The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1participates in isoproterenol-induced cardiac hypertrophy

作     者：Lu Jing Zhang Renwei Hong Huiqi Yang Zuolong Sun Duanping Sun Shuya Guo Xiaolei Ye Jiantao Li Zhuoming Liu Peiqing 

会议名称：《第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会》

会议日期：1000年

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

关 键 词：ADP-ribosyl)ation of FoxO3 mediated by PARP1participates in isoproterenol-induced cardiac hypertrophy The poly 

摘      要：The Forkhead box-containing protein,O subfamily 3(FoxO3) transcription factor negatively regulates myocardial hypertrophy,and its transcriptional activity is finely conditioned by diverse posttranslational modifications,such as phosphorylation,acetylation,ubiquitination,methylation and ***,we introduce a novel modification of the FoxO3 protein in cardiomyocytes:poly(ADP-ribosyl)ation(PARylation) mediated by poly(ADP-ribose) polymerase-1(PARP1).This