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MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B

Acta Pharmaceutica Sinica B 2022年第5期12卷 2374-2390页

作者： Yuhong Zhang Yanqing Ding Min Li Jing Yuan Youhui Yu Xueying Bi huiqi hong Jiantao Ye Peiqing Liu Department of Pharmacology and Toxicology School of Pharmaceutical SciencesNational and Local United Engineering Lab of Druggability and New Drugs EvaluationSun Yat-sen UniversityGuangzhou 510006China State Key Laboratory of Oncology in Southern China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510006China

Pathological cardiac hypertrophy serves as a significant foundation for cardiac dysfunction and heart failure. Recently, growing evidence has revealed that microRNAs(miRNAs) play multiple roles in biological processes and participate in cardiovascular diseases. In the present research, we investigate the impact of miRNA-34 c-5 p on cardiac hypertrophy and the mechanism involved. The expression of miR-34 c-5 p was proved to be elevated in heart tissues from isoprenaline(ISO)-infused mice. ISO also promoted miR-34 c-5 p level in primary cultures of neonatal rat cardiomyocytes(NRCMs). Transfection with miR-34 c-5 p mimic enhanced cell surface area and expression levels of foetal-type genes atrial natriuretic factor(Anf) and β-myosin heavy chain(β-Mhc) in NRCMs. In contrast, treatment with miR-34 c-5 p inhibitor attenuated ISO-induced hypertrophic responses. Enforced expression of miR-34 c-5 p by tail intravenous injection of its agomir led to cardiac dysfunction and hypertrophy in mice, whereas inhibiting miR-34 c-5 p by specific antagomir could protect the animals against ISO-triggered hypertrophic abnormalities. Mechanistically, miR-34 c-5 p suppressed autophagic flux in cardiomyocytes, which contributed to the development of hypertrophy. Furthermore, the autophagy-related gene 4 B(ATG4 B) was identified as a direct target of miR-34 c-5 p, and miR-34 c-5 p was certified to interact with 3’untranslated region of Atg4 b mRNA by dual-luciferase reporter assay. miR-34 c-5 p reduced the expression of ATG4 B, thereby resulting in decreased autophagy activity and induction of hypertrophy. Inhibition of miR-34 c-5 p abolished the detrimental effects of ISO by restoring ATG4 B and increasing autophagy. In conclusion, our findings illuminate that miR-34 c-5 p participates in ISO-induced cardiac hypertrophy, at least partly through suppressing ATG4 B and autophagy. It suggests that regulation of miR-34 c-5 p may offer a new way for handling hypertrophy-related cardiac dysfuncti

关键词： Pathological cardiac hypertrophy Isoprenaline miR-34c-5p ATG4B LC3 Autophagy Autophagic flux Neonatal rat cardiomyocytes Mice

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Advancing mid-infrared microdisk laser emission with Tm:YAG

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 91-96页

作者： Zhaocong Wang huiqi Li Lei Wang Yang Tan Feng Chen School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China

Mid-infrared microcavity lasers have important applications in biosensing,mid-infrared spectroscopy,and environmental ***,the low output power of existing mid-infrared microcavity lasers hinders their practical *** drawback is attributed to the insufficient laser gain medium,which limits the development of mid-infrared whispering-gallerymode(WGM)*** address this issue,we have employed ion implantation-enhanced etching to fabricate Tm:YAG thin films as effective gain media for mid-infrared WGM *** Tm:YAG thin film,with a thickness of 2μm,exhibits excellent fluorescence ***,the Tm:YAG thin film is processed using focused ion beam to form microdisks with a diameter of 30μ*** 785 nm laser pumping,the maximum output power of the Tm:YAG microdisk at 2023.1 nm is229μW,with a slope efficiency of 2.9%.This work demonstrates the outstanding potential of Tm:YAG as a mid-infrared laser gain medium,providing a new option for the development of mid-infrared lasers.

关键词： microdisk microlaser ultrathin film

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MSADCN:Multi-Scale Attentional Densely Connected Network for Automated Bone Age Assessment

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Computers, Materials & Continua 2024年第2期78卷 2225-2243页

作者： Yanjun Yu Lei Yu huiqi Wang Haodong Zheng Yi Deng College of Computer and Information Science Chongqing Normal UniversityChongqing401331China College of Mathematics and Statistics Chongqing UniversityChongqing401331China

Bone age assessment(BAA)helps doctors determine how a child’s bones grow and develop in clinical *** BAA methods rely on clinician expertise,leading to time-consuming predictions and inaccurate *** deep learning-based BAA methods feed the extracted critical points of images into the network by providing additional *** operation is costly and *** address these problems,we propose a multi-scale attentional densely connected network(MSADCN)in this *** constructs a multi-scale dense connectivity mechanism,which can avoid overfitting,obtain the local features effectively and prevent gradient vanishing even in limited training ***,MSADCN designs multi-scale structures in the densely connected network to extract fine-grained features at different ***,coordinate attention is embedded to focus on critical features and automatically locate the regions of interest(ROI)without additional *** addition,to improve the model’s generalization,transfer learning is applied to train the proposed MSADCN on the public dataset IMDB-WIKI,and the obtained pre-trained weights are loaded onto the Radiological Society of North America(RSNA)***,label distribution learning(LDL)and expectation regression techniques are introduced into our model to exploit the correlation between hand bone images of different ages,which can obtain stable age *** experiments confirm that our model can converge more efficiently and obtain a mean absolute error(MAE)of 4.64 months,outperforming some state-of-the-art BAA methods.

