor localization(stage Ⅱ; P = 0.381 and P = 0.947, respectively; stage Ⅲ; P = 0.378 and P = 0.904, respectively). The difference between median OS of recurrent RCC(26 ± 6.2 mo) and LCC(34 ± 4.9 mo) cases was eight months(P = 0.092).CONCLUSION Our study showed no association of tumor localization with either DFS or OS in patients with stage Ⅱ or Ⅲ colon cancer managed with or without adjuvant therapy. However, post-recurrence OS appeared to be worse in RCC patients.

关键词： Colon cancer Tumor localization Adjuvant treatment Overall survival Disease free survival

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All-optical control of exciton flow in a colloidal quantum well complex

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Light(Science & Applications) 2020年第1期9卷 1749-1756页

作者： Junhong Yu Manoj Sharma Ashma Sharma Savas Delikanli Hilmi Volkan demir Cuong Dang LUMINOUS Centre of Excellence for Semiconductor Lighting and DisplaysSchool of Electrical and Electronic EngineeringThe Photonics Institute(TPI)Nanyang Technological University50 Nanyang Avenue639798 SingaporeSingapore Department of Electrical and Electronics Engineering and Department of Physics UNAM-Institute of Materials Science and NanotechnologyBilkent UniversityBilkent06800 AnkaraTurkey School of Physical and Mathematical Sciences Division of Physics and Applied PhysicsNanyang Technological University639798 SingaporeSingapore CINTRA UMI CNRS/NTU/THALES 3288 Research Techno Plaza50 Nanyang DriveBorder X BlockLevel 6637553 SingaporeSingapore

Excitonics,an alternative to romising for processing information since semiconductor electronics is rapidly approaching the end of Moore’s ***,the development of excitonic devices,where exciton flow is controlled,is mainly focused on electric-field modulation or exciton polaritons in high-Q ***,we show an alloptical strategy to manipulate the exciton flow in a binary colloidal quantum well complex through mediation of the Förster resonance energy transfer(FRET)by stimulated *** the spontaneous emission regime,FRET naturally occurs between a donor and an *** contrast,upon stronger excitation,the ultrafast consumption of excitons by stimulated emission effectively engineers the excitonic flow from the donors to the ***,the acceptors’stimulated emission significantly accelerates the exciton flow,while the donors’stimulated emission almost stops this *** this basis,a FRET-coupled rate equation model is derived to understand the controllable exciton flow using the density of the excited donors and the unexcited *** results will provide an effective alloptical route for realizing excitonic devices under room temperature operation.

关键词： process flow quantum

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Estimating the Properties of Ground-Waste-Brick Mortars Using DNN and ANN

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Computer Modeling in Engineering & Sciences 2019年第1期118卷 207-228页

作者： Abdulkadir Karaci Hasbi Yaprak Osman Ozkaraca Ilhami demir Osman Simsek Department of Computer Engineering Kastamonu UniversityKastamonuTurkey Department of Civil Engineering Kastamonu UniversityKastamonuTurkey Department of Information Systems Engineering Mugla Sitki Kocman UniversityTurkey Department of Civil Engineering Kirikkale UniversityKirikkaleTurkey Department of Civil Engineering Gazi UniversityAnkaraTurkey.

In this study,deep-neural-network(DNN)-and artificial-neural-network(ANN)-based models along with regression models have been developed to estimate the pressure,bending and elongation values of ground-brick(GB)-added mortar *** study is aimed at utilizing GB as a mineral additive in concrete in the ratios 0.0%,2.5%,5.0%,7.5%,10.0%,12.5%and 15.0%.In this study,756 mortar samples were produced for 84 different series and were cured in tap water(W),5%sodium sulphate solution(SS5)and 5%ammonium nitrate solution(AN5)for 7 days,28 days,90 days and 180 *** developed DNN models have three inputs and two hidden layers with 20 neurons and one output,whereas the ANN models have three inputs,one output and one hidden layer with 15 ***-five previously obtained experimental sample datasets were used to train these developed models and to generate the regression ***-nine non-training-attributed datasets were used to test the *** these test values were attributed to the trained DNN,ANN and regression models,the brick-dust pressure as well as the bending and elongation values have been observed to be very close to the experimental *** only a small fraction(30%)of the experimental data were used for training,both the models performed the estimation process at a level that was in accordance with the opinions of *** fact that this success has been achieved using very little training data shows that the models have been appropriately *** addition,the DNN models exhibited better performance as compared with that exhibited by the ANN *** regression model is a model whose performance is worst and unacceptable;further,the prediction error is observed to be considerably *** conclusion,ANN-and DNN-based models are practical and effective to estimate these values.

关键词： Deep neural network artificial neural networks ground-brick pressure,bending elongation

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The effect of α-blocker therapy on erectile functions in patients with lower urinary tract symptoms due to benign prostate hyperplasia

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Asian Journal of Andrology 2009年第6期11卷 716-722页

作者： Omer demir Ismail Ozdemir Ozan Bozkurt Guven Asian Ahmet Adil Esen Dokuz Eylul University Medical School Department of Urology Inciralti Izmir 35340 Turkey