关键词： Bone age assessment deep learning attentional densely connected network muti-scale

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A Modified CycleGAN for Multi-Organ Ultrasound Image Enhancement via Unpaired Pre-Training

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Journal of Beijing Institute of Technology 2024年第3期33卷 194-203页

作者： Haonan Han Bingyu Yang Weihang Zhang Dongwei Li huiqi Li School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China School of Medical Technology Beijing Institute of TechnologyBeijing 100081China

Handheld ultrasound devices are known for their portability and affordability,making them widely utilized in underdeveloped areas and community healthcare for rapid diagnosis and early ***,the image quality of handheld ultrasound devices is not always satisfactory due to the limited equipment size,which hinders accurate diagnoses by *** the same time,paired ultrasound images are difficult to obtain from the clinic because imaging process is ***,we propose a modified cycle generative adversarial network(cycleGAN) for ultrasound image enhancement from multiple organs via unpaired *** introduce an ultrasound image pre-training method that does not require paired images,alleviating the requirement for large-scale paired *** also propose an enhanced block with different structures in the pre-training and fine-tuning phases,which can help achieve the goals of different training *** improve the robustness of the model,we add Gaussian noise to the training images as data *** approach is effective in obtaining the best quantitative evaluation results using a small number of parameters and less training costs to improve the quality of handheld ultrasound devices.

关键词： ultrasound image enhancement handheld devices unpaired images pre-train and finetune cycleGAN

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A Deformable Network with Attention Mechanism for Retinal Vessel Segmentation

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Journal of Beijing Institute of Technology 2024年第3期33卷 186-193页

作者： Xiaolong Zhu Wenjian Li Weihang Zhang Dongwei Li huiqi Li School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China

The intensive application of deep learning in medical image processing has facilitated the advancement of automatic retinal vessel segmentation *** overcome the limitation that traditional U-shaped vessel segmentation networks fail to extract features in fundus image sufficiently,we propose a novel network(DSeU-net)based on deformable convolution and squeeze excitation residual *** deformable convolution is utilized to dynamically adjust the receptive field for the feature extraction of retinal *** the squeeze excitation residual module is used to scale the weights of the low-level features so that the network learns the complex relationships of the different feature layers *** validate the DSeU-net on three public retinal vessel segmentation datasets including DRIVE,CHASEDB1,and STARE,and the experimental results demonstrate the satisfactory segmentation performance of the network.

关键词： retinal vessel segmentation deformable convolution attention mechanism deep learning

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Interpretability of Neural Networks Based on Game-theoretic Interactions

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Machine Intelligence Research 2024年第4期21卷 718-739页

作者： Huilin Zhou Jie Ren huiqi Deng Xu Cheng Jinpeng Zhang Quanshi Zhang School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China XLAB The Second Academy of China Aerospace Science and Industry CorporationBeijing 100854China

This paper introduces the system of game-theoretic interactions,which connects both the explanation of knowledge encoded in a deep neural networks(DNN)and the explanation of the representation power of a *** this system,we define two gametheoretic interaction indexes,namely the multi-order interaction and the multivariate *** crucially,we use these interaction indexes to explain feature representations encoded in a DNN from the following four aspects:(1)Quantifying knowledge concepts encoded by a DNN;(2)Exploring how a DNN encodes visual concepts,and extracting prototypical concepts encoded in the DNN;(3)Learning optimal baseline values for the Shapley value,and providing a unified perspective to compare fourteen different attribution methods;(4)Theoretically explaining the representation bottleneck of ***,we prove the relationship between the interaction encoded in a DNN and the representation power of a DNN(e.g.,generalization power,adversarial transferability,and adversarial robustness).In this way,game-theoretic interactions successfully bridge the gap between“the explanation of knowledge concepts encoded in a DNN”and"the explanation of the representation capacity of a DNN"as a unified explanation.

关键词： Model interpretability and transparency explainable AI game theory interaction deep learning.

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Mesenchymal stem cell-derived exosomes: Versatile nanomaterials for skin wound treatment

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Nano Research 2024年第4期17卷 2836-2856页

作者： Yuzhen Xiao Hexi Li Junhui Zhang Songyun Yang Chunsen Zhang Yizhou Huang Xin Tang huiqi Xie Department of Orthopedic Surgery and Orthopedic Research Institute Laboratory of Stem Cell and Tissue EngineeringState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China School of Basic Medical Sciences and Forensic Medicine Sichuan UniversityChengdu 610041China West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610041China Sports Medicine Center West China HospitalSichuan UniversityChengdu 610041China

Accumulating studies reveal that mesenchymal stem cells(MSCs)promote skin wound healing mainly through the paracrine ***,one of the crucial paracrine mediators in wound healing,are cell-derived nanosized membranous vesicles containing diverse bioactive *** the potent ability of modulating skin cell behaviors,MSC-derived exosomes(MSC-Exos)are regarded as a promising nanomaterial for regenerative wound *** hostile conditions,MSC-Exos are efficient in protecting skin cells from severe damage and restoring their *** to recent studies,MSC-Exos possess remarkable pro-healing effects in a variety of skin wounds,typically resulting in increased wound closure,inhibited scar tissue formation,and better restoration of skin *** further enhance the therapeutic potential of MSC-Exos,the development of applicable pretreatment strategies and the optimization of exosome delivery are under intensive ***,we summarize current research progress of MSC-Exos for skin wound treatment,with an emphasis on the biological effects of these nanovesicles,the repair mechanisms,and future challenges in clinical translation.

关键词： exosomes mesenchymal stem cells diabetic wounds burn wounds scar wound healing

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Intelligent Recognition Using Ultralight Multifunctional Nano‑Layered Carbon Aerogel Sensors with Human‑Like Tactile Perception

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Nano-Micro Letters 2024年第1期16卷 172-186页

作者： huiqi Zhao Yizheng Zhang Lei Han Weiqi Qian Jiabin Wang Heting Wu Jingchen Li Yuan Dai Zhengyou Zhang Chris RBowen Ya Yang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro‑Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400People’s Republic of China Tencent Robotics X Shenzhen 518054People’s Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Department of Mechanical Engineering University of BathBath BA27AKUK Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004People’s Republic of China

Humans can perceive our complex world through multi-sensory *** limited visual conditions,people can sense a variety of tactile signals to identify objects accurately and ***,replicating this unique capability in robots remains a significant ***,we present a new form of ultralight multifunctional tactile nano-layered carbon aerogel sensor that provides pressure,temperature,material recognition and 3D location capabilities,which is combined with multimodal supervised learning algorithms for object *** sensor exhibits human-like pressure(0.04–100 kPa)and temperature(21.5–66.2℃)detection,millisecond response times(11 ms),a pressure sensitivity of 92.22 kPa^(−1)and triboelectric durability of over 6000 *** devised algorithm has universality and can accommodate a range of application *** tactile system can identify common foods in a kitchen scene with 94.63%accuracy and explore the topographic and geomorphic features of a Mars scene with 100%*** sensing approach empowers robots with versatile tactile perception to advance future society toward heightened sensing,recognition and intelligence.

关键词： Multifunctional sensor Tactile perception Multimodal machine learning algorithms Universal tactile system Intelligent object recognition

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The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1participates in isoproterenol-induced cardiac hypertrophy

The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1partici...

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第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： Lu Jing Zhang Renwei hong huiqi Yang Zuolong Sun Duanping Sun Shuya Guo Xiaolei Ye Jiantao Li Zhuoming Liu Peiqing

The Forkhead box-containing protein,O subfamily 3(FoxO3) transcription factor negatively regulates myocardial hypertrophy,and its transcriptional activity is finely conditioned by diverse posttranslational modifications,such as phosphorylation,acetylation,ubiquitination,methylation and ***,we introduce a novel modification of the FoxO3 protein in cardiomyocytes:poly(ADP-ribosyl)ation(PARylation) mediated by poly(ADP-ribose) polymerase-1(PARP1).This

关键词： ADP-ribosyl)ation of FoxO3 mediated by PARP1participates in isoproterenol-induced cardiac hypertrophy The poly

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W-band CMOS beamforming ICs and integrated phased-array antennas with 20+ Gb/s data rates

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Science China(Information Sciences) 2024年第11期67卷 300-316页

作者： Dixian ZHAO Peigen YU Shan JIANG Weihan GAO Pingyang HE huiqi LIU School of Information Science and Engineering Southeast University Purple Mountain Laboratories Chengdu Xphased Technology Co. Ltd.

This article presents the design and implementation of W-band transmitter(TX) and receiver(RX) phased-array antennas, which leverage CMOS and printed circuit board(PCB) technologies to integrate the phased-array antennas with eight-channel beamforming ICs. The beamforming IC applies the variable gain amplifier(VGA) with fractional bits and the vector-modulated variable gain phase shifter(VGPS) for wide range and high precision of gain and phase shifting, providing moderate power gain. The phased-array board consists of 384 TX and 384 RX antenna elements, along with 48 TX and 48 RX beamforming *** also incorporates Wilkinson power dividers/combiners, a power management system, and a beamforming control module, all integrated into a cost-effective multi-layer PCB. Fabricated in 65-nm bulk CMOS, the IC achieves 3° RMS phase error for phase shifting and 0.5 d B RMS gain error for gain shifting, ensuring high precision of antenna pointing. The over-the-air(OTA) measurement of the proposed W-band phased-array antennas achieves a 64-QAM constellation with a symbol rate of 3.5 GS/s, resulting in raw data rates of21 Gb/s.

关键词： W-band phased array CMOS Gigabit wireless link antenna on PCB

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