In this study we aimed to evaluate the impact of doxazosin treatment on erectile functions in patients with lower urinary tract symptoms （LUTS） and having erectile dysfunction （ED） at baseline. Fifty-three patients with LUTS （IPSS score 〉 7） whose maximum flow rate （Qmax）〈 15 mL s-1 and PSA 〈 4 ng dL^-1 were enrolled in the study. Patients received doxazosin 4 nag once daily for 6 weeks. Subjective efficacy was assessed by IPSS, IPSS- Quality of Life （IPSS-QoL） for LUTS and efficacy was assessed by International Index of Erectile Function （IIEF） for erectile functions at baseline and sixth weeks. The objective efficacy was assessed by Q The patients were classified according to their self reported erectile status： group I had ED and group II did not have ED. At the endpoint, doxazosin significantly improved the total IPSS score （-7.7 ±6.1, P = 0.006）, IPSS-QoL score （-1.5 ± 1.5, P = 0.024） and Qmax （3.2 ± 4.6 mL s^-1, P = 0.002） over baseline. Mean decrease in IPSS and IPSS-QoL scores after the treatment period were 6.9 ＋ 6.4 （P 〈 0.001） and 0.95 4- 1.80 （P 〈 0.05） in group I, whereas 8.2 4- 5.8 （P 〈 0.001） and 1.9 4- 1.1 in group IX （P 〈 0.001）, respectively. Mean changes of Qmax values were 2.3 4- 3.3 mL s^-1 in group I （P 〈 0.05） and 3.7 4- 5.3 mL s-1 in group II （P 〈 0.001）. The improvement of IIEF-EF scores after the treatment period was only significant for group I. The efficacy of a-blocker therapy for LUTS was better by means of symptomatic relief for patients who did not have ED when compared with patients who had ED at baseline. However, slight improvement in erectile functions with a-blocker therapy was only seen in LUTS patients with ED.

关键词： benign prostate hyperplasia doxazosinlerectile dysfunction lower urinary tract symptoms treatment outcome

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Effect of thulium substitution on conductivity and dielectric belongings of nanospinel cobalt ferrite

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Journal of Rare Earths 2020年第10期38卷 1103-1113,I0003页

作者： B.Unal M.A Almessiere A.demir Korkmaz Y.Slimani A.Baykale Institute of Forensic Sciences and Legal Medicine Istanbul University-CerrahpasaBuyukcekmece CampusAlkent 2000BuyukcekmeceIstanbul 34500Turkey Department of Biophysics.Institute for Research&Medical Consultations(IRMC) Imam Abdulrahman Bin Faisal UniversityP.O.Box 198231441DammamSaudi Arabia Department of Physics College of ScienceImam Abdulrahman Bin Faisal UniversityP.O.Box 198231441DammamSaudi Arabia Department of Chemistry Istanbul Medeniyet University34700 IstanbulUskudarTurkey Department of Nano-Medicine Research Institute for Research&Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityP.O.Box 198231441 DammamSaudi Arabia

The CoTmx Fe2-x O4(x≤0.1) NPs were synthesized sonochemically.X-ray powder diffraction patterns and TEM images of the samples prove their chemical purity and cubic structure-morphology,*** substitution ratio of thulium ions to cobalt ferrites have an important effect on the characteristic evaluation of both electrical and dielectric characteristic measured at frequencies up to 3.0 MHz between room temperature and 120℃.Since the thulium substitution has a very strong effect on the characteristic evaluation of both electrical and dielectric properties of cobalt-ferrite samples,four substitutio nal ranges-none,small,medium and high were determined for the interpretation of contribution of thulium ratio to ac/dc conductivity,dielectric constant,dielectric loss and tangent *** increases with the incremental frequencies,in general depending on a variety of tendencies of both temperature and substitutional Tm ratios while the activation energy varies with a high dependency to the regional level of Tm substitution in Co-ferrites *** Arrhenius graph appears to provide us with a single activation energy much higher than 400 meV for x=0.02,which can be attributed to electron hopping mechanisms,apart from other substituted spinel ferrites.

关键词： Spinel ferrites Dielectric properties Conductivity CoFe2O4 Tm3+substitution Rare earths

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A bibliometric analysis of academic publication on diabetic retinopathy disease trends during 1980-2014:a global and medical view

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1663-1668页

作者： Cagatay Caglar Emre demir Ferit Kerim Kucukler Mustafa Durmus Department of Ophthalmology Faculty of MedicineHitit University Department of Biostatistic Faculty of MedicineHitit University Department of Endocrinology Faculty of MedicineHitit University

AIM： To investigate diabetic retinopathy（DR） literature using the Institute for Scientific Information（ISI） Web of Science（Wo S） database and to analyse the correlation results between socio-economic development datas and number of DR ***： The statistical analysis of the documents published during 1980-2014 was analysed. The data of this study were based on the database of Wo S. ＂Diabetic retinopathy＂ was used as the keywords to search the Wo S ***： The United States ranked first in the DR research with 1840 publications and 24.38% of the world production followed by England and Japan. Besides, the most productive country was Iceland. A high correlation was found between number of publications and 2014 gross domestic product（ GDP） values of 81 countries（r =0.800, P 〈0.001）. We found a significant correlation between number of publications and Human Development Index（HDI）（r =0.645, P =0.001）. There is a moderate correlation between people with diabetes and number of DR publications for 81 countries（r =0.514, P 〈0.01）. It could be analysed that estimated publication number with DR title will be 445 according to the regression curve constituted with cubic model in 2015（R2=1.000）.CONCLUSION： More DR studies have been published in developed countries, DR and other complications of diabetes have gradually increased in developing countries over recent decades. It can be expected that the number of DR studies will gradually increase in developing countries.

关键词： bibliometrics correlation analysis developingcountries diabetic retinopathy socio-economic development

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